DGIdb - ZONISAMIDE Drug Record

ZONISAMIDE chembl:CHEMBL750 Approved

Alternate Names:

PD-110843
ZONISAMIDE
CI-912
ZONEGRAN
AD-810
ZONISAMIDUM
ZONISAMIDA
BENZO[D]ISOXAZOL-3-YL-METHANESULFONAMIDE
1,2-BENZISOXAZOLE-3-METHANESULFONAMIDE
ZONEGRAN®
3-(SULFAMOYLMETHYL)-1,2-BENZISOXAZOLE
chembl:CHEMBL750
rxcui:39998
pubchem.compound:5734
drugbank:00909
chemidplus:68291-97-4

Drug Info:

Year of Approval	2000
Drug Class	anticonvulsants
Drug Indications	anticonvulsant
Drug Indications	antipsychotic agent
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	appetite suppressant
Drug Categories	agents causing hyperkalemia
Drug Categories	amides
Drug Categories	anti-epileptic agent
Drug Categories	antiarrhythmic agents
Drug Categories	bradycardia-causing agents
Drug Categories	calcium channel blockers
Drug Categories	calcium-regulating hormones and agents
Drug Categories	carbonic anhydrase inhibitors
Drug Categories	cardiovascular agents
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	cytochrome p-450 cyp2c19 inhibitors (weak)
Drug Categories	cytochrome p-450 cyp2c19 substrates
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	decreased central nervous system disorganized electrical activity
Drug Categories	diuretics
Drug Categories	drugs that are mainly renally excreted
Drug Categories	genito urinary system and sex hormones
Drug Categories	gynecological antiinfectives and antiseptics
Drug Categories	isoxazoles
Drug Categories	membrane transport modulators
Drug Categories	monoamine oxidase a inhibitors for interaction with monoamine oxidase a substrates
Drug Categories	p-glycoprotein inhibitors
Drug Categories	potential qtc-prolonging agents
Drug Categories	qtc prolonging agents
Drug Categories	sulfonamides
Drug Categories	sulfones
Drug Categories	sulfur compounds
Drug Categories	ugt1a1 substrates

(5 More Sources)

Publications:

Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
Temperini et al., 2008, Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
De Simone et al., 2009, Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?, Chem Biol Drug Des
Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
Kaniwa N et al., 2013, Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects., Pharmacogenomics
Masuda et al., 1993, Inhibitory effect of zonisamide on human carbonic anhydrase in vitro., Arzneimittelforschung
De Simone et al., 2005, Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
Shank et al., 2008, Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate., J Enzyme Inhib Med Chem
Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem
Murata, 2010, Zonisamide: a new drug for Parkinson's disease., Drugs Today
Murata, 2004, Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease., Curr. Pharm. Des.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics
Okada et al., 1995, Effects of zonisamide on dopaminergic system., Epilepsy Res.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Murata et al., 2001, Zonisamide has beneficial effects on Parkinson's disease patients., Neurosci. Res.
Okada, 1994, [Effects of carbamazepine and zonisamide on dopaminergic system in rat striatum and hippocampus]., Nihon Shinkei Seishin Yakurigaku Zasshi

ZONISAMIDE SCN4B

Interaction Score: 13.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial
ZONISAMIDE SCN3B

Interaction Score: 13.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial
ZONISAMIDE SCN2B

Interaction Score: 13.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial
ZONISAMIDE CA11

Interaction Score: 9.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank
ZONISAMIDE CA8

Interaction Score: 9.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank
ZONISAMIDE SCN1B

Interaction Score: 6.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial
ZONISAMIDE CA10

Interaction Score: 4.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank
ZONISAMIDE CA13

Interaction Score: 4.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank
ZONISAMIDE CA5B

Interaction Score: 3.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19703035 17762320 18782051 18537527 15837316 17582922

Sources:
DrugBank
ZONISAMIDE CA5A

Interaction Score: 1.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19703035 17762320 18782051 18537527 15837316 17582922

Sources:
DrugBank
ZONISAMIDE CA6

Interaction Score: 1.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank
ZONISAMIDE CACNA1G

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Novel drug target Established target

Trial Name Empatic

PMIDs:
19948168 17762320 15511691 20502722 14704463 18433351 20001433 20025128 19557119 14965331 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND
ZONISAMIDE CA12

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21278619 18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank PharmGKB
ZONISAMIDE CA3

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18162396 19703035 17762320 18782051 18537527 17582922

Sources:
DrugBank
ZONISAMIDE CACNA1I

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 17762320 15511691 20502722 14704463 20001433 18433351 20025128 14965331 19557119

Sources:
DrugBank TdgClinicalTrial
ZONISAMIDE CA7

Interaction Score: 0.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank GuideToPharmacology
ZONISAMIDE CA14

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank
ZONISAMIDE CA9

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank
ZONISAMIDE CACNA1H

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19557119 20001433 17762320 19948168 15511691 14965331 20025128 20502722 14704463 18433351

Sources:
DrugBank TdgClinicalTrial
ZONISAMIDE CA1

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
18162396 18537527 17762320 18782051 8494570 15837316 17582922 18343915

