DGIdb - VALDECOXIB Drug Record

VALDECOXIB chembl:CHEMBL865

Alternate Names:

VALDECOXIB
BEXTRA
SC-65872
P-(5-METHYL-3-PHENYL-4-ISOXAZOLYL)BENZENESULFONAMIDE
BEXTRA®
4-(5-METHYL-3-PHENYL-4-ISOXAZOLYL)BENZENESULFONAMIDE
chembl:CHEMBL865
rxcui:278567
pubchem.compound:119607
chemidplus:181695-72-7
drugbank:00580

Drug Info:

Drug Groups	approved
Drug Categories	agents causing hyperkalemia
Drug Categories	agents that produce hypertension
Drug Categories	cox-2 inhibitors
Drug Categories	cytochrome p-450 cyp2c9 inhibitors (weak)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	nephrotoxic agents
Drug Categories	selective cyclooxygenase 2 inhibitors (nsaids)
Drug Categories	ugt1a9 substrates

(4 More Sources)

Publications:

Tacconelli et al., 2002, The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity., Curr Med Res Opin
Onnis V et al., 2010, Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors., J Med Chem
Gierse et al., 2005, Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity., J. Pharmacol. Exp. Ther.
Talley et al., 2000, 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2., J. Med. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hood et al., 2003, Characterization of celecoxib and valdecoxib binding to cyclooxygenase., Mol. Pharmacol.
Yuan et al., 2002, Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human., Drug Metab. Dispos.
Jain, 2000, Evaluation of intravenous parecoxib for the relief of acute post-surgical pain., Expert Opin Investig Drugs
Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
Pyrko et al., 2006, Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo., Mol. Cancer
Nishimori I et al., 2007, Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides., Bioorg Med Chem

VALDECOXIB CA3

Interaction Score: 2.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17826101

Sources:
DrugBank
VALDECOXIB PTGS2

Interaction Score: 1.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase-2 inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
12564662 20143779 15494548 10715145 11752352 12644588 12167567 11060833 19602986

Sources:
DTC PharmGKB TTD DrugBank GuideToPharmacology ChemblInteractions
VALDECOXIB BIRC5

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16707021

Sources:
NCI
VALDECOXIB CA2

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17826101

Sources:
DrugBank

DrugBank: DB00580

Version: 5.1.7

Alternate Names:

VALDECOXIB DrugBank Drug Name

181695-72-7 CAS Number

Bextra Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Tacconelli et al., 2002, The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity., Curr Med Res Opin

Gierse et al., 2005, Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity., J. Pharmacol. Exp. Ther.

Talley et al., 2000, 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2., J. Med. Chem.

NCI: VALDECOXIB

Version: 14-September-2017

Alternate Names:

C1869 NCI drug code

Drug Info:

Publications:

Pyrko et al., 2006, Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo., Mol. Cancer

DTC: VALDECOXIB
- Version: 02-September-2020
Alternate Names:

CHEMBL865 ChEMBL Drug ID

Drug Info:

Publications:

Onnis V et al., 2010, Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors., J Med Chem
PharmGKB: valdecoxib
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
TTD: Valdecoxib
- Version: 2020.06.01
Alternate Names:

D0L6DA TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178100243
- Version: 29-September-2020
Alternate Names:

VALDECOXIB GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL865
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL865
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Cyclooxygenase-2 inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

VALDECOXIB	DrugBank Drug Name
181695-72-7	CAS Number
Bextra	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

VALDECOXIB Drug Record

VALDECOXIB chembl:CHEMBL865

Alternate Names:

Drug Info:

Publications:

VALDECOXIB CA3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17826101

Sources: DrugBank

VALDECOXIB PTGS2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase-2 inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 12564662 20143779 15494548 10715145 11752352 12644588 12167567 11060833 19602986

Sources: DTC PharmGKB TTD DrugBank GuideToPharmacology ChemblInteractions

VALDECOXIB BIRC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16707021

Sources: NCI

VALDECOXIB CA2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17826101

Sources: DrugBank

DrugBank: DB00580

Alternate Names: VALDECOXIB DrugBank Drug Name 181695-72-7 CAS Number Bextra Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

NCI: VALDECOXIB

Alternate Names: C1869 NCI drug code

Drug Info:

Publications: Pyrko et al., 2006, Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo., Mol. Cancer

DTC: VALDECOXIB

Alternate Names: CHEMBL865 ChEMBL Drug ID

Drug Info:

Publications: Onnis V et al., 2010, Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors., J Med Chem

PharmGKB: valdecoxib

Alternate Names:

Drug Info:

Publications: Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

TTD: Valdecoxib

Alternate Names: D0L6DA TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178100243

Alternate Names: VALDECOXIB GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL865

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL865

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17826101

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase-2 inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
12564662 20143779 15494548 10715145 11752352 12644588 12167567 11060833 19602986

Sources:
DTC PharmGKB TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16707021

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17826101

Sources:
DrugBank

Alternate Names:

VALDECOXIB DrugBank Drug Name

181695-72-7 CAS Number

Bextra Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

C1869 NCI drug code

Publications:

Pyrko et al., 2006, Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo., Mol. Cancer

Alternate Names:

CHEMBL865 ChEMBL Drug ID

Publications:

Onnis V et al., 2010, Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors., J Med Chem

Publications:

Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

Alternate Names:

D0L6DA TTD Drug ID

Alternate Names:

VALDECOXIB GuideToPharmacology Ligand Name