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ABCB4 Gene Record

  • Summary
  • Interactions
  • Claims
  • ABCB4 5244 Druggable Genome

    Alternate Names:

    5244
    ATP BINDING CASSETTE SUBFAMILY B MEMBER 4
    ABCB4
    ABC21
    GBD1
    ICP3
    MDR2
    MDR2/3
    MDR3
    PFIC-3
    PGY3
    171060
    45
    ENSG00000005471
    OTTHUMG00000023396
    P21439
    MULTIDRUG RESISTANCE PROTEIN 3
    MDR3_HUMAN
    MULTIDRUG RESISTANCE PROTEIN
    PA268
    MULTIDRUG RESISTANCE PROTEIN 3 (P-GLYCOPROTEIN 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21439]
    MDR
    T16422
    Phosphatidylcholine translocator ABCB4

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name ABC_transptr_TM_dom
    Interpro Acc IPR001140
    Human Readable Name ABC TRANSPORTER
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Name ABC transporter, transmembrane domain
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    ABC TRANSPORTER
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Bornmann et al., 1994, Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound., Biochemistry
    Schinkel et al., 1991, Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies., Cancer Res.
    Herweijer et al., 1990, Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine., J. Natl. Cancer Inst.
    Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J
  • ORTATAXEL   ABCB4

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BENZQUINAMIDE   ABCB4

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • VINBLASTINE   ABCB4

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7918493


    Sources:
    NCI

  • VINCRISTINE   ABCB4

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1673638


    Sources:
    NCI

  • CYCLOSPORINE   ABCB4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1972761


    Sources:
    NCI

  • IMATINIB   ABCB4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30237583


    Sources:
    PharmGKB

  • CURCUMIN   ABCB4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000005471

    • Version: 101_38

    Alternate Names:
    ABCB4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000005471

    • Version: 26-July-2011

    Alternate Names:
    MULTIDRUG RESISTANCE PROTEIN 3 (P-GLYCOPROTEIN 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21439] Description
    ABCB4 Display Id
    ENSG00000005471 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P21439

    • Version: 11-September-2012

    Alternate Names:
    MDR3_HUMAN Uniprot Id
    P21439 Uniprot Accession
    MULTIDRUG RESISTANCE PROTEIN 3 Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name ABC_transptr_TM_dom

    Gene Categories:
    ABC TRANSPORTER, DRUGGABLE GENOME

    Publications:

  • PharmGKB: ABCB4

    • Version: 18-August-2020

    Alternate Names:
    PA268 PharmGKB ID

    Gene Info:

    Publications:
    Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J
    Visscher H et al., 2013, Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children., Pediatr Blood Cancer
    Visscher H et al., 2012, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children., J Clin Oncol

  • NCI: ABCB4

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bornmann et al., 1994, Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound., Biochemistry
    Hayes et al., 2001, Cellular resistance to mitomycin C is associated with overexpression of MDR-1 in a urothelial cancer cell line (MGH-U1)., BJU Int.
    Herweijer et al., 1990, Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine., J. Natl. Cancer Inst.

  • HingoraniCasas: ENSG00000005471

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000005471 Gene Symbol
    ABCB4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: ABCB4

    • Version: 19.3

    Alternate Names:
    ENSG00000005471 Ensembl Gene ID
    GBD1 Human Protein Atlas Gene Synonym
    MDR2 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER, ENZYME

    Publications:

  • GO: ABCB4

    • Version: 01-February-2022

    Alternate Names:
    MDR3 GO Gene Synonym
    PGY3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    ABC TRANSPORTER

    Publications:

  • TTD: Multidrug resistance protein

    • Version: 2020.06.01

    Alternate Names:
    MDR TTD Gene Abbreviation
    T16422 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ABCB4

    • Version: 01-February-2022

    Alternate Names:
    Phosphatidylcholine translocator ABCB4 Gene Name
    P21439 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21