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ACE Gene Record

  • Summary
  • Interactions
  • Claims
  • ACE 1636 Druggable Genome

    Alternate Names:

    1636
    ANGIOTENSIN I CONVERTING ENZYME
    ACE
    ACE1
    CD143
    DCP
    DCP1
    106180
    2707
    ENSG00000159640
    ENSG00000264813
    OTTHUMG00000154927
    OTTHUMG00000178900
    BE0000221
    P12821
    ACE_HUMAN
    CD_antigen=CD143
    Angiotensin-converting enzyme
    Angiotensin-converting enzyme, soluble form
    Dipeptidyl carboxypeptidase I
    Kininase II
    1613
    PA139
    ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM PRECURSOR (EC 3.4.15.1) (ACE) (DIPEPTIDYL CARBOXYPEPTIDASE I) (KININASE II) (CD143 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P12821]
    P01019
    ENSG00000135744
    ANGT_HUMAN
    183
    NP_000780|NP_001171528|NP_690043
    NM_000789|NM_001178057|NM_152830
    T82577
    AC113554.1
    ICH
    MVCD3

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.4.15
    Target Class Other
    Target Subclass 3.4.15
    Transmembrane Helix Count 1
    Target Main Class Enzymes
    Human Readable Name DRUGGABLE GENOME
    Target Subclass Ligand
    Target Subclass Hormone
    Target Main Class Other
    GuideToPharmacology Gene Category Name M2: Angiotensin-converting (ACE and ACE2)
    GuideToPharmacology Gene Category ID 741
    Gene Biotype PROTEIN_CODING
    (14 More Sources)

