15AU81 |
15-AU-81 |
TREPROSTINIL |
LRX-15 |
TYVASO |
UT-15 |
REMODULIN |
TRESPROSTINIL |
ORENITRAM |
[[(1R,2R,3AS,9AS)-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-2,3,3A,4,9,9A-HEXAHYDRO-1H-CYCLOPENTA[B]NAPHTALEN-5-YL]OXY]ACETIC ACID |
TREPROSTINILO |
TYVASO® |
(1R,2R,3AS,9AS)-[[2,3,3A,4,9,9A-HEXAHYDRO-2-HYDROXY- 1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[F]INDEN-5-YL] OXY]ACETIC ACID |
UNIPROST |
TREPROSTINILUM |
REMODULIN® |
chembl:CHEMBL1237119 |
rxcui:343048 |
drugbank:00374 |
chemidplus:81846-19-7 |
pubchem.compound:6918140 |
Drug Class | antihypertensive agents |
Year of Approval | 2002 |
Drug Class | antithrombotic agents |
FDA Approval | 2002 |
Drug Class | small molecule |
Drug Indications | Antithrombotic Agents |
Drug Indications | Antihypertensive Agents |
Drug Categories | platelet aggregation inhibitors excl. heparin |
Drug Categories | cytochrome p-450 substrates |
Drug Categories | potential qtc-prolonging agents |
Drug Categories | prostacycline vasodilator |
Drug Categories | qtc prolonging agents |
Drug Categories | vasodilating agents |
Drug Categories | vasodilation |
agonist (activating) |
Mechanism of Interaction | Prostanoid IP receptor agonist |
Direct Interaction | yes |
Specific Action of the Ligand | Full agonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Endogenous Drug? | False |
Details of Interaction | EP<sub>3</sub>-I isoform |
Specific Action of the Ligand | Full agonist |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | - |
Novel drug target | Established target |
TREPROSTINIL | DrugBank Drug Name |
81846-19-7 | CAS Number |
Orenitram | Drug Brand |
Drug Type | small molecule |
Drug Groups | approved |
Drug Groups | investigational |
TREPROSTINIL | Primary Drug Name |
Drug Class | antithrombotic agents |
Year of Approval | 2002 |
Drug Class | antihypertensive agents |
Drug Indications | Antihypertensive Agents |
Drug Indications | Antithrombotic Agents |
Drug Class | small molecule |
D01WUA | TTD Drug ID |
TREPROSTINIL | GuideToPharmacology Ligand Name |