DGIdb - VASOPRESSIN Drug Record

VASOPRESSIN chembl:CHEMBL373742 Approved

Alternate Names:

ARGININE VASOPRESSIN
VASOPRESSIN
VASOSTRICT
VASOPHYSIN
VASOPRESSIN INJECTION
LEIORMONE
PITRESSIN
BETA-HYPOPHAMINE
AVP
ARGIPRESSIN TANNATE
8-L-ARGININE VASOPRESSIN
ANTIDIURETIC HORMONE
ADH
[CYCLO S-S]CYFQNCPRG-NH2
ARGININE-VASOPRESSIN
ARGIPRESSIN
[ARG8]-VASOPRESSIN
chembl:CHEMBL373742
rxcui:11149
drugbank:00067
chemidplus:113-79-1
pubchem.compound:644077

Drug Info:

Drug Class	antidiuretic agents
Year of Approval	approved before 1982
Name of the Ligand Species (if a Peptide)	Human\|Mouse\|Rat
FDA Approval	Approved before 1982
Drug Class	peptide
Drug Indications	Antidiuretic Agents
Name of the Ligand Species (if a Peptide)	Pig

(4 More Sources)

Publications:

Adikesavan et al., 2005, A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
Liedman et al., 2006, Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea., Acta Obstet Gynecol Scand
Aoyagi et al., 2007, Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice., Endocrinology
Hammock et al., 2005, Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior., Genes Brain Behav.
Hiroyama et al., 2007, Vasopressin promotes cardiomyocyte hypertrophy via the vasopressin V1A receptor in neonatal mice., Eur. J. Pharmacol.
Volpi et al., 2006, Vasopressin increases GAGA binding activity to the V1b receptor promoter through transactivation of the MAP kinase pathway., J. Mol. Endocrinol.
Slusarz et al., 2006, Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors-molecular dynamics study of the activated receptor-vasopressin-G(alpha) systems., J. Pept. Sci.
Jurkevich et al., 2005, Characterization and immunohistochemical visualization of the vasotocin VT2 receptor in the pituitary gland of the chicken, Gallus gallus., Gen. Comp. Endocrinol.
Wersinger et al., 2007, Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice., Genes Brain Behav.
Young et al., 2006, The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy., Neuroscience
Boson et al., 2006, Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients., Genet. Test.
Yi et al., 2007, Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R., Am. J. Physiol. Renal Physiol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Slusarz et al., 2006, Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system., Biopolymers
Bouley et al., 2006, Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment., Biol. Cell
Naert et al., 2006, Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats., Neuroscience
Fujita et al., 2002, Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells., Am. J. Physiol. Heart Circ. Physiol.
Juszczak et al., 2007, Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies., J. Physiol. Pharmacol.
Fan et al., 2005, G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II., J. Biol. Chem.
Aninat et al., 2008, Catecholamines induce an inflammatory response in human hepatocytes., Crit. Care Med.
Pedersen et al., 1995, Plasminogen activator inhibitor type-1 determines plasmin formation in patients with ischaemic heart disease., Thromb. Haemost.
Kaida et al., 1999, Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells., Exp. Cell Res.
Nishimura et al., 1998, Roles of brain angiotensin II and C-type natriuretic peptide in deoxycorticosterone acetate-salt hypertension in rats., J. Hypertens.
Mustonen et al., 2008, Thrombospondin-4 expression is rapidly upregulated by cardiac overload., Biochem. Biophys. Res. Commun.
Zhukova et al., 2001, Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells., J. Biol. Chem.
Kozawa et al., 2000, Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase., J. Cell. Biochem.
Ito et al., 2000, p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells., Hypertension
Xu et al., 1997, Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension., Hypertension
Saavedra et al., 1982, Vasopressin-reversible increase in angiotensin-converting enzyme in specific hypothalamic nuclei of Brattleboro rats., Brain Res.

