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ABCC5 Gene Record

  • Summary
  • Interactions
  • Claims
  • ABCC5 10057 Druggable Genome

    Alternate Names:

    10057
    ATP BINDING CASSETTE SUBFAMILY C MEMBER 5
    ABCC5
    ABC33
    EST277145
    MOAT-C
    MOATC
    MRP5
    SMRP
    pABC11
    605251
    56
    ENSG00000114770
    OTTHUMG00000156871
    PA395
    O15440
    MRP5_HUMAN
    MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-C) (MOAT-C) (PABC11) (SMRP). [SOURCE:UNIPROT/SWISSPROT;ACC:O15440]
    MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Name ABC transporter, transmembrane domain
    Interpro Short Name ABC_transptr_TM_dom
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name ABC TRANSPORTER
    Interpro Acc IPR001140
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    ABC TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Chen S et al., 2015, ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients., Pharmacogenet Genomics
    Hariani GD et al., 2014, Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics., BMC Res Notes
    Nambaru PK et al., 2011, Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil., Drug Metab Dispos
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Ren Q et al., 2016, Genetic and Clinical Predictive Factors of Sulfonylurea Failure in Patients with Type 2 Diabetes., Diabetes Technol Ther
  • FLOXURIDINE   ABCC5

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20930123


    Sources:
    DTC

  • GLYBURIDE   ABCC5

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27403931


    Sources:
    PharmGKB

  • LEUCOVORIN   ABCC5

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26352872


    Sources:
    PharmGKB

  • ZIDOVUDINE   ABCC5

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • OXALIPLATIN   ABCC5

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24924344


    Sources:
    PharmGKB

  • IRINOTECAN   ABCC5

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26352872


    Sources:
    PharmGKB

  • FLUOROURACIL   ABCC5

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26352872


    Sources:
    PharmGKB

  • Ensembl: ENSG00000114770

    • Version: 101_38

    Alternate Names:
    ABCC5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000114770

    • Version: 26-July-2011

    Alternate Names:
    ABCC5 Display Id
    MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5 (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-C) (MOAT-C) (PABC11) (SMRP). [SOURCE:UNIPROT/SWISSPROT;ACC:O15440] Description
    ENSG00000114770 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: O15440

    • Version: 11-September-2012

    Alternate Names:
    ABCC5 Uniprot Gene Name
    10057 Entrez Gene Id
    MRP5_HUMAN Uniprot Id

    Gene Info:
    Interpro Name ABC transporter, transmembrane domain
    Interpro Short Name ABC_transptr_TM_dom
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    ABC TRANSPORTER, DRUGGABLE GENOME

    Publications:

  • PharmGKB: ABCC5

    • Version: 18-August-2020

    Alternate Names:
    PA395 PharmGKB ID

    Gene Info:

    Publications:
    Chen S et al., 2015, ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients., Pharmacogenet Genomics
    Hariani GD et al., 2014, Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics., BMC Res Notes
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

  • DTC: ABCC5

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Nambaru PK et al., 2011, Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil., Drug Metab Dispos

  • HingoraniCasas: ENSG00000114770

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000114770 Gene Symbol
    ABCC5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ABCC5

    • Version: 01-February-2022

    Alternate Names:
    MRP5 GO Gene Synonym

    Gene Info:

    Gene Categories:
    ABC TRANSPORTER

    Publications:

  • Pharos: ABCC5

    • Version: 01-February-2022

    Alternate Names:
    Multidrug resistance-associated protein 5 Gene Name
    O15440 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21