DGIdb - VINDESINE Drug Record

VINDESINE chembl:CHEMBL238071 ApprovedAntineoplasticImmunotherapy

Alternate Names:

COMPOUND 112531
COMPOUND-112531
VINDESINE

Drug Info:

FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Antineoplastic Agents
Drug Class	antineoplastic agents
Year of Approval	not approved by the fda

(1 More Sources)

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Yoshida et al., Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells., Anticancer Res.
Fiebig et al., Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs., Cancer Genomics Proteomics
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Natsume et al., 2000, Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin., Jpn. J. Cancer Res.
Jordheim LP et al., 2015, Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma., Haematologica

VINDESINE TUBB1

Interaction Score: 2.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17465195 17878523 17016423 17139284 10920282

Sources:
TdgClinicalTrial TEND
VINDESINE TUBB

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VINDESINE ABCB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25637052

Sources:
PharmGKB
VINDESINE CYP3A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: VINDESINE
- Version: 01-August-2011
Alternate Names:

VINDESINE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class antineoplastic agents

Publications:
TdgClinicalTrial: VINDESINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antineoplastic Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:

PharmGKB: vindesine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Jordheim LP et al., 2015, Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma., Haematologica

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Vindesine
- Version: 2020.06.01
Alternate Names:

D04RLY TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL238071
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

VINDESINE Drug Record

VINDESINE chembl:CHEMBL238071 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

VINDESINE TUBB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17465195 17878523 17016423 17139284 10920282

Sources: TdgClinicalTrial TEND

VINDESINE TUBB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

VINDESINE ABCB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25637052

Sources: PharmGKB

VINDESINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

TEND: VINDESINE

Alternate Names: VINDESINE Primary Drug Name

Drug Info: Year of Approval not approved by the fda Drug Class antineoplastic agents

Publications:

TdgClinicalTrial: VINDESINE

Alternate Names:

Drug Info: Drug Indications Antineoplastic Agents Drug Class small molecule FDA Approval not approved by the FDA

Publications:

PharmGKB: vindesine

Alternate Names:

Drug Info:

TTD: Vindesine

Alternate Names: D04RLY TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL238071

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17465195 17878523 17016423 17139284 10920282

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
25637052

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

VINDESINE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class antineoplastic agents

Drug Info:

Drug Indications Antineoplastic Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Alternate Names:

D04RLY TTD Drug ID