DGIdb - THROMBIN Drug Record

THROMBIN chembl:CHEMBL2108110 Approved

Alternate Names:

THROMBIN
THROMBOSTAT

Drug Info:

FDA Approval	not approved
Drug Class	protein
Drug Indications	topical tissue sealant

(0 More Sources)

Publications:

Minnema et al., 1998, Activation of clotting factor XI without detectable contact activation in experimental human endotoxemia., Blood
Crawley JT et al., 2007, The central role of thrombin in hemostasis., J Thromb Haemost
Chambers et al., 2000, Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1., J. Biol. Chem.
Sapet et al., 2006, Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2., Blood
Whinna et al., 1993, Interaction of thrombin with antithrombin, heparin cofactor II, and protein C inhibitor., J. Protein Chem.
Torti et al., 1998, Thrombin induces the association of cyclic ADP-ribose-synthesizing CD38 with the platelet cytoskeleton., FEBS Lett.
Heider et al., 2004, PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism., Oncol. Res.
Turcotte et al., 2004, von Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation., Int. J. Cancer
Darmoul et al., 2004, Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation., Mol. Cancer Res.
Shi et al., 2004, Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis., Mol. Cancer Res.
Chen et al., 2004, Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation., J. Biol. Chem.
Darmoul et al., 2003, Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells., Am. J. Pathol.
Suo et al., 2002, Participation of protease-activated receptor-1 in thrombin-induced microglial activation., J. Neurochem.
Rudroff et al., 2001, Thrombin enhances adhesion in pancreatic cancer in vitro through the activation of the thrombin receptor PAR 1., Eur J Surg Oncol
Henrikson et al., 1999, Role of thrombin receptor in breast cancer invasiveness., Br. J. Cancer
Leger AJ et al., 2006, Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis., Circulation
Lampugnani et al., 1990, Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2(+)-dependent mechanism., Blood
Pumiglia et al., 1993, Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but is dependent on formation of large aggregate structures., Biochem. J.
Derhaschnig et al., 2003, Blockade of GPIIb/IIIa by eptifibatide and tirofiban does not alter tissue factor induced thrombin generation in human endotoxemia., Thromb. Haemost.
Rao et al., 1995, Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aortic smooth muscle cells., J. Biol. Chem.
Du et al., 2001, Thrombin regulates insulin-like growth factor-1 receptor transcription in vascular smooth muscle: characterization of the signaling pathway., Circ. Res.
Ma et al., 2005, Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets., Proc. Natl. Acad. Sci. U.S.A.
Philippeaux et al., 1996, Activated human platelets express beta2 integrin., Eur. J. Haematol.
Naldini et al., 1998, Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation., J. Cell. Physiol.
Molino et al., 1997, Interactions of mast cell tryptase with thrombin receptors and PAR-2., J. Biol. Chem.
Benezra et al., 1992, Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase., Exp. Cell Res.
Magnaldo et al., 1986, The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts., J. Biol. Chem.
Weber et al., 1980, Leucocyte migration inhibition factor (LIF) and antithrombin III (AT III)., J Clin Lab Immunol
Zeng et al., 2005, [Enhancement of NMDA receptor sensitivity by thrombin and its relationship with tissue transglutaminase]., Zhonghua Nei Ke Za Zhi
Ariyoshi et al., 1993, Translocation of human platelet calpain-I., Biochem. Mol. Biol. Int.
Perides et al., 1987, Probing of the structural stability of vimentin and desmin-type intermediate filaments with Ca2+-activated proteinase, thrombin and lysine-specific endoproteinase Lys-C., Eur. J. Cell Biol.
Sloan et al., 1986, Effects of EACA on thrombin generation as measured by the chromagen S2238., Thromb. Res.
Weinstein et al., 2005, Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations., J. Neurochem.

