DGIdb - TRIAMTERENE Drug Record

TRIAMTERENE chembl:CHEMBL585 Approved

Alternate Names:

NSC-77625
DYRENIUM
DYTAC
TRIAMTERENE
SK-8542
NSC-639359
SK&F-8542
6-PHENYLPTERIDINE-2,4,7-TRIAMINE
TERIDIN
TRIAMTEREN
TRIAMTÉRÈNE
TRIAMTERENUM
TRIAMTERENO
chembl:CHEMBL585
rxcui:10763
chemidplus:396-01-0
drugbank:00384
pubchem.compound:5546

Drug Info:

FDA Approval	1964
Drug Class	small molecule
Drug Indications	Diuretics
Drug Indications	Antihypertensive Agents
Drug Class	antihypertensive agents
Drug Class	diuretics
Year of Approval	1964
Drug Categories	sodium channel blockers
Drug Categories	agents causing hyperkalemia
Drug Categories	cytochrome p-450 substrates
Drug Categories	decreased renal k+ excretion
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	increased diuresis
Drug Categories	nephrotoxic agents
Drug Categories	photosensitizing agents

(5 More Sources)

Publications:

Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics
Busch et al., 1996, Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis., Pflugers Arch.
Wagner et al., 2001, Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis., Cell. Physiol. Biochem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Hiraoka et al., 2003, Pharmacological characterization of unique prazosin-binding sites in human kidney., Naunyn Schmiedebergs Arch. Pharmacol.
Steinberg et al., 1984, Effect of triamterene on tyrosine hydroxylase activity., Naunyn Schmiedebergs Arch. Pharmacol.

TRIAMTERENE SCNN1D

Interaction Score: 9.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11509829 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
TRIAMTERENE SCNN1G

Interaction Score: 8.68

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

PMIDs:
23788015 12827214 8772124 11509829 17139284 17016423

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions
TRIAMTERENE SCNN1A

Interaction Score: 8.68

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

Trial Name -

PMIDs:
23788015 8772124 11509829 11752352 17139284 17016423

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions
TRIAMTERENE SCNN1B

Interaction Score: 5.26

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

PMIDs:
23788015 8772124 11509829 17139284 17016423

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions
TRIAMTERENE TH

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6149469

Sources:
NCI
TRIAMTERENE HSPB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE GAA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE JAK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE HIF1A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE ESR1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE IDH1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE HSD17B10

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00384

Version: 5.1.7

Alternate Names:

TRIAMTERENE DrugBank Drug Name

396-01-0 CAS Number

Apo Triazide Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents causing hyperkalemia

Publications:

Wagner et al., 2001, Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis., Cell. Physiol. Biochem.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

TEND: TRIAMTERENE
- Version: 01-August-2011
Alternate Names:

TRIAMTERENE Primary Drug Name

Drug Info:

Year of Approval 1964

Drug Class diuretics

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: TRIAMTERENE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Publications:
NCI: TRIAMTERENE
- Version: 14-September-2017
Alternate Names:

C29519 NCI drug code

Drug Info:

Publications:

Steinberg et al., 1984, Effect of triamterene on tyrosine hydroxylase activity., Naunyn Schmiedebergs Arch. Pharmacol.
PharmGKB: triamterene
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics
TTD: Triamterene
- Version: 2020.06.01
Alternate Names:

D00NKB TTD Drug ID

Drug Info:

Publications:
DTC: TRIAMTERENE
- Version: 02-September-2020
Alternate Names:

CHEMBL585 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL585
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL585
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Amiloride-sensitive sodium channel, ENaC blocker

Direct Interaction	yes
Mechanism of Interaction	Amiloride-sensitive sodium channel, ENaC blocker
Trial Name	-

TRIAMTERENE	DrugBank Drug Name
396-01-0	CAS Number
Apo Triazide	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	agents causing hyperkalemia

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

TRIAMTERENE Drug Record

TRIAMTERENE chembl:CHEMBL585 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11509829 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

PMIDs: 23788015 12827214 8772124 11509829 17139284 17016423

Sources: TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker Trial Name -

PMIDs: 23788015 8772124 11509829 11752352 17139284 17016423

Sources: TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

PMIDs: 23788015 8772124 11509829 17139284 17016423

Sources: TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6149469

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00384

Alternate Names: TRIAMTERENE DrugBank Drug Name 396-01-0 CAS Number Apo Triazide Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories agents causing hyperkalemia

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11509829 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

PMIDs:
23788015 12827214 8772124 11509829 17139284 17016423

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

Trial Name -

PMIDs:
23788015 8772124 11509829 11752352 17139284 17016423

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

PMIDs:
23788015 8772124 11509829 17139284 17016423

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
6149469

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TRIAMTERENE DrugBank Drug Name

396-01-0 CAS Number

Apo Triazide Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents causing hyperkalemia

Alternate Names:

TRIAMTERENE Primary Drug Name

Drug Info:

Year of Approval 1964

Drug Class diuretics

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Alternate Names:

C29519 NCI drug code

Publications:

Steinberg et al., 1984, Effect of triamterene on tyrosine hydroxylase activity., Naunyn Schmiedebergs Arch. Pharmacol.

Publications:

Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

D00NKB TTD Drug ID

Alternate Names:

CHEMBL585 ChEMBL Drug ID