    Gene Categories: Category Details

    NEUTRAL ZINC METALLOPEPTIDASE
    PROTEASE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Kostova et al., 2005, Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats., Bratisl Lek Listy
    Dumoulin et al., 2001, Comparison of a vasopeptidase inhibitor with neutral endopeptidase and angiotensin-converting enzyme inhibitors on bradykinin metabolism in the rat coronary bed., J. Cardiovasc. Pharmacol.
    Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
    Cicoira M et al., 2004, Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure., Am J Med
    Azhar et al., 2005, Colorimetric determination of indolic drugs., Pak J Pharm Sci
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Ambrosioni, 2007, Defining the role of zofenopril in the management of hypertension and ischemic heart disorders., Am J Cardiovasc Drugs
    Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
    Chrysant et al., 2004, Pharmacological and clinical profile of moexipril: a concise review., J Clin Pharmacol
    Edling et al., 1995, Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril., J. Pharmacol. Exp. Ther.
    Eisenhardt A et al., 2003, ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction., Urology
    Furuta et al., 1993, Pharmacokinetics of temocapril, an ACE inhibitor with preferential biliary excretion, in patients with impaired liver function., Eur. J. Clin. Pharmacol.
    Rudnicki M et al., 2009, Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease., Pharmacogenomics
    Zee RY et al., 1998, Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis., Hypertension
    Sasaki M et al., 1996, Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies., J Hypertens
    Yu Y et al., 2005, Associations of baseline blood pressure levels and efficacy of Benazepril treatment with interaction of alpha-adducin and ACE gene polymorphisms in hypertensives., Clin Exp Hypertens
    Takahashi T et al., 2001, The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage., Respir Med
    Kohno M et al., 1999, Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors., Am J Med
    Penno G et al., 1998, Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinopril in IDDM., Diabetes
    He H et al., 2005, A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril., Ann Hum Biol
    Ohmichi N et al., 1997, Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype., Am J Hypertens
    Arnett DK et al., 2005, Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study., Circulation
    Ha SK et al., 2000, ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus., Nephrol Dial Transplant
    Stavroulakis GA et al., 2000, Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism., Cardiovasc Drugs Ther
    Piepho, 2000, Overview of the angiotensin-converting-enzyme inhibitors., Am J Health Syst Pharm
    Ondetti, 1988, Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity., Circulation
    Sharma et al., 1999, The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group., Am J Ther
    Ferreira de Oliveira F et al., 2016, Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease., Colomb Med (Cali)
    Kumakura et al., 1988, Role of bradykinin in the vascular permeability response induced by carrageenin in rats., Br. J. Pharmacol.
    Tzakos et al., 2006, The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme., Bioorg. Med. Chem. Lett.
    Marumo et al., 1987, Mechanisms for the inhibition of vasopressin-stimulated water flow by captopril in the toad bladder., Pharmacology
    Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.
    Kumakura et al., 1987, Role of bradykinin generating and degrading systems in the vascular permeability response induced with kaolin in rats., J. Pharmacol. Exp. Ther.
    Volkan-Salanci B et al., 2009, Impact of renin-angiotensin system polymorphisms on renal haemodynamic responsiveness to acute angiotensin-converting enzyme inhibition in type 2 diabetes mellitus., J Renin Angiotensin Aldosterone Syst
    Andújar-Sánchez et al., 2007, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method., FEBS Lett.
    Dietze et al., 1987, [Captopril in hypertensive patients with type II diabetes mellitus]., Herz
    Metting et al., 1987, Enzymatic formation of angiotensins II and III in the hindlimb circulation of dogs., Can. J. Physiol. Pharmacol.
    Natesh et al., 2004, Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme., Biochemistry
    Felehgari V et al., 2011, ACE gene polymorphism and serum ACE activity in Iranians type II diabetic patients with macroalbuminuria., Mol Cell Biochem
    Dalkas et al., 2010, Study of a lipophilic captopril analogue binding to angiotensin I converting enzyme., J. Pept. Sci.
    Kiowski et al., 1982, Antihypertensive and renal effects of captopril in relation to renin activity and bradykinin-induced vasodilation., Clin. Pharmacol. Ther.
    Suzuki et al., 1981, Converting enzyme inhibition and modulation of plasma renin activity with captopril in anesthetized rats., Arch Int Pharmacodyn Ther
    O'Toole L et al., 1998, Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure., J Cardiovasc Pharmacol
    Todorov et al., 2003, Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes., FASEB J.
    Morinelli et al., 2002, Utilization of a radioimmunoassay to detect the generation of Arg-Pro-Pro-Gly-Phe, a stable endproduct of bradykinin metabolism (from cultured rat aortic smooth muscle cells exposed to bradykinin)., Int. Immunopharmacol.
    Regoli et al., 1986, Conversion of kinins and their antagonists into B1 receptor activators and blockers in isolated vessels., Eur. J. Pharmacol.
    Jacobsen P et al., 1998, Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy., Kidney Int
    Mizuiri S et al., 1997, Renal hemodynamic changes induced by captopril and angiotensin-converting enzyme gene polymorphism., Nephron
    Hu et al., 1996, Effect of chronic captopril treatment on circulating and tissue renin-angiotensin system in SHR rats., Zhongguo Yao Li Xue Bao
    Davis et al., 1996, Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors., Br. J. Pharmacol.
    Maul et al., 2005, Central angiotensin II controls alcohol consumption via its AT1 receptor., FASEB J.
    Arend et al., 2002, [Influence of ACE inhibitor spirapril on left ventricular hypertrophy]., Fortschr Med Orig
    Hermida et al., 2010, Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension., Chronobiol. Int.
    Levitt et al., 2006, Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat., BMC Clin Pharmacol
    Téllez-Sanz et al., 1998, Calorimetric analysis of lisinopril binding to angiotensin I-converting enzyme., FEBS Lett.
    Culy et al., 2002, Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders., Drugs
    Klutchko et al., 1986, Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types., J. Med. Chem.
    Potaczek DP et al., 2005, The angiotensin-converting enzyme gene insertion/deletion polymorphism and effects of quinapril and atorvastatin on haemostatic parameters in patients with coronary artery disease., Thromb Haemost
    Butler R et al., 1999, DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans., Hypertension
    Bray PF et al., 2001, The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction., Am J Cardiol
    Marian AJ et al., 2000, Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study., J Am Coll Cardiol
    Bahramali E et al., 2016, Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial., Eur J Clin Pharmacol
    Alfakih et al., 2006, Perindopril., Expert Opin Pharmacother
    Brugts et al., 2009, Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease., Expert Rev Cardiovasc Ther
    Pérez-Castrillón JL et al., 2003, Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: relationship with angiotensin converting enzyme polymorphisms., Am J Hypertens
    Haas M et al., 1998, Angiotensin-converting enzyme gene polymorphism determines the antiproteinuric and systemic hemodynamic effect of enalapril in patients with proteinuric renal disease. Austrian Study Group of the Effects of Enalapril Treatment in Proteinuric Renal Disease., Kidney Blood Press Res
    Liu et al., 2006, Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice., J. Cardiovasc. Pharmacol.
    Prasad A et al., 2000, Insertion-deletion polymorphism of the ACE gene modulates reversibility of endothelial dysfunction with ACE inhibition., Circulation
    van Essen GG et al., 1996, Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy., Lancet
    Kihara et al., 1999, Altered vasoreactivity to angiotensin II in experimental diabetic neuropathy: role of nitric oxide., Muscle Nerve
    Yoshiyama et al., 1999, Effects of candesartan and cilazapril on rats with myocardial infarction assessed by echocardiography., Hypertension
    Rosendorff et al., 1992, Alpha-adrenergic and angiotensin II pressor sensitivity in hypertensive patients treated with an angiotensin-converting enzyme inhibitor., J. Cardiovasc. Pharmacol.
    Hannedouche et al., 1992, Renal effects of angiotensin II in normotensive subjects on short-term cilazapril treatment., J. Cardiovasc. Pharmacol.
    Mervaala et al., 1999, Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes., J. Am. Soc. Nephrol.
    Tylicki et al., 2008, Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial., Am. J. Kidney Dis.
    Kurland L et al., 2001, Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients., J Hypertens
    Dudley C et al., 1996, Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes., J Hypertens
    Johnson et al., 2003, Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol., Clin. Pharmacol. Ther.
    Ortlepp JR et al., 2002, Variants of the CYP11B2 gene predict response to therapy with candesartan., Eur J Pharmacol
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
    Li Y et al., 2011, Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients., Clin Exp Hypertens
    Schwartz GL et al., 2002, Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide., Kidney Int
    Sciarrone MT et al., 2003, ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy., Hypertension
    Kim TH et al., 2008, Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics., Clin Exp Allergy
    Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
    Ferdinand, Advances in antihypertensive combination therapy: benefits of low-dose thiazide diuretics in conjunction with omapatrilat, a vasopeptidase inhibitor., J Clin Hypertens (Greenwich)
    Trippodo et al., 1999, Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic hamsters more than does ACE inhibition with captopril., J. Cardiovasc. Pharmacol.
    Neal et al., 2002, Effects of the vasopeptidase inhibitor, omapatrilat, in 723 patients with coronary heart disease., J Renin Angiotensin Aldosterone Syst
    Azizi et al., 2000, In vitro and in vivo inhibition of the 2 active sites of ACE by omapatrilat, a vasopeptidase inhibitor., Hypertension
    Heudi et al., 2002, Investigation of bradykinin metabolism in human and rat plasma in the presence of the dual ACE/NEP inhibitors GW660511X and omapatrilat., J. Pept. Sci.
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Mulder HJ et al., 2003, DD ACE gene polymorphism is associated with increased coronary artery endothelial dysfunction: the PREFACE trial., Heart
    Saavedra et al., 1982, Vasopressin-reversible increase in angiotensin-converting enzyme in specific hypothalamic nuclei of Brattleboro rats., Brain Res.
    Bossé Y et al., 2002, Influence of the angiotensin-converting enzyme gene insertion/deletion polymorphism on lipoprotein/lipid response to gemfibrozil., Clin Genet
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
  • CILAZAPRIL   ACE

