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ABCC4 Gene Record

  • Summary
  • Interactions
  • Claims
  • ABCC4 10257 Druggable Genome

    Alternate Names:

    10257
    ATP BINDING CASSETTE SUBFAMILY C MEMBER 4
    ABCC4
    MOAT-B
    MOATB
    MRP4
    605250
    55
    ENSG00000125257
    OTTHUMG00000017216
    O15439
    MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4
    MRP4_HUMAN
    MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4 (MRP/CMOAT-RELATED ABC TRANSPORTER) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-B) (MOAT-B). [SOURCE:UNIPROT/SWISSPROT;ACC:O15439]
    PA397

    Gene Info:

    Interpro Name ABC transporter, transmembrane domain
    Interpro Type Domain
    Interpro Short Name ABC_transptr_TM_dom
    Human Readable Name ABC TRANSPORTER
    Interpro Acc IPR001140
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    ABC TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Anderson PL et al., 2006, Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study., J Acquir Immune Defic Syndr
    Chen et al., 2002, Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system., Cancer Res.
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    den Hoed MA et al., 2015, Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia., Pharmacogenomics J
    Lopez-Lopez E et al., 2013, Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia., Pharmacogenet Genomics
    Kool et al., 1997, Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines., Cancer Res.
    Han JY et al., 2014, A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy., Pharmacogenomics J
    Ban H et al., 2010, The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease., J Gastroenterol
    Gao LC et al., 2015, Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients., Eur J Clin Pharmacol
    de Denus S et al., 2017, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials., Pharmacogenomics J
    Low SK et al., 2009, Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients., J Hum Genet
    Adachi et al., 2002, Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing., J. Biol. Chem.
    Bai et al., 2004, Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione., Int. J. Biochem. Cell Biol.
    Drenberg CD et al., 2016, ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression., Clin Transl Sci
    Billat PA et al., 2016, Multidrug resistance-associated protein 4 (MRP4) controls ganciclovir intracellular accumulation and contributes to ganciclovir-induced neutropenia in renal transplant patients., Pharmacol Res
    Angelini S et al., 2013, Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy., Pharmacol Res
    Wittgen HG et al., 2011, Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4., Drug Metab Dispos
  • VALGANCICLOVIR   ABCC4

    Interaction Score: 2.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27402191


    Sources:
    PharmGKB

  • CEFOXITIN   ABCC4

    Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • CEFAMANDOLE   ABCC4

    Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • LATANOPROST   ABCC4

    Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25339146


    Sources:
    PharmGKB

  • CEFMETAZOLE   ABCC4

    Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • CEPHRADINE   ABCC4

    Interaction Score: 1.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • GANCICLOVIR   ABCC4

    Interaction Score: 1.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12105214


    Sources:
    NCI

  • CEFUROXIME   ABCC4

    Interaction Score: 1.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • CEPHALEXIN   ABCC4

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • RIMONABANT   ABCC4

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21511945


    Sources:
    DTC

  • CEFOPERAZONE   ABCC4

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • FUROSEMIDE   ABCC4

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26927285


    Sources:
    PharmGKB

  • CEFTRIAXONE   ABCC4

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • CEFACLOR   ABCC4

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • ZIDOVUDINE   ABCC4

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662 16791115


    Sources:
    PharmGKB

  • AZATHIOPRINE   ABCC4

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20393862


    Sources:
    PharmGKB

  • THIOGUANINE   ABCC4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14643890


    Sources:
    NCI

  • LEUCOVORIN   ABCC4

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12036927


    Sources:
    NCI

  • MERCAPTOPURINE   ABCC4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20393862


    Sources:
    PharmGKB

  • METHOTREXATE   ABCC4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12036927 25502615 25348617 23222202


    Sources:
    NCI PharmGKB

  • CYTARABINE   ABCC4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26842729


    Sources:
    PharmGKB

  • LAMIVUDINE   ABCC4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • IRINOTECAN   ABCC4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23478653


    Sources:
    PharmGKB

  • IMATINIB   ABCC4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23127916


    Sources:
    PharmGKB

  • RUCAPARIB   ABCC4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CISPLATIN   ABCC4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9270026 23478653


    Sources:
    NCI PharmGKB

  • CYCLOPHOSPHAMIDE   ABCC4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19696793


    Sources:
    PharmGKB

  • DOXORUBICIN   ABCC4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19696793


    Sources:
    PharmGKB

  • FLUOROURACIL   ABCC4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19696793


    Sources:
    PharmGKB

  • Ensembl: ENSG00000125257

    • Version: 101_38

    Alternate Names:
    ABCC4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: O15439

    • Version: 11-September-2012

    Alternate Names:
    MRP4_HUMAN Uniprot Id
    ABCC4 Uniprot Gene Name
    O15439 Uniprot Accession

    Gene Info:
    Interpro Name ABC transporter, transmembrane domain
    Interpro Type Domain
    Interpro Short Name ABC_transptr_TM_dom

    Gene Categories:
    ABC TRANSPORTER, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000125257

    • Version: 26-July-2011

    Alternate Names:
    MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4 (MRP/CMOAT-RELATED ABC TRANSPORTER) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-B) (MOAT-B). [SOURCE:UNIPROT/SWISSPROT;ACC:O15439] Description
    ABCC4 Display Id
    ENSG00000125257 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ABCC4

    • Version: 18-August-2020

    Alternate Names:
    PA397 PharmGKB ID

    Gene Info:

    Publications:
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Anderson PL et al., 2006, Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study., J Acquir Immune Defic Syndr
    de Denus S et al., 2017, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials., Pharmacogenomics J

  • NCI: ABCC4

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kool et al., 1997, Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines., Cancer Res.
    Adachi et al., 2002, Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing., J. Biol. Chem.
    Reid et al., 2003, Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5., Mol. Pharmacol.

  • DTC: ABCC4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos
    Wittgen HG et al., 2011, Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4., Drug Metab Dispos

  • HingoraniCasas: ENSG00000125257

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000125257 Gene Symbol
    ABCC4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ABCC4

    • Version: 01-February-2022

    Alternate Names:
    MOATB GO Gene Synonym
    MRP4 GO Gene Synonym

    Gene Info:

    Gene Categories:
    ABC TRANSPORTER

    Publications:

  • Pharos: ABCC4

    • Version: 01-February-2022

    Alternate Names:
    Multidrug resistance-associated protein 4 Gene Name
    O15439 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21