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ABL2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ABL2 27 Druggable GenomeClinically Actionable

    Alternate Names:

    27
    ABL PROTO-ONCOGENE 2, NON-RECEPTOR TYROSINE KINASE
    ABL2
    ABLL
    ARG
    164690
    77
    ENSG00000143322
    OTTHUMG00000035199
    P42684
    ABELSON TYROSINE-PROTEIN KINASE 2
    ABL2_HUMAN
    BE0000435
    1924
    Q5W0C5_HUMAN
    NP_005149
    NM_001136000
    101
    Tyrosine-protein kinase ABL2

    Gene Info:

    Initial Gene Query ARG/abl2
    Counted Citations from 1950-2000 2609
    Human Readable Name KINASE
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001245
    Interpro Type Domain
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Uniprot Status Swiss-Prot
    Target Class Enzymes
    Target Subclass EC:2.7.10.2
    Target Main Class Enzymes
    Target Subclass 2.7.10.2
    GuideToPharmacology Gene Category Name Abl family
    GuideToPharmacology Gene Category ID 553
    Gene Biotype PROTEIN_CODING
    (13 More Sources)

    Gene Categories: Category Details

    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Lindauer et al., 2010, Dasatinib., Recent Results Cancer Res.
    Roberts et al., 2014, Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia., N. Engl. J. Med.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Huang et al., 2010, Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant., J. Med. Chem.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
  • CHEMBL261720   ABL2

    Interaction Score: 2.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • DASATINIB   ABL2

    Interaction Score: 0.63

    Interaction Types & Directionality:
    multitarget

    Interaction Info:
    Trial Name dasatinib, BMS-354825,Sprycel
    Novel drug target Established target

    PMIDs:
    20072833 25207766 11752352 17016423


    Sources:
    TEND TdgClinicalTrial CIViC DrugBank

  • ADENOSINE TRIPHOSPHATE   ABL2

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11752352 17139284 17016423


    Sources:
    DrugBank

  • PEXMETINIB   ABL2

    Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PONATINIB   ABL2

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20513156


    Sources:
    DTC

  • XL-228   ABL2

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • IMATINIB   ABL2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25207766


    Sources:
    CIViC

  • TOZASERTIB   ABL2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • FOSTAMATINIB   ABL2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

  • Ensembl: ENSG00000143322

    • Version: 101_38

    Alternate Names:
    ABL2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: ABL2

    • Version: February-2014

    Alternate Names:
    27 Entrez Gene ID

    Gene Info:
    Initial Gene Query ARG/abl2
    Counted Citations from 1950-2000 2609

    Gene Categories:
    KINASE

    Publications:

  • TEND: P42684

    • Version: 01-August-2011

    Alternate Names:
    27 Entrez Gene Id
    P42684 Uniprot Accession
    ENSG00000143322 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 2.7.10.2

    Publications:

  • HopkinsGroom: P42684

    • Version: 11-September-2012

    Alternate Names:
    ABL2 Uniprot Gene Name
    P42684 Uniprot Accession
    27 Entrez Gene Id

    Gene Info:
    Human Readable Name KINASE
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000143322

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000143322 Ensembl Gene Id
    Q5W0C5_HUMAN Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P42684

    • Version: January-2014

    Alternate Names:
    ABL2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.10.2

    Publications:

  • GuideToPharmacology: 27

    • Version: 29-September-2020

    Alternate Names:
    77 HUGO Gene ID
    77 HUGO Gene Symbol
    ABL proto-oncogene 2, non-receptor tyrosine kinase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Abl family
    GuideToPharmacology Gene Category ID 553

    Gene Categories:
    ENZYME

    Publications:

  • CIViC: ABL2

    • Version: 14-September-2020

    Alternate Names:
    27 Entrez Gene ID
    101 CIViC Gene ID

    Gene Info:

    Publications:
    Roberts et al., 2014, Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia., N. Engl. J. Med.

  • DrugBank: BE0000435

    • Version: 5.1.7

    Alternate Names:
    ABL2 DrugBank Gene Name
    P42684 UniProt Accession
    27 Entrez Gene Id

    Gene Info:

    Publications:
    Lindauer et al., 2010, Dasatinib., Recent Results Cancer Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • DTC: ABL2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Huang et al., 2010, Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant., J. Med. Chem.

  • HingoraniCasas: ENSG00000143322

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000143322 Gene Symbol
    ABL2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: ABL2

    • Version: 03-September-2020

    Alternate Names:
    Tyrosine-protein kinase ABL2 Gene Name
    P42684 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • GO: ABL2

    • Version: 05-September-2020

    Alternate Names:
    ABLL GO Gene Synonym
    ARG GO Gene Synonym

    Gene Info:

    Gene Categories:
    TYROSINE KINASE

    Publications:

  • Tempus: ABL2

    • Version: 11-November-2018

    Alternate Names:
    ABL2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: ABL2

    • Version: 27-Jun-2013

    Alternate Names:
    27 Gene ID
    ABLL dGene Synonym
    ARG dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

  • FoundationOneGenes: ABL2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: ABL2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21