DGIdb - TREPROSTINIL Drug Record

TREPROSTINIL chembl:CHEMBL1237119 Approved

Alternate Names:

15AU81
15-AU-81
TREPROSTINIL
LRX-15
TYVASO
UT-15
REMODULIN
TRESPROSTINIL
ORENITRAM
[[(1R,2R,3AS,9AS)-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-2,3,3A,4,9,9A-HEXAHYDRO-1H-CYCLOPENTA[B]NAPHTALEN-5-YL]OXY]ACETIC ACID
TREPROSTINILO
TYVASO®
(1R,2R,3AS,9AS)-[[2,3,3A,4,9,9A-HEXAHYDRO-2-HYDROXY- 1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[F]INDEN-5-YL] OXY]ACETIC ACID
UNIPROST
TREPROSTINILUM
REMODULIN®
chembl:CHEMBL1237119
rxcui:343048
drugbank:00374
chemidplus:81846-19-7
pubchem.compound:6918140

Drug Info:

Drug Class	antihypertensive agents
Year of Approval	2002
Drug Class	antithrombotic agents
FDA Approval	2002
Drug Class	small molecule
Drug Indications	Antithrombotic Agents
Drug Indications	Antihypertensive Agents
Drug Categories	platelet aggregation inhibitors excl. heparin
Drug Categories	cytochrome p-450 substrates
Drug Categories	potential qtc-prolonging agents
Drug Categories	prostacycline vasodilator
Drug Categories	qtc prolonging agents
Drug Categories	vasodilating agents
Drug Categories	vasodilation

(3 More Sources)

Publications:

Ali et al., 2006, Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts., Am. J. Respir. Cell Mol. Biol.
Falcetti et al., 2010, Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension., Am. J. Respir. Crit. Care Med.
Sprague et al., 2008, Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes., Microcirculation
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Olschewski et al., 2004, Prostacyclin and its analogues in the treatment of pulmonary hypertension., Pharmacol. Ther.
Bacha NC et al., 2019, Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension., Pediatr Pulmonol
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

TREPROSTINIL PTGIR

Interaction Score: 2.81

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid IP receptor agonist

Direct Interaction yes

Specific Action of the Ligand Full agonist

PMIDs:
20622039 18574748 11752352 15163595

Sources:
TTD DrugBank GuideToPharmacology ChemblInteractions
TREPROSTINIL P2RY12

Interaction Score: 1.99

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
30485728 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
TREPROSTINIL PTGDR

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
TREPROSTINIL PTGER2

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
TREPROSTINIL PTGER3

Interaction Score: 0.35

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Details of Interaction EP<sub>3</sub>-I isoform

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
TREPROSTINIL PTGER4

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
TREPROSTINIL PTGER1

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
TREPROSTINIL PPARD

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16239641

Sources:
DrugBank
TREPROSTINIL PPARG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial

DrugBank: DB00374

Version: 5.1.7

Alternate Names:

TREPROSTINIL DrugBank Drug Name

81846-19-7 CAS Number

Orenitram Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Ali et al., 2006, Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts., Am. J. Respir. Cell Mol. Biol.

Bacha NC et al., 2019, Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension., Pediatr Pulmonol

Falcetti et al., 2010, Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension., Am. J. Respir. Crit. Care Med.

TEND: TREPROSTINIL
- Version: 01-August-2011
Alternate Names:

TREPROSTINIL Primary Drug Name

Drug Info:

Drug Class antithrombotic agents

Year of Approval 2002

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: TREPROSTINIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Antithrombotic Agents

Drug Class small molecule

Publications:
TTD: Treprostinil
- Version: 2020.06.01
Alternate Names:

D01WUA TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178102445
- Version: 29-September-2020
Alternate Names:

TREPROSTINIL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1237119
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1237119
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Prostanoid IP receptor agonist
Direct Interaction	yes
Specific Action of the Ligand	Full agonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	False

Endogenous Drug?	False
Details of Interaction	EP<sub>3</sub>-I isoform
Specific Action of the Ligand	Full agonist

TREPROSTINIL	DrugBank Drug Name
81846-19-7	CAS Number
Orenitram	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

TREPROSTINIL Drug Record

TREPROSTINIL chembl:CHEMBL1237119 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Prostanoid IP receptor agonist Direct Interaction yes Specific Action of the Ligand Full agonist

PMIDs: 20622039 18574748 11752352 15163595

Sources: TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 30485728 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Details of Interaction EP<sub>3</sub>-I isoform Specific Action of the Ligand Full agonist

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 16239641

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TEND TdgClinicalTrial

DrugBank: DB00374

Alternate Names: TREPROSTINIL DrugBank Drug Name 81846-19-7 CAS Number Orenitram Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: TREPROSTINIL

Alternate Names: TREPROSTINIL Primary Drug Name

Drug Info: Drug Class antithrombotic agents Year of Approval 2002 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: TREPROSTINIL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Antithrombotic Agents Drug Class small molecule

Publications:

TTD: Treprostinil

Alternate Names: D01WUA TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178102445

Alternate Names: TREPROSTINIL GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1237119

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1237119

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid IP receptor agonist

Direct Interaction yes

Specific Action of the Ligand Full agonist

PMIDs:
20622039 18574748 11752352 15163595

Sources:
TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
30485728 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Details of Interaction EP<sub>3</sub>-I isoform

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

PMIDs:
16239641

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial

Alternate Names:

TREPROSTINIL DrugBank Drug Name

81846-19-7 CAS Number

Orenitram Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

TREPROSTINIL Primary Drug Name

Drug Info:

Drug Class antithrombotic agents

Year of Approval 2002

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Antithrombotic Agents

Drug Class small molecule

Alternate Names:

D01WUA TTD Drug ID

Alternate Names:

TREPROSTINIL GuideToPharmacology Ligand Name