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VALDECOXIB Drug Record

  • Summary
  • Interactions
  • Claims
  • VALDECOXIB chembl:CHEMBL865

    Alternate Names:

    VALDECOXIB
    BEXTRA
    SC-65872
    P-(5-METHYL-3-PHENYL-4-ISOXAZOLYL)BENZENESULFONAMIDE
    BEXTRA®
    4-(5-METHYL-3-PHENYL-4-ISOXAZOLYL)BENZENESULFONAMIDE
    chembl:CHEMBL865
    rxcui:278567
    pubchem.compound:119607
    chemidplus:181695-72-7
    drugbank:00580

    Drug Info:

    (2 More Sources)

    Publications:

    Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
    Tacconelli et al., 2002, The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity., Curr Med Res Opin
    Jain, 2000, Evaluation of intravenous parecoxib for the relief of acute post-surgical pain., Expert Opin Investig Drugs
    Yuan et al., 2002, Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human., Drug Metab. Dispos.
    Gierse et al., 2005, Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity., J. Pharmacol. Exp. Ther.
    Talley et al., 2000, 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2., J. Med. Chem.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Hood et al., 2003, Characterization of celecoxib and valdecoxib binding to cyclooxygenase., Mol. Pharmacol.
    Onnis V et al., 2010, Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors., J Med Chem
    Pyrko et al., 2006, Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo., Mol. Cancer
  • VALDECOXIB   PTGS2

    Interaction Score: 4.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclooxygenase-2 inhibitor
    Direct Interaction yes

    PMIDs:
    19602986 12564662 11060833 12167567 15494548 10715145 11752352 12644588 20143779


    Sources:
    DTC ChemblInteractions PharmGKB TTD

  • VALDECOXIB   BIRC5

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16707021


    Sources:
    NCI

  • NCI: VALDECOXIB

    • Version: 14-September-2017

    Alternate Names:
    C1869 NCI drug code

    Drug Info:

    Publications:
    Pyrko et al., 2006, Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo., Mol. Cancer

  • DTC: VALDECOXIB

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL865 ChEMBL Drug ID

    Drug Info:

    Publications:
    Onnis V et al., 2010, Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors., J Med Chem

  • PharmGKB: valdecoxib

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

  • TTD: Valdecoxib

    • Version: 2020.06.01

    Alternate Names:
    D0L6DA TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL865

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL865

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21