DGIdb - ABCC4 Gene Record

ABCC4 10257 Druggable GenomeDrug Resistance

Alternate Names:

10257
ATP BINDING CASSETTE SUBFAMILY C MEMBER 4
ABCC4
MOAT-B
MOATB
MRP4
605250
55
ENSG00000125257
OTTHUMG00000017216
O15439
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4
MRP4_HUMAN
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4 (MRP/CMOAT-RELATED ABC TRANSPORTER) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-B) (MOAT-B). [SOURCE:UNIPROT/SWISSPROT;ACC:O15439]
782
PA397

Gene Info:

Interpro Name	ABC transporter, transmembrane domain
Interpro Type	Domain
Interpro Short Name	ABC_transptr_TM_dom
Human Readable Name	ABC TRANSPORTER
Interpro Acc	IPR001140
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
GuideToPharmacology Gene Category Name	ABCC subfamily
GuideToPharmacology Gene Category ID	153
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUG RESISTANCE
ABC TRANSPORTER
DRUGGABLE GENOME

Publications:

de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos
Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
Anderson PL et al., 2006, Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study., J Acquir Immune Defic Syndr
Chen et al., 2002, Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system., Cancer Res.
Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
den Hoed MA et al., 2015, Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia., Pharmacogenomics J
Lopez-Lopez E et al., 2013, Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia., Pharmacogenet Genomics
Kool et al., 1997, Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines., Cancer Res.
Han JY et al., 2014, A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy., Pharmacogenomics J
Ban H et al., 2010, The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease., J Gastroenterol
Gao LC et al., 2015, Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients., Eur J Clin Pharmacol
de Denus S et al., 2017, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials., Pharmacogenomics J
Low SK et al., 2009, Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients., J Hum Genet
Adachi et al., 2002, Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing., J. Biol. Chem.
Bai et al., 2004, Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione., Int. J. Biochem. Cell Biol.
Drenberg CD et al., 2016, ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression., Clin Transl Sci
Billat PA et al., 2016, Multidrug resistance-associated protein 4 (MRP4) controls ganciclovir intracellular accumulation and contributes to ganciclovir-induced neutropenia in renal transplant patients., Pharmacol Res
Angelini S et al., 2013, Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy., Pharmacol Res
Wittgen HG et al., 2011, Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4., Drug Metab Dispos

VALGANCICLOVIR ABCC4

Interaction Score: 2.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27402191

Sources:
PharmGKB
CEFOXITIN ABCC4

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFAMANDOLE ABCC4

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
LATANOPROST ABCC4

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25339146

Sources:
PharmGKB
CEFMETAZOLE ABCC4

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEPHRADINE ABCC4

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
GANCICLOVIR ABCC4

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12105214

Sources:
NCI
CEFUROXIME ABCC4

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEPHALEXIN ABCC4

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
RIMONABANT ABCC4

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21511945

Sources:
DTC
CEFOPERAZONE ABCC4

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFTRIAXONE ABCC4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
FUROSEMIDE ABCC4

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26927285

Sources:
PharmGKB
CEFACLOR ABCC4

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
ZIDOVUDINE ABCC4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22960662 16791115

Sources:
PharmGKB
AZATHIOPRINE ABCC4

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20393862

Sources:
PharmGKB
THIOGUANINE ABCC4

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14643890

Sources:
NCI
LEUCOVORIN ABCC4

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12036927

Sources:
NCI
MERCAPTOPURINE ABCC4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20393862

Sources:
PharmGKB
METHOTREXATE ABCC4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12036927 25502615 25348617 23222202

Sources:
NCI PharmGKB
CYTARABINE ABCC4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26842729

Sources:
PharmGKB
LAMIVUDINE ABCC4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
IRINOTECAN ABCC4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23478653

Sources:
PharmGKB
RUCAPARIB ABCC4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
IMATINIB ABCC4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23127916

Sources:
PharmGKB
CISPLATIN ABCC4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9270026 23478653

Sources:
NCI PharmGKB
CYCLOPHOSPHAMIDE ABCC4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19696793

Sources:
PharmGKB
DOXORUBICIN ABCC4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19696793

Sources:
PharmGKB
FLUOROURACIL ABCC4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19696793

Sources:
PharmGKB

Ensembl: ENSG00000125257
- Version: 101_38
Alternate Names:

ABCC4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: O15439
- Version: 11-September-2012
Alternate Names:

MRP4_HUMAN Uniprot Id

ABCC4 Uniprot Gene Name

O15439 Uniprot Accession

Gene Info:

Interpro Name ABC transporter, transmembrane domain

Interpro Type Domain

Interpro Short Name ABC_transptr_TM_dom

Gene Categories:

ABC TRANSPORTER, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000125257

Version: 26-July-2011

Alternate Names:

MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4 (MRP/CMOAT-RELATED ABC TRANSPORTER) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-B) (MOAT-B). [SOURCE:UNIPROT/SWISSPROT;ACC:O15439] Description

ABCC4 Display Id

ENSG00000125257 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 10257
- Version: 29-September-2020
Alternate Names:

55 HUGO Gene ID

55 HUGO Gene Symbol

ATP binding cassette subfamily C member 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name ABCC subfamily

GuideToPharmacology Gene Category ID 153

Gene Categories:

TRANSPORTER

Publications:

PharmGKB: ABCC4

Version: 18-August-2020

Alternate Names:

PA397 PharmGKB ID

Gene Info:

Publications:

Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

Anderson PL et al., 2006, Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study., J Acquir Immune Defic Syndr

de Denus S et al., 2017, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials., Pharmacogenomics J

NCI: ABCC4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kool et al., 1997, Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines., Cancer Res.

Adachi et al., 2002, Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing., J. Biol. Chem.

Reid et al., 2003, Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5., Mol. Pharmacol.

DTC: ABCC4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos

Wittgen HG et al., 2011, Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4., Drug Metab Dispos

HingoraniCasas: ENSG00000125257
- Version: 31-May-2017
Alternate Names:

ENSG00000125257 Gene Symbol

ABCC4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ABCC4
- Version: 01-May-2021
Alternate Names:

MRP4 GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE, ABC TRANSPORTER

Publications:
Pharos: ABCC4
- Version: 01-May-2021
Alternate Names:

Multidrug resistance-associated protein 4 Gene Name

O15439 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

MRP4_HUMAN	Uniprot Id
ABCC4	Uniprot Gene Name
O15439	Uniprot Accession

MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4 (MRP/CMOAT-RELATED ABC TRANSPORTER) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-B) (MOAT-B). [SOURCE:UNIPROT/SWISSPROT;ACC:O15439]	Description
ABCC4	Display Id
ENSG00000125257	Ensembl Gene Id

55	HUGO Gene ID
55	HUGO Gene Symbol
ATP binding cassette subfamily C member 4	HUGO Gene Name

Multidrug resistance-associated protein 4	Gene Name
O15439	UniProt ID

ABCC4 Gene Record

ABCC4 10257 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27402191

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25339146

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12105214

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21511945

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26927285

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22960662 16791115

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20393862

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14643890

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12036927

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
27402191

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25339146

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12105214

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21511945

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26927285

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22960662 16791115

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20393862

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
14643890

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12036927

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20393862

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12036927 25502615 25348617 23222202

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26842729

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23478653

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23127916

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9270026 23478653

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19696793