DGIdb - TRICHOSTATIN Drug Record

TRICHOSTATIN chembl:CHEMBL99 Antineoplastic

Alternate Names:

TRICHOSTATIN
GNF-PF-1011
ANTIBIOTIC A-300
A-300-I
TRICHOSTATIN(S)

Drug Info:

Drug Categories	protein synthesis inhibitors
Drug Categories	hydroxylamines
Drug Categories	hydroxy acids
Drug Categories	histone deacetylase inhibitors
Drug Categories	enzyme inhibitors
Drug Categories	antineoplastic agents
Drug Categories	antifungal agents
Drug Categories	anti-infective agents
Drug Categories	amines
Drug Groups	experimental
Drug Type	small molecule

(0 More Sources)

Publications:

Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
Schäfer S et al., 2008, Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Bioorg Med Chem
Baud MG et al., 2012, Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets., J Med Chem
Huber K et al., 2010, Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins)., J Med Chem
Trapp J et al., 2006, Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition., J Med Chem

TRICHOSTATIN SIRT2

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20030343 17149860

Sources:
DTC
TRICHOSTATIN HDAC7

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 10592235 19385600

Sources:
DTC DrugBank
TRICHOSTATIN HDAC8

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 10592235 19385600 17139284 17016423

Sources:
DTC DrugBank
TRICHOSTATIN HDAC11

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
TRICHOSTATIN HDAC6

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 18054239 19966789 22280363 19385600

Sources:
DTC
TRICHOSTATIN HDAC9

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
TRICHOSTATIN HDAC10

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
TRICHOSTATIN HDAC1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 18054239 19966789 22280363 19385600

Sources:
DTC
TRICHOSTATIN HDAC5

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
TRICHOSTATIN HDAC3

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
TRICHOSTATIN HDAC4

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
TRICHOSTATIN HDAC2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600 24074025

Sources:
DTC
TRICHOSTATIN CFTR

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789

Sources:
DTC
TRICHOSTATIN GBA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN SMN2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN SMN1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN ALDH1A1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICHOSTATIN EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB04297

Version: 5.1.7

Alternate Names:

TRICHOSTATIN A DrugBank Drug Name

58880-19-6 CAS Number

CHEMBL99 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups experimental

Drug Categories amines

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DTC: TRICHOSTATIN

Version: 02-September-2020

Alternate Names:

CHEMBL99 ChEMBL Drug ID

Drug Info:

Publications:

Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol

Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem

Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol

ChemblDrugs: chembl:CHEMBL99
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

TRICHOSTATIN A	DrugBank Drug Name
58880-19-6	CAS Number
CHEMBL99	ChEMBL ID

TRICHOSTATIN Drug Record

TRICHOSTATIN chembl:CHEMBL99 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20030343 17149860

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 10592235 19385600

Sources: DTC DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 10592235 19385600 17139284 17016423

Sources: DTC DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 18054239 19966789 22280363 19385600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 18054239 19966789 22280363 19385600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600 24074025

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
20030343 17149860

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 10592235 19385600

Sources:
DTC DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 10592235 19385600 17139284 17016423

Sources:
DTC DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 18054239 19966789 22280363 19385600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 18054239 19966789 22280363 19385600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600 24074025

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TRICHOSTATIN A DrugBank Drug Name

58880-19-6 CAS Number

CHEMBL99 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups experimental

Drug Categories amines

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Alternate Names:

CHEMBL99 ChEMBL Drug ID