DGIdb - ACE Gene Record

ACE 1636 Druggable Genome

Alternate Names:

1636
ANGIOTENSIN I CONVERTING ENZYME
ACE
ACE1
CD143
DCP
DCP1
106180
2707
ENSG00000159640
ENSG00000264813
OTTHUMG00000154927
OTTHUMG00000178900
P12821
ACE_HUMAN
CD_antigen=CD143
Angiotensin-converting enzyme
Angiotensin-converting enzyme, soluble form
Dipeptidyl carboxypeptidase I
Kininase II
PA139
ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM PRECURSOR (EC 3.4.15.1) (ACE) (DIPEPTIDYL CARBOXYPEPTIDASE I) (KININASE II) (CD143 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P12821]
P01019
ENSG00000135744
ANGT_HUMAN
183

T82577
AC113554.1
ICH
MVCD3

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.4.15
Target Class	Other
Target Subclass	3.4.15
Transmembrane Helix Count	1
Target Main Class	Enzymes
Human Readable Name	DRUGGABLE GENOME
Target Subclass	Ligand
Target Subclass	Hormone
Target Main Class	Other
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

NEUTRAL ZINC METALLOPEPTIDASE
PROTEASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
ENZYME

Publications:

Dumoulin et al., 2001, Comparison of a vasopeptidase inhibitor with neutral endopeptidase and angiotensin-converting enzyme inhibitors on bradykinin metabolism in the rat coronary bed., J. Cardiovasc. Pharmacol.
Kostova et al., 2005, Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats., Bratisl Lek Listy
Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
Cicoira M et al., 2004, Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure., Am J Med
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Azhar et al., 2005, Colorimetric determination of indolic drugs., Pak J Pharm Sci
Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
Edling et al., 1995, Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril., J. Pharmacol. Exp. Ther.
Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
Chrysant et al., 2004, Pharmacological and clinical profile of moexipril: a concise review., J Clin Pharmacol
Eisenhardt A et al., 2003, ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction., Urology
He H et al., 2005, A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril., Ann Hum Biol
Kohno M et al., 1999, Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors., Am J Med
Penno G et al., 1998, Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinopril in IDDM., Diabetes
Zee RY et al., 1998, Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis., Hypertension
Ohmichi N et al., 1997, Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype., Am J Hypertens
Sasaki M et al., 1996, Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies., J Hypertens
Rudnicki M et al., 2009, Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease., Pharmacogenomics
Arnett DK et al., 2005, Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study., Circulation
Yu Y et al., 2005, Associations of baseline blood pressure levels and efficacy of Benazepril treatment with interaction of alpha-adducin and ACE gene polymorphisms in hypertensives., Clin Exp Hypertens
Takahashi T et al., 2001, The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage., Respir Med
Ha SK et al., 2000, ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus., Nephrol Dial Transplant
Stavroulakis GA et al., 2000, Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism., Cardiovasc Drugs Ther
Piepho, 2000, Overview of the angiotensin-converting-enzyme inhibitors., Am J Health Syst Pharm
Sharma et al., 1999, The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group., Am J Ther
Ondetti, 1988, Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity., Circulation
Hu et al., 1996, Effect of chronic captopril treatment on circulating and tissue renin-angiotensin system in SHR rats., Zhongguo Yao Li Xue Bao
Davis et al., 1996, Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors., Br. J. Pharmacol.
Kiowski et al., 1982, Antihypertensive and renal effects of captopril in relation to renin activity and bradykinin-induced vasodilation., Clin. Pharmacol. Ther.
Suzuki et al., 1981, Converting enzyme inhibition and modulation of plasma renin activity with captopril in anesthetized rats., Arch Int Pharmacodyn Ther
Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.
Dietze et al., 1987, [Captopril in hypertensive patients with type II diabetes mellitus]., Herz
Kumakura et al., 1987, Role of bradykinin generating and degrading systems in the vascular permeability response induced with kaolin in rats., J. Pharmacol. Exp. Ther.
Metting et al., 1987, Enzymatic formation of angiotensins II and III in the hindlimb circulation of dogs., Can. J. Physiol. Pharmacol.
Regoli et al., 1986, Conversion of kinins and their antagonists into B1 receptor activators and blockers in isolated vessels., Eur. J. Pharmacol.
Kumakura et al., 1988, Role of bradykinin in the vascular permeability response induced by carrageenin in rats., Br. J. Pharmacol.
Marumo et al., 1987, Mechanisms for the inhibition of vasopressin-stimulated water flow by captopril in the toad bladder., Pharmacology
Morinelli et al., 2002, Utilization of a radioimmunoassay to detect the generation of Arg-Pro-Pro-Gly-Phe, a stable endproduct of bradykinin metabolism (from cultured rat aortic smooth muscle cells exposed to bradykinin)., Int. Immunopharmacol.
Todorov et al., 2003, Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes., FASEB J.
O'Toole L et al., 1998, Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure., J Cardiovasc Pharmacol
Jacobsen P et al., 1998, Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy., Kidney Int
