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UREA Drug Record

  • Summary
  • Interactions
  • Claims
  • UREA chembl:CHEMBL985 Approved

    Alternate Names:

    INS NO.927A
    STERILE UREA
    E927B
    AQUADRATE
    NUTRAPLUS
    ST.JAMES BALM
    E-927A
    HYDROMOL INTENSIVE
    CARBAMIDE
    UREA
    BALNEUM PLUS
    FLEXIFOOT
    CALMURID
    UREAPHIL
    FLEXITOL
    NSC-34375
    SENTIAL E
    EUCERIN
    INS-927A

    Drug Info:

    Drug Groups investigational
    Drug Categories blood and blood forming organs
    Drug Categories blood substitutes and perfusion solutions
    Drug Categories carbamide products
    Drug Categories dermatologicals
    Drug Categories diuretics, osmotic
    Drug Categories emollients and protectives
    Drug Categories i.v. solutions
    Drug Categories keratolytic agents
    Drug Categories solutions producing osmotic diuresis
    Drug Categories astringents and deodorants
    Drug Categories biocompatible materials
    Drug Categories coloring agents
    Drug Categories compounds used in a research, industrial, or household setting
    Drug Categories cosmetics
    Drug Categories elements
    Drug Categories household products
    Drug Categories metals
    Drug Categories metals, light
    Drug Categories photosensitizing agents
    Drug Categories protective agents
    Drug Categories radiation-protective agents
    Drug Categories radiation-sensitizing agents
    Drug Categories sunscreen agents
    Drug Categories transition elements
    Drug Categories water pollutants, chemical
    (0 More Sources)

    Publications:

    Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor
    Hansen et al., 1995, Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins., Biochim. Biophys. Acta
    Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.
    Bagley et al., 2006, Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing., Org. Biomol. Chem.
    Zhang et al., 1998, Urea activates ribosomal S6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells., Am. J. Physiol.
    Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Prakash A et al., 2018, Elucidation of stable intermediates in urea-induced unfolding pathway of human carbonic anhydrase IX., J Biomol Struct Dyn
    Temperini C et al., 2010, Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme., Bioorg Med Chem Lett
    Wahiduzzaman et al., 2017, Characterization of folding intermediates during urea-induced denaturation of human carbonic anhydrase II., Int J Biol Macromol
    Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.
    Carbrey et al., 2003, Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver., Proc. Natl. Acad. Sci. U.S.A.
    Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.
    Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci
  • UREA   MARCO

    Interaction Score: 4.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18836211


    Sources:
    DrugBank

  • UREA   ARG1

    Interaction Score: 2.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • UREA   AQP9

    Interaction Score: 1.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12594337


    Sources:
    NCI

  • UREA   CTSB

    Interaction Score: 1.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3223934


    Sources:
    NCI

  • UREA   CTNNB1

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • UREA   HMGB1

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3342876


    Sources:
    NCI

  • UREA   HNF4A

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8167573


    Sources:
    NCI

  • UREA   CA2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28705076 20005709 17139284 17016423 27789330


    Sources:
    DrugBank

  • UREA   HSPA4

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7548155


    Sources:
    NCI

  • UREA   HSPB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9094264


    Sources:
    NCI

  • UREA   RPS6KA3

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9458825


    Sources:
    NCI

  • UREA   THPO

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9726418


    Sources:
    NCI

  • UREA   WRN

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17312972


    Sources:
    NCI

  • DrugBank: DB03904

    • Version: 5.1.7

    Alternate Names:
    UREA DrugBank Drug Name
    57-13-6 CAS Number
    Aluvea Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • DrugBank: DB09536

    • Version: 5.1.7

    Alternate Names:
    Durascreen SPF 30 Drug Brand
    Sport Lip Balm Drug Brand
    Sun Stick SPF 45 Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories astringents and deodorants

    Publications:
    Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

  • NCI: UREA

    • Version: 14-September-2017

    Alternate Names:
    C29531 NCI drug code

    Drug Info:

    Publications:
    Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor
    Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins
    Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.

  • ChemblDrugs: chembl:CHEMBL985

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21