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ACE Gene Record

  • Summary
  • Interactions
  • Claims
  • ACE 1636 Druggable Genome

    Alternate Names:

    1636
    ANGIOTENSIN I CONVERTING ENZYME
    ACE
    ACE1
    CD143
    DCP
    DCP1
    106180
    2707
    ENSG00000159640
    ENSG00000264813
    OTTHUMG00000154927
    OTTHUMG00000178900
    P12821
    ACE_HUMAN
    CD_antigen=CD143
    Angiotensin-converting enzyme
    Angiotensin-converting enzyme, soluble form
    Dipeptidyl carboxypeptidase I
    Kininase II
    PA139
    ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM PRECURSOR (EC 3.4.15.1) (ACE) (DIPEPTIDYL CARBOXYPEPTIDASE I) (KININASE II) (CD143 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P12821]
    P01019
    ENSG00000135744
    ANGT_HUMAN
    183
    T82577
    AC113554.1
    ICH
    MVCD3

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.4.15
    Target Class Other
    Target Subclass 3.4.15
    Transmembrane Helix Count 1
    Target Main Class Enzymes
    Human Readable Name DRUGGABLE GENOME
    Target Subclass Ligand
    Target Subclass Hormone
    Target Main Class Other
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    NEUTRAL ZINC METALLOPEPTIDASE
    PROTEASE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Dumoulin et al., 2001, Comparison of a vasopeptidase inhibitor with neutral endopeptidase and angiotensin-converting enzyme inhibitors on bradykinin metabolism in the rat coronary bed., J. Cardiovasc. Pharmacol.
    Kostova et al., 2005, Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats., Bratisl Lek Listy
    Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
    Cicoira M et al., 2004, Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure., Am J Med
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Azhar et al., 2005, Colorimetric determination of indolic drugs., Pak J Pharm Sci
    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Edling et al., 1995, Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril., J. Pharmacol. Exp. Ther.
    Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
    Chrysant et al., 2004, Pharmacological and clinical profile of moexipril: a concise review., J Clin Pharmacol
    Eisenhardt A et al., 2003, ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction., Urology
    He H et al., 2005, A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril., Ann Hum Biol
    Kohno M et al., 1999, Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors., Am J Med
    Penno G et al., 1998, Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinopril in IDDM., Diabetes
    Zee RY et al., 1998, Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis., Hypertension
    Ohmichi N et al., 1997, Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype., Am J Hypertens
    Sasaki M et al., 1996, Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies., J Hypertens
    Rudnicki M et al., 2009, Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease., Pharmacogenomics
    Arnett DK et al., 2005, Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study., Circulation
    Yu Y et al., 2005, Associations of baseline blood pressure levels and efficacy of Benazepril treatment with interaction of alpha-adducin and ACE gene polymorphisms in hypertensives., Clin Exp Hypertens
    Takahashi T et al., 2001, The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage., Respir Med
    Ha SK et al., 2000, ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus., Nephrol Dial Transplant
    Stavroulakis GA et al., 2000, Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism., Cardiovasc Drugs Ther
    Piepho, 2000, Overview of the angiotensin-converting-enzyme inhibitors., Am J Health Syst Pharm
    Sharma et al., 1999, The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group., Am J Ther
    Ondetti, 1988, Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity., Circulation
    Hu et al., 1996, Effect of chronic captopril treatment on circulating and tissue renin-angiotensin system in SHR rats., Zhongguo Yao Li Xue Bao
    Davis et al., 1996, Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors., Br. J. Pharmacol.
    Kiowski et al., 1982, Antihypertensive and renal effects of captopril in relation to renin activity and bradykinin-induced vasodilation., Clin. Pharmacol. Ther.
    Suzuki et al., 1981, Converting enzyme inhibition and modulation of plasma renin activity with captopril in anesthetized rats., Arch Int Pharmacodyn Ther
    Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.
    Dietze et al., 1987, [Captopril in hypertensive patients with type II diabetes mellitus]., Herz
    Kumakura et al., 1987, Role of bradykinin generating and degrading systems in the vascular permeability response induced with kaolin in rats., J. Pharmacol. Exp. Ther.
    Metting et al., 1987, Enzymatic formation of angiotensins II and III in the hindlimb circulation of dogs., Can. J. Physiol. Pharmacol.
    Regoli et al., 1986, Conversion of kinins and their antagonists into B1 receptor activators and blockers in isolated vessels., Eur. J. Pharmacol.
    Kumakura et al., 1988, Role of bradykinin in the vascular permeability response induced by carrageenin in rats., Br. J. Pharmacol.
    Marumo et al., 1987, Mechanisms for the inhibition of vasopressin-stimulated water flow by captopril in the toad bladder., Pharmacology
    Morinelli et al., 2002, Utilization of a radioimmunoassay to detect the generation of Arg-Pro-Pro-Gly-Phe, a stable endproduct of bradykinin metabolism (from cultured rat aortic smooth muscle cells exposed to bradykinin)., Int. Immunopharmacol.
    Todorov et al., 2003, Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes., FASEB J.
    O'Toole L et al., 1998, Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure., J Cardiovasc Pharmacol