Mizuiri S et al., 1997, Renal hemodynamic changes induced by captopril and angiotensin-converting enzyme gene polymorphism., Nephron
Ferreira de Oliveira F et al., 2016, Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease., Colomb Med (Cali)
Felehgari V et al., 2011, ACE gene polymorphism and serum ACE activity in Iranians type II diabetic patients with macroalbuminuria., Mol Cell Biochem
Volkan-Salanci B et al., 2009, Impact of renin-angiotensin system polymorphisms on renal haemodynamic responsiveness to acute angiotensin-converting enzyme inhibition in type 2 diabetes mellitus., J Renin Angiotensin Aldosterone Syst
Dalkas et al., 2010, Study of a lipophilic captopril analogue binding to angiotensin I converting enzyme., J. Pept. Sci.
Andújar-Sánchez et al., 2007, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method., FEBS Lett.
Natesh et al., 2004, Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme., Biochemistry
Tzakos et al., 2006, The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme., Bioorg. Med. Chem. Lett.
Arend et al., 2002, [Influence of ACE inhibitor spirapril on left ventricular hypertrophy]., Fortschr Med Orig
Hermida et al., 2010, Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension., Chronobiol. Int.
Maul et al., 2005, Central angiotensin II controls alcohol consumption via its AT1 receptor., FASEB J.
Levitt et al., 2006, Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat., BMC Clin Pharmacol
Téllez-Sanz et al., 1998, Calorimetric analysis of lisinopril binding to angiotensin I-converting enzyme., FEBS Lett.
Potaczek DP et al., 2005, The angiotensin-converting enzyme gene insertion/deletion polymorphism and effects of quinapril and atorvastatin on haemostatic parameters in patients with coronary artery disease., Thromb Haemost
Klutchko et al., 1986, Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types., J. Med. Chem.
Culy et al., 2002, Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders., Drugs
Butler R et al., 1999, DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans., Hypertension
Marian AJ et al., 2000, Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study., J Am Coll Cardiol
Bray PF et al., 2001, The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction., Am J Cardiol
Bahramali E et al., 2016, Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial., Eur J Clin Pharmacol
Brugts et al., 2009, Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease., Expert Rev Cardiovasc Ther
Alfakih et al., 2006, Perindopril., Expert Opin Pharmacother
Haas M et al., 1998, Angiotensin-converting enzyme gene polymorphism determines the antiproteinuric and systemic hemodynamic effect of enalapril in patients with proteinuric renal disease. Austrian Study Group of the Effects of Enalapril Treatment in Proteinuric Renal Disease., Kidney Blood Press Res
van Essen GG et al., 1996, Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy., Lancet
Pérez-Castrillón JL et al., 2003, Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: relationship with angiotensin converting enzyme polymorphisms., Am J Hypertens
Prasad A et al., 2000, Insertion-deletion polymorphism of the ACE gene modulates reversibility of endothelial dysfunction with ACE inhibition., Circulation
Liu et al., 2006, Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice., J. Cardiovasc. Pharmacol.
Tylicki et al., 2008, Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial., Am. J. Kidney Dis.
Yoshiyama et al., 1999, Effects of candesartan and cilazapril on rats with myocardial infarction assessed by echocardiography., Hypertension
Mervaala et al., 1999, Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes., J. Am. Soc. Nephrol.
Kihara et al., 1999, Altered vasoreactivity to angiotensin II in experimental diabetic neuropathy: role of nitric oxide., Muscle Nerve
Hannedouche et al., 1992, Renal effects of angiotensin II in normotensive subjects on short-term cilazapril treatment., J. Cardiovasc. Pharmacol.
Rosendorff et al., 1992, Alpha-adrenergic and angiotensin II pressor sensitivity in hypertensive patients treated with an angiotensin-converting enzyme inhibitor., J. Cardiovasc. Pharmacol.
Kurland L et al., 2001, Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients., J Hypertens
Dudley C et al., 1996, Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes., J Hypertens
Johnson et al., 2003, Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol., Clin. Pharmacol. Ther.
Ortlepp JR et al., 2002, Variants of the CYP11B2 gene predict response to therapy with candesartan., Eur J Pharmacol
Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
Li Y et al., 2011, Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients., Clin Exp Hypertens
Schwartz GL et al., 2002, Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide., Kidney Int
Sciarrone MT et al., 2003, ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy., Hypertension
Kim TH et al., 2008, Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics., Clin Exp Allergy
Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
Mulder HJ et al., 2003, DD ACE gene polymorphism is associated with increased coronary artery endothelial dysfunction: the PREFACE trial., Heart
Saavedra et al., 1982, Vasopressin-reversible increase in angiotensin-converting enzyme in specific hypothalamic nuclei of Brattleboro rats., Brain Res.
Bossé Y et al., 2002, Influence of the angiotensin-converting enzyme gene insertion/deletion polymorphism on lipoprotein/lipid response to gemfibrozil., Clin Genet

