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VASOPRESSIN Drug Record

  • Summary
  • Interactions
  • Claims
  • VASOPRESSIN chembl:CHEMBL373742 Approved

    Alternate Names:

    ARGININE VASOPRESSIN
    VASOPRESSIN
    VASOSTRICT
    VASOPHYSIN
    VASOPRESSIN INJECTION
    LEIORMONE
    PITRESSIN
    BETA-HYPOPHAMINE
    AVP
    ARGIPRESSIN TANNATE
    8-L-ARGININE VASOPRESSIN
    ANTIDIURETIC HORMONE
    ADH
    [CYCLO S-S]CYFQNCPRG-NH2
    ARGININE-VASOPRESSIN
    ARGIPRESSIN
    [ARG8]-VASOPRESSIN
    chembl:CHEMBL373742
    rxcui:11149
    drugbank:00067
    chemidplus:113-79-1
    pubchem.compound:644077

    Drug Info:

    Drug Class antidiuretic agents
    Year of Approval approved before 1982
    Drug Categories vasopressins
    Drug Categories hormones
    Drug Categories antidiuretic agents
    Name of the Ligand Species (if a Peptide) Human|Mouse|Rat
    FDA Approval Approved before 1982
    Drug Class peptide
    Drug Indications Antidiuretic Agents
    Name of the Ligand Species (if a Peptide) Pig
    Drug Type small molecule
    Drug Categories arginine vasopressin
    Drug Categories arginine vasopressin, agonists
    Drug Categories arginine vasopressin, analogs & derivatives
    Drug Categories arginine vasopressin, antagonists & inhibitors
    Drug Categories pituitary
    Drug Categories vasopressins, antagonists & inhibitors
    (5 More Sources)

    Publications:

    Hiroyama et al., 2007, Vasopressin promotes cardiomyocyte hypertrophy via the vasopressin V1A receptor in neonatal mice., Eur. J. Pharmacol.
    Hammock et al., 2005, Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior., Genes Brain Behav.
    Adikesavan et al., 2005, A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
    Liedman et al., 2006, Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea., Acta Obstet Gynecol Scand
    Aoyagi et al., 2007, Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice., Endocrinology
    Wersinger et al., 2007, Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice., Genes Brain Behav.
    Young et al., 2006, The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy., Neuroscience
    Jurkevich et al., 2005, Characterization and immunohistochemical visualization of the vasotocin VT2 receptor in the pituitary gland of the chicken, Gallus gallus., Gen. Comp. Endocrinol.
    Volpi et al., 2006, Vasopressin increases GAGA binding activity to the V1b receptor promoter through transactivation of the MAP kinase pathway., J. Mol. Endocrinol.
    Slusarz et al., 2006, Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors-molecular dynamics study of the activated receptor-vasopressin-G(alpha) systems., J. Pept. Sci.
    Boson et al., 2006, Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients., Genet. Test.
    Slusarz et al., 2006, Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system., Biopolymers
    Yi et al., 2007, Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R., Am. J. Physiol. Renal Physiol.
    Bouley et al., 2006, Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment., Biol. Cell
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Naert et al., 2006, Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats., Neuroscience
    Fujita et al., 2002, Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells., Am. J. Physiol. Heart Circ. Physiol.
    Juszczak et al., 2007, Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies., J. Physiol. Pharmacol.
    Fan et al., 2005, G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II., J. Biol. Chem.
    Aninat et al., 2008, Catecholamines induce an inflammatory response in human hepatocytes., Crit. Care Med.
    Pedersen et al., 1995, Plasminogen activator inhibitor type-1 determines plasmin formation in patients with ischaemic heart disease., Thromb. Haemost.
    Kaida et al., 1999, Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells., Exp. Cell Res.
    Nishimura et al., 1998, Roles of brain angiotensin II and C-type natriuretic peptide in deoxycorticosterone acetate-salt hypertension in rats., J. Hypertens.
    Mustonen et al., 2008, Thrombospondin-4 expression is rapidly upregulated by cardiac overload., Biochem. Biophys. Res. Commun.
    Zhukova et al., 2001, Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells., J. Biol. Chem.
    Ito et al., 2000, p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells., Hypertension
    Kozawa et al., 2000, Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase., J. Cell. Biochem.
    Xu et al., 1997, Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension., Hypertension
    Saavedra et al., 1982, Vasopressin-reversible increase in angiotensin-converting enzyme in specific hypothalamic nuclei of Brattleboro rats., Brain Res.
  • VASOPRESSIN   THBS4

