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WITHAFERIN A Drug Record

  • Summary
  • Interactions
  • Claims
  • WITHAFERIN A chembl:CHEMBL1221986

    Alternate Names:

    NSC-101088

    Drug Info:

    (0 More Sources)

    Publications:

    Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod
    Llanos GG et al., 2012, Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells., Eur J Med Chem
    Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod
    Falsey RR et al., 2006, Actin microfilament aggregation induced by withaferin A is mediated by annexin II., Nat Chem Biol
    Yoneyama T et al., 2015, Hedgehog inhibitors from Withania somnifera., Bioorg Med Chem Lett
  • WITHAFERIN A   ANXA2

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16408090


    Sources:
    DTC

  • WITHAFERIN A   CDC25C

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • WITHAFERIN A   GLI1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26169123


    Sources:
    DTC

  • WITHAFERIN A   WEE1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • WITHAFERIN A   CHEK2

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • WITHAFERIN A   CASP3

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705001


    Sources:
    DTC

  • WITHAFERIN A   CHEK1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • WITHAFERIN A   MAPK3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20726569


    Sources:
    DTC

  • WITHAFERIN A   CDK1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • WITHAFERIN A   AURKB

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • WITHAFERIN A   AKT1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20726569


    Sources:
    DTC

  • WITHAFERIN A   MAPK1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20726569


    Sources:
    DTC

  • DTC: WITHAFERIN A

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1221986 ChEMBL Drug ID

    Drug Info:

    Publications:
    Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod
    Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod
    Yoneyama T et al., 2015, Hedgehog inhibitors from Withania somnifera., Bioorg Med Chem Lett

  • ChemblDrugs: chembl:CHEMBL1221986

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21