DGIdb - ABCB4 Gene Record

ABCB4 5244 Druggable GenomeDrug Resistance

Alternate Names:

5244
ATP BINDING CASSETTE SUBFAMILY B MEMBER 4
ABCB4
ABC21
GBD1
ICP3
MDR2
MDR2/3
MDR3
PFIC-3
PGY3
171060
45
ENSG00000005471
OTTHUMG00000023396
771
P21439
ATP-binding cassette, sub-family B (MDR/TAP), member 4
O60895
P30988
AMY<sub>2</sub> receptor
MULTIDRUG RESISTANCE PROTEIN 3
MDR3_HUMAN
TTDC00030
P-GLYCOPROTEIN
ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 4
MULTIDRUG RESISTANCE PROTEIN
P-GP
PA268
MULTIDRUG RESISTANCE PROTEIN 3 (P-GLYCOPROTEIN 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21439]
TTDS00255
ENSG00000004948
AMY<sub>1</sub> receptor
O60894
AMY<sub>3</sub> receptor
O60896
CT receptor
MDR
T16422
Phosphatidylcholine translocator ABCB4

Gene Info:

GuideToPharmacology Gene Category Name	ABCB subfamily
GuideToPharmacology Gene Category ID	152
GuideToPharmacology Gene Type	transporter
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	ABC_transptr_TM_dom
Interpro Acc	IPR001140
Human Readable Name	ABC TRANSPORTER
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Interpro Name	ABC transporter, transmembrane domain
Is VIP	false
Has Variant Annotation	true
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUG RESISTANCE
ABC TRANSPORTER
DRUGGABLE GENOME
ENZYME

Publications:

Bornmann et al., 1994, Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound., Biochemistry
Schinkel et al., 1991, Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies., Cancer Res.
Herweijer et al., 1990, Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine., J. Natl. Cancer Inst.
Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J

PRAMLINTIDE ABCB4

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measuring ligand-induced cAMP in COS and KEK293 cells.

Details of the Assay for Interaction Measuring ligand-induced cAMP production in COS and HEK293 cells.

Specific Action of the Ligand Agonist

Publications:

CALCITONIN ABCB4

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Publications:
AMYLIN ABCB4

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measuring ligand-induced cAMP production in COS and HEK293 cells.

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Publications:
DAVALINTIDE ABCB4

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction β-arrestin recruitment assay.

Specific Action of the Ligand Agonist

Endogenous Drug? False

Publications:
OLCEGEPANT ABCB4

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Direct Interaction? False

Publications:
VINBLASTINE ABCB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bornmann et al., 1994, Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound., Biochemistry
VINCRISTINE ABCB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Schinkel et al., 1991, Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies., Cancer Res.

CYCLOSPORINE ABCB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Herweijer et al., 1990, Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine., J. Natl. Cancer Inst.

IMATINIB ABCB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J
ORTATAXEL ABCB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN ABCB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
BENZQUINAMIDE ABCB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000005471
- Version: 101_38
Alternate Names:

ABCB4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacologyGenes: 771
- Version: 4-March-2015
Alternate Names:

ATP-binding cassette, sub-family B (MDR/TAP), member 4 HUGO Gene Name

45 HUGO Gene ID

ABCB4 Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name ABCB subfamily

GuideToPharmacology Gene Category ID 152

GuideToPharmacology Gene Type transporter

Gene Categories:

ABC TRANSPORTER, TRANSPORTER

Publications:
RussLampel: ENSG00000005471
- Version: 26-July-2011
Alternate Names:

MULTIDRUG RESISTANCE PROTEIN 3 (P-GLYCOPROTEIN 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21439] Description

ABCB4 Display Id

ENSG00000005471 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P21439
- Version: 11-September-2012
Alternate Names:

MDR3_HUMAN Uniprot Id

P21439 Uniprot Accession

MULTIDRUG RESISTANCE PROTEIN 3 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Interpro Short Name ABC_transptr_TM_dom

Gene Categories:

ABC TRANSPORTER, DRUGGABLE GENOME

Publications:

PharmGKB: ABCB4

Version: 18-August-2020

Alternate Names:

PA268 PharmGKB ID

Gene Info:

Publications:

Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J

Visscher H et al., 2012, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children., J Clin Oncol

Visscher H et al., 2013, Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children., Pediatr Blood Cancer

NCI: ABCB4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Bornmann et al., 1994, Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound., Biochemistry

Hayes et al., 2001, Cellular resistance to mitomycin C is associated with overexpression of MDR-1 in a urothelial cancer cell line (MGH-U1)., BJU Int.

