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ZIDOVUDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • ZIDOVUDINE chembl:CHEMBL129 ApprovedImmunotherapy

    Alternate Names:

    RETROVIR
    COMPOUND-S
    AZIDOTHYMIDINE
    BW-A509U
    NSC-602670
    BWA509U
    BW-A-509U
    COMPOUND S
    AZT
    ZIDOVUDINE
    RETROVIR®
    ZIDOVUDIN
    3'-AZIDO-3'-DEOXYTHYMIDINE
    ZDV
    ZIDOVUDINUM
    drugbank:00495
    rxcui:11413
    chembl:CHEMBL129
    pubchem.compound:35370
    chemidplus:30516-87-1

    Drug Info:

    (3 More Sources)

    Publications:

    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Anderson PL et al., 2006, Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study., J Acquir Immune Defic Syndr
    Habtewold A et al., 2013, Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients., Pharmacogenomics J
    Karanth et al., Effects of azido-3'-deoxy-thymidine on luteinizing hormone, follicle-stimulating hormone and prolactin release by the pituitary-hypothalamus complex., Neuroimmunomodulation
    Kelland, 2000, Telomerase inhibitors: targeting the vulnerable end of cancer?, Anticancer Drugs
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Coelho AV et al., 2013, ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients., J Clin Pharmacol
    Jorajuria et al., 2004, ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages., Antivir. Ther. (Lond.)
    Miranda et al., 2005, The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations., Antimicrob. Agents Chemother.
    Gisolf et al., 2000, Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy., J. Acquir. Immune Defic. Syndr.
    Kang et al., 1999, Modulation of ex vivo cytokine production by splenocytes using in vitro combined therapeutics in murine retroviral model., DNA Cell Biol.
  • ZIDOVUDINE   TERC

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11036953


    Sources:
    NCI

  • ZIDOVUDINE   SLC22A11

    Interaction Score: 1.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   SLC22A7

    Interaction Score: 1.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   DTYMK

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   NME1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   NME2

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   ENOSF1

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15980332


    Sources:
    NCI

  • ZIDOVUDINE   SLC28A1

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   SLC28A3

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   TK1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   ABCC5

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   SLC22A6

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   POR

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   CXCL10

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11141242


    Sources:
    NCI

  • ZIDOVUDINE   SLC22A8

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   IL10

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10433557


    Sources:
    NCI

  • ZIDOVUDINE   ABCC4

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662 16791115


    Sources:
    PharmGKB

  • ZIDOVUDINE   UGT2B7

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   CYP2E1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   CYP2A6

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   PRL

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9500147


    Sources:
    NCI

  • ZIDOVUDINE   CYP2B6

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23089673


    Sources:
    PharmGKB

  • ZIDOVUDINE   ABCC1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23996099


    Sources:
    PharmGKB

  • ZIDOVUDINE   ABCG2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • ZIDOVUDINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23996099 22960662 15456083


    Sources:
    NCI PharmGKB

  • ZIDOVUDINE   FLT3

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ZIDOVUDINE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662 22931300


    Sources:
    DTC PharmGKB

  • ZIDOVUDINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528 22960662 22931300


    Sources:
    DTC PharmGKB

  • ZIDOVUDINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • ZIDOVUDINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • ZIDOVUDINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NCI: ZIDOVUDINE

    • Version: 14-September-2017

    Alternate Names:
    C947 NCI drug code

    Drug Info:

    Publications:
    Gisolf et al., 2000, Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy., J. Acquir. Immune Defic. Syndr.

  • NCI: AZIDOTHYMIDINE

    • Version: 14-September-2017

    Alternate Names:
    C947 NCI drug code

    Drug Info:

    Publications:
    Kelland, 2000, Telomerase inhibitors: targeting the vulnerable end of cancer?, Anticancer Drugs

  • NCI: AZT

    • Version: 14-September-2017

    Alternate Names:
    C947 NCI drug code

    Drug Info:

    Publications:
    Miranda et al., 2005, The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations., Antimicrob. Agents Chemother.
    Kang et al., 1999, Modulation of ex vivo cytokine production by splenocytes using in vitro combined therapeutics in murine retroviral model., DNA Cell Biol.
    Karanth et al., Effects of azido-3'-deoxy-thymidine on luteinizing hormone, follicle-stimulating hormone and prolactin release by the pituitary-hypothalamus complex., Neuroimmunomodulation

  • DTC: ZIDOVUDINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL129 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: zidovudine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Anderson PL et al., 2006, Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study., J Acquir Immune Defic Syndr
    Coelho AV et al., 2013, ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients., J Clin Pharmacol

  • TTD: Zidovudine

    • Version: 2020.06.01

    Alternate Names:
    D01XYJ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL129

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21