DGIdb - UREA Drug Record

UREA chembl:CHEMBL985 Approved

Alternate Names:

INS NO.927A
STERILE UREA
E927B
AQUADRATE
NUTRAPLUS
ST.JAMES BALM
E-927A
HYDROMOL INTENSIVE
CARBAMIDE
UREA
BALNEUM PLUS
FLEXIFOOT
CALMURID
UREAPHIL
FLEXITOL
NSC-34375
SENTIAL E
EUCERIN
INS-927A

Drug Info:

Drug Groups	investigational
Drug Categories	blood and blood forming organs
Drug Categories	blood substitutes and perfusion solutions
Drug Categories	carbamide products
Drug Categories	dermatologicals
Drug Categories	diuretics, osmotic
Drug Categories	emollients and protectives
Drug Categories	i.v. solutions
Drug Categories	keratolytic agents
Drug Categories	solutions producing osmotic diuresis
Drug Categories	astringents and deodorants
Drug Categories	biocompatible materials
Drug Categories	coloring agents
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	cosmetics
Drug Categories	elements
Drug Categories	household products
Drug Categories	metals
Drug Categories	metals, light
Drug Categories	photosensitizing agents
Drug Categories	protective agents
Drug Categories	radiation-protective agents
Drug Categories	radiation-sensitizing agents
Drug Categories	sunscreen agents
Drug Categories	transition elements
Drug Categories	water pollutants, chemical

(0 More Sources)

Publications:

Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor
Hansen et al., 1995, Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins., Biochim. Biophys. Acta
Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.
Bagley et al., 2006, Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing., Org. Biomol. Chem.
Zhang et al., 1998, Urea activates ribosomal S6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells., Am. J. Physiol.
Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Prakash A et al., 2018, Elucidation of stable intermediates in urea-induced unfolding pathway of human carbonic anhydrase IX., J Biomol Struct Dyn
Temperini C et al., 2010, Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme., Bioorg Med Chem Lett
Wahiduzzaman et al., 2017, Characterization of folding intermediates during urea-induced denaturation of human carbonic anhydrase II., Int J Biol Macromol
Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.
Carbrey et al., 2003, Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver., Proc. Natl. Acad. Sci. U.S.A.
Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.
Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

UREA MARCO

Interaction Score: 4.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18836211

Sources:
DrugBank
UREA ARG1

Interaction Score: 2.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
UREA AQP9

Interaction Score: 1.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12594337

Sources:
NCI
UREA CTSB

Interaction Score: 1.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3223934

Sources:
NCI
UREA CTNNB1

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
UREA HMGB1

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3342876

Sources:
NCI
UREA HNF4A

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8167573

Sources:
NCI
UREA CA2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28705076 20005709 17139284 17016423 27789330

Sources:
DrugBank
UREA HSPA4

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7548155

Sources:
NCI
UREA HSPB1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9094264

Sources:
NCI
UREA RPS6KA3

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9458825

Sources:
NCI
UREA THPO

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9726418

Sources:
NCI
UREA WRN

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17312972

Sources:
NCI

DrugBank: DB03904

Version: 5.1.7

Alternate Names:

UREA DrugBank Drug Name

57-13-6 CAS Number

Aluvea Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DrugBank: DB09536
- Version: 5.1.7
Alternate Names:

Durascreen SPF 30 Drug Brand

Sport Lip Balm Drug Brand

Sun Stick SPF 45 Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories astringents and deodorants

Publications:

Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

NCI: UREA

Version: 14-September-2017

Alternate Names:

C29531 NCI drug code

Drug Info:

Publications:

Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor

Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins

Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.

ChemblDrugs: chembl:CHEMBL985
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

Durascreen SPF 30	Drug Brand
Sport Lip Balm	Drug Brand
Sun Stick SPF 45	Drug Brand

UREA Drug Record

UREA chembl:CHEMBL985 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18836211

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12594337

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3223934

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3342876

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8167573

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28705076 20005709 17139284 17016423 27789330

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7548155

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9094264

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9458825

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9726418

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17312972

Sources: NCI

DrugBank: DB03904

Alternate Names: UREA DrugBank Drug Name 57-13-6 CAS Number Aluvea Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DrugBank: DB09536

Alternate Names: Durascreen SPF 30 Drug Brand Sport Lip Balm Drug Brand Sun Stick SPF 45 Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories astringents and deodorants

Publications: Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

NCI: UREA

Alternate Names: C29531 NCI drug code

Drug Info:

ChemblDrugs: chembl:CHEMBL985

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18836211

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12594337

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3223934

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
3342876

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8167573

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
28705076 20005709 17139284 17016423 27789330

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
7548155

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9094264

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9458825

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9726418

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17312972

Sources:
NCI

Alternate Names:

UREA DrugBank Drug Name

57-13-6 CAS Number

Aluvea Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Alternate Names:

Durascreen SPF 30 Drug Brand

Sport Lip Balm Drug Brand

Sun Stick SPF 45 Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories astringents and deodorants

Publications:

Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

Alternate Names:

C29531 NCI drug code