DGIdb - ABCC2 Gene Record

ABCC2 1244 Druggable Genome

Alternate Names:

1244
ATP BINDING CASSETTE SUBFAMILY C MEMBER 2
ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
601107
53
ENSG00000023839
OTTHUMG00000018895
Q92887
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1
MRP2_HUMAN
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1 (ATP-BINDING CASSETTE, SUB-FAMILY C, MEMBER 2) (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2) (CANALICULAR MULTIDRUG RESISTANCE PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92887]
PA116
CMOAT1

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Human Readable Name	ABC TRANSPORTER
Interpro Short Name	ABC_transptr_TM_dom
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Name	ABC transporter, transmembrane domain
Interpro Acc	IPR001140
Uniprot Evidence	1: Evidence at protein level
Target Main Class	Transporters
Transmembrane Helix Count	16
Target Subclass	ABCC
Target Subclass	Active_transporters
Target Class	Transporters
Target Subclass	TC:3.A.1.208.8
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

TRANSPORTER
CELL SURFACE
ABC TRANSPORTER
DRUGGABLE GENOME

Publications:

Wojnowski L et al., 2005, NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity., Circulation
Marano M et al., 2016, Deferasirox-induced serious adverse reaction in a pediatric patient: pharmacokinetic and pharmacogenetic analysis., Eur J Clin Pharmacol
Cusato J et al., 2015, Influence of single-nucleotide polymorphisms on deferasirox C trough levels and effectiveness., Pharmacogenomics J
de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos
da Rocha IM et al., 2015, Polymorphisms associated with renal adverse effects of antiretroviral therapy in a Southern Brazilian HIV cohort., Pharmacogenet Genomics
Niemi M et al., 2006, Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics., Pharmacogenet Genomics
Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
Jenko B et al., 2017, Clinical-pharmacogenetic predictive models for MTX discontinuation due to adverse events in rheumatoid arthritis., Pharmacogenomics J
Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Yanagimachi M et al., 2013, Influence of pre-hydration and pharmacogenetics on plasma methotrexate concentration and renal dysfunction following high-dose methotrexate therapy., Int J Hematol
Lopez-Lopez E et al., 2013, Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia., Pharmacogenet Genomics
Simon N et al., 2013, Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy., Pharmacogenomics J
Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
Ranganathan P et al., 2008, Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis., J Rheumatol
Soko ND et al., 2019, An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C., Pharmacogenomics J
Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
Rädisch S et al., 2014, A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine., Pharmacogenomics J
Sporis D et al., 2013, Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy., Coll Antropol
Puranik YG et al., 2013, Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy., Pharmacogenomics
Qu J et al., 2012, ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients., CNS Neurosci Ther
Hilger E et al., 2012, Lack of association between ABCC2 gene variants and treatment response in epilepsy., Pharmacogenomics
Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics
Ufer M et al., 2011, Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy., Pharmacogenet Genomics
Thorn CF et al., 2011, PharmGKB summary: carbamazepine pathway., Pharmacogenet Genomics
Kwan P et al., 2011, Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy., Pharmacogenomics
Kim WJ et al., 2010, A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy., Pharmacogenet Genomics
Cusato J et al., 2020, Pharmacogenetic determinants of kidney-associated urinary and serum abnormalities in antiretroviral-treated HIV-positive patients., Pharmacogenomics J
Likanonsakul S et al., 2016, A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection., PLoS One
Nishijima T et al., 2015, Drug Transporter Genetic Variants Are Not Associated with TDF-Related Renal Dysfunction in Patients with HIV-1 Infection: A Pharmacogenetic Study., PLoS One
Dahlin A et al., 2015, A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome., Pharmacogenet Genomics
Rodríguez-Nóvoa S et al., 2009, Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study., Clin Infect Dis
Izzedine H et al., 2006, Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy., J Infect Dis
Weiss J et al., 2007, Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors., Drug Metab Dispos
Ito et al., 2001, Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity., J. Biol. Chem.
Morrow et al., 2000, Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells., Mol. Carcinog.
Flanagan et al., 2002, Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2)., Pharmacology
Hagos et al., 2007, Human renal organic anion transporter 4 operates as an asymmetric urate transporter., J. Am. Soc. Nephrol.
Bakos et al., 2000, Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions., Mol. Pharmacol.
Evers et al., 2000, Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export., Br. J. Cancer
Božina N et al., 2017, Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients' and donors' ABCC2 gene variants, and their interactions., Eur J Clin Pharmacol
Han N et al., 2014, Population pharmacogenetic pharmacokinetic modeling for flip-flop phenomenon of enteric-coated mycophenolate sodium in kidney transplant recipients., Eur J Clin Pharmacol
Prado Y et al., 2018, Gender-Specific Association Between ABCC2 -24C>T SNP and Reduction in Triglycerides in Chilean Patients Treated With Atorvastatin., Basic Clin Pharmacol Toxicol
Becker ML et al., 2013, Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy., Pharmacogenomics J
Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother
Cusato J et al., 2016, Efavirenz pharmacogenetics in a cohort of Italian patients., Int J Antimicrob Agents
Lee KH et al., 2013, Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer., Cancer Chemother Pharmacol
Fujita K et al., 2008, Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI)., Biol Pharm Bull
Han JY et al., 2009, Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer., Lung Cancer
Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
Allegra S et al., 2018, Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations., J Clin Pharmacol
Elens L et al., 2011, Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition., Pharmacogenet Genomics
Elens L et al., 2009, Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients., Pharmacogenomics
Haenisch S et al., 2008, Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol., Pharmacogenet Genomics
Oetting WS et al., 2018, Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients., Pharmacogenomics
Genvigir FDV et al., 2017, Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients., Pharmacotherapy
Wittgen HG et al., 2011, Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4., Drug Metab Dispos
Oh ES et al., 2013, Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans., Drug Metab Pharmacokinet
Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos
Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J
Tsuchiya N et al., 2013, Risk factors for sorafenib-induced high-grade skin rash in Japanese patients with advanced renal cell carcinoma., Anticancer Drugs
Lewis LD et al., 2013, The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance)., Pharmacogenet Genomics
Kiyotani K et al., 2008, Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia., Cancer Sci

