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TONAPOFYLLINE Drug Record

  • Summary
  • Interactions
  • Claims
  • TONAPOFYLLINE chembl:CHEMBL414157

    Alternate Names:

    TONAPOFYLLINE
    BG-9928

    Drug Info:

    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications for treatment of congestive heart failure
    (0 More Sources)

    Publications:

    Greenberg B et al., 2007, Effects of multiple oral doses of an A1 adenosine antagonist, BG9928, in patients with heart failure: results of a placebo-controlled, dose-escalation study., J Am Coll Cardiol
    Vu CB et al., 2006, Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists., J Med Chem
  • TONAPOFYLLINE   ADORA1

    Interaction Score: 2.49

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Trial Name BG-9928

    PMIDs:
    17692744 17125265


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • TONAPOFYLLINE   ADORA3

    Interaction Score: 0.81

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TONAPOFYLLINE   ADORA2B

    Interaction Score: 0.7

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TONAPOFYLLINE   ADORA2A

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TdgClinicalTrial: BG-9928

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of congestive heart failure
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • TTD: Tonapofylline

    • Version: 2020.06.01

    Alternate Names:
    D00SUK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL414157

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL414157

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21