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VORICONAZOLE Drug Record

  • Summary
  • Interactions
  • Claims
  • VORICONAZOLE chembl:CHEMBL638 Approved

    Alternate Names:

    VFEND
    UK-109496
    VORICONAZOLE
    VORICONAZOL
    VORICONAZOLUM
    (R-(R*,S*))-ALPHA-(2,4-DIFLUOROPHENYL)-5-FLUORO-BETA-METHYL-ALPHA-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-4-PYRIMIDINEETHANOL
    VCZ
    (ALPHAR,BETAS)-ALPHA-(2,4-DIFLUOROPHENYL)-5-FLUORO-BETA-METHYL-ALPHA(1H-1,2,4-TRIAZOL-1-YLMETHYL)-4-PYRIMIDINEETHANOL
    chembl:CHEMBL638
    pubchem.compound:71616
    rxcui:121243
    drugbank:00582
    chemidplus:137234-62-9

    Drug Info:

    (2 More Sources)

    Publications:

    Jeong S et al., 2009, Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A., Antimicrob Agents Chemother
    Weiss J et al., 2009, CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole., J Clin Pharmacol
    Simitsopoulou M et al., 2008, Immunomodulatory effects of voriconazole on monocytes challenged with Aspergillus fumigatus: differential role of Toll-like receptors., Antimicrob Agents Chemother
    Niwa et al., 2005, Effect of antifungal drugs on cytochrome P450 (CYP) 1A2, CYP2D6, and CYP2E1 activities in human liver microsomes., Biol. Pharm. Bull.
    Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci
  • VORICONAZOLE   CYP2B6

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19029318


    Sources:
    DTC

  • VORICONAZOLE   RELA

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18625774


    Sources:
    DTC

  • VORICONAZOLE   ABCG2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17518356


    Sources:
    NCI

  • VORICONAZOLE   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19033450


    Sources:
    PharmGKB

  • VORICONAZOLE   CYP2D6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16141569


    Sources:
    NCI

  • VORICONAZOLE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • DTC: VORICONAZOLE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL638 ChEMBL Drug ID

    Drug Info:

    Publications:
    Jeong S et al., 2009, Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A., Antimicrob Agents Chemother
    Simitsopoulou M et al., 2008, Immunomodulatory effects of voriconazole on monocytes challenged with Aspergillus fumigatus: differential role of Toll-like receptors., Antimicrob Agents Chemother

  • NCI: VORICONAZOLE

    • Version: 14-September-2017

    Alternate Names:
    C1707 NCI drug code

    Drug Info:

    Publications:
    Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci
    Niwa et al., 2005, Effect of antifungal drugs on cytochrome P450 (CYP) 1A2, CYP2D6, and CYP2E1 activities in human liver microsomes., Biol. Pharm. Bull.

  • PharmGKB: voriconazole

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Weiss J et al., 2009, CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole., J Clin Pharmacol

  • TTD: Voriconazole

    • Version: 2020.06.01

    Alternate Names:
    D0N3VR TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL638

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Voriconazole

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21