Sources:
DrugBank TEND GuideToPharmacology
ZONISAMIDE CA4

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank
ZONISAMIDE AQP4

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18572411

Sources:
DTC
ZONISAMIDE SCN11A

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial ChemblInteractions
ZONISAMIDE SCN3A

Interaction Score: 0.26

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Trial Name Empatic

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial ChemblInteractions
ZONISAMIDE SCN1A

Interaction Score: 0.25

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19948168 15511691 14704463 18433351 20001433 11752352 20025128 19557119

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND
ZONISAMIDE SCN2A

Interaction Score: 0.24

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Trial Name Empatic

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial ChemblInteractions
ZONISAMIDE SCN4A

Interaction Score: 0.23

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Trial Name Empatic

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial ChemblInteractions
ZONISAMIDE SCN9A

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial ChemblInteractions
ZONISAMIDE CA2

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8494570 19703035 17762320 18782051 18537527 15837316 17582922 18343915 18162396

Sources:
DrugBank
ZONISAMIDE MAOB

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11755227 8991786 18782051 20502722 19948168 7856330 14965331

Sources:
DrugBank
ZONISAMIDE HLA-A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24236482

Sources:
PharmGKB
ZONISAMIDE SCN5A

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial ChemblInteractions
ZONISAMIDE MAOA

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
20502722 8991786

Sources:
DrugBank
ZONISAMIDE SCN7A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ZONISAMIDE SCN8A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ZONISAMIDE SCN10A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ZONISAMIDE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

DrugBank: DB00909

Version: 5.1.7

Alternate Names:

ZONISAMIDE DrugBank Drug Name

68291-97-4 CAS Number

Exceglan Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol

Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.

Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure

TEND: ZONISAMIDE
- Version: 01-August-2011
Alternate Names:

ZONISAMIDE Primary Drug Name

Drug Info:

Drug Class anticonvulsants

Year of Approval 2000

Publications:
TdgClinicalTrial: ZONISAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications appetite suppressant

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: ZONISAMIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL750 ChEMBL Drug ID

Drug Info:

Publications:

Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

PharmGKB: zonisamide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Kaniwa N et al., 2013, Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects., Pharmacogenomics

Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics

GuideToPharmacology: 178103626
- Version: 29-September-2020
Alternate Names:

ZONISAMIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Zonisamide
- Version: 2020.06.01
Alternate Names:

D09ZIS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL750
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL750
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	Empatic
Novel drug target	Established target
Trial Name	OREX-003, olanzapine plus zonisamide SR

Trial Name	zonisamide,Zonegran, Trerief
Trial Name	OREX-003, olanzapine plus zonisamide SR
Novel drug target	Established target

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Direct Interaction	yes
Mechanism of Interaction	Sodium channel alpha subunit blocker
Trial Name	OREX-003, olanzapine plus zonisamide SR

ZONISAMIDE	DrugBank Drug Name
68291-97-4	CAS Number
Exceglan	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

ZONISAMIDE Drug Record

ZONISAMIDE chembl:CHEMBL750 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Empatic Novel drug target Established target Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs: 19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources: DrugBank TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Empatic Novel drug target Established target Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs: 19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources: DrugBank TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Empatic Novel drug target Established target Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs: 19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources: DrugBank TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name zonisamide,Zonegran, Trerief Trial Name OREX-003, olanzapine plus zonisamide SR Novel drug target Established target

PMIDs: 19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources: DrugBank TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19703035 17762320 18782051 18537527 15837316 17582922

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19703035 17762320 18782051 18537527 15837316 17582922

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name zonisamide,Zonegran, Trerief Novel drug target Established target Trial Name Empatic

PMIDs: 19948168 17762320 15511691 20502722 14704463 18433351 20001433 20025128 19557119 14965331 17016423 17139284

Sources: DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21278619 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18162396 19703035 17762320 18782051 18537527 17582922

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Empatic Novel drug target Established target Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs: 19948168 17762320 15511691 20502722 14704463 20001433 18433351 20025128 14965331 19557119

Sources: DrugBank TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18537527 19703035 17582922 17762320 18782051

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name zonisamide,Zonegran, Trerief Trial Name OREX-003, olanzapine plus zonisamide SR Novel drug target Established target

PMIDs: 19557119 20001433 17762320 19948168 15511691 14965331 20025128 20502722 14704463 18433351

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19703035 17762320 18782051 18537527 15837316 17582922

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19703035 17762320 18782051 18537527 15837316 17582922

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Novel drug target Established target

Trial Name Empatic

PMIDs:
19948168 17762320 15511691 20502722 14704463 18433351 20001433 20025128 19557119 14965331 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21278619 18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18162396 19703035 17762320 18782051 18537527 17582922

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Empatic

Novel drug target Established target

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 17762320 15511691 20502722 14704463 20001433 18433351 20025128 14965331 19557119

Sources:
DrugBank TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19557119 20001433 17762320 19948168 15511691 14965331 20025128 20502722 14704463 18433351

Sources:
DrugBank TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
18162396 18537527 17762320 18782051 8494570 15837316 17582922 18343915

Sources:
DrugBank TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18537527 19703035 17582922 17762320 18782051

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
18572411

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Trial Name OREX-003, olanzapine plus zonisamide SR

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
DrugBank TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)