    Jacobsen P et al., 1998, Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy., Kidney Int
    Mizuiri S et al., 1997, Renal hemodynamic changes induced by captopril and angiotensin-converting enzyme gene polymorphism., Nephron
    Ferreira de Oliveira F et al., 2016, Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease., Colomb Med (Cali)
    Felehgari V et al., 2011, ACE gene polymorphism and serum ACE activity in Iranians type II diabetic patients with macroalbuminuria., Mol Cell Biochem
    Volkan-Salanci B et al., 2009, Impact of renin-angiotensin system polymorphisms on renal haemodynamic responsiveness to acute angiotensin-converting enzyme inhibition in type 2 diabetes mellitus., J Renin Angiotensin Aldosterone Syst
    Dalkas et al., 2010, Study of a lipophilic captopril analogue binding to angiotensin I converting enzyme., J. Pept. Sci.
    Andújar-Sánchez et al., 2007, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method., FEBS Lett.
    Natesh et al., 2004, Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme., Biochemistry
    Tzakos et al., 2006, The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme., Bioorg. Med. Chem. Lett.
    Arend et al., 2002, [Influence of ACE inhibitor spirapril on left ventricular hypertrophy]., Fortschr Med Orig
    Hermida et al., 2010, Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension., Chronobiol. Int.
    Maul et al., 2005, Central angiotensin II controls alcohol consumption via its AT1 receptor., FASEB J.
    Levitt et al., 2006, Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat., BMC Clin Pharmacol
    Téllez-Sanz et al., 1998, Calorimetric analysis of lisinopril binding to angiotensin I-converting enzyme., FEBS Lett.
    Potaczek DP et al., 2005, The angiotensin-converting enzyme gene insertion/deletion polymorphism and effects of quinapril and atorvastatin on haemostatic parameters in patients with coronary artery disease., Thromb Haemost
    Klutchko et al., 1986, Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types., J. Med. Chem.
    Culy et al., 2002, Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders., Drugs
    Butler R et al., 1999, DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans., Hypertension
    Marian AJ et al., 2000, Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study., J Am Coll Cardiol
    Bray PF et al., 2001, The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction., Am J Cardiol
    Bahramali E et al., 2016, Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial., Eur J Clin Pharmacol
    Brugts et al., 2009, Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease., Expert Rev Cardiovasc Ther
    Alfakih et al., 2006, Perindopril., Expert Opin Pharmacother
    Haas M et al., 1998, Angiotensin-converting enzyme gene polymorphism determines the antiproteinuric and systemic hemodynamic effect of enalapril in patients with proteinuric renal disease. Austrian Study Group of the Effects of Enalapril Treatment in Proteinuric Renal Disease., Kidney Blood Press Res
    van Essen GG et al., 1996, Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy., Lancet
    Pérez-Castrillón JL et al., 2003, Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: relationship with angiotensin converting enzyme polymorphisms., Am J Hypertens
    Prasad A et al., 2000, Insertion-deletion polymorphism of the ACE gene modulates reversibility of endothelial dysfunction with ACE inhibition., Circulation
    Liu et al., 2006, Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice., J. Cardiovasc. Pharmacol.
    Tylicki et al., 2008, Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial., Am. J. Kidney Dis.
    Yoshiyama et al., 1999, Effects of candesartan and cilazapril on rats with myocardial infarction assessed by echocardiography., Hypertension
    Mervaala et al., 1999, Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes., J. Am. Soc. Nephrol.
    Kihara et al., 1999, Altered vasoreactivity to angiotensin II in experimental diabetic neuropathy: role of nitric oxide., Muscle Nerve
    Hannedouche et al., 1992, Renal effects of angiotensin II in normotensive subjects on short-term cilazapril treatment., J. Cardiovasc. Pharmacol.
    Rosendorff et al., 1992, Alpha-adrenergic and angiotensin II pressor sensitivity in hypertensive patients treated with an angiotensin-converting enzyme inhibitor., J. Cardiovasc. Pharmacol.
    Kurland L et al., 2001, Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients., J Hypertens
    Dudley C et al., 1996, Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes., J Hypertens
    Johnson et al., 2003, Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol., Clin. Pharmacol. Ther.
    Ortlepp JR et al., 2002, Variants of the CYP11B2 gene predict response to therapy with candesartan., Eur J Pharmacol
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
    Li Y et al., 2011, Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients., Clin Exp Hypertens
    Schwartz GL et al., 2002, Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide., Kidney Int
    Sciarrone MT et al., 2003, ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy., Hypertension
    Kim TH et al., 2008, Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics., Clin Exp Allergy
    Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Mulder HJ et al., 2003, DD ACE gene polymorphism is associated with increased coronary artery endothelial dysfunction: the PREFACE trial., Heart
    Saavedra et al., 1982, Vasopressin-reversible increase in angiotensin-converting enzyme in specific hypothalamic nuclei of Brattleboro rats., Brain Res.
    Bossé Y et al., 2002, Influence of the angiotensin-converting enzyme gene insertion/deletion polymorphism on lipoprotein/lipid response to gemfibrozil., Clin Genet
  • CILAZAPRIL   ACE

