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THIORIDAZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • THIORIDAZINE chembl:CHEMBL479

    Alternate Names:

    MELLERIL
    MELLARIL
    RIDERIL
    TP-21
    MELLARIL-S
    THIORIDAZINE
    THIORIDAZIN
    MEL269
    TIORIDAZINA
    THIORIDAZINUM
    3-METHYLMERCAPTO-N-(2'-(N-METHYL-2-PIPERIDYL)ETHYL)PHENOTHIAZINE
    MELLARIL®
    10-[2-(1-METHYL-2-PIPERIDYL)ETHYL]-2-METHYLSULFANYL-PHENOTHIAZINE
    2-METHYLMERCAPTO-10-(2-(N-METHYL-2-PIPERIDYL)ETHYL)PHENOTHIAZINE
    chemidplus:50-52-2
    chembl:CHEMBL479
    drugbank:00679
    rxcui:10502
    pubchem.compound:5452

    Drug Info:

    Drug Class antipsychotic agents
    Year of Approval 1962
    FDA Approval 1962
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    Drug Categories psycholeptics
    Drug Groups withdrawn
    Drug Categories adrenergic alpha-1 receptor antagonists
    Drug Categories adrenergic alpha-antagonists
    Drug Categories adrenergic antagonists
    Drug Categories agents that produce hypertension
    Drug Categories antidepressive agents
    Drug Categories cytochrome p-450 cyp2e1 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories dopamine d2 receptor antagonists
    Drug Categories drugs causing inadvertant photosensitivity
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories neurotoxic agents
    Drug Categories photosensitizing agents
    Drug Categories qtc prolonging agents
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 5-ht2 receptor antagonists
    Drug Categories serotonin agents
    Drug Categories serotonin receptor antagonists
    (6 More Sources)

    Publications:

    Cahir et al., 2005, Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat., Eur Neuropsychopharmacol
    Tay JK et al., 2007, Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia., Prog Neuropsychopharmacol Biol Psychiatry
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
    Dorado P et al., 2009, Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients., Pharmacogenomics
    von Bahr C et al., 1991, Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype., Clin Pharmacol Ther
    Hammock et al., 1995, The effect of clozapine on self-injurious behavior., J Autism Dev Disord
    Katchman AN et al., 2006, Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs., J Pharmacol Exp Ther
    Milnes et al., 2006, hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656., Biochem. Biophys. Res. Commun.
    Costall et al., 1995, Behavioural interactions between 5-hydroxytryptophan, neuroleptic agents and 5-HT receptor antagonists in modifying rodent responding to aversive situations., Br. J. Pharmacol.
    Morisset et al., 1999, Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade., J. Pharmacol. Exp. Ther.
    Canton et al., 1994, Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptor-mediated phosphoinositide (PI) turnover by clozapine in the rat: a comparison to other antipsychotics., Neurosci. Lett.
    Andree et al., 1986, Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex., J. Neurochem.
    Burki, 1986, Binding of psychoactive drugs to rat brain amine receptors, measured ex vivo, and their effects on the metabolism of biogenic amines., Naunyn Schmiedebergs Arch. Pharmacol.
    Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
    Assié et al., 1993, Biphasic displacement of [3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics., Eur. J. Pharmacol.
    Carey et al., 1997, Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs., Psychopharmacology (Berl.)
    Seeman, 1990, Atypical neuroleptics: role of multiple receptors, endogenous dopamine, and receptor linkage., Acta Psychiatr Scand Suppl
    Barth et al., 2006, Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer., Life Sci.
    Dimpfel et al., 1992, Different neuroleptics show common dose and time dependent effects in quantitative field potential analysis in freely moving rats., Psychopharmacology (Berl.)
  • THIORIDAZINE   CYP2J2

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • THIORIDAZINE   HTR2A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    8680734 9918563 7898773 2866233 2423886


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • THIORIDAZINE   DRD2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction D2-like dopamine receptor antagonist

    PMIDs:
    7689973 9292626 1978482 16434058 1352051


    Sources:
    TEND TdgClinicalTrial TTD DrugBank ChemblInteractions

  • THIORIDAZINE   DRD1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Endogenous Drug? False

    PMIDs:
    8720030


    Sources:
    TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology

  • THIORIDAZINE   ADRA1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7691623 15695070


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIORIDAZINE   DRD5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIORIDAZINE   HTR6

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIORIDAZINE   ADRA1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15695070


    Sources:
    DrugBank

  • THIORIDAZINE   HTR2C

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • THIORIDAZINE   HTR7

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIORIDAZINE   DRD4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction D2-like dopamine receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THIORIDAZINE   KCNH2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16278312 17056009


    Sources:
    PharmGKB DrugBank

  • THIORIDAZINE   DRD3

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THIORIDAZINE   PPARD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIORIDAZINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19604081 2007317


    Sources:
    FDA PharmGKB

  • THIORIDAZINE   HTR1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIORIDAZINE   HRH1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIORIDAZINE   CBX1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIORIDAZINE   ATXN2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIORIDAZINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17611010


    Sources:
    PharmGKB

  • THIORIDAZINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00679

    • Version: 5.1.7

    Alternate Names:
    THIORIDAZINE DrugBank Drug Name
    50-52-2 CAS Number
    Aldazine Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups withdrawn

    Publications:
    Milnes et al., 2006, hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656., Biochem. Biophys. Res. Commun.
    Assié et al., 1993, Biphasic displacement of [3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics., Eur. J. Pharmacol.
    Carey et al., 1997, Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs., Psychopharmacology (Berl.)

  • TEND: THIORIDAZINE

    • Version: 01-August-2011

    Alternate Names:
    THIORIDAZINE Primary Drug Name

    Drug Info:
    Year of Approval 1962
    Drug Class antipsychotic agents

    Publications:

  • TdgClinicalTrial: THIORIDAZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antipsychotic Agents
    Drug Class small molecule
    FDA Approval 1962

    Publications:

  • PharmGKB: thioridazine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Tay JK et al., 2007, Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia., Prog Neuropsychopharmacol Biol Psychiatry
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
    Dorado P et al., 2009, Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients., Pharmacogenomics

  • DTC: THIORIDAZINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL479 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Thioridazine

    • Version: 2020.06.01

    Alternate Names:
    D0U1OE TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135651259

    • Version: 29-September-2020

    Alternate Names:
    THIORIDAZINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL479

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Thioridazine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL479

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21