DGIdb - ABCA1 Gene Record

ABCA1 19 Druggable Genome

Alternate Names:

19
ATP BINDING CASSETTE SUBFAMILY A MEMBER 1
ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
600046
29
ENSG00000165029
OTTHUMG00000020417
Cholesterol efflux regulatory protein
ATP-binding cassette 1
ATP-binding cassette sub-family A member 1
ATP-binding cassette transporter 1
O95477
PA24373
ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1 (ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE 1) (ABC-1) (CHOLESTEROL EFFLUX REGULATORY PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:O95477]
ATP-binding cassette transporter A1
T00494
HDLCQTL13
HPALP1

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

TRANSPORTER
CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
ABC TRANSPORTER
DRUGGABLE GENOME

Publications:

Voora D et al., 2008, Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response., Circ Cardiovasc Genet
Li J et al., 2009, Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease., Clin Exp Pharmacol Physiol
Favari et al., 2004, Probucol inhibits ABCA1-mediated cellular lipid efflux., Arterioscler. Thromb. Vasc. Biol.
Sirtori et al., 1991, Mechanisms of lipid-lowering agents., Cardiology
de la Llera-Moya et al., 2010, The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages., Arterioscler. Thromb. Vasc. Biol.
Arakawa et al., 2009, Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis., J. Lipid Res.
Yamamoto, 2008, A uniqe antilipidemic drug--probucol., J. Atheroscler. Thromb.
Shichiri et al., 2010, ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion., J. Nutr. Biochem.
Jin et al., 2004, Insights into cyclosporine A-induced atherosclerotic risk in transplant recipients: macrophage scavenger receptor regulation., Transplantation

PROBUCOL ABCA1

Interaction Score: 41.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction ATP-binding cassette sub-family A member 1 inhibitor

PMIDs:
15514211 1868500 20075420 19458386 19075491 19427182

Sources:
ChemblInteractions TTD
PRAVASTATIN ABCA1

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20031551 19673941

Sources:
PharmGKB
SIMVASTATIN ABCA1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20031551

Sources:
PharmGKB
FENOFIBRATE ABCA1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ATORVASTATIN ABCA1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20031551

Sources:
PharmGKB
CYCLOSPORINE ABCA1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15084924

Sources:
NCI

Ensembl: ENSG00000165029
- Version: 101_38
Alternate Names:

ABCA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000165029

Version: 26-July-2011

Alternate Names:

ABCA1 Display Id

ENSG00000165029 Ensembl Gene Id

ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1 (ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE 1) (ABC-1) (CHOLESTEROL EFFLUX REGULATORY PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:O95477] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: ABCA1

Version: 18-August-2020

Alternate Names:

PA24373 PharmGKB ID

Gene Info:

Publications:

Li J et al., 2009, Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease., Clin Exp Pharmacol Physiol

Voora D et al., 2008, Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response., Circ Cardiovasc Genet

NCI: ABCA1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Jin et al., 2004, Insights into cyclosporine A-induced atherosclerotic risk in transplant recipients: macrophage scavenger receptor regulation., Transplantation
HingoraniCasas: ENSG00000165029
- Version: 31-May-2017
Alternate Names:

ENSG00000165029 Gene Symbol

ABCA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ABC1
- Version: chembl_23
Alternate Names:

CERP GENE_SYMBOL

ABCA1 GENE_SYMBOL

ATP-binding cassette sub-family A member 1 UNIPROT

Gene Info:

Publications:
GO: ABCA1
- Version: 01-February-2022
Alternate Names:

ABC1 GO Gene Synonym

CERP GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, ABC TRANSPORTER

Publications:
TTD: ATP-binding cassette transporter A1
- Version: 2020.06.01
Alternate Names:

ABCA1 TTD Gene Abbreviation

T00494 TTD Target ID

Gene Info:

Publications:
Pharos: ABCA1
- Version: 01-February-2022
Alternate Names:

