DGIdb - ABCC5 Gene Record

ABCC5 10057 Druggable Genome

Alternate Names:

10057
ATP BINDING CASSETTE SUBFAMILY C MEMBER 5
ABCC5
ABC33
EST277145
MOAT-C
MOATC
MRP5
SMRP
pABC11
605251
56
ENSG00000114770
OTTHUMG00000156871
PA395
O15440
MRP5_HUMAN
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-C) (MOAT-C) (PABC11) (SMRP). [SOURCE:UNIPROT/SWISSPROT;ACC:O15440]
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Name	ABC transporter, transmembrane domain
Interpro Short Name	ABC_transptr_TM_dom
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	ABC TRANSPORTER
Interpro Acc	IPR001140
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

TRANSPORTER
ABC TRANSPORTER
DRUGGABLE GENOME

Publications:

Chen S et al., 2015, ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients., Pharmacogenet Genomics
Hariani GD et al., 2014, Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics., BMC Res Notes
Nambaru PK et al., 2011, Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil., Drug Metab Dispos
Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
Ren Q et al., 2016, Genetic and Clinical Predictive Factors of Sulfonylurea Failure in Patients with Type 2 Diabetes., Diabetes Technol Ther

FLOXURIDINE ABCC5

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20930123

Sources:
DTC
GLYBURIDE ABCC5

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27403931

Sources:
PharmGKB
LEUCOVORIN ABCC5

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26352872

Sources:
PharmGKB
ZIDOVUDINE ABCC5

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22960662

Sources:
PharmGKB
OXALIPLATIN ABCC5

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24924344

Sources:
PharmGKB
IRINOTECAN ABCC5

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26352872

Sources:
PharmGKB
FLUOROURACIL ABCC5

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26352872

Sources:
PharmGKB

Ensembl: ENSG00000114770
- Version: 101_38
Alternate Names:

ABCC5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000114770

Version: 26-July-2011

Alternate Names:

ABCC5 Display Id

MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-C) (MOAT-C) (PABC11) (SMRP). [SOURCE:UNIPROT/SWISSPROT;ACC:O15440] Description

ENSG00000114770 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: O15440
- Version: 11-September-2012
Alternate Names:

ABCC5 Uniprot Gene Name

10057 Entrez Gene Id

MRP5_HUMAN Uniprot Id

Gene Info:

Interpro Name ABC transporter, transmembrane domain

Interpro Short Name ABC_transptr_TM_dom

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ABC TRANSPORTER, DRUGGABLE GENOME

Publications:

PharmGKB: ABCC5

Version: 18-August-2020

Alternate Names:

PA395 PharmGKB ID

Gene Info:

Publications:

Chen S et al., 2015, ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients., Pharmacogenet Genomics

Hariani GD et al., 2014, Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics., BMC Res Notes

Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

DTC: ABCC5

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Nambaru PK et al., 2011, Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil., Drug Metab Dispos

HingoraniCasas: ENSG00000114770
- Version: 31-May-2017
Alternate Names:

ENSG00000114770 Gene Symbol

ABCC5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ABCC5
- Version: 01-February-2022
Alternate Names:

MRP5 GO Gene Synonym

Gene Info:

Gene Categories:

ABC TRANSPORTER

Publications:
Pharos: ABCC5
- Version: 01-February-2022
Alternate Names:

Multidrug resistance-associated protein 5 Gene Name

O15440 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

ABCC5	Display Id
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-C) (MOAT-C) (PABC11) (SMRP). [SOURCE:UNIPROT/SWISSPROT;ACC:O15440]	Description
ENSG00000114770	Ensembl Gene Id

ABCC5	Uniprot Gene Name
10057	Entrez Gene Id
MRP5_HUMAN	Uniprot Id

Multidrug resistance-associated protein 5	Gene Name
O15440	UniProt ID

ABCC5 Gene Record

ABCC5 10057 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

FLOXURIDINE ABCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20930123

Sources: DTC

GLYBURIDE ABCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27403931

Sources: PharmGKB

LEUCOVORIN ABCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26352872

Sources: PharmGKB

ZIDOVUDINE ABCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22960662

Sources: PharmGKB

OXALIPLATIN ABCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24924344

Sources: PharmGKB

IRINOTECAN ABCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26352872

Sources: PharmGKB

FLUOROURACIL ABCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26352872

Sources: PharmGKB

Ensembl: ENSG00000114770

Alternate Names: ABCC5 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000114770

Alternate Names: ABCC5 Display Id MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-C) (MOAT-C) (PABC11) (SMRP). [SOURCE:UNIPROT/SWISSPROT;ACC:O15440] Description ENSG00000114770 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: O15440

Alternate Names: ABCC5 Uniprot Gene Name 10057 Entrez Gene Id MRP5_HUMAN Uniprot Id

Gene Info: Interpro Name ABC transporter, transmembrane domain Interpro Short Name ABC_transptr_TM_dom Human Readable Name DRUGGABLE GENOME

Gene Categories: ABC TRANSPORTER, DRUGGABLE GENOME

Publications:

PharmGKB: ABCC5

Alternate Names: PA395 PharmGKB ID

Gene Info:

DTC: ABCC5

Alternate Names:

Gene Info:

Publications: Nambaru PK et al., 2011, Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil., Drug Metab Dispos

HingoraniCasas: ENSG00000114770

Alternate Names: ENSG00000114770 Gene Symbol ABCC5 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: ABCC5

Alternate Names: MRP5 GO Gene Synonym

Gene Info:

Gene Categories: ABC TRANSPORTER

Publications:

Pharos: ABCC5

Alternate Names: Multidrug resistance-associated protein 5 Gene Name O15440 UniProt ID

Gene Info:

Gene Categories: TRANSPORTER

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20930123

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
27403931

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26352872

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22960662

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24924344

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26352872

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26352872

Sources:
PharmGKB

Alternate Names:

ABCC5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ABCC5 Display Id

MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-C) (MOAT-C) (PABC11) (SMRP). [SOURCE:UNIPROT/SWISSPROT;ACC:O15440] Description

ENSG00000114770 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ABCC5 Uniprot Gene Name

10057 Entrez Gene Id

MRP5_HUMAN Uniprot Id

Gene Info:

Interpro Name ABC transporter, transmembrane domain

Interpro Short Name ABC_transptr_TM_dom

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ABC TRANSPORTER, DRUGGABLE GENOME

Alternate Names:

PA395 PharmGKB ID

Publications:

Nambaru PK et al., 2011, Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil., Drug Metab Dispos

Alternate Names:

ENSG00000114770 Gene Symbol

ABCC5 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MRP5 GO Gene Synonym

Gene Categories:

ABC TRANSPORTER

Alternate Names:

Multidrug resistance-associated protein 5 Gene Name

O15440 UniProt ID

Gene Categories:

TRANSPORTER