CILAZAPRIL ACE

Interaction Score: 24.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650 18423812 10205231 10446934 11752352 10398211 1382161 1382157

Sources:
TdgClinicalTrial TEND PharmGKB TTD
SPIRAPRIL ACE

Interaction Score: 8.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11929321 12613273 20524801 11752352 16126915

Sources:
TdgClinicalTrial TEND TTD
FOSINOPRIL ACE

Interaction Score: 7.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11030016 11329095 11752352 2836111

Sources:
TdgClinicalTrial TEND TTD
MOEXIPRIL ACE

Interaction Score: 7.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7473177 11929321 15286086 11752352

Sources:
TdgClinicalTrial TEND TTD
LISINOPRIL ACE

Interaction Score: 3.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name lisinopril ,Zestril, Prinivil

Novel drug target Established target

Trial Name MC-4232

PMIDs:
11030016 11929321 9506845 17618628 11752352 9869506 20577119 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources:
TdgClinicalTrial TEND PharmGKB TTD
QUINAPRIL ACE

Interaction Score: 3.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name quinapril hydrochloride,Accupril

Novel drug target Established target

PMIDs:
16116691 11929321 3020249 11752352 11817979

Sources:
TdgClinicalTrial TEND PharmGKB TTD
BENAZEPRIL ACE

Interaction Score: 2.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name benazepril,Lotensin

Novel drug target Established target

PMIDs:
11929321 11752352 15788353 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources:
TdgClinicalTrial TEND PharmGKB TTD
PERINDOPRIL ACE

Interaction Score: 2.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15788353 11007831 11929321 11752352 19379059 16370923

Sources:
TdgClinicalTrial TEND PharmGKB TTD
CAPTOPRIL ACE

Interaction Score: 2.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
9863143 8864563 7042175 6275810 3937925 3325392 3320343 3038284 2875891 2839262 2442780 12489813 12424228 9869506 9551410 9069453 27546928 20830509 19286758 11929321 20014331 17618628 15236580 16889963 11752352 11030016

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD
TRANDOLAPRIL ACE

Interaction Score: 2.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name trandolapril,Gopten, Mavik, Odrik

Novel drug target Established target

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
11030016 11929321 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
RAMIPRIL ACE

Interaction Score: 2.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
16398929 11929321 11752352 11030016

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
CGS-27023A ACE

Interaction Score: 2.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
ACETYLCHOLINE ACE

Interaction Score: 2.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10334805

Sources:
PharmGKB
CANDOXATRIL ACE

Interaction Score: 2.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11300648 16642666

Sources:
TdgClinicalTrial TEND
RESCINNAMINE ACE

Interaction Score: 1.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352 16431399

Sources:
TdgClinicalTrial TEND TTD
PERINDOPRIL ARGININE ACE

Interaction Score: 1.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALACEPRIL ACE

Interaction Score: 1.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ENALAPRILAT ACE

Interaction Score: 1.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
SPIRAPRIL HYDROCHLORIDE ACE

Interaction Score: 1.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DELAPRIL ACE

Interaction Score: 1.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PERINDOPRIL ERBUMINE ACE

Interaction Score: 1.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MOEXIPRIL HYDROCHLORIDE ACE

Interaction Score: 1.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
FOSINOPRIL SODIUM ACE

Interaction Score: 1.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DESERPIDINE ACE

