DGIdb - UREA Drug Record

UREA chembl:CHEMBL985 Approved

Alternate Names:

INS NO.927A
STERILE UREA
E927B
AQUADRATE
NUTRAPLUS
ST.JAMES BALM
E-927A
HYDROMOL INTENSIVE
CARBAMIDE
UREA
BALNEUM PLUS
FLEXIFOOT
CALMURID
UREAPHIL
FLEXITOL
NSC-34375
SENTIAL E
EUCERIN
INS-927A

Drug Info:

Drug Categories	organic chemicals
Drug Groups	approved
Drug Type	small molecule
Drug Categories	water pollutants, chemical
Drug Categories	transition elements
Drug Categories	sunscreen agents
Drug Categories	radiation-sensitizing agents
Drug Categories	radiation-protective agents
Drug Categories	protective agents
Drug Categories	photosensitizing agents
Drug Categories	household products
Drug Categories	elements
Drug Categories	dermatologicals
Drug Categories	cosmetics
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	coloring agents
Drug Categories	biocompatible materials
Drug Categories	astringents and deodorants
Drug Categories	metals, light
Drug Categories	metals
Drug Categories	solutions producing osmotic diuresis
Drug Categories	keratolytic agents
Drug Categories	i.v. solutions
Drug Categories	emollients and protectives
Drug Categories	diuretics, osmotic
Drug Categories	carbamide products
Drug Categories	blood substitutes and perfusion solutions
Drug Categories	blood and blood forming organs
Drug Groups	investigational

(0 More Sources)

Publications:

Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor
Hansen et al., 1995, Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins., Biochim. Biophys. Acta
Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.
Bagley et al., 2006, Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing., Org. Biomol. Chem.
Zhang et al., 1998, Urea activates ribosomal S6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells., Am. J. Physiol.
Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Temperini C et al., 2010, Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme., Bioorg Med Chem Lett
Prakash A et al., 2018, Elucidation of stable intermediates in urea-induced unfolding pathway of human carbonic anhydrase IX., J Biomol Struct Dyn
Wahiduzzaman et al., 2017, Characterization of folding intermediates during urea-induced denaturation of human carbonic anhydrase II., Int J Biol Macromol
Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.
Carbrey et al., 2003, Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver., Proc. Natl. Acad. Sci. U.S.A.
Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.
Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

UREA HNF4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor
UREA HSPA4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hansen et al., 1995, Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins., Biochim. Biophys. Acta
UREA HSPB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.
UREA WRN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bagley et al., 2006, Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing., Org. Biomol. Chem.
UREA RPS6KA3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Zhang et al., 1998, Urea activates ribosomal S6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells., Am. J. Physiol.
UREA THPO

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins

UREA CTNNB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

UREA CA2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Temperini C et al., 2010, Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme., Bioorg Med Chem Lett

UREA HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.

UREA ARG1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

UREA AQP9

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Carbrey et al., 2003, Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver., Proc. Natl. Acad. Sci. U.S.A.
UREA CTSB

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.
UREA MARCO

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

DrugBank: DB03904

Version: 5.1.7

Alternate Names:

UREA DrugBank Drug Name

57-13-6 CAS Number

Aluvea Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DrugBank: DB09536
- Version: 5.1.7
Alternate Names:

Safe Sea SPF 40 Drug Brand

Safe Sea SPF 50 Drug Brand

Sunspray Drug Brand

Drug Info:

Drug Categories metals

Drug Categories metals, light

Drug Type small molecule

Publications:

Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

NCI: UREA

Version: 14-September-2017

Alternate Names:

C29531 NCI drug code

Drug Info:

Publications:

Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor

Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins

Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.

ChemblDrugs: chembl:CHEMBL985
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Safe Sea SPF 40	Drug Brand
Safe Sea SPF 50	Drug Brand
Sunspray	Drug Brand

UREA Drug Record

UREA chembl:CHEMBL985 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hansen et al., 1995, Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins., Biochim. Biophys. Acta

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Bagley et al., 2006, Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing., Org. Biomol. Chem.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Zhang et al., 1998, Urea activates ribosomal S6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells., Am. J. Physiol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Carbrey et al., 2003, Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

DrugBank: DB03904

Alternate Names: UREA DrugBank Drug Name 57-13-6 CAS Number Aluvea Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

Publications: Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DrugBank: DB09536

Alternate Names: Safe Sea SPF 40 Drug Brand Safe Sea SPF 50 Drug Brand Sunspray Drug Brand

Drug Info: Drug Categories metals Drug Categories metals, light Drug Type small molecule

Publications: Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

NCI: UREA

Alternate Names: C29531 NCI drug code

Drug Info:

ChemblDrugs: chembl:CHEMBL985

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

Publications:

Sladek, 1993, Orphan receptor HNF-4 and liver-specific gene expression., Receptor

Interaction Types & Directionality:

n/a

Publications:

Hansen et al., 1995, Identification of a homologous heparin binding peptide sequence present in fibronectin and the 70 kDa family of heat-shock proteins., Biochim. Biophys. Acta

Interaction Types & Directionality:

n/a

Publications:

Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.

Interaction Types & Directionality:

n/a

Publications:

Bagley et al., 2006, Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing., Org. Biomol. Chem.

Interaction Types & Directionality:

n/a

Publications:

Zhang et al., 1998, Urea activates ribosomal S6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells., Am. J. Physiol.

Interaction Types & Directionality:

n/a

Publications:

Hamburger et al., 1998, Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation., Proteins

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality:

n/a

Publications:

Carbrey et al., 2003, Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality:

n/a

Publications:

Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.

Interaction Types & Directionality:

n/a

Publications:

Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

Alternate Names:

UREA DrugBank Drug Name

57-13-6 CAS Number

Aluvea Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Alternate Names:

Safe Sea SPF 40 Drug Brand

Safe Sea SPF 50 Drug Brand

Sunspray Drug Brand

Drug Info:

Drug Categories metals

Drug Categories metals, light

Drug Type small molecule

Publications:

Thakur SA et al., 2009, Differential binding of inorganic particles to MARCO., Toxicol Sci

Alternate Names:

C29531 NCI drug code