• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

VORTIOXETINE Drug Record

  • Summary
  • Interactions
  • Claims
  • VORTIOXETINE chembl:CHEMBL2104993 Approved

    Alternate Names:

    LU AA21004
    LU-AA21004
    BRINTELLIX
    LUAA21004
    VORTIOXETINE
    VORTIOXÉTINE
    VORTIOXETINA
    TRINTELLIX
    VORTIOXETINUM
    chembl:CHEMBL2104993
    rxcui:1455099
    pubchem.compound:9966051
    drugbank:09068
    chemidplus:508233-74-7

    Drug Info:

    FDA Approval not approved
    Drug Class small molecule
    Drug Indications antidepressant
    Drug Categories serotonin 5-ht3 receptor antagonists
    Drug Groups investigational
    Drug Categories agents that produce hypertension
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories piperazines
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin receptor antagonists
    (3 More Sources)

    Publications:

    Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.
    Kamei K et al., 2006, Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan., Bioorg Med Chem
  • VORTIOXETINE   HTR7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    21486038


    Sources:
    DrugBank TdgClinicalTrial GuideToPharmacology

  • VORTIOXETINE   HTR5A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VORTIOXETINE   HTR1B

    Interaction Score: 0.27

    Interaction Types & Directionality:
    agonist (activating)
    partial agonist (activating)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    21486038


    Sources:
    DrugBank TdgClinicalTrial GuideToPharmacology

  • VORTIOXETINE   HTR3A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Lu AA21004

    PMIDs:
    21486038


    Sources:
    DrugBank TdgClinicalTrial

  • VORTIOXETINE   SLC6A4

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Lu AA21004
    Specific Action of the Ligand Inhibition

    PMIDs:
    21486038


    Sources:
    DrugBank TdgClinicalTrial GuideToPharmacology

  • VORTIOXETINE   HTR1A

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Lu AA21004
    Novel drug target Established target
    Specific Action of the Ligand Partial agonist

    PMIDs:
    21486038 16290165


    Sources:
    DrugBank TdgClinicalTrial GuideToPharmacology

  • VORTIOXETINE   SLC6A2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:

    PMIDs:
    21486038


    Sources:
    DrugBank

  • VORTIOXETINE   HTR6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VORTIOXETINE   ADRB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    21486038


    Sources:
    DrugBank

  • VORTIOXETINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VORTIOXETINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • DrugBank: DB09068

    • Version: 5.1.7

    Alternate Names:
    VORTIOXETINE DrugBank Drug Name
    508233-74-7 CAS Number
    Brintellix Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Kamei K et al., 2006, Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan., Bioorg Med Chem
    Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.

  • TdgClinicalTrial: VORTIOXETINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antidepressant
    Drug Class small molecule
    FDA Approval not approved

    Publications:

  • GuideToPharmacology: 178103923

    • Version: 29-September-2020

    Alternate Names:
    VORTIOXETINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: Vortioxetine

    • Version: 2020.06.01

    Alternate Names:
    D03WEX TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2104993

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: vortioxetine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Vortioxetine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21