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ABCC10 Gene Record

  • Summary
  • Interactions
  • Claims
  • ABCC10 89845 Druggable GenomeDrug Resistance

    Alternate Names:

    89845
    ATP BINDING CASSETTE SUBFAMILY C MEMBER 10
    ABCC10
    EST182763
    MRP7
    SIMRP7
    612509
    52
    ENSG00000124574
    OTTHUMG00000014733
    Q5T3U5
    MRP7_HUMAN
    MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 7
    ATP-BINDING CASSETTE, SUB-FAMILY C, MEMBER 10 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_258261]
    16656
    PA24392
    785

    Gene Info:

    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name ABC_transptr_TM_dom
    Interpro Type Domain
    Human Readable Name ABC TRANSPORTER
    Interpro Acc IPR001140
    Interpro Name ABC transporter, transmembrane domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    GuideToPharmacology Gene Category Name ABCC subfamily
    GuideToPharmacology Gene Category ID 153
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUG RESISTANCE
    ABC TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Pushpakom SP et al., 2011, Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction., J Infect Dis
    Liptrott NJ et al., 2012, Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS., Pharmacogenet Genomics
    Oguri et al., 2008, MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer., Mol. Cancer Ther.
  • TENOFOVIR   ABCC10

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21628669


    Sources:
    PharmGKB

  • NEVIRAPINE   ABCC10

    Interaction Score: 1.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22082652


    Sources:
    PharmGKB

  • PACLITAXEL   ABCC10

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18445659


    Sources:
    CIViC

  • VINCRISTINE   ABCC10

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000124574

    • Version: 101_38

    Alternate Names:
    ABCC10 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q5T3U5

    • Version: 11-September-2012

    Alternate Names:
    MRP7_HUMAN Uniprot Id
    89845 Entrez Gene Id
    ENSG00000124574 Ensembl Gene Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name ABC_transptr_TM_dom
    Interpro Type Domain

    Gene Categories:
    ABC TRANSPORTER, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000124574

    • Version: 26-July-2011

    Alternate Names:
    ABCC10 Display Id
    ATP-BINDING CASSETTE, SUB-FAMILY C, MEMBER 10 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_258261] Description
    ENSG00000124574 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 89845

    • Version: 29-September-2020

    Alternate Names:
    52 HUGO Gene ID
    52 HUGO Gene Symbol
    ATP binding cassette subfamily C member 10 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name ABCC subfamily
    GuideToPharmacology Gene Category ID 153

    Gene Categories:
    TRANSPORTER

    Publications:

  • PharmGKB: ABCC10

    • Version: 18-August-2020

    Alternate Names:
    PA24392 PharmGKB ID

    Gene Info:

    Publications:
    Pushpakom SP et al., 2011, Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction., J Infect Dis
    Liptrott NJ et al., 2012, Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS., Pharmacogenet Genomics

  • CIViC: ABCC10

    • Version: 14-September-2020

    Alternate Names:
    89845 Entrez Gene ID
    16656 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Oguri et al., 2008, MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer., Mol. Cancer Ther.

  • HingoraniCasas: ENSG00000124574

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000124574 Gene Symbol
    ABCC10 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: ABCC10

    • Version: 03-September-2020

    Alternate Names:
    Multidrug resistance-associated protein 7 Gene Name
    Q5T3U5 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • GO: ABCC10

    • Version: 05-September-2020

    Alternate Names:
    MRP7 GO Gene Synonym
    SIMRP7 GO Gene Synonym

    Gene Info:

    Gene Categories:
    ABC TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21