DGIdb - WORTMANNIN Drug Record

WORTMANNIN chembl:CHEMBL428496 Immunotherapy

Alternate Names:

WORTMANNIN

Drug Info:

(0 More Sources)

Publications:

Quevedo et al., 2000, Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells., J. Biol. Chem.
Davis et al., 1998, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma., J. Neurosci.
Kim et al., 2003, Effects of ethanol on the rat glutamate excitatory amino acid transporter type 3 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase., Alcohol. Clin. Exp. Res.
Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.
Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.
Okaichi et al., Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway., Oncol. Rep.
Yan et al., 2008, [Induction of insulin resistance induced by PI-3K inhibitor in porcine granulosa cells]., Zhonghua Fu Chan Ke Za Zhi
Semiz et al., 2003, Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules., EMBO J.
Bose et al., Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c., Nature
Somwar et al., 2001, Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport., J. Biol. Chem.
Hartwig et al., 1996, D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate., J. Biol. Chem.
Zhang et al., 1995, Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets., J. Biol. Chem.
Pigazzi et al., 1999, Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets., J. Biol. Chem.
Oki et al., 1999, Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4., Int. Immunol.
Zhang et al., 2003, [EGF/PI3K signaling pathway regulates the expression of osteopontin in liver cancer HepG2 cells]., Zhonghua Yi Xue Za Zhi
Kotelevets et al., 1998, Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion., J. Biol. Chem.
Stein et al., 2006, Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane., J. Gen. Physiol.
Liu et al., 2007, Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects., J. Biol. Chem.
Wilson et al., 2005, Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697., Biochem. J.
Ulrich et al., 1998, Specific TrkA survival signals interfere with different apoptotic pathways., Oncogene
Nusser et al., 2002, Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells., J. Biol. Chem.
Tirosh et al., 1999, Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation., J. Biol. Chem.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Wang et al., 2006, HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways., J. Surg. Res.
Duncan et al., 2005, Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress., Free Radic. Biol. Med.
Dunzendorfer et al., 1998, Signaling in neuropeptide-induced migration of human eosinophils., J. Leukoc. Biol.
Yamaguchi et al., 2005, Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes., Am. J. Physiol. Endocrinol. Metab.
Kang et al., 2002, Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress., Mol. Pharmacol.

WORTMANNIN PLK2

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17135248

Sources:
DTC
WORTMANNIN EIF2B1

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10764740

Sources:
NCI
WORTMANNIN SLC1A1

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9502808 14574224 12401608

Sources:
NCI
WORTMANNIN PRKAB1

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15928020

Sources:
NCI
WORTMANNIN GADD45A

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12066222

Sources:
NCI
WORTMANNIN SPP1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14703434

Sources:
NCI
WORTMANNIN F2R

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8955143 7559410 10318860

Sources:
NCI
WORTMANNIN PLK3

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17135248

Sources:
DTC
WORTMANNIN MYO9B

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15823093

Sources:
NCI
WORTMANNIN HGF

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9603913

Sources:
NCI
WORTMANNIN SLC2A4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18366935 12743033 12490950 11598141

Sources:
NCI
WORTMANNIN CTLA4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10464177

Sources:
NCI
WORTMANNIN TAC1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9850167

Sources:
NCI
WORTMANNIN NRG1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10559227

Sources:
NCI
WORTMANNIN MAPK10

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15683719

Sources:
NCI
WORTMANNIN HSPA4

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16979664

Sources:
NCI
WORTMANNIN NTRK1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9484773 12133829

Sources:
NCI
WORTMANNIN TRPV1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17074976

Sources:
NCI
WORTMANNIN AKT1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10187855

Sources:
NCI
WORTMANNIN PLK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17135248 10592235

Sources:
NCI
WORTMANNIN THRB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN HSP90AA1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN RECQL

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN POLI

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12391262

Sources:
DTC NCI
WORTMANNIN MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN VDR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: WORTMANNIN

Version: 14-September-2017

Alternate Names:

C1277 NCI drug code

Drug Info:

Publications:

Quevedo et al., 2000, Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells., J. Biol. Chem.

Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.

Davis et al., 1998, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma., J. Neurosci.

DTC: WORTMANNIN
- Version: 02-September-2020
Alternate Names:

CHEMBL428496 ChEMBL Drug ID

Drug Info:

Publications:

Liu et al., 2007, Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects., J. Biol. Chem.
ChemblDrugs: chembl:CHEMBL428496
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

WORTMANNIN Drug Record

WORTMANNIN chembl:CHEMBL428496 Immunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17135248

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10764740

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9502808 14574224 12401608

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15928020

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12066222

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14703434

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8955143 7559410 10318860

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17135248

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15823093

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9603913

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18366935 12743033 12490950 11598141

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10464177

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9850167

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10559227

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15683719

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16979664

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9484773 12133829

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17074976

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10187855

Interaction Types & Directionality:

n/a

PMIDs:
17135248

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10764740

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9502808 14574224 12401608

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15928020

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12066222

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14703434

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8955143 7559410 10318860

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17135248

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15823093

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9603913

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18366935 12743033 12490950 11598141

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10464177

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9850167

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10559227

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15683719

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16979664

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9484773 12133829

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17074976

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10187855

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17135248 10592235

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12391262

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found