TALINOLOL ABCC2

Interaction Score: 1.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18334920

Sources:
PharmGKB
TENOFOVIR ABCC2

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31619748 26807589 26535588 26287941 25485598 19400747 17083032 17172311

Sources:
DTC PharmGKB
CEFOXITIN ABCC2

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFADROXIL ABCC2

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
EMTRICITABINE ABCC2

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
CEFMETAZOLE ABCC2

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
SULFINPYRAZONE ABCC2

Interaction Score: 0.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11500505 11108662 11834888 17229912 10727523 10917554

Sources:
TdgClinicalTrial TEND
CEFAMANDOLE ABCC2

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
MK-571 ABCC2

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23073734

Sources:
DTC
CEPHRADINE ABCC2

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
PITAVASTATIN ABCC2

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007012

Sources:
PharmGKB
CEFUROXIME ABCC2

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
OXCARBAZEPINE ABCC2

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25155934 24567120 23697249 22630058 22256867 22188362 21799461 21449672

Sources:
PharmGKB
LOPINAVIR ABCC2

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26287941 22027652 19842932

Sources:
PharmGKB
DELAVIRDINE ABCC2

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
CEPHALEXIN ABCC2

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFTRIAXONE ABCC2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29873816 22166395

Sources:
DTC PharmGKB
DEFERASIROX ABCC2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26403473 25348619

Sources:
PharmGKB
RIMONABANT ABCC2

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21511945

Sources:
DTC
CARBAMAZEPINE ABCC2

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25155934 24567120 23697249 23252947 22630058 22256867 22188362 21799461 21738081 21449672 20216337

Sources:
PharmGKB
CEFOPERAZONE ABCC2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
EFAVIRENZ ABCC2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21189339 17172311 26774523

Sources:
DTC PharmGKB
ATAZANAVIR ABCC2

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26287941

Sources:
PharmGKB
ABACAVIR ABCC2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
ROSUVASTATIN ABCC2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30100615

Sources:
PharmGKB
CEFACLOR ABCC2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
LAMIVUDINE ABCC2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC PharmGKB
RITONAVIR ABCC2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26287941

Sources:
PharmGKB
TACROLIMUS ABCC2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29318894 28316087

Sources:
PharmGKB
NEVIRAPINE ABCC2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
METHOTREXATE ABCC2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29791011 27217051 25502615 24241962 23222202 23069858 21317831 18381794

Sources:
PharmGKB
LEUCOVORIN ABCC2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23314736

Sources:
PharmGKB
PEMETREXED ABCC2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
BENZBROMARONE ABCC2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOSPORINE ABCC2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28624888 25163792

Sources:
DTC PharmGKB
PRAVASTATIN ABCC2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17047488

Sources:
PharmGKB
IRINOTECAN ABCC2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18981587 18221820

Sources:
PharmGKB
OXALIPLATIN ABCC2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23314736

Sources:
PharmGKB
ERYTHROMYCIN ABCC2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DOCETAXEL ABCC2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23188068 21151855 18294295

Sources:
PharmGKB
ATORVASTATIN ABCC2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29178257 22186618

Sources:
PharmGKB
SIMVASTATIN ABCC2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22186618

