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THIOGUANINE Drug Record

  • Summary
  • Interactions
  • Claims
  • THIOGUANINE chembl:CHEMBL727 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    LANVIS
    TIOGUANINE HEMIHYDRATE
    TABLOID
    NSC-76504
    THIOGUANINE
    TIOGUANINE
    NSC-752
    TG
    2-AMINO-1,7-DIHYDRO-6H-PURINE-6-THIONE
    2-AMINO-6-MERCAPTOPURINE
    6-TG
    2-AMINOPURINE-6-THIOL
    2-AMINOPURINE-6(1H)-THIONE
    THG
    2-AMINOPURIN-6-THIOL
    6-MERCAPTOGUANINE
    THIOGUANINE ANHYDROUS
    2-AMINO-6-PURINETHIOL
    6-MERCAPTO-2-AMINOPURINE
    2-AMINO-1,9-DIHYDROPURINE-6-THIONE
    TIOGUANIN
    2-AMINO 6MP
    chemidplus:154-42-7
    chembl:CHEMBL727
    rxcui:1546005
    pubchem.compound:2723601
    drugbank:00352

    Drug Info:

    (6 More Sources)

    Publications:

    Ciesielski-Treska et al., 1975, Morphological, histochemical and chromosomal patterns of neuroblastoma parental and purine resistant lines., Neurobiology
    Meyer JA et al., 2013, Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia., Nat Genet
    Tzoneva et al., 2013, Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL., Nat. Med.
    Li B et al., 2015, Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL., Nat Med
    Perez-Andreu V et al., 2013, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse., Nat Genet
    French et al., 1991, Queuine, a tRNA anticodon wobble base, maintains the proliferative and pluripotent potential of HL-60 cells in the presence of the differentiating agent 6-thioguanine., Proc. Natl. Acad. Sci. U.S.A.
    Valerie NC et al., 2016, NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine., Cancer Res
    Moriyama T et al., 2016, NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity., Nat Genet
    Mirzayans et al., 1992, Cytotoxic and mutagenic effects of methylnitrosourea in two human fetal fibroblast strains differing in O6-methylguanine-DNA methyltransferase activity., Carcinogenesis
    Karol SE et al., 2016, Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Blood
    Cheng et al., 2005, Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes., Nat. Genet.
    Bai et al., 2004, Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione., Int. J. Biochem. Cell Biol.
    Volonté et al., 1993, A purine analog-sensitive protein kinase activity associates with Trk nerve growth factor receptors., J. Neurochem.
    Saxena et al., 1980, New imidazolylthiocarbamides as guanine deaminase inhibitors., Pharmazie
  • THIOGUANINE   NUDT15

    Interaction Score: 3.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27530327 26878724


    Sources:
    CIViC PharmGKB FDA

  • THIOGUANINE   GDA

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7384171


    Sources:
    NCI

  • THIOGUANINE   PRPS1

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25962120


    Sources:
    CIViC

  • THIOGUANINE   NT5C2

    Interaction Score: 1.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23377183 23377281


    Sources:
    CIViC

  • THIOGUANINE   GGH

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16041371


    Sources:
    NCI

  • THIOGUANINE   TPM3

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7687657


    Sources:
    NCI

  • THIOGUANINE   DOK5

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • THIOGUANINE   LINC00251

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • THIOGUANINE   BMP7

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • THIOGUANINE   GATA3

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24141364


    Sources:
    PharmGKB

  • THIOGUANINE   IMPDH2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THIOGUANINE   TPMT

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • THIOGUANINE   MGMT

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1638685


    Sources:
    NCI

  • THIOGUANINE   IMPDH1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THIOGUANINE   ABCC4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14643890


    Sources:
    NCI

  • THIOGUANINE   MYC

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1988936


    Sources:
    NCI

  • THIOGUANINE   ACHE

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1207869


    Sources:
    NCI

  • THIOGUANINE   HBB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOGUANINE   NAT1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • THIOGUANINE   PAX8

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOGUANINE   HPGD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOGUANINE   IDH1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOGUANINE   KDM4A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOGUANINE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOGUANINE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOGUANINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: THIOGUANINE

    • Version: 14-September-2017

    Alternate Names:
    C876 NCI drug code

    Drug Info:

    Publications:
    Saxena et al., 1980, New imidazolylthiocarbamides as guanine deaminase inhibitors., Pharmazie
    Cheng et al., 2005, Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes., Nat. Genet.

  • NCI: 6-TG

    • Version: 14-September-2017

    Alternate Names:
    C876 NCI drug code

    Drug Info:

    Publications:
    French et al., 1991, Queuine, a tRNA anticodon wobble base, maintains the proliferative and pluripotent potential of HL-60 cells in the presence of the differentiating agent 6-thioguanine., Proc. Natl. Acad. Sci. U.S.A.

  • NCI: 6-THIOGUANINE

    • Version: 14-September-2017

    Alternate Names:
    C876 NCI drug code

    Drug Info:

    Publications:
    Ciesielski-Treska et al., 1975, Morphological, histochemical and chromosomal patterns of neuroblastoma parental and purine resistant lines., Neurobiology
    Mirzayans et al., 1992, Cytotoxic and mutagenic effects of methylnitrosourea in two human fetal fibroblast strains differing in O6-methylguanine-DNA methyltransferase activity., Carcinogenesis
    Bai et al., 2004, Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione., Int. J. Biochem. Cell Biol.

  • PharmGKB: thioguanine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Perez-Andreu V et al., 2013, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse., Nat Genet
    Karol SE et al., 2016, Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Blood
    Valerie NC et al., 2016, NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine., Cancer Res

  • CIViC: THIOGUANINE

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Meyer JA et al., 2013, Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia., Nat Genet
    Tzoneva et al., 2013, Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL., Nat. Med.
    Moriyama T et al., 2016, NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity., Nat Genet

  • TTD: Thioguanine

    • Version: 2020.06.01

    Alternate Names:
    D02ZXM TTD Drug ID

    Drug Info:

    Publications:

  • DTC: THIOGUANINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL727 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL727

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL727

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Thioguanine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21