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THROMBIN Drug Record

  • Summary
  • Interactions
  • Claims
  • THROMBIN chembl:CHEMBL2108110 Approved

    Alternate Names:

    THROMBIN
    THROMBOSTAT

    Drug Info:

    FDA Approval not approved
    Drug Class protein
    Drug Indications topical tissue sealant
    (0 More Sources)

    Publications:

    Minnema et al., 1998, Activation of clotting factor XI without detectable contact activation in experimental human endotoxemia., Blood
    Crawley JT et al., 2007, The central role of thrombin in hemostasis., J Thromb Haemost
    Chambers et al., 2000, Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1., J. Biol. Chem.
    Sapet et al., 2006, Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2., Blood
    Whinna et al., 1993, Interaction of thrombin with antithrombin, heparin cofactor II, and protein C inhibitor., J. Protein Chem.
    Torti et al., 1998, Thrombin induces the association of cyclic ADP-ribose-synthesizing CD38 with the platelet cytoskeleton., FEBS Lett.
    Heider et al., 2004, PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism., Oncol. Res.
    Turcotte et al., 2004, von Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation., Int. J. Cancer
    Darmoul et al., 2004, Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation., Mol. Cancer Res.
    Shi et al., 2004, Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis., Mol. Cancer Res.
    Chen et al., 2004, Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation., J. Biol. Chem.
    Darmoul et al., 2003, Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells., Am. J. Pathol.
    Suo et al., 2002, Participation of protease-activated receptor-1 in thrombin-induced microglial activation., J. Neurochem.
    Rudroff et al., 2001, Thrombin enhances adhesion in pancreatic cancer in vitro through the activation of the thrombin receptor PAR 1., Eur J Surg Oncol
    Henrikson et al., 1999, Role of thrombin receptor in breast cancer invasiveness., Br. J. Cancer
    Leger AJ et al., 2006, Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis., Circulation
    Lampugnani et al., 1990, Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2(+)-dependent mechanism., Blood
    Pumiglia et al., 1993, Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but is dependent on formation of large aggregate structures., Biochem. J.
    Derhaschnig et al., 2003, Blockade of GPIIb/IIIa by eptifibatide and tirofiban does not alter tissue factor induced thrombin generation in human endotoxemia., Thromb. Haemost.
    Rao et al., 1995, Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aortic smooth muscle cells., J. Biol. Chem.
    Du et al., 2001, Thrombin regulates insulin-like growth factor-1 receptor transcription in vascular smooth muscle: characterization of the signaling pathway., Circ. Res.
    Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.
    Philippeaux et al., 1996, Activated human platelets express beta2 integrin., Eur. J. Haematol.
    Naldini et al., 1998, Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation., J. Cell. Physiol.
    Molino et al., 1997, Interactions of mast cell tryptase with thrombin receptors and PAR-2., J. Biol. Chem.
    Benezra et al., 1992, Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase., Exp. Cell Res.
    Magnaldo et al., 1986, The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts., J. Biol. Chem.
    Weber et al., 1980, Leucocyte migration inhibition factor (LIF) and antithrombin III (AT III)., J Clin Lab Immunol
    Zeng et al., 2005, [Enhancement of NMDA receptor sensitivity by thrombin and its relationship with tissue transglutaminase]., Zhonghua Nei Ke Za Zhi
    Ariyoshi et al., 1993, Translocation of human platelet calpain-I., Biochem. Mol. Biol. Int.
    Perides et al., 1987, Probing of the structural stability of vimentin and desmin-type intermediate filaments with Ca2+-activated proteinase, thrombin and lysine-specific endoproteinase Lys-C., Eur. J. Cell Biol.
    Sloan et al., 1986, Effects of EACA on thrombin generation as measured by the chromagen S2238., Thromb. Res.
    Weinstein et al., 2005, Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations., J. Neurochem.
  • THROMBIN   A2M

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2432677


    Sources:
    NCI

  • THROMBIN   F11

    Interaction Score: 3.86

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    9787166 17635715


    Sources:
    NCI

  • THROMBIN   DES

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3040412


    Sources:
    NCI

  • THROMBIN   F2R

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15559761 15386385 15383630 15280447 14699102 12707033 11841573 11504518 10027305 16505172


    Sources:
    NCI

  • THROMBIN   TPSAB1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9020112


    Sources:
    NCI

  • THROMBIN   CD38

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9654134


    Sources:
    NCI

  • THROMBIN   CAST

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8358337


    Sources:
    NCI

  • THROMBIN   SERPINA5

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8136018


    Sources:
    NCI

  • THROMBIN   ITGA2B

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7689831 14652636


    Sources:
    NCI

  • THROMBIN   COL18A1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15615851


    Sources:
    NCI

  • THROMBIN   F5

    Interaction Score: 0.64

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Trial Name ProFibrix B.V/
    Novel drug target Established target

    PMIDs:
    17635715


    Sources:
    TdgClinicalTrial

  • THROMBIN   FOS

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2119237


    Sources:
    NCI

  • THROMBIN   LIF

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7007650


    Sources:
    NCI

  • THROMBIN   F8

    Interaction Score: 0.43

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name ProFibrix B.V/

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • THROMBIN   HPSE

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1612123


    Sources:
    NCI

  • THROMBIN   IFNG

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9731747


    Sources:
    NCI

  • THROMBIN   ITGAL

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8598231


    Sources:
    NCI

  • THROMBIN   FAS

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16271051


    Sources:
    NCI

  • THROMBIN   CCN2

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10952976


    Sources:
    NCI

  • THROMBIN   TGM2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16202257


    Sources:
    NCI

  • THROMBIN   IGF1R

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7499260 11375274


    Sources:
    NCI

  • THROMBIN   ROCK2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16720831


    Sources:
    NCI

  • THROMBIN   MYC

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3023371


    Sources:
    NCI

  • THROMBIN   F10

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ProFibrix B.V/
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TdgClinicalTrial: THROMBIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications topical tissue sealant
    Drug Class protein
    FDA Approval not approved

    Publications:

  • NCI: THROMBIN

    • Version: 14-September-2017

    Alternate Names:
    C29499 NCI drug code

    Drug Info:

    Publications:
    Minnema et al., 1998, Activation of clotting factor XI without detectable contact activation in experimental human endotoxemia., Blood
    Whinna et al., 1993, Interaction of thrombin with antithrombin, heparin cofactor II, and protein C inhibitor., J. Protein Chem.
    Derhaschnig et al., 2003, Blockade of GPIIb/IIIa by eptifibatide and tirofiban does not alter tissue factor induced thrombin generation in human endotoxemia., Thromb. Haemost.

  • ChemblDrugs: chembl:CHEMBL2108110

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21