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND TTD
NITROPRUSSIDE ACE

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10334805

Sources:
PharmGKB
ENALAPRIL ACE

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

PMIDs:
9661139 8986921 8538349 12799093 10880412 16424790 17618628 15236580 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
ILEPATRIL ACE

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ilepatril, AVE-7688

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
LISINOPRIL HYDRATE ACE

Interaction Score: 0.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METOPROLOL ACE

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11593098 8728305 12844134

Sources:
PharmGKB
BENAZEPRIL HYDROCHLORIDE ACE

Interaction Score: 0.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ENALAPRIL MALEATE ACE

Interaction Score: 0.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINAPRIL HYDROCHLORIDE ACE

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GALLOPAMIL ACE

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CANDESARTAN ACE

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11593098 12065207

Sources:
PharmGKB
CHLORTHALIDONE ACE

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20577119

Sources:
PharmGKB
IRBESARTAN ACE

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11593098 12065207

Sources:
PharmGKB
SILDENAFIL ACE

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12837457

Sources:
PharmGKB
GEMFIBROZIL ACE

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12123487

Sources:
PharmGKB
FUROSEMIDE ACE

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
TORSEMIDE ACE

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
AMLODIPINE ACE

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20577119

Sources:
PharmGKB
BUMETANIDE ACE

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
PRAVASTATIN ACE

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16103896 12695469 10636265 11545752

Sources:
PharmGKB
FLUVASTATIN ACE

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10636265 11545752

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE ACE

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21269061 12371972 12623934

Sources:
PharmGKB TTD
VASOPRESSIN ACE

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6289972

Sources:
NCI
ATENOLOL ACE

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11593098 8728305 12844134

Sources:
PharmGKB
BUPROPION ACE

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22947179

Sources:
PharmGKB
SPIRONOLACTONE ACE

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15121491

Sources:
PharmGKB
SERTRALINE ACE

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27262302

Sources:
PharmGKB
FLUOXETINE ACE

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27262302

Sources:
PharmGKB
INDOMETHACIN ACE

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3937925

Sources:
NCI
VORINOSTAT ACE

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
ATORVASTATIN ACE

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16116691

Sources:
PharmGKB
ASPIRIN ACE

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18727619

Sources:
PharmGKB

Ensembl: ENSG00000264813
- Version: 101_38
Alternate Names:

AC113554.1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
Ensembl: ENSG00000159640
- Version: 101_38
Alternate Names:

ACE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P01019
- Version: 01-August-2011
Alternate Names:

P01019 Uniprot Accession

ACE Gene Symbol

183 Entrez Gene Id

Gene Info:

Target Subclass Ligand

Target Subclass Hormone

Target Main Class Other

Publications:

RussLampel: ENSG00000159640

Version: 26-July-2011

Alternate Names:

ACE Display Id

ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM PRECURSOR (EC 3.4.15.1) (ACE) (DIPEPTIDYL CARBOXYPEPTIDASE I) (KININASE II) (CD143 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P12821] Description

ENSG00000159640 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P12821
- Version: January-2014
Alternate Names:

ACE Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.15

Target Class Other

Publications:
TEND: P12821
- Version: 01-August-2011
Alternate Names:

1636 Entrez Gene Id

ACE Gene Symbol

ENSG00000159640 Ensembl Gene Id

Gene Info:

Target Subclass 3.4.15

Transmembrane Helix Count 1

Target Main Class Enzymes

Publications:

PharmGKB: ACE

Version: 18-August-2020

Alternate Names:

PA139 PharmGKB ID

Gene Info:

Publications:

Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens

Bray PF et al., 2001, The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction., Am J Cardiol

Marian AJ et al., 2000, Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study., J Am Coll Cardiol

NCI: ACE

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.

Correa et al., 1986, Quantitative distribution of angiotensin-converting enzyme (kininase II) in discrete areas of the rat brain by autoradiography with computerized microdensitometry., Brain Res.

Piedimonte et al., 1991, Neutral endopeptidase and kininase II mediate glucocorticoid inhibition of neurogenic inflammation in the rat trachea., J. Clin. Invest.

