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VITAMIN E Drug Record

  • Summary
  • Interactions
  • Claims
  • VITAMIN E chembl:CHEMBL47

    Alternate Names:

    AQUASOL E
    E307
    ALPHA TOCOPHEROL
    VITAMIN E
    TOCOPHEROL
    5,7,8-TRIMETHYLTOCOL
    E-VIMIN
    (2R,4'R,8'R)-Α-TOCOPHEROL
    D-Α-TOCOPHEROL
    EVITAMINUM
    (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
    PROFECUNDIN
    (+)-ALPHA-TOCOPHEROL
    (R,R,R)-Α-TOCOPHEROL
    NATOPHEROL
    (+)-Α-TOCOPHEROL
    Α-TOCOPHEROL
    EPROLIN
    (2R,4'R,8'R)-ALPHA-TOCOPHEROL
    (R,R,R)-ALPHA-TOCOPHEROL
    D-ALPHA-TOCOPHEROL
    drugbank:00163
    rxcui:220892
    rxcui:11256
    chembl:CHEMBL47
    chemidplus:59-02-9
    pubchem.compound:14985

    Drug Info:

    (0 More Sources)

    Publications:

    Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.
    Desrumaux et al., 2005, Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice., FASEB J.
    Desrumaux et al., 1999, Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering alpha-tocopherol to endothelial cells., FASEB J.
    Heaton et al., 2004, Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells., Brain Res. Dev. Brain Res.
    Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis
    Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.
    Yang et al., 2006, Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial., Eur. J. Cancer Prev.
    Galli et al., 2004, The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation., Arch. Biochem. Biophys.
    An et al., 2007, Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor., Oncogene
    Azzi et al., 2002, Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)., FEBS Lett.
    Ralat et al., 2006, Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi., Biochemistry
    Chan et al., 1998, alpha-Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat., Mol. Genet. Metab.
  • VITAMIN E   PLTP

    Interaction Score: 8.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15576481 10224231


    Sources:
    NCI

  • VITAMIN E   XRCC1

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12618330


    Sources:
    NCI

  • VITAMIN E   CXCR2

    Interaction Score: 1.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16679868


    Sources:
    NCI

  • VITAMIN E   APOB

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7649489


    Sources:
    NCI

  • VITAMIN E   CCN2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12023009


    Sources:
    NCI

  • VITAMIN E   CCND1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14871472


    Sources:
    NCI

  • VITAMIN E   DDIT3

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15271854


    Sources:
    NCI

  • VITAMIN E   TGFB1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9608545


    Sources:
    NCI

  • VITAMIN E   MAPK8

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16909121


    Sources:
    NCI

  • VITAMIN E   BCL2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15158075


    Sources:
    NCI

  • VITAMIN E   GSTP1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17029404


    Sources:
    NCI

  • NCI: ALPHA-TOCOPHEROL

    • Version: 14-September-2017

    Alternate Names:
    C2832 NCI drug code

    Drug Info:

    Publications:
    Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.
    Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.
    Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis

  • ChemblDrugs: chembl:CHEMBL47

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21