DGIdb - TICLOPIDINE Drug Record

TICLOPIDINE chembl:CHEMBL833 Approved

Alternate Names:

TICLOPIDINE
4-C-32
TICLID®
53-32C
TICLOPIDINUM
TICLOPIDINA
chembl:CHEMBL833
pubchem.compound:5472
chemidplus:55142-85-3
rxcui:10594
drugbank:00208

Drug Info:

FDA Approval	1991
Drug Class	small molecule
Drug Indications	Platelet Aggregation Inhibitors
Drug Class	platelet aggregation inhibitors
Year of Approval	1991

(2 More Sources)

Publications:

Hirata K et al., 2008, Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study., Pharmacogenomics J
Storey, 2001, The P2Y12 receptor as a therapeutic target in cardiovascular disease., Platelets
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Gachet, 2005, The platelet P2 receptors as molecular targets for old and new antiplatelet drugs., Pharmacol. Ther.
Zhan et al., 2007, Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists., J. Mol. Graph. Model.
Boeynaems et al., 2005, P2Y receptor antagonists in thrombosis., Curr Opin Investig Drugs
Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics

TICLOPIDINE P2RY12

Interaction Score: 3.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11454254 11752352 15955565 17110146 15816504 20938371

Sources:
TdgClinicalTrial TEND PharmGKB
TICLOPIDINE HLA-C

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17339877

Sources:
PharmGKB
TICLOPIDINE PTAFR

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TICLOPIDINE HLA-DQB1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17339877

Sources:
PharmGKB
TICLOPIDINE HLA-A

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17339877

Sources:
PharmGKB
TICLOPIDINE HLA-B

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17339877

Sources:
PharmGKB
TICLOPIDINE HLA-DRB1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17339877

Sources:
PharmGKB
TICLOPIDINE CYP2B6

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17638512

Sources:
PharmGKB
TICLOPIDINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TICLOPIDINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TICLOPIDINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TICLOPIDINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TICLOPIDINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: TICLOPIDINE
- Version: 01-August-2011
Alternate Names:

TICLOPIDINE Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class platelet aggregation inhibitors

Publications:
TdgClinicalTrial: TICLOPIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Platelet Aggregation Inhibitors

Drug Class small molecule

FDA Approval 1991

Publications:
DTC: TICLOPIDINE
- Version: 02-September-2020
Alternate Names:

CHEMBL833 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: ticlopidine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Hirata K et al., 2008, Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study., Pharmacogenomics J

Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics

Gachet, 2005, The platelet P2 receptors as molecular targets for old and new antiplatelet drugs., Pharmacol. Ther.

TTD: Ticlopidine
- Version: 2020.06.01
Alternate Names:

D05LBU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL833
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

TICLOPIDINE Drug Record

TICLOPIDINE chembl:CHEMBL833 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11454254 11752352 15955565 17110146 15816504 20938371

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17339877

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17339877

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17339877

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17339877

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17339877

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17638512

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: TICLOPIDINE

Alternate Names: TICLOPIDINE Primary Drug Name

Drug Info: Year of Approval 1991 Drug Class platelet aggregation inhibitors

Publications:

TdgClinicalTrial: TICLOPIDINE

Alternate Names:

Drug Info: Drug Indications Platelet Aggregation Inhibitors Drug Class small molecule FDA Approval 1991

Publications:

DTC: TICLOPIDINE

Alternate Names: CHEMBL833 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: ticlopidine

Alternate Names:

Drug Info:

TTD: Ticlopidine

Alternate Names: D05LBU TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL833

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11454254 11752352 15955565 17110146 15816504 20938371

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17339877

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
17339877

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17339877

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17339877

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17339877

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17638512

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TICLOPIDINE Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class platelet aggregation inhibitors

Drug Info:

Drug Indications Platelet Aggregation Inhibitors

Drug Class small molecule

FDA Approval 1991

Alternate Names:

CHEMBL833 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D05LBU TTD Drug ID