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YOHIMBINE Drug Record

  • Summary
  • Interactions
  • Claims
  • YOHIMBINE chembl:CHEMBL15245 Approved

    Alternate Names:

    YOHIMBINE
    17ALPHA-HYDROXYYOHIMBAN-16ALPHA-CARBOXYLIC ACID METHYL ESTER
    QUEBRACHINE
    ACTIBINE®
    JOHIMBIN
    YOHIMBIN
    YOHIMBIC ACID METHYL ESTER
    QUEBRACHIN
    CORYNINE
    (16ALPHA,17ALPHA)-17-HYDROXYYOHIMBAN-16-CARBOXYLIC ACID METHYL ESTER
    APHRODINE
    (+)-YOHIMBINE
    chemidplus:146-48-5
    chembl:CHEMBL15245
    pubchem.compound:8969
    rxcui:220982
    drugbank:01392

    Drug Info:

    Drug Class anti-impotence agents
    Drug Class mydriatics
    Year of Approval not approved by the fda
    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Anti-impotence Agents
    Drug Indications Mydriatics
    Drug Categories indole alkaloids
    Drug Groups investigational
    Drug Categories agents that produce hypertension
    Drug Categories antidepressive agents
    Drug Categories central nervous system depressants
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories dopamine antagonists
    Drug Categories dopamine d2 receptor antagonists
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories other miscellaneous therapeutic agents
    Drug Categories p-glycoprotein inhibitors
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 5-ht1 receptor antagonists
    Drug Categories serotonin 5-ht2 receptor antagonists
    Drug Categories serotonin agents
    Drug Categories serotonin receptor antagonists
    (4 More Sources)

    Publications:

    Baxter et al., 1994, Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle., Br. J. Pharmacol.
    Kaumann, 1983, Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors., Naunyn Schmiedebergs Arch. Pharmacol.
    Millan et al., 2000, Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states., Synapse
    Rizzo et al., 2001, Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein., Eur. J. Pharmacol.
    Cleary et al., 2005, The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist., Auton Autacoid Pharmacol
    Kalkman et al., 2003, alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs., Eur. J. Pharmacol.
    Lalchandani et al., 2002, Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype., J. Pharmacol. Exp. Ther.
    Cleary et al., 2002, Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice., Br. J. Pharmacol.
    Plant et al., 1990, Phentolamine and yohimbine inhibit ATP-sensitive K+ channels in mouse pancreatic beta-cells., Br. J. Pharmacol.
    Laurila et al., 2007, The second extracellular loop of alpha2A-adrenoceptors contributes to the binding of yohimbine analogues., Br. J. Pharmacol.
    Paul et al., 1999, Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors., J. Biol. Chem.
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
    Ozdoğan et al., 2006, The analgesic efficacy of partial opioid agonists is increased in mice with targeted inactivation of the alpha2A-adrenoceptor gene., Eur. J. Pharmacol.
    Zádori et al., 2007, Pre- and postsynaptic mechanisms in the clonidine- and oxymetazoline-induced inhibition of gastric motility in the rat., Neurochem. Int.
    Freitag et al., 1996, Adrenoceptor- and cholinoceptor-mediated mechanisms in the regulation of 5-hydroxytryptamine release from isolated tracheae of newborn rabbits., Br. J. Pharmacol.
    Alonso et al., 2007, Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus., Neurosci. Lett.
    Takada et al., 2002, Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype., Anesthesiology
    Gyires et al., 2000, Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat., Eur. J. Pharmacol.
    Bonhaus et al., RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist., Neuropharmacology
    Le Corre P et al., 2004, Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism., Clin Pharmacol Ther
  • YOHIMBINE   ADRA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    8872361 17123717 12110610 12170055 10822066 10611634


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • YOHIMBINE   KCNJ1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    2282453


    Sources:
    DrugBank

  • YOHIMBINE   ADRA2C

    Interaction Score: 0.31

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11226402 16176444 12591093 12438517 12110610 10611634


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • YOHIMBINE   ADRA2A

    Interaction Score: 0.31

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    17558432 10506165 12591093 16407989 16325800 17664022 10611634


    Sources:
    TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • YOHIMBINE   HTR5A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • YOHIMBINE   HTR1B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    6136920 10611634


    Sources:
    DrugBank GuideToPharmacology

  • YOHIMBINE   HTR2B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    9225287 8032658


    Sources:
    DrugBank GuideToPharmacology

  • YOHIMBINE   HTR1D

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    10611634


    Sources:
    DrugBank GuideToPharmacology

  • YOHIMBINE   HTR1F

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • YOHIMBINE   HTR1E

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • YOHIMBINE   HTR1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    partial agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    6136920 10611634


    Sources:
    DrugBank GuideToPharmacology

  • YOHIMBINE   HTR2C

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8032658 6136920


    Sources:
    DrugBank

  • YOHIMBINE   DRD3

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10611634


    Sources:
    DrugBank

  • YOHIMBINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8032658 6136920


    Sources:
    DrugBank

  • YOHIMBINE   HTR7

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • YOHIMBINE   DRD2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10611634


    Sources:
    DrugBank

  • YOHIMBINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • YOHIMBINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15289791


    Sources:
    PharmGKB

  • YOHIMBINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB01392

    • Version: 5.1.7

    Alternate Names:
    Yohimbine HCl 2mg Drug Brand
    YOHIMBINE DrugBank Drug Name
    146-48-5 CAS Number

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Kaumann, 1983, Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors., Naunyn Schmiedebergs Arch. Pharmacol.
    Millan et al., 2000, Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states., Synapse
    Bonhaus et al., RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist., Neuropharmacology

  • TEND: YOHIMBINE

    • Version: 01-August-2011

    Alternate Names:
    YOHIMBINE Primary Drug Name

    Drug Info:
    Year of Approval not approved by the fda
    Drug Class mydriatics
    Drug Class anti-impotence agents

    Publications:

  • TdgClinicalTrial: YOHIMBINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Mydriatics
    Drug Indications Anti-impotence Agents
    Drug Class small molecule

    Publications:

  • DTC: YOHIMBINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL15245 ChEMBL Drug ID

    Drug Info:

    Publications:
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

  • PharmGKB: yohimbine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Le Corre P et al., 2004, Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism., Clin Pharmacol Ther

  • TTD: Yohimbine

    • Version: 2020.06.01

    Alternate Names:
    D0H4JM TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135652727

    • Version: 29-September-2020

    Alternate Names:
    YOHIMBINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL15245

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21