    Interaction Score: 19.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    19290794 9535416 10398211 8986921 15773232 11217909 10205231 10335726 1382157 1382161 9726242 11752352 9270093 10446934 18423812 15967849 11007831 10999650


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • SPIRAPRIL   ACE

    Interaction Score: 8.0

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11929321 16126915 12613273 11752352 20524801


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • FOSINOPRIL   ACE

    Interaction Score: 7.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Inhibition

    PMIDs:
    11030016 11752352 2836111 11329095


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • MOEXIPRIL   ACE

    Interaction Score: 7.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction? True

    PMIDs:
    11929321 15286086 7473177 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • CILAZAPRILAT   ACE

    Interaction Score: 6.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10398211 10205231 1382157 1382161 11752352 10446934 18423812


    Sources:
    DrugBank

  • CHEMBL269634   ACE

    Interaction Score: 3.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • QUINAPRIL   ACE

    Interaction Score: 2.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name quinapril hydrochloride,Accupril
    Novel drug target Established target

    PMIDs:
    11929321 11817979 3020249 16116691 11752352


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank

  • TRANDOLAPRIL   ACE

    Interaction Score: 2.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name trandolapril,Gopten, Mavik, Odrik
    Novel drug target Established target
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    11030016 11929321 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • LISINOPRIL   ACE

