DGIdb - VITAMIN E Drug Record

VITAMIN E chembl:CHEMBL47

Alternate Names:

AQUASOL E
E307
ALPHA TOCOPHEROL
VITAMIN E
TOCOPHEROL
5,7,8-TRIMETHYLTOCOL
E-VIMIN
(2R,4'R,8'R)-Α-TOCOPHEROL
D-Α-TOCOPHEROL
EVITAMINUM
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
PROFECUNDIN
(+)-ALPHA-TOCOPHEROL
(R,R,R)-Α-TOCOPHEROL
NATOPHEROL
(+)-Α-TOCOPHEROL
Α-TOCOPHEROL
EPROLIN
(2R,4'R,8'R)-ALPHA-TOCOPHEROL
(R,R,R)-ALPHA-TOCOPHEROL
D-ALPHA-TOCOPHEROL
drugbank:00163
rxcui:220892
rxcui:11256
chembl:CHEMBL47
chemidplus:59-02-9
pubchem.compound:14985

Drug Info:

Drug Categories	vitamins (fat soluble)
Drug Categories	vitamins
Drug Categories	vitamin e
Drug Categories	tocopherols
Drug Categories	supplements
Drug Categories	specialty uses of chemicals
Drug Categories	pyrans
Drug Categories	protective agents
Drug Categories	physiological phenomena
Drug Categories	physiological effects of drugs
Drug Categories	pharmacologic actions
Drug Categories	molecular mechanisms of pharmacological action
Drug Categories	micronutrients
Drug Categories	heterocyclic compounds, 2-ring
Drug Categories	heterocyclic compounds, 1-ring
Drug Categories	heterocyclic compounds
Drug Categories	growth substances
Drug Categories	food and beverages
Drug Categories	food
Drug Categories	dietary supplements
Drug Categories	diet, food, and nutrition
Drug Categories	chemical actions and uses
Drug Categories	benzopyrans
Drug Categories	antioxidants
Drug Groups	vet_approved
Drug Groups	nutraceutical
Drug Groups	approved
Drug Type	small molecule
Drug Categories	basic ointments and protectants
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	vitamin e, analogs & derivatives

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Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Hayashi D et al., 2017, Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice., Sci Rep
Fukunaga-Takenaka R et al., 2005, Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol., Genes Cells
Taccone-Gallucci et al., 2006, N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity., Kidney Int.
Rabovsky et al., 2006, Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects., Clin. Chim. Acta
Meijerman et al., Herb-drug interactions in oncology: focus on mechanisms of induction., Oncologist
Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.
Desrumaux et al., 2005, Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice., FASEB J.
Desrumaux et al., 1999, Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering alpha-tocopherol to endothelial cells., FASEB J.
Heaton et al., 2004, Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells., Brain Res. Dev. Brain Res.
Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis
Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.
Yang et al., 2006, Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial., Eur. J. Cancer Prev.
Neuzil et al., 2006, Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells., Biochem. Biophys. Res. Commun.
Ni et al., 2007, Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells., Prostate
Ganz et al., 2000, Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E., Am. J. Physiol. Endocrinol. Metab.
Huang et al., 2002, Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes., Diabetes Res. Clin. Pract.
Wigg et al., 2004, Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats., Diabetologia
Ye et al., 2004, Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP., Mol. Biol. Rep.
Millward TA et al., 1999, Regulation of protein kinase cascades by protein phosphatase 2A., Trends Biochem Sci
Zingg JM, 2007, Modulation of signal transduction by vitamin E., Mol Aspects Med
Ricciarelli R et al., 1998, alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state., Biochem J
Galli et al., 2004, The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation., Arch. Biochem. Biophys.
An et al., 2007, Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor., Oncogene
Azzi et al., 2002, Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)., FEBS Lett.
Ralat et al., 2006, Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi., Biochemistry
Schmölz L et al., 2016, Complexity of vitamin E metabolism., World J Biol Chem
Chan et al., 1998, alpha-Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat., Mol. Genet. Metab.
Sylvester et al., 2001, Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation., Cell Prolif.
Azzi et al., 1997, Alpha-tocopherol as a modulator of smooth muscle cell proliferation., Prostaglandins Leukot. Essent. Fatty Acids

VITAMIN E DGKA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Hayashi D et al., 2017, Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice., Sci Rep

VITAMIN E ALOX5

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Taccone-Gallucci et al., 2006, N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity., Kidney Int.

VITAMIN E NR1I2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Rabovsky et al., 2006, Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects., Clin. Chim. Acta

Meijerman et al., Herb-drug interactions in oncology: focus on mechanisms of induction., Oncologist

VITAMIN E XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

VITAMIN E PLTP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Desrumaux et al., 2005, Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice., FASEB J.

Desrumaux et al., 1999, Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering alpha-tocopherol to endothelial cells., FASEB J.

VITAMIN E BCL2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Heaton et al., 2004, Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells., Brain Res. Dev. Brain Res.

VITAMIN E DDIT3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis

VITAMIN E APOB

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.

VITAMIN E CXCR2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Yang et al., 2006, Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial., Eur. J. Cancer Prev.

VITAMIN E SEC14L2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Neuzil et al., 2006, Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells., Biochem. Biophys. Res. Commun.

