DGIdb - VORTIOXETINE Drug Record

VORTIOXETINE chembl:CHEMBL2104993 Approved

Alternate Names:

LU AA21004
LU-AA21004
BRINTELLIX
LUAA21004
VORTIOXETINE
VORTIOXÉTINE
VORTIOXETINA
TRINTELLIX
VORTIOXETINUM
chembl:CHEMBL2104993
rxcui:1455099
pubchem.compound:9966051
drugbank:09068
chemidplus:508233-74-7

Drug Info:

FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antidepressant
Drug Categories	serotonin 5-ht3 receptor antagonists
Drug Groups	investigational
Drug Categories	agents that produce hypertension
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	piperazines
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin receptor antagonists

(3 More Sources)

Publications:

Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.
Kamei K et al., 2006, Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan., Bioorg Med Chem

VORTIOXETINE HTR7

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
VORTIOXETINE HTR5A

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
VORTIOXETINE HTR1B

Interaction Score: 0.27

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
VORTIOXETINE HTR3A

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Lu AA21004

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank
VORTIOXETINE SLC6A4

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Lu AA21004

Specific Action of the Ligand Inhibition

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
VORTIOXETINE HTR1A

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Lu AA21004

Novel drug target Established target

Specific Action of the Ligand Partial agonist

PMIDs:
21486038 16290165

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
VORTIOXETINE SLC6A2

Interaction Score: 0.13

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
21486038

Sources:
DrugBank
VORTIOXETINE HTR6

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
VORTIOXETINE ADRB1

Interaction Score: 0.08

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
21486038

Sources:
DrugBank
VORTIOXETINE HTR2A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
VORTIOXETINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB

DrugBank: DB09068

Version: 5.1.7

Alternate Names:

VORTIOXETINE DrugBank Drug Name

508233-74-7 CAS Number

Brintellix Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.

Kamei K et al., 2006, Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan., Bioorg Med Chem

TdgClinicalTrial: VORTIOXETINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidepressant

Drug Class small molecule

FDA Approval not approved

Publications:
GuideToPharmacology: 178103923
- Version: 29-September-2020
Alternate Names:

VORTIOXETINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Vortioxetine
- Version: 2020.06.01
Alternate Names:

D03WEX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL2104993
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: vortioxetine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
FDA: Vortioxetine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Novel drug target	Established target
Trial Name	Lu AA21004
Specific Action of the Ligand	Inhibition

VORTIOXETINE	DrugBank Drug Name
508233-74-7	CAS Number
Brintellix	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

partial agonist (activating)
agonist (activating)

VORTIOXETINE Drug Record

VORTIOXETINE chembl:CHEMBL2104993 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 21486038

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Partial agonist

PMIDs: 21486038

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Lu AA21004

PMIDs: 21486038

Sources: TdgClinicalTrial DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Lu AA21004 Specific Action of the Ligand Inhibition

PMIDs: 21486038

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Lu AA21004 Novel drug target Established target Specific Action of the Ligand Partial agonist

PMIDs: 21486038 16290165

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 21486038

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: ligand

Interaction Info:

PMIDs: 21486038

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA PharmGKB

DrugBank: DB09068

Alternate Names: VORTIOXETINE DrugBank Drug Name 508233-74-7 CAS Number Brintellix Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TdgClinicalTrial: VORTIOXETINE

Alternate Names:

Drug Info: Drug Indications antidepressant Drug Class small molecule FDA Approval not approved

Publications:

GuideToPharmacology: 178103923

Alternate Names: VORTIOXETINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Vortioxetine

Alternate Names: D03WEX TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL2104993

Alternate Names:

Drug Info:

Publications:

PharmGKB: vortioxetine

Alternate Names:

Drug Info:

Publications:

FDA: Vortioxetine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Lu AA21004

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Lu AA21004

Specific Action of the Ligand Inhibition

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Lu AA21004

Novel drug target Established target

Specific Action of the Ligand Partial agonist

PMIDs:
21486038 16290165

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
21486038

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

ligand

PMIDs:
21486038

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Alternate Names:

VORTIOXETINE DrugBank Drug Name

508233-74-7 CAS Number

Brintellix Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Drug Info:

Drug Indications antidepressant

Drug Class small molecule

FDA Approval not approved

Alternate Names:

VORTIOXETINE GuideToPharmacology Ligand Name

Alternate Names:

D03WEX TTD Drug ID