• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

TRIAMTERENE Drug Record

  • Summary
  • Interactions
  • Claims
  • TRIAMTERENE chembl:CHEMBL585 Approved

    Alternate Names:

    NSC-77625
    DYRENIUM
    DYTAC
    TRIAMTERENE
    SK-8542
    NSC-639359
    SK&F-8542
    6-PHENYLPTERIDINE-2,4,7-TRIAMINE
    TERIDIN
    TRIAMTEREN
    TRIAMTÉRÈNE
    TRIAMTERENUM
    TRIAMTERENO
    chembl:CHEMBL585
    rxcui:10763
    chemidplus:396-01-0
    drugbank:00384
    pubchem.compound:5546

    Drug Info:

    FDA Approval 1964
    Drug Class small molecule
    Drug Indications Diuretics
    Drug Indications Antihypertensive Agents
    Drug Class antihypertensive agents
    Drug Class diuretics
    Year of Approval 1964
    (4 More Sources)

    Publications:

    Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics
    Busch et al., 1996, Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis., Pflugers Arch.
    Wagner et al., 2001, Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis., Cell. Physiol. Biochem.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Hiraoka et al., 2003, Pharmacological characterization of unique prazosin-binding sites in human kidney., Naunyn Schmiedebergs Arch. Pharmacol.
    Steinberg et al., 1984, Effect of triamterene on tyrosine hydroxylase activity., Naunyn Schmiedebergs Arch. Pharmacol.
  • TRIAMTERENE   SCNN1D

    Interaction Score: 8.59

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11509829 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • TRIAMTERENE   SCNN1G

    Interaction Score: 8.59

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

    PMIDs:
    8772124 11509829 17016423 17139284 12827214 23788015


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • TRIAMTERENE   SCNN1A

    Interaction Score: 8.59

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker
    Trial Name -

    PMIDs:
    23788015 8772124 11509829 17016423 17139284 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • TRIAMTERENE   SCNN1B

    Interaction Score: 5.15

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

    PMIDs:
    8772124 11509829 17016423 17139284 23788015


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • TRIAMTERENE   TH

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6149469


    Sources:
    NCI

  • TRIAMTERENE   HSPB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   JAK2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   GAA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   THRB

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   PPARD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   HIF1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   ESR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   TP53

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   IDH1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   HSD17B10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: TRIAMTERENE

    • Version: 01-August-2011

    Alternate Names:
    TRIAMTERENE Primary Drug Name

    Drug Info:
    Year of Approval 1964
    Drug Class diuretics
    Drug Class antihypertensive agents

    Publications:

  • TdgClinicalTrial: TRIAMTERENE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications Diuretics
    Drug Class small molecule

    Publications:

  • NCI: TRIAMTERENE

    • Version: 14-September-2017

    Alternate Names:
    C29519 NCI drug code

    Drug Info:

    Publications:
    Steinberg et al., 1984, Effect of triamterene on tyrosine hydroxylase activity., Naunyn Schmiedebergs Arch. Pharmacol.

  • PharmGKB: triamterene

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics

  • TTD: Triamterene

    • Version: 2020.06.01

    Alternate Names:
    D00NKB TTD Drug ID

    Drug Info:

    Publications:

  • DTC: TRIAMTERENE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL585 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL585

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL585

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21