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ZONISAMIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • ZONISAMIDE chembl:CHEMBL750 Approved

    Alternate Names:

    PD-110843
    ZONISAMIDE
    CI-912
    ZONEGRAN
    AD-810
    ZONISAMIDUM
    ZONISAMIDA
    BENZO[D]ISOXAZOL-3-YL-METHANESULFONAMIDE
    1,2-BENZISOXAZOLE-3-METHANESULFONAMIDE
    ZONEGRAN®
    3-(SULFAMOYLMETHYL)-1,2-BENZISOXAZOLE
    chembl:CHEMBL750
    rxcui:39998
    pubchem.compound:5734
    drugbank:00909
    chemidplus:68291-97-4

    Drug Info:

    Year of Approval 2000
    Drug Class anticonvulsants
    Drug Indications anticonvulsant
    Drug Indications antipsychotic agent
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications appetite suppressant
    (3 More Sources)

    Publications:

    Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
    Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
    Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
    Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
    Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
    Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
    Kaniwa N et al., 2013, Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects., Pharmacogenomics
    Temperini et al., 2008, Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
    Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
    Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
    Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
    Masuda et al., 1993, Inhibitory effect of zonisamide on human carbonic anhydrase in vitro., Arzneimittelforschung
    De Simone et al., 2005, Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
    2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
    Shank et al., 2008, Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate., J Enzyme Inhib Med Chem
    Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem
    Murata, 2010, Zonisamide: a new drug for Parkinson's disease., Drugs Today
    Murata, 2004, Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease., Curr. Pharm. Des.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics
    De Simone et al., 2009, Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?, Chem Biol Drug Des
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
  • ZONISAMIDE   SCN4B

    Interaction Score: 22.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Empatic
    Novel drug target Established target
    Trial Name OREX-003, olanzapine plus zonisamide SR

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial

  • ZONISAMIDE   SCN3B

    Interaction Score: 22.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Empatic
    Novel drug target Established target
    Trial Name OREX-003, olanzapine plus zonisamide SR

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial

  • ZONISAMIDE   SCN2B

    Interaction Score: 22.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Empatic
    Novel drug target Established target
    Trial Name OREX-003, olanzapine plus zonisamide SR

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial

  • ZONISAMIDE   SCN1B

    Interaction Score: 22.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name zonisamide,Zonegran, Trerief
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Novel drug target Established target

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial

  • ZONISAMIDE   CACNA1G

    Interaction Score: 2.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name zonisamide,Zonegran, Trerief
    Novel drug target Established target
    Trial Name Empatic

    PMIDs:
    19948168 17762320 15511691 20502722 14704463 18433351 20001433 20025128 19557119 14965331 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ZONISAMIDE   CACNA1I

    Interaction Score: 1.93

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Empatic
    Novel drug target Established target
    Trial Name OREX-003, olanzapine plus zonisamide SR

    PMIDs:
    19948168 17762320 15511691 20502722 14704463 20001433 18433351 20025128 14965331 19557119


    Sources:
    TdgClinicalTrial

  • ZONISAMIDE   CA12

    Interaction Score: 1.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21278619 18537527 19703035 17582922 17762320 18782051


    Sources:
    PharmGKB

  • ZONISAMIDE   CA1

    Interaction Score: 1.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    18162396 18537527 17762320 18782051 8494570 15837316 17582922 18343915


    Sources:
    TEND

  • ZONISAMIDE   CACNA1H

    Interaction Score: 1.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name zonisamide,Zonegran, Trerief
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Novel drug target Established target

    PMIDs:
    19557119 20001433 17762320 19948168 15511691 14965331 20025128 20502722 14704463 18433351


    Sources:
    TdgClinicalTrial

  • ZONISAMIDE   AQP4

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18572411


    Sources:
    DTC

  • ZONISAMIDE   SCN1A

    Interaction Score: 0.52

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name zonisamide,Zonegran, Trerief
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Novel drug target Established target

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 11752352 20025128 19557119


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ZONISAMIDE   SCN3A

    Interaction Score: 0.44

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Trial Name Empatic

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ZONISAMIDE   SCN2A

    Interaction Score: 0.42

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes
    Trial Name Empatic

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ZONISAMIDE   SCN11A

    Interaction Score: 0.42

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Trial Name OREX-003, olanzapine plus zonisamide SR

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ZONISAMIDE   SCN4A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes
    Trial Name Empatic

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ZONISAMIDE   SCN9A

    Interaction Score: 0.38

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name zonisamide,Zonegran, Trerief
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Novel drug target Established target

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ZONISAMIDE   HLA-A

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24236482


    Sources:
    PharmGKB

  • ZONISAMIDE   SCN5A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Empatic
    Novel drug target Established target
    Trial Name OREX-003, olanzapine plus zonisamide SR

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ZONISAMIDE   SCN7A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZONISAMIDE   SCN8A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZONISAMIDE   SCN10A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZONISAMIDE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • TEND: ZONISAMIDE

    • Version: 01-August-2011

    Alternate Names:
    ZONISAMIDE Primary Drug Name

    Drug Info:
    Drug Class anticonvulsants
    Year of Approval 2000

    Publications:

  • TdgClinicalTrial: ZONISAMIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications appetite suppressant
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: ZONISAMIDE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL750 ChEMBL Drug ID

    Drug Info:

    Publications:
    Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

  • PharmGKB: zonisamide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Kaniwa N et al., 2013, Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects., Pharmacogenomics
    Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics

  • TTD: Zonisamide

    • Version: 2020.06.01

    Alternate Names:
    D09ZIS TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL750

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL750

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21