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ABCC2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ABCC2 1244 Druggable Genome

    Alternate Names:

    1244
    ATP BINDING CASSETTE SUBFAMILY C MEMBER 2
    ABCC2
    ABC30
    CMOAT
    DJS
    MRP2
    cMRP
    601107
    53
    ENSG00000023839
    OTTHUMG00000018895
    Q92887
    CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1
    MRP2_HUMAN
    CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1 (ATP-BINDING CASSETTE, SUB-FAMILY C, MEMBER 2) (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2) (CANALICULAR MULTIDRUG RESISTANCE PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92887]
    PA116
    CMOAT1

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name ABC TRANSPORTER
    Interpro Short Name ABC_transptr_TM_dom
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Name ABC transporter, transmembrane domain
    Interpro Acc IPR001140
    Uniprot Evidence 1: Evidence at protein level
    Target Main Class Transporters
    Transmembrane Helix Count 16
    Target Subclass ABCC
    Target Subclass Active_transporters
    Target Class Transporters
    Target Subclass TC:3.A.1.208.8
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    CELL SURFACE
    ABC TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Wojnowski L et al., 2005, NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity., Circulation
    Marano M et al., 2016, Deferasirox-induced serious adverse reaction in a pediatric patient: pharmacokinetic and pharmacogenetic analysis., Eur J Clin Pharmacol
    Cusato J et al., 2015, Influence of single-nucleotide polymorphisms on deferasirox C trough levels and effectiveness., Pharmacogenomics J
    de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos
    da Rocha IM et al., 2015, Polymorphisms associated with renal adverse effects of antiretroviral therapy in a Southern Brazilian HIV cohort., Pharmacogenet Genomics
    Niemi M et al., 2006, Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics., Pharmacogenet Genomics
    Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
    Jenko B et al., 2017, Clinical-pharmacogenetic predictive models for MTX discontinuation due to adverse events in rheumatoid arthritis., Pharmacogenomics J
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Yanagimachi M et al., 2013, Influence of pre-hydration and pharmacogenetics on plasma methotrexate concentration and renal dysfunction following high-dose methotrexate therapy., Int J Hematol
    Lopez-Lopez E et al., 2013, Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia., Pharmacogenet Genomics
    Simon N et al., 2013, Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy., Pharmacogenomics J
    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
    Ranganathan P et al., 2008, Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis., J Rheumatol
    Soko ND et al., 2019, An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C., Pharmacogenomics J
    Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
    Rädisch S et al., 2014, A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine., Pharmacogenomics J
    Sporis D et al., 2013, Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy., Coll Antropol
    Puranik YG et al., 2013, Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy., Pharmacogenomics
    Qu J et al., 2012, ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients., CNS Neurosci Ther
    Hilger E et al., 2012, Lack of association between ABCC2 gene variants and treatment response in epilepsy., Pharmacogenomics
    Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics
    Ufer M et al., 2011, Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy., Pharmacogenet Genomics
    Thorn CF et al., 2011, PharmGKB summary: carbamazepine pathway., Pharmacogenet Genomics
    Kwan P et al., 2011, Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy., Pharmacogenomics
    Kim WJ et al., 2010, A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy., Pharmacogenet Genomics
    Cusato J et al., 2020, Pharmacogenetic determinants of kidney-associated urinary and serum abnormalities in antiretroviral-treated HIV-positive patients., Pharmacogenomics J
    Likanonsakul S et al., 2016, A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection., PLoS One
    Nishijima T et al., 2015, Drug Transporter Genetic Variants Are Not Associated with TDF-Related Renal Dysfunction in Patients with HIV-1 Infection: A Pharmacogenetic Study., PLoS One
    Dahlin A et al., 2015, A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome., Pharmacogenet Genomics
    Rodríguez-Nóvoa S et al., 2009, Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study., Clin Infect Dis
    Izzedine H et al., 2006, Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy., J Infect Dis
    Weiss J et al., 2007, Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors., Drug Metab Dispos
    Ito et al., 2001, Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity., J. Biol. Chem.
    Morrow et al., 2000, Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells., Mol. Carcinog.
    Flanagan et al., 2002, Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2)., Pharmacology
    Hagos et al., 2007, Human renal organic anion transporter 4 operates as an asymmetric urate transporter., J. Am. Soc. Nephrol.
    Bakos et al., 2000, Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions., Mol. Pharmacol.
    Evers et al., 2000, Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export., Br. J. Cancer
    Božina N et al., 2017, Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients' and donors' ABCC2 gene variants, and their interactions., Eur J Clin Pharmacol
    Han N et al., 2014, Population pharmacogenetic pharmacokinetic modeling for flip-flop phenomenon of enteric-coated mycophenolate sodium in kidney transplant recipients., Eur J Clin Pharmacol
    Prado Y et al., 2018, Gender-Specific Association Between ABCC2 -24C>T SNP and Reduction in Triglycerides in Chilean Patients Treated With Atorvastatin., Basic Clin Pharmacol Toxicol
    Becker ML et al., 2013, Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy., Pharmacogenomics J
    Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother
    Cusato J et al., 2016, Efavirenz pharmacogenetics in a cohort of Italian patients., Int J Antimicrob Agents
    Lee KH et al., 2013, Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer., Cancer Chemother Pharmacol
    Fujita K et al., 2008, Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI)., Biol Pharm Bull
    Han JY et al., 2009, Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer., Lung Cancer
    Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
    Allegra S et al., 2018, Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations., J Clin Pharmacol
    Elens L et al., 2011, Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition., Pharmacogenet Genomics
    Elens L et al., 2009, Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients., Pharmacogenomics
    Haenisch S et al., 2008, Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol., Pharmacogenet Genomics
    Oetting WS et al., 2018, Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients., Pharmacogenomics
    Genvigir FDV et al., 2017, Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients., Pharmacotherapy
    Wittgen HG et al., 2011, Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4., Drug Metab Dispos
    Oh ES et al., 2013, Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans., Drug Metab Pharmacokinet
    Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos
    Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J
    Tsuchiya N et al., 2013, Risk factors for sorafenib-induced high-grade skin rash in Japanese patients with advanced renal cell carcinoma., Anticancer Drugs
    Lewis LD et al., 2013, The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance)., Pharmacogenet Genomics
    Kiyotani K et al., 2008, Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia., Cancer Sci
  • TALINOLOL   ABCC2