VASOPRESSIN THBS4

Interaction Score: 7.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18541142

Sources:
NCI
VASOPRESSIN DUSP1

Interaction Score: 2.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9231829

Sources:
NCI
VASOPRESSIN AVPR1B

Interaction Score: 1.88

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
16720725 16114100 15993108 17284170 17027167

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
VASOPRESSIN AVPR2

Interaction Score: 1.5

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Direct Interaction? True

PMIDs:
17020465 17287200 11752352 16333859 16563128

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
VASOPRESSIN AVPR1A

Interaction Score: 1.41

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Full agonist

PMIDs:
16511036 16532916 17303660 16011575 17275806

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
VASOPRESSIN PRKD1

Interaction Score: 0.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11514571

Sources:
NCI
VASOPRESSIN NPPC

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9794722

Sources:
NCI
VASOPRESSIN E2F1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12063292

Sources:
NCI
VASOPRESSIN SERPINE1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7482412

Sources:
NCI
VASOPRESSIN CAMK2B

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15845548

Sources:
NCI
VASOPRESSIN HSPB1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9925748

Sources:
NCI
VASOPRESSIN TACR1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18195491

Sources:
NCI
VASOPRESSIN OXTR

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Partial agonist

PMIDs:
None found

Sources:
GuideToPharmacology
VASOPRESSIN MAPK14

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11029753 10679516

Sources:
NCI
VASOPRESSIN BDNF

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16457953

Sources:
NCI
VASOPRESSIN ACE

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6289972

Sources:
NCI
VASOPRESSIN CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18431272

Sources:
NCI

TEND: VASOPRESSIN
- Version: 01-August-2011
Alternate Names:

VASOPRESSIN Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class antidiuretic agents

Publications:
GuideToPharmacology: 135651625
- Version: 29-September-2020
Alternate Names:

AVP Gene Symbol (for Endogenous Peptides)

Avp Gene Symbol (for Endogenous Peptides)

VASOPRESSIN GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Publications:
GuideToPharmacology: 135652273
- Version: 29-September-2020
Alternate Names:

AVP Gene Symbol (for Endogenous Peptides)

LVP GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Pig

Publications:
TdgClinicalTrial: VASOPRESSIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidiuretic Agents

Drug Class peptide

FDA Approval Approved before 1982

Publications:

NCI: VASOPRESSIN

Version: 14-September-2017

Alternate Names:

C926 NCI drug code

Drug Info:

Publications:

Juszczak et al., 2007, Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies., J. Physiol. Pharmacol.

Fan et al., 2005, G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II., J. Biol. Chem.

Aninat et al., 2008, Catecholamines induce an inflammatory response in human hepatocytes., Crit. Care Med.

TTD: Vasopressin
- Version: 2020.06.01
Alternate Names:

D0N4OW TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL373742
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL373742
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Full agonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	True
Direct Interaction?	True

AVP	Gene Symbol (for Endogenous Peptides)
Avp	Gene Symbol (for Endogenous Peptides)
VASOPRESSIN	GuideToPharmacology Ligand Name

VASOPRESSIN Drug Record

VASOPRESSIN chembl:CHEMBL373742 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18541142

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9231829

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Full agonist

PMIDs: 16720725 16114100 15993108 17284170 17027167

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True Direct Interaction? True

PMIDs: 17020465 17287200 11752352 16333859 16563128

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name - Specific Action of the Ligand Full agonist

PMIDs: 16511036 16532916 17303660 16011575 17275806

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11514571

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9794722

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12063292

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7482412

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15845548

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9925748

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18195491

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? True Specific Action of the Ligand Partial agonist

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11029753 10679516

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16457953

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6289972

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18431272

Sources: NCI

TEND: VASOPRESSIN

Alternate Names: VASOPRESSIN Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class antidiuretic agents

Publications:

GuideToPharmacology: 135651625

Alternate Names: AVP Gene Symbol (for Endogenous Peptides) Avp Gene Symbol (for Endogenous Peptides) VASOPRESSIN GuideToPharmacology Ligand Name

Drug Info: Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Interaction Types & Directionality:

n/a

PMIDs:
18541142

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9231829

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
16720725 16114100 15993108 17284170 17027167

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Direct Interaction? True

PMIDs:
17020465 17287200 11752352 16333859 16563128

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Full agonist

PMIDs:
16511036 16532916 17303660 16011575 17275806

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11514571

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9794722

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12063292

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7482412

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15845548

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9925748

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18195491

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Partial agonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11029753 10679516

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16457953

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6289972

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18431272

Sources:
NCI

Alternate Names:

VASOPRESSIN Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class antidiuretic agents

Alternate Names:

AVP Gene Symbol (for Endogenous Peptides)

Avp Gene Symbol (for Endogenous Peptides)

VASOPRESSIN GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Alternate Names:

AVP Gene Symbol (for Endogenous Peptides)

LVP GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Pig

Drug Info:

Drug Indications Antidiuretic Agents

Drug Class peptide

FDA Approval Approved before 1982

Alternate Names:

C926 NCI drug code

Alternate Names:

D0N4OW TTD Drug ID