THROMBIN A2M

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2432677

Sources:
NCI
THROMBIN F11

Interaction Score: 3.86

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
9787166 17635715

Sources:
NCI
THROMBIN DES

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3040412

Sources:
NCI
THROMBIN F2R

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15559761 15386385 15383630 15280447 14699102 12707033 11841573 11504518 10027305 16505172

Sources:
NCI
THROMBIN TPSAB1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9020112

Sources:
NCI
THROMBIN CD38

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9654134

Sources:
NCI
THROMBIN CAST

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8358337

Sources:
NCI
THROMBIN SERPINA5

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8136018

Sources:
NCI
THROMBIN ITGA2B

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7689831 14652636

Sources:
NCI
THROMBIN COL18A1

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15615851

Sources:
NCI
THROMBIN F5

Interaction Score: 0.64

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name ProFibrix B.V/

Novel drug target Established target

PMIDs:
17635715

Sources:
TdgClinicalTrial
THROMBIN FOS

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2119237

Sources:
NCI
THROMBIN LIF

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7007650

Sources:
NCI
THROMBIN F8

Interaction Score: 0.43

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Novel drug target Established target

Trial Name ProFibrix B.V/

PMIDs:
None found

Sources:
TdgClinicalTrial
THROMBIN HPSE

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1612123

Sources:
NCI
THROMBIN IFNG

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9731747

Sources:
NCI
THROMBIN ITGAL

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8598231

Sources:
NCI
THROMBIN FAS

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16271051

Sources:
NCI
THROMBIN CCN2

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10952976

Sources:
NCI
THROMBIN TGM2

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16202257

Sources:
NCI
THROMBIN IGF1R

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7499260 11375274

Sources:
NCI
THROMBIN ROCK2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16720831

Sources:
NCI
THROMBIN MYC

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3023371

Sources:
NCI
THROMBIN F10

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ProFibrix B.V/

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

TdgClinicalTrial: THROMBIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications topical tissue sealant

Drug Class protein

FDA Approval not approved

Publications:

NCI: THROMBIN

Version: 14-September-2017

Alternate Names:

C29499 NCI drug code

Drug Info:

Publications:

Minnema et al., 1998, Activation of clotting factor XI without detectable contact activation in experimental human endotoxemia., Blood

Whinna et al., 1993, Interaction of thrombin with antithrombin, heparin cofactor II, and protein C inhibitor., J. Protein Chem.

Derhaschnig et al., 2003, Blockade of GPIIb/IIIa by eptifibatide and tirofiban does not alter tissue factor induced thrombin generation in human endotoxemia., Thromb. Haemost.

ChemblDrugs: chembl:CHEMBL2108110
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	ProFibrix B.V/
Novel drug target	Established target

Novel drug target	Established target
Trial Name	ProFibrix B.V/

THROMBIN Drug Record

THROMBIN chembl:CHEMBL2108110 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2432677

Sources: NCI

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 9787166 17635715

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3040412

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15559761 15386385 15383630 15280447 14699102 12707033 11841573 11504518 10027305 16505172

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9020112

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9654134

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8358337

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8136018

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7689831 14652636

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15615851

Sources: NCI

Interaction Types & Directionality: activator (activating)

Interaction Info: Trial Name ProFibrix B.V/ Novel drug target Established target

PMIDs: 17635715

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2119237

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7007650

Sources: NCI

Interaction Types & Directionality: activator (activating)

Interaction Info: Novel drug target Established target Trial Name ProFibrix B.V/

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1612123

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9731747

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8598231

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16271051

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10952976

Interaction Types & Directionality:

n/a

PMIDs:
2432677

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

PMIDs:
9787166 17635715

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3040412

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15559761 15386385 15383630 15280447 14699102 12707033 11841573 11504518 10027305 16505172

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9020112

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9654134

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8358337

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8136018

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7689831 14652636

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15615851

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name ProFibrix B.V/

Novel drug target Established target

PMIDs:
17635715

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
2119237

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7007650

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Novel drug target Established target

Trial Name ProFibrix B.V/

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
1612123

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9731747

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8598231

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16271051

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10952976

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16202257

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7499260 11375274

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16720831

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3023371

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ProFibrix B.V/

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Drug Info:

Drug Indications topical tissue sealant

Drug Class protein

FDA Approval not approved

Alternate Names:

C29499 NCI drug code