DGIdb - TORSEMIDE Drug Record

TORSEMIDE chembl:CHEMBL1148 Approved

Alternate Names:

TOREM 10
BM-02.015
TORASEMIDE
AC4464
DEMADEX
TOREM 5
TORSEMIDE
BM-02015
TOREM 2.5
AC-4464
DEMADEX®
N-(((1-METHYLETHYL)AMINO)CARBONYL)-4-((3-METHYLPHENYL)AMINO)-3-PYRIDINESULFONAMIDE
TORASEMIDA
LUPRAC
TORASEMIDUM
1-ISOPROPYL-3-((4-M-TOLUIDINO-3-PYRIDYL)SULFONYL)UREA
chemidplus:56211-40-6
chembl:CHEMBL1148
drugbank:00214
pubchem.compound:41781
rxcui:38413

Drug Info:

Drug Class	diuretics
Year of Approval	1993
Drug Class	antihypertensive agents
FDA Approval	1993
Drug Class	small molecule
Drug Indications	Diuretics
Drug Indications	Antihypertensive Agents

(3 More Sources)

Publications:

Fortuño et al., 1999, Torasemide inhibits angiotensin II-induced vasoconstriction and intracellular calcium increase in the aorta of spontaneously hypertensive rats., Hypertension
Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

TORSEMIDE NPPA-AS1

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
TORSEMIDE SLC12A1

Interaction Score: 3.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10406837 17460608 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
TORSEMIDE ADD1

Interaction Score: 2.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
TORSEMIDE SLC12A3

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298 17460608

Sources:
PharmGKB
TORSEMIDE GNB3

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
TORSEMIDE ACE

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
TORSEMIDE CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TORSEMIDE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TORSEMIDE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TORSEMIDE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TORSEMIDE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: TORASEMIDE
- Version: 01-August-2011
Alternate Names:

TORASEMIDE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1993

Drug Class diuretics

Publications:
TdgClinicalTrial: TORASEMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Publications:
DTC: TORSEMIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL1148 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: torasemide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J

Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.

TTD: Torasemide
- Version: 2020.06.01
Alternate Names:

D0J9XZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1148
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1148
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Sodium-(potassium)-chloride cotransporter 2 inhibitor
Direct Interaction	yes
Trial Name	-

TORSEMIDE Drug Record

TORSEMIDE chembl:CHEMBL1148 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor Direct Interaction yes Trial Name -

PMIDs: 10406837 17460608 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298 17460608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: TORASEMIDE

Alternate Names: TORASEMIDE Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1993 Drug Class diuretics

Publications:

TdgClinicalTrial: TORASEMIDE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Diuretics Drug Class small molecule

Publications:

DTC: TORSEMIDE

Alternate Names: CHEMBL1148 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: torasemide

Alternate Names:

Drug Info:

Publications: Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.

TTD: Torasemide

Alternate Names: D0J9XZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1148

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1148

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10406837 17460608 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298 17460608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

TORASEMIDE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1993

Drug Class diuretics

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Alternate Names:

CHEMBL1148 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Publications:

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J

Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.

Alternate Names:

D0J9XZ TTD Drug ID