DGIdb - WORTMANNIN Drug Record

WORTMANNIN chembl:CHEMBL428496 Immunotherapy

Alternate Names:

WORTMANNIN

Drug Info:

Drug Type	small molecule
Drug Groups	experimental
Drug Categories	androstadienes
Drug Categories	androstanes
Drug Categories	androstenes
Drug Categories	anti-infective agents
Drug Categories	antidepressive agents
Drug Categories	antifungal agents
Drug Categories	central nervous system depressants
Drug Categories	enzyme inhibitors
Drug Categories	fused-ring compounds
Drug Categories	hormone antagonists
Drug Categories	hormones, hormone substitutes, and hormone antagonists
Drug Categories	immunologic factors
Drug Categories	immunosuppressive agents
Drug Categories	insulin antagonists
Drug Categories	protein kinase inhibitors
Drug Categories	radiation-sensitizing agents
Drug Categories	serotonin agents
Drug Categories	serotonin receptor antagonists
Drug Categories	steroids

(1 More Sources)

Publications:

Quevedo et al., 2000, Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells., J. Biol. Chem.
Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.
Davis et al., 1998, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma., J. Neurosci.
Kim et al., 2003, Effects of ethanol on the rat glutamate excitatory amino acid transporter type 3 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase., Alcohol. Clin. Exp. Res.
Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.
Okaichi et al., Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway., Oncol. Rep.
Somwar et al., 2001, Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport., J. Biol. Chem.
Bose et al., Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c., Nature
Semiz et al., 2003, Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules., EMBO J.
Yan et al., 2008, [Induction of insulin resistance induced by PI-3K inhibitor in porcine granulosa cells]., Zhonghua Fu Chan Ke Za Zhi
Pigazzi et al., 1999, Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets., J. Biol. Chem.
Zhang et al., 1995, Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets., J. Biol. Chem.
Hartwig et al., 1996, D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate., J. Biol. Chem.
Oki et al., 1999, Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4., Int. Immunol.
Zhang et al., 2003, [EGF/PI3K signaling pathway regulates the expression of osteopontin in liver cancer HepG2 cells]., Zhonghua Yi Xue Za Zhi
Kotelevets et al., 1998, Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion., J. Biol. Chem.
Stein et al., 2006, Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane., J. Gen. Physiol.
Liu et al., 2007, Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects., J. Biol. Chem.
Wilson et al., 2005, Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697., Biochem. J.
Nusser et al., 2002, Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells., J. Biol. Chem.
Ulrich et al., 1998, Specific TrkA survival signals interfere with different apoptotic pathways., Oncogene
Tirosh et al., 1999, Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation., J. Biol. Chem.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Wang et al., 2006, HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways., J. Surg. Res.
Duncan et al., 2005, Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress., Free Radic. Biol. Med.
Dunzendorfer et al., 1998, Signaling in neuropeptide-induced migration of human eosinophils., J. Leukoc. Biol.
Yamaguchi et al., 2005, Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes., Am. J. Physiol. Endocrinol. Metab.
Kang et al., 2002, Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress., Mol. Pharmacol.

WORTMANNIN EIF2B1

Interaction Score: 3.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10764740

Sources:
NCI
WORTMANNIN PI4KA

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
WORTMANNIN PLK2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17135248

Sources:
DTC
WORTMANNIN PI4KB

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
WORTMANNIN SLC1A1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12401608 9502808 14574224

Sources:
NCI
WORTMANNIN GADD45A

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12066222

Sources:
NCI
WORTMANNIN PRKAB1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15928020

Sources:
NCI
WORTMANNIN SPP1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14703434

Sources:
NCI
WORTMANNIN F2R

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10318860 7559410 8955143

Sources:
NCI
WORTMANNIN MYO9B

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15823093

Sources:
NCI
WORTMANNIN PLK3

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17135248

Sources:
DTC
WORTMANNIN PRKDC

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
WORTMANNIN HGF

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9603913

Sources:
NCI
WORTMANNIN SLC2A4

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11598141 12490950 12743033 18366935

Sources:
NCI
WORTMANNIN CTLA4

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10464177

Sources:
NCI
WORTMANNIN TAC1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9850167

Sources:
NCI
WORTMANNIN NRG1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10559227

Sources:
NCI
WORTMANNIN HSPA4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16979664

Sources:
NCI
WORTMANNIN PIK3R1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
WORTMANNIN NTRK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12133829 9484773

Sources:
NCI
WORTMANNIN MAPK10

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15683719

Sources:
NCI
WORTMANNIN TRPV1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17074976

Sources:
NCI
WORTMANNIN PIK3CG

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
10592235

Sources:
DrugBank GuideToPharmacology
WORTMANNIN AKT1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10187855

Sources:
NCI
WORTMANNIN PLK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17135248 10592235

Sources:
NCI DrugBank
WORTMANNIN PIK3CA

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10592235

Sources:
DrugBank GuideToPharmacology
WORTMANNIN PIK3CD

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
WORTMANNIN PIK3CB

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
WORTMANNIN THRB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN MTOR

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
WORTMANNIN RECQL

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN HSP90AA1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN POLI

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12391262

Sources:
NCI DTC
WORTMANNIN MAPT

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN VDR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB08059
- Version: 5.1.7
Alternate Names:

WORTMANNIN DrugBank Drug Name

19545-26-7 CAS Number

CHEMBL428496 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups experimental

Drug Categories androstadienes

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: WORTMANNIN

Version: 14-September-2017

Alternate Names:

C1277 NCI drug code

Drug Info:

Publications:

Quevedo et al., 2000, Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells., J. Biol. Chem.

Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.

Davis et al., 1998, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma., J. Neurosci.

DTC: WORTMANNIN
- Version: 02-September-2020
Alternate Names:

CHEMBL428496 ChEMBL Drug ID

Drug Info:

Publications:

Liu et al., 2007, Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects., J. Biol. Chem.
GuideToPharmacology: 178102681
- Version: 29-September-2020
Alternate Names:

WORTMANNIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL428496
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

WORTMANNIN	DrugBank Drug Name
19545-26-7	CAS Number
CHEMBL428496	ChEMBL ID

WORTMANNIN Drug Record

WORTMANNIN chembl:CHEMBL428496 Immunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10764740

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17135248

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12401608 9502808 14574224

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12066222

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15928020

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14703434

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10318860 7559410 8955143

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15823093

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17135248

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9603913

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11598141 12490950 12743033 18366935

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10464177

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9850167

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10559227

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16979664

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Interaction Types & Directionality:

n/a

PMIDs:
10764740

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
17135248

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
12401608 9502808 14574224

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12066222

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15928020

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14703434

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10318860 7559410 8955143

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15823093

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17135248

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
9603913

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11598141 12490950 12743033 18366935

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10464177

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9850167

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10559227

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16979664

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12133829 9484773

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15683719

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17074976

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
10592235

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10187855

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17135248 10592235

Sources:
NCI DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)