Ni et al., 2007, Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells., Prostate

VITAMIN E PRKCB

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ganz et al., 2000, Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E., Am. J. Physiol. Endocrinol. Metab.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

VITAMIN E SEC14L3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ye et al., 2004, Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP., Mol. Biol. Rep.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

VITAMIN E PPP2CA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Millward TA et al., 1999, Regulation of protein kinase cascades by protein phosphatase 2A., Trends Biochem Sci

VITAMIN E CCND1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Galli et al., 2004, The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation., Arch. Biochem. Biophys.
VITAMIN E MAPK8

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

An et al., 2007, Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor., Oncogene
VITAMIN E CCN2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Azzi et al., 2002, Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)., FEBS Lett.
VITAMIN E GSTP1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ralat et al., 2006, Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi., Biochemistry

VITAMIN E SEC14L4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Schmölz L et al., 2016, Complexity of vitamin E metabolism., World J Biol Chem

VITAMIN E PPP2CB

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Millward TA et al., 1999, Regulation of protein kinase cascades by protein phosphatase 2A., Trends Biochem Sci

VITAMIN E TGFB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chan et al., 1998, alpha-Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat., Mol. Genet. Metab.

VITAMIN E PRKCA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sylvester et al., 2001, Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation., Cell Prolif.

Azzi et al., 1997, Alpha-tocopherol as a modulator of smooth muscle cell proliferation., Prostaglandins Leukot. Essent. Fatty Acids

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DrugBank: DB00163

Version: 5.1.7

Alternate Names:

VITAMIN E DrugBank Drug Name

59-02-9 CAS Number

24 Multivitamins + Minerals Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups nutraceutical

Publications:

Ricciarelli R et al., 1998, alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state., Biochem J

Zingg JM, 2007, Modulation of signal transduction by vitamin E., Mol Aspects Med

Millward TA et al., 1999, Regulation of protein kinase cascades by protein phosphatase 2A., Trends Biochem Sci

NCI: ALPHA-TOCOPHEROL

Version: 14-September-2017

Alternate Names:

C2832 NCI drug code

Drug Info:

Publications:

Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.

Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis

ChemblDrugs: chembl:CHEMBL47
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

VITAMIN E	DrugBank Drug Name
59-02-9	CAS Number
24 Multivitamins + Minerals	Drug Brand

VITAMIN E Drug Record

VITAMIN E chembl:CHEMBL47

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Taccone-Gallucci et al., 2006, N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity., Kidney Int.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Rabovsky et al., 2006, Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects., Clin. Chim. Acta Meijerman et al., Herb-drug interactions in oncology: focus on mechanisms of induction., Oncologist

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Heaton et al., 2004, Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells., Brain Res. Dev. Brain Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Yang et al., 2006, Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial., Eur. J. Cancer Prev.

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Galli et al., 2004, The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation., Arch. Biochem. Biophys.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: An et al., 2007, Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor., Oncogene

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Azzi et al., 2002, Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)., FEBS Lett.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ralat et al., 2006, Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi., Biochemistry

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Schmölz L et al., 2016, Complexity of vitamin E metabolism., World J Biol Chem

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chan et al., 1998, alpha-Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat., Mol. Genet. Metab.

Interaction Types & Directionality: n/a

Interaction Info:

DrugBank: DB00163

Alternate Names: VITAMIN E DrugBank Drug Name 59-02-9 CAS Number 24 Multivitamins + Minerals Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups nutraceutical

NCI: ALPHA-TOCOPHEROL

Alternate Names: C2832 NCI drug code

Drug Info:

ChemblDrugs: chembl:CHEMBL47

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Taccone-Gallucci et al., 2006, N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity., Kidney Int.

Interaction Types & Directionality:

n/a

Publications:

Rabovsky et al., 2006, Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects., Clin. Chim. Acta

Meijerman et al., Herb-drug interactions in oncology: focus on mechanisms of induction., Oncologist

Interaction Types & Directionality:

n/a

Publications:

Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Heaton et al., 2004, Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells., Brain Res. Dev. Brain Res.

Interaction Types & Directionality:

n/a

Publications:

Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis

Interaction Types & Directionality:

n/a

Publications:

Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.

Interaction Types & Directionality:

n/a

Publications:

Yang et al., 2006, Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial., Eur. J. Cancer Prev.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Galli et al., 2004, The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation., Arch. Biochem. Biophys.

Interaction Types & Directionality:

n/a

Publications:

An et al., 2007, Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor., Oncogene

Interaction Types & Directionality:

n/a

Publications:

Azzi et al., 2002, Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)., FEBS Lett.

Interaction Types & Directionality:

n/a

Publications:

Ralat et al., 2006, Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi., Biochemistry

Interaction Types & Directionality:

n/a

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Schmölz L et al., 2016, Complexity of vitamin E metabolism., World J Biol Chem

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Chan et al., 1998, alpha-Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat., Mol. Genet. Metab.

Interaction Types & Directionality:

n/a

Alternate Names:

VITAMIN E DrugBank Drug Name

59-02-9 CAS Number

24 Multivitamins + Minerals Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups nutraceutical

Alternate Names:

C2832 NCI drug code