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ZILEUTON Drug Record

  • Summary
  • Interactions
  • Claims
  • ZILEUTON chembl:CHEMBL93 Approved

    Alternate Names:

    ZYFLO CR
    ABBOTT-64077
    A-64077
    ZILEUTON
    ZYFLO
    LEUTROL
    ZILEUTONUM
    N-[1-(BENZO[B]THIOPHEN-2-YL)ETHYL]-N-HYDROXYUREA
    ZYFLO®
    N-(1-BENZO(B)THIEN-2-YLETHYL)-N-HYDROXYUREA
    (+-)-1-(1-BENZO[B]THIEN-2-YLETHYL)-1-HYDROXYUREA
    chemidplus:111406-87-2
    rxcui:40575
    pubchem.compound:60490
    chembl:CHEMBL93
    drugbank:00744

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiinflammatory agent
    Year of Approval 1996
    Drug Class anti-asthmatic agents
    (4 More Sources)

    Publications:

    Yamashita et al., 2000, Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells., Br. J. Pharmacol.
    Wenzel, Leukotriene receptor antagonists and related compounds., Can. Respir. J.
    Qian et al., 2001, Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor., Pharmacol. Res.
    Coffey et al., 2001, Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton., J. Pharmacol. Exp. Ther.
    Hardy et al., 1999, Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells., Biol. Reprod.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Wenzel et al., Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma., Ann Pharmacother
    Guidot et al., 1994, Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity., Proc. Natl. Acad. Sci. U.S.A.
    Berger et al., 2007, Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease., Int. J. Clin. Pract.
    Zouboulis et al., 2010, Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis., Exp. Dermatol.
    Zouboulis, 2009, Zileuton, a new efficient and safe systemic anti-acne drug., Dermatoendocrinol
    Vicente et al., 2001, Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages., Br. J. Pharmacol.
    Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
    Karg EM et al., 2009, Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase., J Med Chem
    Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod
    Tan EC et al., 2016, Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy., Pharmacogenomics J
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
  • ZILEUTON   PRORP

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25963335


    Sources:
    PharmGKB

  • ZILEUTON   ALOX5

    Interaction Score: 6.8

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Zyflo
    Novel drug target Established target
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

    PMIDs:
    10694244 10322101 11529688 11561080 10377029 11752352 8826571 8058773 17394438 19645854 20436887 11454666 24697244 19492852 25686392


    Sources:
    DTC TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD

  • ZILEUTON   MMP12

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • ZILEUTON   MMP2

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • ZILEUTON   CYP2C9

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • ZILEUTON   CYP2C19

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • ZILEUTON   CYP2D6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • ZILEUTON   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: ZILEUTON

    • Version: 01-August-2011

    Alternate Names:
    ZILEUTON Primary Drug Name

    Drug Info:
    Drug Class anti-asthmatic agents
    Year of Approval 1996

    Publications:

  • TdgClinicalTrial: ZILEUTON

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiinflammatory agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: ZILEUTON

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL93 ChEMBL Drug ID

    Drug Info:

    Publications:
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
    Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
    Karg EM et al., 2009, Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase., J Med Chem

  • NCI: ZILEUTON

    • Version: 14-September-2017

    Alternate Names:
    C26667 NCI drug code

    Drug Info:

    Publications:
    Vicente et al., 2001, Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages., Br. J. Pharmacol.

  • PharmGKB: zileuton

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Tan EC et al., 2016, Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy., Pharmacogenomics J

  • TTD: Zileuton

    • Version: 2020.06.01

    Alternate Names:
    D09JUG TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL93

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL93

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21