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TRICHOSTATIN Drug Record

  • Summary
  • Interactions
  • Claims
  • TRICHOSTATIN chembl:CHEMBL99 Antineoplastic

    Alternate Names:

    TRICHOSTATIN
    GNF-PF-1011
    ANTIBIOTIC A-300
    A-300-I
    TRICHOSTATIN(S)

    Drug Info:

    Drug Categories protein synthesis inhibitors
    Drug Categories hydroxylamines
    Drug Categories hydroxy acids
    Drug Categories histone deacetylase inhibitors
    Drug Categories enzyme inhibitors
    Drug Categories antineoplastic agents
    Drug Categories antifungal agents
    Drug Categories anti-infective agents
    Drug Categories amines
    Drug Groups experimental
    Drug Type small molecule
    (0 More Sources)

    Publications:

    Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
    Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
    Schäfer S et al., 2008, Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Bioorg Med Chem
    Baud MG et al., 2012, Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets., J Med Chem
    Huber K et al., 2010, Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins)., J Med Chem
    Trapp J et al., 2006, Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition., J Med Chem
  • TRICHOSTATIN   SIRT2

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20030343 17149860


    Sources:
    DTC

  • TRICHOSTATIN   HDAC7

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 10592235 19385600


    Sources:
    DTC DrugBank

  • TRICHOSTATIN   HDAC8

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 10592235 19385600 17139284 17016423


    Sources:
    DTC DrugBank

  • TRICHOSTATIN   HDAC11

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 19385600


    Sources:
    DTC

  • TRICHOSTATIN   HDAC6

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 18054239 19966789 22280363 19385600


    Sources:
    DTC

  • TRICHOSTATIN   HDAC9

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 19385600


    Sources:
    DTC

  • TRICHOSTATIN   HDAC10

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 19385600


    Sources:
    DTC

  • TRICHOSTATIN   HDAC1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 18054239 19966789 22280363 19385600


    Sources:
    DTC

  • TRICHOSTATIN   HDAC5

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 19385600


    Sources:
    DTC

  • TRICHOSTATIN   HDAC3

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 19385600


    Sources:
    DTC

  • TRICHOSTATIN   HDAC4

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 19385600


    Sources:
    DTC

  • TRICHOSTATIN   HDAC2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 19385600 24074025


    Sources:
    DTC

  • TRICHOSTATIN   CFTR

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19966789


    Sources:
    DTC

  • TRICHOSTATIN   GBA

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRICHOSTATIN   SMN2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRICHOSTATIN   SMN1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRICHOSTATIN   ATAD5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRICHOSTATIN   ALDH1A1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRICHOSTATIN   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB04297

    • Version: 5.1.7

    Alternate Names:
    TRICHOSTATIN A DrugBank Drug Name
    58880-19-6 CAS Number
    CHEMBL99 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups experimental
    Drug Categories amines

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • DTC: TRICHOSTATIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL99 ChEMBL Drug ID

    Drug Info:

    Publications:
    Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
    Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol

  • ChemblDrugs: chembl:CHEMBL99

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21