    Interaction Score: 24.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650 18423812 10205231 10446934 11752352 10398211 1382161 1382157


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • SPIRAPRIL   ACE

    Interaction Score: 8.99

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11929321 12613273 20524801 11752352 16126915


    Sources:
    TdgClinicalTrial TEND TTD

  • FOSINOPRIL   ACE

    Interaction Score: 7.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11030016 11329095 11752352 2836111


    Sources:
    TdgClinicalTrial TEND TTD

  • MOEXIPRIL   ACE

    Interaction Score: 7.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7473177 11929321 15286086 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • LISINOPRIL   ACE

    Interaction Score: 3.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name lisinopril ,Zestril, Prinivil
    Novel drug target Established target
    Trial Name MC-4232

    PMIDs:
    11030016 11929321 9506845 17618628 11752352 9869506 20577119 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • QUINAPRIL   ACE

    Interaction Score: 3.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name quinapril hydrochloride,Accupril
    Novel drug target Established target

    PMIDs:
    16116691 11929321 3020249 11752352 11817979


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • BENAZEPRIL   ACE

    Interaction Score: 2.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name benazepril,Lotensin
    Novel drug target Established target

    PMIDs:
    11929321 11752352 15788353 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • PERINDOPRIL   ACE

    Interaction Score: 2.81

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15788353 11007831 11929321 11752352 19379059 16370923


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • CAPTOPRIL   ACE

    Interaction Score: 2.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    9863143 8864563 7042175 6275810 3937925 3325392 3320343 3038284 2875891 2839262 2442780 12489813 12424228 9869506 9551410 9069453 27546928 20830509 19286758 11929321 20014331 17618628 15236580 16889963 11752352 11030016


    Sources:
    TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD

  • TRANDOLAPRIL   ACE

    Interaction Score: 2.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name trandolapril,Gopten, Mavik, Odrik
    Novel drug target Established target
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    11030016 11929321 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • RAMIPRIL   ACE

    Interaction Score: 2.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    16398929 11929321 11752352 11030016


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • CGS-27023A   ACE

    Interaction Score: 2.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • ACETYLCHOLINE   ACE

    Interaction Score: 2.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10334805


    Sources:
    PharmGKB

  • CANDOXATRIL   ACE

    Interaction Score: 2.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11300648 16642666


    Sources:
    TdgClinicalTrial TEND

  • RESCINNAMINE   ACE

    Interaction Score: 1.57

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 11752352 16431399


    Sources:
    TdgClinicalTrial TEND TTD

  • PERINDOPRIL ARGININE   ACE

    Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALACEPRIL   ACE

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ENALAPRILAT   ACE

    Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SPIRAPRIL HYDROCHLORIDE   ACE

    Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DELAPRIL   ACE

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PERINDOPRIL ERBUMINE   ACE

    Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MOEXIPRIL HYDROCHLORIDE   ACE

    Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSINOPRIL SODIUM   ACE

    Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DESERPIDINE   ACE

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND TTD

  • NITROPRUSSIDE   ACE

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10334805


    Sources:
    PharmGKB

  • ENALAPRIL   ACE

    Interaction Score: 0.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name enalapril + felodipine,Lexxel
    Novel drug target Established target

    PMIDs:
    9661139 8986921 8538349 12799093 10880412 16424790 17618628 15236580 11752352


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • ILEPATRIL   ACE

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ilepatril, AVE-7688
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LISINOPRIL HYDRATE   ACE

    Interaction Score: 0.56

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METOPROLOL   ACE

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593098 8728305 12844134


    Sources:
    PharmGKB

  • BENAZEPRIL HYDROCHLORIDE   ACE

    Interaction Score: 0.56

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ENALAPRIL MALEATE   ACE

    Interaction Score: 0.56

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINAPRIL HYDROCHLORIDE   ACE

    Interaction Score: 0.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GALLOPAMIL   ACE