Herweijer et al., 1990, Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine., J. Natl. Cancer Inst.

HingoraniCasas: ENSG00000005471
- Version: 31-May-2017
Alternate Names:

ENSG00000005471 Gene Symbol

ABCB4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacologyInteractions: ENSG00000004948
- Version: 20-July-2020
Alternate Names:

AMY<sub>1</sub> receptor GuideToPharmacology Name

P30988 UniProtKB ID

O60894 UniProtKB ID

Gene Info:

Publications:
TTD: Multidrug resistance protein
- Version: 2020.06.01
Alternate Names:

MDR TTD Gene Abbreviation

T16422 TTD Target ID

Gene Info:

Publications:
HumanProteinAtlas: ABCB4
- Version: 19.3
Alternate Names:

ENSG00000005471 Ensembl Gene ID

GBD1 Human Protein Atlas Gene Synonym

MDR2 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME, TRANSPORTER

Publications:
Pharos: ABCB4
- Version: 03-September-2020
Alternate Names:

Phosphatidylcholine translocator ABCB4 Gene Name

P21439 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: ABCB4
- Version: 05-September-2020
Alternate Names:

MDR3 GO Gene Synonym

PGY3 GO Gene Synonym

Gene Info:

Gene Categories:

ABC TRANSPORTER

Publications:

Details of the Assay for Interaction	Measuring ligand-induced cAMP in COS and KEK293 cells.
Details of the Assay for Interaction	Measuring ligand-induced cAMP production in COS and HEK293 cells.
Specific Action of the Ligand	Agonist

Direct Interaction?	True
Specific Action of the Ligand	Full agonist
Endogenous Drug?	True

Details of the Assay for Interaction	β-arrestin recruitment assay.
Specific Action of the Ligand	Agonist
Endogenous Drug?	False

ATP-binding cassette, sub-family B (MDR/TAP), member 4	HUGO Gene Name
45	HUGO Gene ID
ABCB4	Gene Symbol

MULTIDRUG RESISTANCE PROTEIN 3 (P-GLYCOPROTEIN 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21439]	Description
ABCB4	Display Id
ENSG00000005471	Ensembl Gene Id

MDR3_HUMAN	Uniprot Id
P21439	Uniprot Accession
MULTIDRUG RESISTANCE PROTEIN 3	Uniprot Protein Name

AMY<sub>1</sub> receptor	GuideToPharmacology Name
P30988	UniProtKB ID
O60894	UniProtKB ID

Phosphatidylcholine translocator ABCB4	Gene Name
P21439	UniProt ID

ABCB4 Gene Record

ABCB4 5244 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Details of the Assay for Interaction Measuring ligand-induced cAMP in COS and KEK293 cells. Details of the Assay for Interaction Measuring ligand-induced cAMP production in COS and HEK293 cells. Specific Action of the Ligand Agonist

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? True Specific Action of the Ligand Full agonist Endogenous Drug? True

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Details of the Assay for Interaction Measuring ligand-induced cAMP production in COS and HEK293 cells. Specific Action of the Ligand Full agonist Endogenous Drug? True

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Details of the Assay for Interaction &beta;-arrestin recruitment assay. Specific Action of the Ligand Agonist Endogenous Drug? False

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist Direct Interaction? False

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Bornmann et al., 1994, Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound., Biochemistry

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Schinkel et al., 1991, Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies., Cancer Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Herweijer et al., 1990, Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine., J. Natl. Cancer Inst.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Ensembl: ENSG00000005471

Alternate Names: ABCB4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacologyGenes: 771