    Interaction Score: 6.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18541142


    Sources:
    NCI

  • VASOPRESSIN   DUSP1

    Interaction Score: 2.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9231829


    Sources:
    NCI

  • VASOPRESSIN   AVPR1B

    Interaction Score: 1.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Full agonist

    PMIDs:
    17284170 17027167 15993108 16720725 16114100


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • VASOPRESSIN   AVPR1A

    Interaction Score: 1.39

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Specific Action of the Ligand Full agonist

    PMIDs:
    17275806 16011575 16511036 16532916 17303660


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • VASOPRESSIN   AVPR2

    Interaction Score: 1.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True
    Direct Interaction? True

    PMIDs:
    17020465 16333859 17287200 16563128 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • VASOPRESSIN   PRKD1

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11514571


    Sources:
    NCI

  • VASOPRESSIN   NPPC

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9794722


    Sources:
    NCI

  • VASOPRESSIN   E2F1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12063292


    Sources:
    NCI

  • VASOPRESSIN   CAMK2B

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15845548


    Sources:
    NCI

  • VASOPRESSIN   SERPINE1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7482412


    Sources:
    NCI

  • VASOPRESSIN   HSPB1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9925748


    Sources:
    NCI

  • VASOPRESSIN   OXTR

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? True
    Specific Action of the Ligand Partial agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VASOPRESSIN   TACR1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18195491


    Sources:
    NCI

  • VASOPRESSIN   BDNF

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16457953


    Sources:
    NCI

  • VASOPRESSIN   ACE

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6289972


    Sources:
    NCI

  • VASOPRESSIN   MAPK14

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10679516 11029753


    Sources:
    NCI

  • VASOPRESSIN   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18431272


    Sources:
    NCI

  • DrugBank: DB00067

    • Version: 5.1.7

    Alternate Names:
    VASOPRESSIN DrugBank Drug Name
    11000-17-2 CAS Number
    Pitressin Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories amino acids, peptides, and proteins

    Publications:
    Hiroyama et al., 2007, Vasopressin promotes cardiomyocyte hypertrophy via the vasopressin V1A receptor in neonatal mice., Eur. J. Pharmacol.
    Hammock et al., 2005, Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior., Genes Brain Behav.
    Adikesavan et al., 2005, A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.

  • TEND: VASOPRESSIN

    • Version: 01-August-2011

    Alternate Names:
    VASOPRESSIN Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class antidiuretic agents

    Publications:

  • GuideToPharmacology: 135651625

    • Version: 29-September-2020

    Alternate Names:
    AVP Gene Symbol (for Endogenous Peptides)
    Avp Gene Symbol (for Endogenous Peptides)
    VASOPRESSIN GuideToPharmacology Ligand Name

    Drug Info:
    Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

    Publications:

  • GuideToPharmacology: 135652273

    • Version: 29-September-2020

    Alternate Names:
    AVP Gene Symbol (for Endogenous Peptides)
    LVP GuideToPharmacology Ligand Name

    Drug Info:
    Name of the Ligand Species (if a Peptide) Pig

    Publications:

  • TdgClinicalTrial: VASOPRESSIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antidiuretic Agents
    Drug Class peptide
    FDA Approval Approved before 1982

    Publications:

  • NCI: VASOPRESSIN

    • Version: 14-September-2017

    Alternate Names:
    C926 NCI drug code

    Drug Info:

    Publications:
    Juszczak et al., 2007, Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies., J. Physiol. Pharmacol.
    Fan et al., 2005, G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II., J. Biol. Chem.
    Aninat et al., 2008, Catecholamines induce an inflammatory response in human hepatocytes., Crit. Care Med.

  • TTD: Vasopressin

    • Version: 2020.06.01

    Alternate Names:
    D0N4OW TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL373742

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL373742

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21