ATP-binding cassette sub-family A member 1 Gene Name

O95477 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

Direct Interaction	yes
Mechanism of Interaction	ATP-binding cassette sub-family A member 1 inhibitor

ABCA1	Display Id
ENSG00000165029	Ensembl Gene Id
ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1 (ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE 1) (ABC-1) (CHOLESTEROL EFFLUX REGULATORY PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:O95477]	Description

CERP	GENE_SYMBOL
ABCA1	GENE_SYMBOL
ATP-binding cassette sub-family A member 1	UNIPROT

ATP-binding cassette sub-family A member 1	Gene Name
O95477	UniProt ID

ABCA1 Gene Record

ABCA1 19 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PROBUCOL ABCA1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction ATP-binding cassette sub-family A member 1 inhibitor

PMIDs: 15514211 1868500 20075420 19458386 19075491 19427182

Sources: ChemblInteractions TTD

PRAVASTATIN ABCA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20031551 19673941

Sources: PharmGKB

SIMVASTATIN ABCA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20031551

Sources: PharmGKB

FENOFIBRATE ABCA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

ATORVASTATIN ABCA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20031551

Sources: PharmGKB

CYCLOSPORINE ABCA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15084924

Sources: NCI

Ensembl: ENSG00000165029

Alternate Names: ABCA1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000165029

Alternate Names: ABCA1 Display Id ENSG00000165029 Ensembl Gene Id ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1 (ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE 1) (ABC-1) (CHOLESTEROL EFFLUX REGULATORY PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:O95477] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: ABCA1

Alternate Names: PA24373 PharmGKB ID

Gene Info:

NCI: ABCA1

Alternate Names:

Gene Info:

Publications: Jin et al., 2004, Insights into cyclosporine A-induced atherosclerotic risk in transplant recipients: macrophage scavenger receptor regulation., Transplantation

HingoraniCasas: ENSG00000165029

Alternate Names: ENSG00000165029 Gene Symbol ABCA1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ABC1

Alternate Names: CERP GENE_SYMBOL ABCA1 GENE_SYMBOL ATP-binding cassette sub-family A member 1 UNIPROT

Gene Info:

Publications:

GO: ABCA1

Alternate Names: ABC1 GO Gene Synonym CERP GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, ABC TRANSPORTER

Publications:

TTD: ATP-binding cassette transporter A1

Alternate Names: ABCA1 TTD Gene Abbreviation T00494 TTD Target ID

Gene Info:

Publications:

Pharos: ABCA1

Alternate Names: ATP-binding cassette sub-family A member 1 Gene Name O95477 UniProt ID

Gene Info:

Gene Categories: TRANSPORTER

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction ATP-binding cassette sub-family A member 1 inhibitor

PMIDs:
15514211 1868500 20075420 19458386 19075491 19427182

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
20031551 19673941

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20031551

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20031551

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15084924

Sources:
NCI

Alternate Names:

ABCA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ABCA1 Display Id

ENSG00000165029 Ensembl Gene Id

ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1 (ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE 1) (ABC-1) (CHOLESTEROL EFFLUX REGULATORY PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:O95477] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA24373 PharmGKB ID

Publications:

Jin et al., 2004, Insights into cyclosporine A-induced atherosclerotic risk in transplant recipients: macrophage scavenger receptor regulation., Transplantation

Alternate Names:

ENSG00000165029 Gene Symbol

ABCA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CERP GENE_SYMBOL

ABCA1 GENE_SYMBOL

ATP-binding cassette sub-family A member 1 UNIPROT

Alternate Names:

ABC1 GO Gene Synonym

CERP GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, ABC TRANSPORTER

Alternate Names:

ABCA1 TTD Gene Abbreviation

T00494 TTD Target ID

Alternate Names:

ATP-binding cassette sub-family A member 1 Gene Name

O95477 UniProt ID

Gene Categories:

TRANSPORTER