DGIdb - VITAMIN E Drug Record

VITAMIN E chembl:CHEMBL47

Alternate Names:

AQUASOL E
E307
ALPHA TOCOPHEROL
VITAMIN E
TOCOPHEROL
5,7,8-TRIMETHYLTOCOL
E-VIMIN
(2R,4'R,8'R)-Α-TOCOPHEROL
D-Α-TOCOPHEROL
EVITAMINUM
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
PROFECUNDIN
(+)-ALPHA-TOCOPHEROL
(R,R,R)-Α-TOCOPHEROL
NATOPHEROL
(+)-Α-TOCOPHEROL
Α-TOCOPHEROL
EPROLIN
(2R,4'R,8'R)-ALPHA-TOCOPHEROL
(R,R,R)-ALPHA-TOCOPHEROL
D-ALPHA-TOCOPHEROL
drugbank:00163
rxcui:220892
rxcui:11256
chembl:CHEMBL47
chemidplus:59-02-9
pubchem.compound:14985

Drug Info:

Drug Categories	vitamin e
Drug Categories	basic ointments and protectants
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	vitamin e, analogs & derivatives

(0 More Sources)

Publications:

Hayashi D et al., 2017, Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice., Sci Rep
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Fukunaga-Takenaka R et al., 2005, Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol., Genes Cells
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Taccone-Gallucci et al., 2006, N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity., Kidney Int.
Meijerman et al., Herb-drug interactions in oncology: focus on mechanisms of induction., Oncologist
Rabovsky et al., 2006, Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects., Clin. Chim. Acta
Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.
Desrumaux et al., 2005, Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice., FASEB J.
Desrumaux et al., 1999, Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering alpha-tocopherol to endothelial cells., FASEB J.
Heaton et al., 2004, Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells., Brain Res. Dev. Brain Res.
Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis
Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.
Yang et al., 2006, Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial., Eur. J. Cancer Prev.
Ni et al., 2007, Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells., Prostate
Neuzil et al., 2006, Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells., Biochem. Biophys. Res. Commun.
Ganz et al., 2000, Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E., Am. J. Physiol. Endocrinol. Metab.
Wigg et al., 2004, Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats., Diabetologia
Huang et al., 2002, Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes., Diabetes Res. Clin. Pract.
Ye et al., 2004, Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP., Mol. Biol. Rep.
Zingg JM, 2007, Modulation of signal transduction by vitamin E., Mol Aspects Med
Millward TA et al., 1999, Regulation of protein kinase cascades by protein phosphatase 2A., Trends Biochem Sci
Ricciarelli R et al., 1998, alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state., Biochem J
Galli et al., 2004, The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation., Arch. Biochem. Biophys.
An et al., 2007, Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor., Oncogene
Azzi et al., 2002, Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)., FEBS Lett.
Ralat et al., 2006, Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi., Biochemistry
Schmölz L et al., 2016, Complexity of vitamin E metabolism., World J Biol Chem
Chan et al., 1998, alpha-Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat., Mol. Genet. Metab.
Azzi et al., 1997, Alpha-tocopherol as a modulator of smooth muscle cell proliferation., Prostaglandins Leukot. Essent. Fatty Acids
Sylvester et al., 2001, Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation., Cell Prolif.

VITAMIN E PPP2CB

Interaction Score: 16.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17320164 10322434 17139284 17016423 9693126

Sources:
DrugBank
VITAMIN E SEC14L4

Interaction Score: 10.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26981194 17139284 17016423

Sources:
DrugBank
VITAMIN E PPP2CA

Interaction Score: 8.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17320164 10322434 17139284 17016423 9693126

Sources:
DrugBank
VITAMIN E DGKA

Interaction Score: 6.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28572624 17139284 15773894 17016423

Sources:
DrugBank
VITAMIN E PLTP

Interaction Score: 4.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15576481 10224231

Sources:
NCI
VITAMIN E SEC14L3

Interaction Score: 3.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 15040456 17016423

Sources:
DrugBank
VITAMIN E SEC14L2

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17252538 16579965

Sources:
DrugBank
VITAMIN E PRKCB

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10644549 15184978 17139284 17016423 11850093

Sources:
DrugBank
VITAMIN E PRKCA

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9430404 11736999 17139284 17016423 11850093

Sources:
DrugBank
VITAMIN E XRCC1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12618330

Sources:
NCI
VITAMIN E CXCR2

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16679868

Sources:
NCI
VITAMIN E CTGF

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12023009

Sources:
NCI
VITAMIN E APOB

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7649489

Sources:
NCI
VITAMIN E CCND1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14871472

Sources:
NCI
VITAMIN E DDIT3

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15271854

Sources:
NCI
VITAMIN E ALOX5

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16531984

Sources:
DrugBank
VITAMIN E TGFB1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9608545

Sources:
NCI
VITAMIN E MAPK8

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16909121

Sources:
NCI
VITAMIN E BCL2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15158075

Sources:
NCI
VITAMIN E GSTP1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17029404

Sources:
NCI
VITAMIN E NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16880233 16603143

Sources:
DrugBank

DrugBank: DB00163

Version: 5.1.7

Alternate Names:

VITAMIN E DrugBank Drug Name

59-02-9 CAS Number

24 Multivitamins + Minerals Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups nutraceutical

Publications:

Azzi et al., 1997, Alpha-tocopherol as a modulator of smooth muscle cell proliferation., Prostaglandins Leukot. Essent. Fatty Acids

Sylvester et al., 2001, Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation., Cell Prolif.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

NCI: ALPHA-TOCOPHEROL

Version: 14-September-2017

Alternate Names:

C2832 NCI drug code

Drug Info:

Publications:

Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.

Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis

ChemblDrugs: chembl:CHEMBL47
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

VITAMIN E	DrugBank Drug Name
59-02-9	CAS Number
24 Multivitamins + Minerals	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	nutraceutical

VITAMIN E Drug Record

VITAMIN E chembl:CHEMBL47

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17320164 10322434 17139284 17016423 9693126

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26981194 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17320164 10322434 17139284 17016423 9693126

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28572624 17139284 15773894 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15576481 10224231

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 15040456 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17252538 16579965

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10644549 15184978 17139284 17016423 11850093

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9430404 11736999 17139284 17016423 11850093

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12618330

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16679868

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12023009

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7649489

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14871472

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15271854

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16531984

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9608545

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16909121

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15158075

Interaction Types & Directionality:

n/a

PMIDs:
17320164 10322434 17139284 17016423 9693126

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
26981194 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17320164 10322434 17139284 17016423 9693126

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
28572624 17139284 15773894 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15576481 10224231

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17139284 15040456 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17252538 16579965

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10644549 15184978 17139284 17016423 11850093

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9430404 11736999 17139284 17016423 11850093

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12618330

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16679868

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12023009

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7649489

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14871472

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15271854

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16531984

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9608545

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16909121

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15158075

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17029404

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16880233 16603143

Sources:
DrugBank

Alternate Names:

VITAMIN E DrugBank Drug Name

59-02-9 CAS Number

24 Multivitamins + Minerals Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups nutraceutical

Alternate Names:

C2832 NCI drug code