    Interaction Score: 2.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    19290794 11030016 11929321 9535416 17618628 9506845 8986921 15773232 11217909 10335726 20577119 9726242 11752352 9869506 9270093 15967849 11007831 10999650


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • ZOFENOPRIL   ACE

    Interaction Score: 2.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    17355163


    Sources:
    DrugBank GuideToPharmacology

  • BENAZEPRIL   ACE

    Interaction Score: 2.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    19290794 11929321 9535416 8986921 15773232 11217909 10335726 9726242 15788353 11752352 9270093 15967849 11007831 10999650


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • CANDOXATRIL   ACE

    Interaction Score: 2.0

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16642666 11300648


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PERINDOPRIL   ACE

    Interaction Score: 1.92

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11929321 16370923 15788353 11752352 19379059 11007831


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • RAMIPRIL   ACE

    Interaction Score: 1.76

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    11030016 11929321 16398929 11752352


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • OMAPATRILAT   ACE

    Interaction Score: 1.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11588409 10598120 12584671 10856268 12487427


    Sources:
    DrugBank

  • CAPTOPRIL   ACE

    Interaction Score: 1.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    27546928 2839262 16889963 2442780 3937925 11030016 11929321 3320343 19286758 17618628 3325392 3038284 15236580 20830509 20014331 7042175 6275810 11752352 9869506 12424228 12489813 2875891 9551410 9069453 9863143 8864563


    Sources:
    NCI TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • TEMOCAPRIL   ACE

    Interaction Score: 1.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    8513851


    Sources:
    DrugBank

  • RESCINNAMINE   ACE

    Interaction Score: 1.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16431399 11752352 17139284 17016423


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • ENALAPRILAT   ACE

    Interaction Score: 1.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    TTD DrugBank GuideToPharmacology

  • RAMIPRILAT   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BENAZEPRILAT   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PERINDOPRIL ARGININE   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PERINDOPRILAT   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Direct Interaction? True
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ALACEPRIL   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SPIRAPRIL HYDROCHLORIDE   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRANDOLAPRILAT   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DELAPRIL   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PERINDOPRIL ERBUMINE   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINAPRILAT   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • MOEXIPRIL HYDROCHLORIDE   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SPIRAPRILAT   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • IMIDAPRILAT   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • FOSINOPRIL SODIUM   ACE

    Interaction Score: 0.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ENALAPRIL   ACE

    Interaction Score: 0.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Direct Interaction? True
    Endogenous Drug? False

    PMIDs:
    12799093 17618628 9661139 16424790 15236580 8986921 10880412 8538349 11752352


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • DESERPIDINE   ACE

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial TTD

  • NITROPRUSSIDE   ACE

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10334805


    Sources:
    PharmGKB

  • CHEMBL1234669   ACE

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • FASIDOTRIL   ACE

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ILEPATRIL   ACE

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ilepatril, AVE-7688
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • FASIDOTRILAT   ACE

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LISINOPRIL HYDRATE   ACE

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METOPROLOL   ACE

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593098 8728305 12844134


    Sources:
    PharmGKB

  • BENAZEPRIL HYDROCHLORIDE   ACE

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ENALAPRIL MALEATE   ACE

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINAPRIL HYDROCHLORIDE   ACE

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Angiotensin-converting enzyme inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GALLOPAMIL   ACE

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CANDESARTAN   ACE

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593098 12065207


    Sources:
    PharmGKB

  • CGS-27023A   ACE

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • IRBESARTAN   ACE

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593098 12065207


    Sources:
    PharmGKB

  • IMIDAPRIL   ACE

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ACETYLCHOLINE   ACE

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10334805


    Sources:
    PharmGKB

  • CHLORTHALIDONE   ACE

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20577119


    Sources:
    PharmGKB

  • TORSEMIDE   ACE

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • GEMFIBROZIL   ACE

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12123487


    Sources:
    PharmGKB

  • SILDENAFIL   ACE

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12837457


    Sources:
    PharmGKB

  • FUROSEMIDE   ACE

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • PRAVASTATIN   ACE

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11545752 16103896 10636265 12695469