    Interaction Score: 1.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18334920


    Sources:
    PharmGKB

  • TENOFOVIR   ABCC2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31619748 26807589 26535588 26287941 25485598 19400747 17083032 17172311


    Sources:
    DTC PharmGKB

  • CEFOXITIN   ABCC2

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • CEFADROXIL   ABCC2

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • EMTRICITABINE   ABCC2

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17172311


    Sources:
    DTC

  • CEFMETAZOLE   ABCC2

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • SULFINPYRAZONE   ABCC2

    Interaction Score: 0.78

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11500505 11108662 11834888 17229912 10727523 10917554


    Sources:
    TdgClinicalTrial TEND

  • CEFAMANDOLE   ABCC2

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • MK-571   ABCC2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23073734


    Sources:
    DTC

  • CEPHRADINE   ABCC2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • PITAVASTATIN   ABCC2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23007012


    Sources:
    PharmGKB

  • CEFUROXIME   ABCC2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • OXCARBAZEPINE   ABCC2

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25155934 24567120 23697249 22630058 22256867 22188362 21799461 21449672


    Sources:
    PharmGKB

  • LOPINAVIR   ABCC2

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26287941 22027652 19842932


    Sources:
    PharmGKB

  • DELAVIRDINE   ABCC2

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17172311


    Sources:
    DTC

  • CEPHALEXIN   ABCC2

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • CEFTRIAXONE   ABCC2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29873816 22166395


    Sources:
    DTC PharmGKB

  • DEFERASIROX   ABCC2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26403473 25348619


    Sources:
    PharmGKB

  • RIMONABANT   ABCC2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21511945


    Sources:
    DTC

  • CARBAMAZEPINE   ABCC2

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25155934 24567120 23697249 23252947 22630058 22256867 22188362 21799461 21738081 21449672 20216337


    Sources:
    PharmGKB

  • CEFOPERAZONE   ABCC2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • EFAVIRENZ   ABCC2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21189339 17172311 26774523


    Sources:
    DTC PharmGKB

  • ATAZANAVIR   ABCC2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26287941


    Sources:
    PharmGKB

  • ABACAVIR   ABCC2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17172311


    Sources:
    DTC

  • ROSUVASTATIN   ABCC2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30100615


    Sources:
    PharmGKB

  • CEFACLOR   ABCC2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22166395


    Sources:
    DTC

  • LAMIVUDINE   ABCC2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17172311