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN ABCC2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
IMATINIB ABCC2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30237583

Sources:
PharmGKB
SORAFENIB ABCC2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23237922

Sources:
PharmGKB
LOVASTATIN ABCC2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DOXORUBICIN ABCC2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16330681

Sources:
PharmGKB
PACLITAXEL ABCC2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21151855

Sources:
PharmGKB
FLUOROURACIL ABCC2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23314736

Sources:
PharmGKB
VINCRISTINE ABCC2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TAMOXIFEN ABCC2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CYCLOPHOSPHAMIDE ABCC2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CISPLATIN ABCC2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000023839
- Version: 101_38
Alternate Names:

ABCC2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q92887
- Version: 11-September-2012
Alternate Names:

ABCC2 Uniprot Gene Name

Q92887 Uniprot Accession

ENSG00000023839 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Human Readable Name ABC TRANSPORTER

Interpro Short Name ABC_transptr_TM_dom

Gene Categories:

ABC TRANSPORTER, DRUGGABLE GENOME

Publications:
TEND: Q92887
- Version: 01-August-2011
Alternate Names:

MRP2_HUMAN Uniprot Id

Q92887 Uniprot Accession

1244 Entrez Gene Id

Gene Info:

Target Main Class Transporters

Transmembrane Helix Count 16

Target Subclass ABCC

Publications:

RussLampel: ENSG00000023839

Version: 26-July-2011

Alternate Names:

ABCC2 Display Id

ENSG00000023839 Ensembl Gene Id

CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1 (ATP-BINDING CASSETTE, SUB-FAMILY C, MEMBER 2) (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2) (CANALICULAR MULTIDRUG RESISTANCE PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92887] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q92887
- Version: January-2014
Alternate Names:

ABCC2 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:3.A.1.208.8

Publications:

PharmGKB: ABCC2

Version: 18-August-2020

Alternate Names:

PA116 PharmGKB ID

Gene Info:

Publications:

Wojnowski L et al., 2005, NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity., Circulation

Kwan P et al., 2011, Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy., Pharmacogenomics

Qu J et al., 2012, ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients., CNS Neurosci Ther

NCI: ABCC2
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

McDonagh et al., 2002, Hepatobiliary excretion of dipyrrinone sulfonates in Mrp2-deficient (TR(-)) rats., Bioorg. Med. Chem. Lett.

DTC: ABCC2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos

Weiss J et al., 2007, Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors., Drug Metab Dispos

Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother

HingoraniCasas: ENSG00000023839
- Version: 31-May-2017
Alternate Names:

ENSG00000023839 Gene Symbol

ABCC2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ABCC2
- Version: 01-February-2022
Alternate Names:

CMOAT GO Gene Synonym

CMOAT1 GO Gene Synonym

CMRP GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, ABC TRANSPORTER

Publications:
Pharos: ABCC2
- Version: 01-February-2022
Alternate Names:

Canalicular multispecific organic anion transporter 1 Gene Name

Q92887 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

ABCC2	Uniprot Gene Name
Q92887	Uniprot Accession
ENSG00000023839	Ensembl Gene Id

MRP2_HUMAN	Uniprot Id
Q92887	Uniprot Accession
1244	Entrez Gene Id

ABCC2	Display Id
ENSG00000023839	Ensembl Gene Id
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1 (ATP-BINDING CASSETTE, SUB-FAMILY C, MEMBER 2) (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2) (CANALICULAR MULTIDRUG RESISTANCE PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92887]	Description

CMOAT	GO Gene Synonym
CMOAT1	GO Gene Synonym
CMRP	GO Gene Synonym

Canalicular multispecific organic anion transporter 1	Gene Name
Q92887	UniProt ID

Trial Name	-
Novel drug target	Established target

ABCC2 Gene Record

ABCC2 1244 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18334920

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31619748 26807589 26535588 26287941 25485598 19400747 17083032 17172311

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11500505 11108662 11834888 17229912 10727523 10917554

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23073734

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007012

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25155934 24567120 23697249 22630058 22256867 22188362 21799461 21449672

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26287941 22027652 19842932

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29873816 22166395

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26403473 25348619

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
18334920

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31619748 26807589 26535588 26287941 25485598 19400747 17083032 17172311

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11500505 11108662 11834888 17229912 10727523 10917554

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23073734

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23007012

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25155934 24567120 23697249 22630058 22256867 22188362 21799461 21449672

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26287941 22027652 19842932

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
29873816 22166395

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26403473 25348619

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21511945

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25155934 24567120 23697249 23252947 22630058 22256867 22188362 21799461 21738081 21449672 20216337

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21189339 17172311 26774523

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26287941

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
30100615

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a