    Sources:
    PharmGKB

  • FLUVASTATIN   ACE

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11545752 10636265


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ACE

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21269061 12371972 12623934


    Sources:
    PharmGKB TTD

  • BUMETANIDE   ACE

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • VASOPRESSIN   ACE

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6289972


    Sources:
    NCI

  • ATENOLOL   ACE

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593098 8728305 12844134


    Sources:
    PharmGKB

  • AMLODIPINE   ACE

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20577119


    Sources:
    PharmGKB

  • BUPROPION   ACE

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22947179


    Sources:
    PharmGKB

  • SERTRALINE   ACE

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27262302


    Sources:
    PharmGKB

  • SPIRONOLACTONE   ACE

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15121491


    Sources:
    PharmGKB

  • FLUOXETINE   ACE

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27262302


    Sources:
    PharmGKB

  • INDOMETHACIN   ACE

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3937925


    Sources:
    NCI

  • VORINOSTAT   ACE

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • ATORVASTATIN   ACE

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16116691


    Sources:
    PharmGKB

  • ASPIRIN   ACE

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18727619


    Sources:
    PharmGKB

  • Ensembl: ENSG00000264813

    • Version: 101_38

    Alternate Names:
    AC113554.1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • Ensembl: ENSG00000159640

    • Version: 101_38

    Alternate Names:
    ACE Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P01019

    • Version: 01-August-2011

    Alternate Names:
    P01019 Uniprot Accession
    ACE Gene Symbol
    183 Entrez Gene Id

    Gene Info:
    Target Subclass Ligand
    Target Subclass Hormone
    Target Main Class Other

    Publications:

  • RussLampel: ENSG00000159640

    • Version: 26-July-2011

    Alternate Names:
    ACE Display Id
    ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM PRECURSOR (EC 3.4.15.1) (ACE) (DIPEPTIDYL CARBOXYPEPTIDASE I) (KININASE II) (CD143 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P12821] Description
    ENSG00000159640 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P12821

    • Version: January-2014

    Alternate Names:
    ACE Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.15
    Target Class Other

    Publications:

  • TEND: P12821

    • Version: 01-August-2011

    Alternate Names:
    1636 Entrez Gene Id
    ACE Gene Symbol
    ENSG00000159640 Ensembl Gene Id

    Gene Info:
    Target Subclass 3.4.15
    Transmembrane Helix Count 1
    Target Main Class Enzymes

    Publications:

  • GuideToPharmacology: 1636

    • Version: 29-September-2020

    Alternate Names:
    2707 HUGO Gene ID
    2707 HUGO Gene Symbol
    angiotensin I converting enzyme HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name M2: Angiotensin-converting (ACE and ACE2)
    GuideToPharmacology Gene Category ID 741

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: ACE

    • Version: 18-August-2020

    Alternate Names:
    PA139 PharmGKB ID

    Gene Info:

    Publications:
    Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
    Bray PF et al., 2001, The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction., Am J Cardiol
    Marian AJ et al., 2000, Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study., J Am Coll Cardiol

  • DrugBank: BE0000221

    • Version: 5.1.7

    Alternate Names:
    ACE DrugBank Gene Name
    P12821 UniProt Accession
    1636 Entrez Gene Id

    Gene Info:

    Publications:
    Piepho, 2000, Overview of the angiotensin-converting-enzyme inhibitors., Am J Health Syst Pharm
    Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
    Levitt et al., 2006, Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat., BMC Clin Pharmacol

  • NCI: ACE

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.
    Correa et al., 1986, Quantitative distribution of angiotensin-converting enzyme (kininase II) in discrete areas of the rat brain by autoradiography with computerized microdensitometry., Brain Res.
    Piedimonte et al., 1991, Neutral endopeptidase and kininase II mediate glucocorticoid inhibition of neurogenic inflammation in the rat trachea., J. Clin. Invest.

  • DTC: ACE

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

  • HingoraniCasas: ENSG00000159640

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000159640 Gene Symbol
    ACE Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000264813

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000264813 Gene Symbol
    Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: DCP

    • Version: chembl_23

    Alternate Names:
    DCP1 GENE_SYMBOL
    ACE GENE_SYMBOL
    Angiotensin-converting enzyme UNIPROT

    Gene Info:

    Publications:

  • Pharos: ACE

    • Version: 03-September-2020

    Alternate Names:
    P12821 UniProt ID
    Angiotensin-converting enzyme Gene Name

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: ACE

    • Version: 05-September-2020

    Alternate Names:
    DCP GO Gene Synonym
    DCP1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: ACE

    • Version: 27-Jun-2013

    Alternate Names:
    1636 Gene ID
    ACE1 dGene Synonym
    CD143 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Angiotensin-converting enzyme

    • Version: 2020.06.01

    Alternate Names:
    ACE TTD Gene Abbreviation
    T82577 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21