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ZOLMITRIPTAN Drug Record

  • Summary
  • Interactions
  • Claims
  • ZOLMITRIPTAN chembl:CHEMBL1185 Approved

    Alternate Names:

    ZOMIG
    311-C-90
    ZOLMITRIPTAN
    311C90
    ZOMIG-ZMT
    (S)-4-({3-[2-(DIMETHYLAMINO)ETHYL]-1H-INDOL-5-YL}METHYL)-1,3-OXAZOLIDIN-2-ONE
    4-[[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]METHYL]OXAZOLIDIN-2-ONE
    ZOMIG®
    ZOLMITRIPTANUM
    chembl:CHEMBL1185
    drugbank:00315
    rxcui:135775
    pubchem.compound:60857
    chemidplus:139264-17-8

    Drug Info:

    Drug Class anti-migraine agents
    Year of Approval 1997
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antimigraine agent
    Drug Categories agents that produce hypertension
    Drug Categories antidepressive agents
    Drug Categories central nervous system depressants
    Drug Categories cytochrome p-450 substrates
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories monoamine oxidase a substrates
    Drug Categories selective serotonin 5-ht1 receptor agonists
    Drug Categories selective serotonin agonists
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 1b receptor agonists
    Drug Categories serotonin 1d receptor agonists
    Drug Categories serotonin-1b and serotonin-1d receptor agonist
    Drug Categories triptans
    (3 More Sources)

    Publications:

    Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
    Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
    Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
    Reuter et al., 2004, Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats., Cephalalgia
    Pascual, 1998, [Mechanism of action of zolmitriptan]., Neurologia
    de Almeida et al., 2001, Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice., Psychopharmacology (Berl.)
    Whale et al., 1999, Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors?, Psychopharmacology (Berl.)
    Le Grand et al., 2000, Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors., Eur. J. Pharmacol.
    Hargreaves et al., 1999, Pathophysiology of migraine--new insights., Can J Neurol Sci
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Gowin et al., 2010, Zolmitriptan and human aggression: interaction with alcohol., Psychopharmacology (Berl.)
    Wainscott et al., 1998, Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation., Eur. J. Pharmacol.
    Bhalla et al., 2002, Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor., Eur. J. Pharmacol.
    Villalón et al., 2002, An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy., Proc. West. Pharmacol. Soc.
    Villalón et al., 2003, Migraine: pathophysiology, pharmacology, treatment and future trends., Curr Vasc Pharmacol
  • ZOLMITRIPTAN   HTR1F

    Interaction Score: 2.52

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name zolmitriptan,Zomig
    Novel drug target Established target
    Specific Action of the Ligand Full agonist

    PMIDs:
    9399012 9718276 11834243 15096229 12434581 15320857 11752352 29352859


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • ZOLMITRIPTAN   HTR1D

    Interaction Score: 1.6

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name zolmitriptan,Zomig
    Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

    PMIDs:
    11513839 9399012 15096229 9859690 11594437 10463324 10844127 10563228 11752352 20407761 29352859


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • ZOLMITRIPTAN   HTR1B

    Interaction Score: 1.39

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes
    Trial Name zolmitriptan,Zomig

    PMIDs:
    11513839 9399012 15096229 9859690 11594437 10463324 10844127 10563228 11752352 20407761 29352859


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • ZOLMITRIPTAN   HTR1E

    Interaction Score: 0.72

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    9399012 29352859


    Sources:
    DrugBank GuideToPharmacology

  • ZOLMITRIPTAN   HTR1A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name zolmitriptan,Zomig
    Novel drug target Established target
    Specific Action of the Ligand Full agonist

    PMIDs:
    11513839 9399012 29352859


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • ZOLMITRIPTAN   HTR7

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    29352859


    Sources:
    DrugBank

  • ZOLMITRIPTAN   HTR4

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • ZOLMITRIPTAN   HTR2B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    29352859


    Sources:
    DrugBank

  • ZOLMITRIPTAN   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    29352859


    Sources:
    DrugBank

  • DrugBank: DB00315

    • Version: 5.1.7

    Alternate Names:
    ZOLMITRIPTAN DrugBank Drug Name
    139264-17-8 CAS Number
    Ag-zolmitriptan ODT Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
    Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
    Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.

  • TEND: ZOLMITRIPTAN

    • Version: 01-August-2011

    Alternate Names:
    ZOLMITRIPTAN Primary Drug Name

    Drug Info:
    Year of Approval 1997
    Drug Class anti-migraine agents

    Publications:

  • TdgClinicalTrial: ZOLMITRIPTAN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antimigraine agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • GuideToPharmacology: 135651366

    • Version: 29-September-2020

    Alternate Names:
    ZOLMITRIPTAN GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: Zolmitriptan

    • Version: 2020.06.01

    Alternate Names:
    D0NG7O TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1185

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1185

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21