DGIdb - TRIAMCINOLONE Drug Record

TRIAMCINOLONE chembl:CHEMBL1451 ApprovedImmunotherapy

Alternate Names:

TRIAMCINOLONE
ARISTOCORT
KENALOG
NSC-13397
KENACORT
VOLON
FLUOXIPREDNISOLONE
ARISTOCORT A
DELPHICORT
9-FLUORO-11Β,16Α,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
11Β,16Α,17Α,21-TETRAHYDROXY-9Α-FLUORO-1,4-PREGNADIENE-3,20-DIONE
TIAMCINOLONUM
TRIAMCINOLONA
TRIAMCINOLONUM
9ALPHA-FLUORO-16ALPHA-HYDROXYPREDNISOLONE
KENALOG®
9ALPHA-FLUORO-11BETA,16ALPHA,17ALPHA,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
9Α-FLUORO-11Β,16Α,17Α,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
NASACORT®
9ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
9Α-FLUORO-11Β,16Α,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
9-FLUORO-11BETA,16ALPHA,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
FLUOXYPREDNISOLONE
9Α-FLUORO-16Α-HYDROXYPREDNISOLONE
11BETA,16ALPHA,17ALPHA,21-TETRAHYDROXY-9ALPHA-FLUORO-1,4-PREGNADIENE-3,20-DIONE
rxcui:10759
pubchem.compound:31307
chemidplus:124-94-7
drugbank:00620
chembl:CHEMBL1451

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of diabetic macular edema
Drug Class	anti-inflammatory agents
Year of Approval	1957
Drug Class	glucocorticoids

(4 More Sources)

Publications:

Spandau et al., 2005, Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo., Br J Ophthalmol
Nehmé et al., 2009, Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells., BMC Med Genomics
Issar et al., 2006, Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids., Eur. Respir. J.
Shahin et al., 2005, Glucocorticoids remodel nuclear envelope structure and permeability., J. Cell. Sci.
Hahn et al., 1999, Placental glucose transporter expression is regulated by glucocorticoids., J. Clin. Endocrinol. Metab.
Carroll et al., 2002, Triamcinolone stimulates bFGF production and inhibits TGF-beta1 production by human dermal fibroblasts., Dermatol Surg
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Chiba et al., 1997, Effects of triamcinolone on brain and cerebrospinal fluid apolipoprotein E levels in rats., Life Sci.
Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.
Hahn et al., 1994, Effects of the synthetic glucocorticoid triamcinolone acetonide on vasoactive hydrolases of the human placenta in vitro., Placenta
Chen et al., 2001, [Immunological regulations of dendritic cell in abnormal scarring tissue]., Zhonghua Zheng Xing Wai Ke Za Zhi
Tantisira KG et al., 2011, Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma., N Engl J Med
Tsartsali L et al., 2012, Association of hypothalamic-pituitary-adrenal axis-related polymorphisms with stress in asthmatic children on inhaled corticosteroids., Neuroimmunomodulation
Kim WJ et al., 2009, Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD., Respirology
Dijkstra A et al., 2008, Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms., J Allergy Clin Immunol
Tantisira KG et al., 2004, Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids., Hum Mol Genet
Sadowski et al., 2002, Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes., Biochem. Pharmacol.
Tan, 1985, Is the glucocorticoid-induced hypertriglyceridemia in uremic rats caused by decreased tissue lipoprotein lipase activity?, Horm. Metab. Res.

TRIAMCINOLONE CD1A

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11767704

Sources:
NCI
TRIAMCINOLONE HCG22

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TRIAMCINOLONE CRHR1

Interaction Score: 1.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22248724 19210659 18539200 15128701

Sources:
PharmGKB
TRIAMCINOLONE GLCCI1

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21991891

Sources:
PharmGKB
TRIAMCINOLONE SLC2A1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10199793

Sources:
NCI
TRIAMCINOLONE SERPINA6

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
TRIAMCINOLONE MMP1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12123742

Sources:
NCI
TRIAMCINOLONE BCHE

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7937594

Sources:
NCI
TRIAMCINOLONE APOE

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9150415

Sources:
NCI
TRIAMCINOLONE LPL

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4077022

Sources:
NCI
TRIAMCINOLONE FGF2

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15923512

Sources:
NCI
TRIAMCINOLONE NR3C1

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name triamcinolone acetonide implant,I-vation

PMIDs:
19744340 16507850 15976447

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD
TRIAMCINOLONE TGFB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12174062

Sources:
NCI
TRIAMCINOLONE ANXA1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
TRIAMCINOLONE G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1197440

Sources:
NCI
TRIAMCINOLONE NFKB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMCINOLONE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TRIAMCINOLONE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TRIAMCINOLONE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TRIAMCINOLONE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TRIAMCINOLONE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TRIAMCINOLONE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMCINOLONE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: TRIAMCINOLONE
- Version: 01-August-2011
Alternate Names:

TRIAMCINOLONE Primary Drug Name

Drug Info:

Drug Class glucocorticoids

Year of Approval 1957

Drug Class anti-inflammatory agents

Publications:
TdgClinicalTrial: TRIAMCINOLONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of diabetic macular edema

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: TRIAMCINOLONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1451 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: TRIAMCINOLONE

Version: 14-September-2017

Alternate Names:

C901 NCI drug code

Drug Info:

Publications:

Spandau et al., 2005, Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo., Br J Ophthalmol

Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.

Sadowski et al., 2002, Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes., Biochem. Pharmacol.

PharmGKB: triamcinolone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Tantisira KG et al., 2011, Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma., N Engl J Med

Kim WJ et al., 2009, Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD., Respirology

Tantisira KG et al., 2004, Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids., Hum Mol Genet

TTD: Triamcinolone
- Version: 2020.06.01
Alternate Names:

D03BLF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1451
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1451
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Glucocorticoid receptor agonist
Direct Interaction	yes
Trial Name	triamcinolone acetonide implant,I-vation

TRIAMCINOLONE Drug Record

TRIAMCINOLONE chembl:CHEMBL1451 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11767704

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22248724 19210659 18539200 15128701

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21991891

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10199793

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12123742

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7937594

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9150415

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4077022

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15923512

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucocorticoid receptor agonist Direct Interaction yes Trial Name triamcinolone acetonide implant,I-vation

PMIDs: 19744340 16507850 15976447

Sources: DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12174062

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1197440

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Interaction Types & Directionality:

n/a

PMIDs:
11767704

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22248724 19210659 18539200 15128701

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21991891

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10199793

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
12123742

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7937594

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9150415

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
4077022

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15923512

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name triamcinolone acetonide implant,I-vation

PMIDs:
19744340 16507850 15976447

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
12174062

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
1197440

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TRIAMCINOLONE Primary Drug Name

Drug Info:

Drug Class glucocorticoids

Year of Approval 1957

Drug Class anti-inflammatory agents

Drug Info:

Drug Indications for treatment of diabetic macular edema

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1451 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

C901 NCI drug code

Alternate Names:

D03BLF TTD Drug ID