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CANDESARTAN   ACE

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593098 12065207


    Sources:
    PharmGKB

  • CHLORTHALIDONE   ACE

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20577119


    Sources:
    PharmGKB

  • IRBESARTAN   ACE

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593098 12065207


    Sources:
    PharmGKB

  • SILDENAFIL   ACE

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12837457


    Sources:
    PharmGKB

  • GEMFIBROZIL   ACE

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12123487


    Sources:
    PharmGKB

  • FUROSEMIDE   ACE

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • TORSEMIDE   ACE

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • AMLODIPINE   ACE

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20577119


    Sources:
    PharmGKB

  • BUMETANIDE   ACE

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • PRAVASTATIN   ACE

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16103896 12695469 10636265 11545752


    Sources:
    PharmGKB

  • FLUVASTATIN   ACE

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10636265 11545752


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ACE

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21269061 12371972 12623934


    Sources:
    PharmGKB TTD

  • VASOPRESSIN   ACE

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6289972


    Sources:
    NCI

  • ATENOLOL   ACE

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593098 8728305 12844134


    Sources:
    PharmGKB

  • BUPROPION   ACE

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22947179


    Sources:
    PharmGKB

  • SPIRONOLACTONE   ACE

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15121491


    Sources:
    PharmGKB

  • SERTRALINE   ACE

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27262302


    Sources:
    PharmGKB

  • FLUOXETINE   ACE

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27262302


    Sources:
    PharmGKB

  • INDOMETHACIN   ACE

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3937925


    Sources:
    NCI

  • VORINOSTAT   ACE

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • ATORVASTATIN   ACE

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16116691


    Sources:
    PharmGKB

  • ASPIRIN   ACE

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18727619


    Sources:
    PharmGKB

  • Ensembl: ENSG00000264813

    • Version: 101_38

    Alternate Names:
    AC113554.1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • Ensembl: ENSG00000159640

    • Version: 101_38

    Alternate Names:
    ACE Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P01019

    • Version: 01-August-2011

    Alternate Names:
    P01019 Uniprot Accession
    ACE Gene Symbol
    183 Entrez Gene Id

    Gene Info:
    Target Subclass Ligand
    Target Subclass Hormone
    Target Main Class Other

    Publications:

  • RussLampel: ENSG00000159640

    • Version: 26-July-2011

    Alternate Names:
    ACE Display Id
    ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM PRECURSOR (EC 3.4.15.1) (ACE) (DIPEPTIDYL CARBOXYPEPTIDASE I) (KININASE II) (CD143 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P12821] Description
    ENSG00000159640 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P12821

    • Version: January-2014

    Alternate Names:
    ACE Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.15
    Target Class Other

    Publications:

  • TEND: P12821

    • Version: 01-August-2011

    Alternate Names:
    1636 Entrez Gene Id
    ACE Gene Symbol
    ENSG00000159640 Ensembl Gene Id

    Gene Info:
    Target Subclass 3.4.15
    Transmembrane Helix Count 1
    Target Main Class Enzymes

    Publications:

  • PharmGKB: ACE

    • Version: 18-August-2020

    Alternate Names:
    PA139 PharmGKB ID

    Gene Info:

    Publications:
    Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
    Bray PF et al., 2001, The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction., Am J Cardiol
    Marian AJ et al., 2000, Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study., J Am Coll Cardiol

  • NCI: ACE

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.
    Correa et al., 1986, Quantitative distribution of angiotensin-converting enzyme (kininase II) in discrete areas of the rat brain by autoradiography with computerized microdensitometry., Brain Res.
    Piedimonte et al., 1991, Neutral endopeptidase and kininase II mediate glucocorticoid inhibition of neurogenic inflammation in the rat trachea., J. Clin. Invest.

  • DTC: ACE

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

  • HingoraniCasas: ENSG00000159640

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000159640 Gene Symbol
    ACE Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000264813

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000264813 Gene Symbol
    Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: DCP

    • Version: chembl_23

    Alternate Names:
    DCP1 GENE_SYMBOL
    ACE GENE_SYMBOL
    Angiotensin-converting enzyme UNIPROT

    Gene Info:

    Publications:

  • GO: ACE

    • Version: 01-February-2022

    Alternate Names:
    DCP GO Gene Synonym
    DCP1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: ACE

    • Version: 27-Jun-2013

    Alternate Names:
    1636 Gene ID
    ACE1 dGene Synonym
    CD143 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Angiotensin-converting enzyme

    • Version: 2020.06.01

    Alternate Names:
    ACE TTD Gene Abbreviation
    T82577 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ACE

    • Version: 01-February-2022

    Alternate Names:
    Angiotensin-converting enzyme Gene Name
    P12821 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21