DGIdb - TRICHOSTATIN Drug Record

TRICHOSTATIN chembl:CHEMBL99 Antineoplastic

Alternate Names:

TRICHOSTATIN
GNF-PF-1011
ANTIBIOTIC A-300
A-300-I
TRICHOSTATIN(S)

Drug Info:

(0 More Sources)

Publications:

Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
Schäfer S et al., 2008, Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Bioorg Med Chem
Baud MG et al., 2012, Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets., J Med Chem
Trapp J et al., 2006, Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition., J Med Chem
Huber K et al., 2010, Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins)., J Med Chem

TRICHOSTATIN SIRT2

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17149860 20030343

Sources:
DTC
TRICHOSTATIN HDAC8

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367 17139284 17016423 10592235

Sources:
DTC
TRICHOSTATIN HDAC7

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19385600 21055848 19966789 16921367 10592235

Sources:
DTC
TRICHOSTATIN HDAC11

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC
TRICHOSTATIN HDAC6

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 18054239 22280363 19385600 21055848 16921367

Sources:
DTC
TRICHOSTATIN HDAC9

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC
TRICHOSTATIN HDAC10

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC
TRICHOSTATIN HDAC1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 18054239 19385600 21055848 16921367 22280363

Sources:
DTC
TRICHOSTATIN HDAC2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367 24074025

Sources:
DTC
TRICHOSTATIN HDAC5

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC
TRICHOSTATIN HDAC4

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC
TRICHOSTATIN HDAC3

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC
TRICHOSTATIN CFTR

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789

Sources:
DTC
TRICHOSTATIN GBA

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN SMN2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN SMN1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN ALDH1A1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: TRICHOSTATIN

Version: 02-September-2020

Alternate Names:

CHEMBL99 ChEMBL Drug ID

Drug Info:

Publications:

Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol

Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem

Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol

ChemblDrugs: chembl:CHEMBL99
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

TRICHOSTATIN Drug Record

TRICHOSTATIN chembl:CHEMBL99 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17149860 20030343

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367 17139284 17016423 10592235

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19385600 21055848 19966789 16921367 10592235

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 18054239 22280363 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 18054239 19385600 21055848 16921367 22280363

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367 24074025

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
17149860 20030343

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367 17139284 17016423 10592235

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19385600 21055848 19966789 16921367 10592235

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 18054239 22280363 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 18054239 19385600 21055848 16921367 22280363

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367 24074025

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL99 ChEMBL Drug ID