RWJ-17021-000 |
MCN-4853 |
QUDEXY XR |
TROKENDI XR |
USL255 |
RWJ-17021 |
EPITOMAX |
TOPAMAX |
USL-255 |
TOPAMAX SPRINKLE |
TOPIRAMATE |
2,3:4,5-DI-O-ISOPROPYLIDENE-BETA-D-FRUCTOPYRANOSE SULFAMATE |
TPM |
TOPAMAX® |
TIPIRAMATE |
[(1R,2S,6S,9R)-4,4,11,11-TETRAMETHYL-3,5,7,10,12-PENTAOXATRICYCLO[7.3.0.0^{2,6}]DODECAN-6-YL]METHYL SULFAMATE |
TIPIRAMATO |
2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-BETA-D-FRUCTOPYRANOSE SULFAMATE |
TOPOMAX |
TOPIRAMATUM |
TOPIRAMATO |
chemidplus:97240-79-4 |
drugbank:00273 |
pubchem.compound:5284627 |
rxcui:38404 |
chembl:CHEMBL220492 |
Drug Categories | hexoses |
Drug Categories | anticonvulsants |
Drug Class | anticonvulsants |
Drug Class | anti-migraine agents |
Year of Approval | 1996 |
FDA Approval | 1996 |
Drug Indications | anti-migraine agents |
Drug Indications | Anticonvulsants |
Drug Indications | anticonvulsant,antimigraine agent |
FDA Approval | approved |
Drug Class | small molecule |
Drug Indications | anticonvulsant |
Drug Categories | cytochrome p-450 cyp2c19 inhibitors (strength unknown) |
Drug Categories | cytochrome p-450 cyp3a4 inducers |
Drug Categories | cytochrome p-450 cyp3a4 inducers (strength unknown) |
Drug Categories | cytochrome p-450 enzyme inducers |
Drug Categories | cytochrome p-450 enzyme inhibitors |
Drug Categories | cytochrome p-450 substrates |
Drug Categories | decreased central nervous system disorganized electrical activity |
Drug Categories | drugs that are mainly renally excreted |
Drug Categories | enzyme inducing antiepileptic drugs |
Drug Categories | fructose |
Drug Categories | miscellaneous anticonvulsants |
Drug Categories | p-glycoprotein substrates |
antagonist (inhibitory) |
Trial Name | topiramate controlled release,Trokesa |
Novel drug target | Established target |
Trial Name | topiramate tablet,Topamax |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic kainate antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate receptor ionotropic kainate antagonist |
inhibitor (inhibitory) |
Trial Name | topiramate controlled release,Trokesa |
Novel drug target | Established target |
Trial Name | topiramate tablet,Topamax |
blocker (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
Trial Name | topiramate controlled release,Trokesa |
inhibitor (inhibitory) |
Direct Interaction? | False |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
positive modulator (activating) |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
Trial Name | topiramate controlled release,Trokesa |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate receptor ionotropic kainate antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
TOPIRAMATE | DrugBank Drug Name |
97240-79-4 | CAS Number |
Abbott-topiramate | Drug Brand |
Drug Type | small molecule |
Drug Groups | approved |
Drug Categories | anti-obesity agents |
TOPIRAMATE | Primary Drug Name |
Year of Approval | 1996 |
Drug Class | anti-migraine agents |
Drug Class | anticonvulsants |
Drug Indications | anticonvulsant |
Drug Class | small molecule |
FDA Approval | approved |
CHEMBL220492 | ChEMBL Drug ID |
D07VDZ | TTD Drug ID |
TOPIRAMATE | GuideToPharmacology Ligand Name |