DGIdb - TIANEPTINE Drug Record

TIANEPTINE chembl:CHEMBL1289110

Alternate Names:

TIANEPTINE
7-[(3-CHLORO-6,11-DIHYDRO-6-METHYLDIBENZO[C,F][1,2]THIAZEPIN-11-YL)-AMINO]HEPTANOIC ACID S,S-DIOXIDE
(±)-TIANEPTINE
STABLON®
drugbank:09289
chemidplus:72797-41-2
chemidplus:66981-73-5
chembl:CHEMBL1289110
pubchem.compound:68870

Drug Info:

Drug Type	small molecule
Drug Groups	investigational
Drug Categories	agents causing muscle toxicity
Drug Categories	agents that produce hypertension
Drug Categories	agents that reduce seizure threshold
Drug Categories	analgesics
Drug Categories	antidepressive agents
Drug Categories	antidepressive agents, tricyclic
Drug Categories	azepines
Drug Categories	central nervous system agents
Drug Categories	central nervous system depressants
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index
Drug Categories	cytochrome p-450 substrates
Drug Categories	narrow therapeutic index drugs
Drug Categories	nervous system
Drug Categories	neurotoxic agents
Drug Categories	psychoanaleptics
Drug Categories	psychotropic drugs
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin agents
Drug Categories	serotonin modulators
Drug Categories	sulfur compounds
Drug Categories	thiepins

(0 More Sources)

Publications:

Gassaway MM et al., 2014, The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist., Transl Psychiatry
Samuels BA et al., 2017, The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor., Neuropsychopharmacology
McEwen BS et al., 2010, The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation., Mol Psychiatry
Dziedzicka-Wasylewska M et al., 2002, Effect of repeated treatment with tianeptine and fluoxetine on central dopamine D(2) /D(3) receptors., Behav Pharmacol
Datla KP et al., 1993, Behavioural and neurochemical evidence for the decrease of brain extracellular 5-HT by the antidepressant drug tianeptine., Neuropharmacology
Sonawalla S et al., 2003, Treatment of major depression and anxiety with the selective serotonin re-uptake enhancer tianeptine in the outpatient psychiatric care setting of India., J Indian Med Assoc

TIANEPTINE GRIA1

Interaction Score: 0.86

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
19704408

Sources:
DrugBank
TIANEPTINE OPRM1

Interaction Score: 0.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
25026323 28303899

Sources:
PharmGKB DrugBank
TIANEPTINE HTR1A

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
7694170 12841497

Sources:
DrugBank
TIANEPTINE DRD3

Interaction Score: 0.28

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11981225

Sources:
DrugBank

DrugBank: DB09289

Version: 5.1.7

Alternate Names:

TIANEPTINE DrugBank Drug Name

72797-41-2 CAS Number

Coaxil Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories agents causing muscle toxicity

Publications:

Dziedzicka-Wasylewska M et al., 2002, Effect of repeated treatment with tianeptine and fluoxetine on central dopamine D(2) /D(3) receptors., Behav Pharmacol

Datla KP et al., 1993, Behavioural and neurochemical evidence for the decrease of brain extracellular 5-HT by the antidepressant drug tianeptine., Neuropharmacology

Sonawalla S et al., 2003, Treatment of major depression and anxiety with the selective serotonin re-uptake enhancer tianeptine in the outpatient psychiatric care setting of India., J Indian Med Assoc

TTD: Tianeptine
- Version: 2020.06.01
Alternate Names:

D06CVT TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1289110
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: tianeptine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

TIANEPTINE	DrugBank Drug Name
72797-41-2	CAS Number
Coaxil	Drug Brand

TIANEPTINE Drug Record

TIANEPTINE chembl:CHEMBL1289110

Alternate Names:

Drug Info:

Publications:

TIANEPTINE GRIA1

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 19704408

Sources: DrugBank

TIANEPTINE OPRM1

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 25026323 28303899

Sources: PharmGKB DrugBank

TIANEPTINE HTR1A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 7694170 12841497

Sources: DrugBank

TIANEPTINE DRD3

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 11981225

Sources: DrugBank

DrugBank: DB09289

Alternate Names: TIANEPTINE DrugBank Drug Name 72797-41-2 CAS Number Coaxil Drug Brand

Drug Info: Drug Type small molecule Drug Groups investigational Drug Categories agents causing muscle toxicity

TTD: Tianeptine

Alternate Names: D06CVT TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1289110

Alternate Names:

Drug Info:

Publications:

PharmGKB: tianeptine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

modulator

PMIDs:
19704408

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
25026323 28303899

Sources:
PharmGKB DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
7694170 12841497

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
11981225

Sources:
DrugBank

Alternate Names:

TIANEPTINE DrugBank Drug Name

72797-41-2 CAS Number

Coaxil Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories agents causing muscle toxicity

Alternate Names:

D06CVT TTD Drug ID