    Sources:
    DTC PharmGKB

  • RITONAVIR   ABCC2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26287941


    Sources:
    PharmGKB

  • TACROLIMUS   ABCC2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29318894 28316087


    Sources:
    PharmGKB

  • NEVIRAPINE   ABCC2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17172311


    Sources:
    DTC

  • METHOTREXATE   ABCC2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29791011 27217051 25502615 24241962 23222202 23069858 21317831 18381794


    Sources:
    PharmGKB

  • LEUCOVORIN   ABCC2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23314736


    Sources:
    PharmGKB

  • PEMETREXED   ABCC2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BENZBROMARONE   ABCC2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLOSPORINE   ABCC2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28624888 25163792


    Sources:
    DTC PharmGKB

  • PRAVASTATIN   ABCC2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17047488


    Sources:
    PharmGKB

  • IRINOTECAN   ABCC2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18981587 18221820


    Sources:
    PharmGKB

  • OXALIPLATIN   ABCC2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23314736


    Sources:
    PharmGKB

  • ERYTHROMYCIN   ABCC2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOCETAXEL   ABCC2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23188068 21151855 18294295


    Sources:
    PharmGKB

  • ATORVASTATIN   ABCC2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29178257 22186618


    Sources:
    PharmGKB

  • SIMVASTATIN   ABCC2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22186618


    Sources:
    PharmGKB

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   ABCC2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • IMATINIB   ABCC2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30237583


    Sources:
    PharmGKB

  • SORAFENIB   ABCC2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23237922


    Sources:
    PharmGKB

  • LOVASTATIN   ABCC2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOXORUBICIN   ABCC2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16330681


    Sources:
    PharmGKB

  • PACLITAXEL   ABCC2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21151855


    Sources:
    PharmGKB

  • FLUOROURACIL   ABCC2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23314736


    Sources:
    PharmGKB

  • VINCRISTINE   ABCC2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TAMOXIFEN   ABCC2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   ABCC2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CISPLATIN   ABCC2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000023839

    • Version: 101_38

    Alternate Names:
    ABCC2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q92887

    • Version: 11-September-2012

    Alternate Names:
    ABCC2 Uniprot Gene Name
    Q92887 Uniprot Accession
    ENSG00000023839 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name ABC TRANSPORTER
    Interpro Short Name ABC_transptr_TM_dom

    Gene Categories:
    ABC TRANSPORTER, DRUGGABLE GENOME

    Publications:

  • TEND: Q92887

    • Version: 01-August-2011

    Alternate Names:
    MRP2_HUMAN Uniprot Id
    Q92887 Uniprot Accession
    1244 Entrez Gene Id

    Gene Info:
    Target Main Class Transporters
    Transmembrane Helix Count 16
    Target Subclass ABCC

    Publications:

  • RussLampel: ENSG00000023839

    • Version: 26-July-2011

    Alternate Names:
    ABCC2 Display Id
    ENSG00000023839 Ensembl Gene Id
    CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1 (ATP-BINDING CASSETTE, SUB-FAMILY C, MEMBER 2) (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2) (CANALICULAR MULTIDRUG RESISTANCE PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92887] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q92887

    • Version: January-2014

    Alternate Names:
    ABCC2 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:3.A.1.208.8

    Publications:

  • PharmGKB: ABCC2

    • Version: 18-August-2020

    Alternate Names:
    PA116 PharmGKB ID

    Gene Info:

    Publications:
    Wojnowski L et al., 2005, NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity., Circulation
    Kwan P et al., 2011, Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy., Pharmacogenomics
    Qu J et al., 2012, ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients., CNS Neurosci Ther

  • NCI: ABCC2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    McDonagh et al., 2002, Hepatobiliary excretion of dipyrrinone sulfonates in Mrp2-deficient (TR(-)) rats., Bioorg. Med. Chem. Lett.

  • DTC: ABCC2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos
    Weiss J et al., 2007, Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors., Drug Metab Dispos
    Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother

  • HingoraniCasas: ENSG00000023839

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000023839 Gene Symbol
    ABCC2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ABCC2

    • Version: 01-February-2022

    Alternate Names:
    CMOAT GO Gene Synonym
    CMOAT1 GO Gene Synonym
    CMRP GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, ABC TRANSPORTER

    Publications:

  • Pharos: ABCC2

    • Version: 01-February-2022

    Alternate Names:
    Canalicular multispecific organic anion transporter 1 Gene Name
    Q92887 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21