DGIdb - ZOLMITRIPTAN Drug Record

ZOLMITRIPTAN chembl:CHEMBL1185 Approved

Alternate Names:

ZOMIG
311-C-90
ZOLMITRIPTAN
311C90
ZOMIG-ZMT
(S)-4-({3-[2-(DIMETHYLAMINO)ETHYL]-1H-INDOL-5-YL}METHYL)-1,3-OXAZOLIDIN-2-ONE
4-[[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]METHYL]OXAZOLIDIN-2-ONE
ZOMIG®
ZOLMITRIPTANUM
chembl:CHEMBL1185
drugbank:00315
rxcui:135775
pubchem.compound:60857
chemidplus:139264-17-8

Drug Info:

Drug Class	anti-migraine agents
Year of Approval	1997
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antimigraine agent

(1 More Sources)

Publications:

Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
Pascual, 1998, [Mechanism of action of zolmitriptan]., Neurologia
Hargreaves et al., 1999, Pathophysiology of migraine--new insights., Can J Neurol Sci
Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
de Almeida et al., 2001, Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice., Psychopharmacology (Berl.)
Gowin et al., 2010, Zolmitriptan and human aggression: interaction with alcohol., Psychopharmacology (Berl.)
Whale et al., 1999, Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors?, Psychopharmacology (Berl.)
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Reuter et al., 2004, Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats., Cephalalgia
Le Grand et al., 2000, Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors., Eur. J. Pharmacol.
Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
Villalón et al., 2002, An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy., Proc. West. Pharmacol. Soc.
Wainscott et al., 1998, Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation., Eur. J. Pharmacol.
Villalón et al., 2003, Migraine: pathophysiology, pharmacology, treatment and future trends., Curr Vasc Pharmacol
Bhalla et al., 2002, Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor., Eur. J. Pharmacol.

ZOLMITRIPTAN HTR1F

Interaction Score: 17.67

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name zolmitriptan,Zomig

Novel drug target Established target

PMIDs:
12434581 9718276 11752352 15096229 15320857 11834243 9399012 29352859

Sources:
TdgClinicalTrial TEND
ZOLMITRIPTAN HTR1D

Interaction Score: 8.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name zolmitriptan,Zomig

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

PMIDs:
9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ZOLMITRIPTAN HTR1B

Interaction Score: 5.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

Trial Name zolmitriptan,Zomig

PMIDs:
9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ZOLMITRIPTAN HTR1A

Interaction Score: 0.88

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name zolmitriptan,Zomig

Novel drug target Established target

PMIDs:
11513839 29352859 9399012

Sources:
TdgClinicalTrial
ZOLMITRIPTAN HTR4

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND

TEND: ZOLMITRIPTAN
- Version: 01-August-2011
Alternate Names:

ZOLMITRIPTAN Primary Drug Name

Drug Info:

Year of Approval 1997

Drug Class anti-migraine agents

Publications:
TdgClinicalTrial: ZOLMITRIPTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Publications:
TTD: Zolmitriptan
- Version: 2020.06.01
Alternate Names:

D0NG7O TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1185
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1185
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	zolmitriptan,Zomig
Novel drug target	Established target

Mechanism of Interaction	Serotonin 1b (5-HT1b) receptor agonist
Direct Interaction	yes
Trial Name	zolmitriptan,Zomig

ZOLMITRIPTAN Drug Record

ZOLMITRIPTAN chembl:CHEMBL1185 Approved

Alternate Names:

Drug Info:

Publications:

ZOLMITRIPTAN HTR1F

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name zolmitriptan,Zomig Novel drug target Established target

PMIDs: 12434581 9718276 11752352 15096229 15320857 11834243 9399012 29352859

Sources: TdgClinicalTrial TEND

ZOLMITRIPTAN HTR1D

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name zolmitriptan,Zomig Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

PMIDs: 9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

ZOLMITRIPTAN HTR1B

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist Direct Interaction yes Trial Name zolmitriptan,Zomig

PMIDs: 9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

ZOLMITRIPTAN HTR1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name zolmitriptan,Zomig Novel drug target Established target

PMIDs: 11513839 29352859 9399012

Sources: TdgClinicalTrial

ZOLMITRIPTAN HTR4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

TEND: ZOLMITRIPTAN

Alternate Names: ZOLMITRIPTAN Primary Drug Name

Drug Info: Year of Approval 1997 Drug Class anti-migraine agents

Publications:

TdgClinicalTrial: ZOLMITRIPTAN

Alternate Names:

Drug Info: Drug Indications antimigraine agent Drug Class Small Molecule FDA Approval approved

Publications:

TTD: Zolmitriptan

Alternate Names: D0NG7O TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1185

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1185

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name zolmitriptan,Zomig

Novel drug target Established target

PMIDs:
12434581 9718276 11752352 15096229 15320857 11834243 9399012 29352859

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name zolmitriptan,Zomig

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

PMIDs:
9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

Trial Name zolmitriptan,Zomig

PMIDs:
9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name zolmitriptan,Zomig

Novel drug target Established target

PMIDs:
11513839 29352859 9399012

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Alternate Names:

ZOLMITRIPTAN Primary Drug Name

Drug Info:

Year of Approval 1997

Drug Class anti-migraine agents

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0NG7O TTD Drug ID