Alternate Names: ATP-binding cassette, sub-family B (MDR/TAP), member 4 HUGO Gene Name 45 HUGO Gene ID ABCB4 Gene Symbol

Gene Info: GuideToPharmacology Gene Category Name ABCB subfamily GuideToPharmacology Gene Category ID 152 GuideToPharmacology Gene Type transporter

Gene Categories: ABC TRANSPORTER, TRANSPORTER

Publications:

RussLampel: ENSG00000005471

Alternate Names: MULTIDRUG RESISTANCE PROTEIN 3 (P-GLYCOPROTEIN 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21439] Description ABCB4 Display Id ENSG00000005471 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P21439

Alternate Names: MDR3_HUMAN Uniprot Id P21439 Uniprot Accession MULTIDRUG RESISTANCE PROTEIN 3 Uniprot Protein Name

Gene Info: Human Readable Name DRUGGABLE GENOME Uniprot Status Swiss-Prot Interpro Short Name ABC_transptr_TM_dom

Gene Categories: ABC TRANSPORTER, DRUGGABLE GENOME

Publications:

PharmGKB: ABCB4

Alternate Names: PA268 PharmGKB ID

Gene Info:

NCI: ABCB4

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000005471

Alternate Names: ENSG00000005471 Gene Symbol ABCB4 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacologyInteractions: ENSG00000004948

Alternate Names: AMY<sub>1</sub> receptor GuideToPharmacology Name P30988 UniProtKB ID O60894 UniProtKB ID

Gene Info:

Publications:

TTD: Multidrug resistance protein

Alternate Names: MDR TTD Gene Abbreviation T16422 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measuring ligand-induced cAMP in COS and KEK293 cells.

Details of the Assay for Interaction Measuring ligand-induced cAMP production in COS and HEK293 cells.

Specific Action of the Ligand Agonist

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measuring ligand-induced cAMP production in COS and HEK293 cells.

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction β-arrestin recruitment assay.

Specific Action of the Ligand Agonist

Endogenous Drug? False

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Direct Interaction? False

Interaction Types & Directionality:

n/a

Publications:

Bornmann et al., 1994, Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound., Biochemistry

Interaction Types & Directionality:

n/a

Publications:

Schinkel et al., 1991, Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies., Cancer Res.

Interaction Types & Directionality:

n/a

Publications:

Herweijer et al., 1990, Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine., J. Natl. Cancer Inst.

Interaction Types & Directionality:

n/a

Publications:

Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

ABCB4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ATP-binding cassette, sub-family B (MDR/TAP), member 4 HUGO Gene Name

45 HUGO Gene ID

ABCB4 Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name ABCB subfamily

GuideToPharmacology Gene Category ID 152

GuideToPharmacology Gene Type transporter

Gene Categories:

ABC TRANSPORTER, TRANSPORTER

Alternate Names:

MULTIDRUG RESISTANCE PROTEIN 3 (P-GLYCOPROTEIN 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P21439] Description

ABCB4 Display Id

ENSG00000005471 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MDR3_HUMAN Uniprot Id

P21439 Uniprot Accession

MULTIDRUG RESISTANCE PROTEIN 3 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Interpro Short Name ABC_transptr_TM_dom

Gene Categories:

ABC TRANSPORTER, DRUGGABLE GENOME

Alternate Names:

PA268 PharmGKB ID

Alternate Names:

ENSG00000005471 Gene Symbol

ABCB4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

AMY<sub>1</sub> receptor GuideToPharmacology Name

P30988 UniProtKB ID

O60894 UniProtKB ID

Alternate Names:

MDR TTD Gene Abbreviation

T16422 TTD Target ID

Alternate Names:

ENSG00000005471 Ensembl Gene ID

GBD1 Human Protein Atlas Gene Synonym

MDR2 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME, TRANSPORTER

Alternate Names:

Phosphatidylcholine translocator ABCB4 Gene Name

P21439 UniProt ID

Gene Categories:

TRANSPORTER

Alternate Names:

MDR3 GO Gene Synonym

PGY3 GO Gene Synonym

Gene Categories:

ABC TRANSPORTER