DTC: ACE
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
HingoraniCasas: ENSG00000159640
- Version: 31-May-2017
Alternate Names:

ENSG00000159640 Gene Symbol

ACE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HingoraniCasas: ENSG00000264813
- Version: 31-May-2017
Alternate Names:

ENSG00000264813 Gene Symbol

Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: DCP
- Version: chembl_23
Alternate Names:

DCP1 GENE_SYMBOL

ACE GENE_SYMBOL

Angiotensin-converting enzyme UNIPROT

Gene Info:

Publications:
GO: ACE
- Version: 01-February-2022
Alternate Names:

DCP GO Gene Synonym

DCP1 GO Gene Synonym

Gene Info:

Gene Categories:

NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
dGene: ACE
- Version: 27-Jun-2013
Alternate Names:

1636 Gene ID

ACE1 dGene Synonym

CD143 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Angiotensin-converting enzyme
- Version: 2020.06.01
Alternate Names:

ACE TTD Gene Abbreviation

T82577 TTD Target ID

Gene Info:

Publications:
Pharos: ACE
- Version: 01-February-2022
Alternate Names:

Angiotensin-converting enzyme Gene Name

P12821 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Trial Name	lisinopril ,Zestril, Prinivil
Novel drug target	Established target
Trial Name	MC-4232

Trial Name	quinapril hydrochloride,Accupril
Novel drug target	Established target

Trial Name	benazepril,Lotensin
Novel drug target	Established target

Trial Name	trandolapril,Gopten, Mavik, Odrik
Novel drug target	Established target
Mechanism of Interaction	Angiotensin-converting enzyme inhibitor

Mechanism of Interaction	Angiotensin-converting enzyme inhibitor
Direct Interaction	yes

Trial Name	enalapril + felodipine,Lexxel
Novel drug target	Established target

Trial Name	ilepatril, AVE-7688
Novel drug target	Established target

ACE	Display Id
ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM PRECURSOR (EC 3.4.15.1) (ACE) (DIPEPTIDYL CARBOXYPEPTIDASE I) (KININASE II) (CD143 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P12821]	Description
ENSG00000159640	Ensembl Gene Id

1636	Entrez Gene Id
ACE	Gene Symbol
ENSG00000159640	Ensembl Gene Id

DCP1	GENE_SYMBOL
ACE	GENE_SYMBOL
Angiotensin-converting enzyme	UNIPROT

ACE Gene Record

ACE 1636 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650 18423812 10205231 10446934 11752352 10398211 1382161 1382157

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11929321 12613273 20524801 11752352 16126915

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11030016 11329095 11752352 2836111

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7473177 11929321 15286086 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name lisinopril ,Zestril, Prinivil Novel drug target Established target Trial Name MC-4232

PMIDs: 11030016 11929321 9506845 17618628 11752352 9869506 20577119 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name quinapril hydrochloride,Accupril Novel drug target Established target

PMIDs: 16116691 11929321 3020249 11752352 11817979

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name benazepril,Lotensin Novel drug target Established target

PMIDs: 11929321 11752352 15788353 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15788353 11007831 11929321 11752352 19379059 16370923

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Direct Interaction yes

PMIDs: 9863143 8864563 7042175 6275810 3937925 3325392 3320343 3038284 2875891 2839262 2442780 12489813 12424228 9869506 9551410 9069453 27546928 20830509 19286758 11929321 20014331 17618628 15236580 16889963 11752352 11030016

Sources: TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name trandolapril,Gopten, Mavik, Odrik Novel drug target Established target Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs: 11030016 11929321 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs: 16398929 11929321 11752352 11030016

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10334805

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11300648 16642666

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352 16431399

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Angiotensin-converting enzyme inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650 18423812 10205231 10446934 11752352 10398211 1382161 1382157

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11929321 12613273 20524801 11752352 16126915

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11030016 11329095 11752352 2836111

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7473177 11929321 15286086 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name lisinopril ,Zestril, Prinivil

Novel drug target Established target

Trial Name MC-4232

PMIDs:
11030016 11929321 9506845 17618628 11752352 9869506 20577119 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name quinapril hydrochloride,Accupril

Novel drug target Established target

PMIDs:
16116691 11929321 3020249 11752352 11817979

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name benazepril,Lotensin

Novel drug target Established target

PMIDs:
11929321 11752352 15788353 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15788353 11007831 11929321 11752352 19379059 16370923

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
9863143 8864563 7042175 6275810 3937925 3325392 3320343 3038284 2875891 2839262 2442780 12489813 12424228 9869506 9551410 9069453 27546928 20830509 19286758 11929321 20014331 17618628 15236580 16889963 11752352 11030016

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name trandolapril,Gopten, Mavik, Odrik

Novel drug target Established target

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
11030016 11929321 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
16398929 11929321 11752352 11030016

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10334805

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11300648 16642666

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352 16431399

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)