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TORSEMIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • TORSEMIDE chembl:CHEMBL1148 Approved

    Alternate Names:

    TOREM 10
    BM-02.015
    TORASEMIDE
    AC4464
    DEMADEX
    TOREM 5
    TORSEMIDE
    BM-02015
    TOREM 2.5
    AC-4464
    DEMADEX®
    N-(((1-METHYLETHYL)AMINO)CARBONYL)-4-((3-METHYLPHENYL)AMINO)-3-PYRIDINESULFONAMIDE
    TORASEMIDA
    LUPRAC
    TORASEMIDUM
    1-ISOPROPYL-3-((4-M-TOLUIDINO-3-PYRIDYL)SULFONYL)UREA
    chemidplus:56211-40-6
    chembl:CHEMBL1148
    drugbank:00214
    pubchem.compound:41781
    rxcui:38413

    Drug Info:

    Drug Class diuretics
    Year of Approval 1993
    Drug Class antihypertensive agents
    FDA Approval 1993
    Drug Class small molecule
    Drug Indications Diuretics
    Drug Indications Antihypertensive Agents
    (3 More Sources)

    Publications:

    Fortuño et al., 1999, Torasemide inhibits angiotensin II-induced vasoconstriction and intracellular calcium increase in the aorta of spontaneously hypertensive rats., Hypertension
    Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
  • TORSEMIDE   NPPA-AS1

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • TORSEMIDE   SLC12A1

    Interaction Score: 3.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    10406837 17460608 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • TORSEMIDE   ADD1

    Interaction Score: 2.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • TORSEMIDE   SLC12A3

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298 17460608


    Sources:
    PharmGKB

  • TORSEMIDE   GNB3

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • TORSEMIDE   ACE

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • TORSEMIDE   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TORSEMIDE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TORSEMIDE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TORSEMIDE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TORSEMIDE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: TORASEMIDE

    • Version: 01-August-2011

    Alternate Names:
    TORASEMIDE Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval 1993
    Drug Class diuretics

    Publications:

  • TdgClinicalTrial: TORASEMIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications Diuretics
    Drug Class small molecule

    Publications:

  • DTC: TORSEMIDE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1148 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: torasemide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.

  • TTD: Torasemide

    • Version: 2020.06.01

    Alternate Names:
    D0J9XZ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1148

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1148

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21