DGIdb - THEOPHYLLINE Drug Record

THEOPHYLLINE chembl:CHEMBL190 Approved

Alternate Names:

THEOCLEAR-100
DIMETHYLXANTHINE
AEROLATE SR
NUELIN SA-250
LABID
NUELIN SA
UNIPHYL
T-PHYL
SOMOPHYLLIN-CRT
UNIPHYLLIN CONTINUS
AEROLATE III
ELIXOMIN
PRO-VENT
SLO-BID
THEOCLEAR-80
SUSTAIRE
AEROLATE
SOMOPHYLLIN-T
THEOLAIR-SR
THEOCLEAR L.A.-130
THEOCLEAR-200
THEOPHYL
NSC-2066
THEOPHYL-SR
LANOPHYLLIN
UNI-DUR
THEOGRAD
THEOPHYL-225
QUIBRON-T
BRONKODYL
THEOPHYLLINE MONOHYDRATE
QUIBRON
LASMA
THEOCLEAR L.A.-260
ELIXOPHYLLIN
THEOLAIR
THEOBID JR.
QUIBRON-T/SR
THEOLIXIR
SLO-PHYLLIN
NUELIN
THEOVENT
THEOCHRON
AEROLATE JR
RESPBID
ACCURBRON
THEOPHYLLINE
THEOPHYLLINE MELTING POINT STANDARD
THEOBID
THEO-24
ELIXICON
THEOCIN
DURAPHYL
THEO-DUR
THEOPHYLLINE-SR
AQUAPHYLLIN
ELIXOPHYLLIN SR
THEACITIN
UNIFYL
SYNOPHYLATE-L.A. CENULES
SLO-BID®
THEOCLEAR 80
AMINOPHYLLINE
TEFAMIN
PSEUDOTHEOPHYLLINE
AUSTYN
ACET-THEOCIN
MEDAPHYLLIN
THEOPHYLLINE, ANHYDROUS
TEOFYLLAMIN
EUPHYLONG
DIPHYLLIN
THEOFOL
UNIPHYLLIN
XANTHIUM
ELIXEX
SOLOSIN
SYNOPHYLATE
TEOLAIR
THEOCLEAR LA
THEOSTAT 80
MAPHYLLINE
THEAL TABLETS
THEOPHYLLINE ANHYDROUS
TEOFILINA
THEOCLAIR-SR
1,3-DIMETHYL-7H-PURINE-2,6-DIONE
OPTIPHYLLIN
DORAPHYLLIN
NUELIN®
PARKOPHYLLIN
ELIXOPHYLLINE
THEOPHYLLIN
ASBRON
THEAL TABL.
THEO-DUR-SPRINKLE
BRONKODYL SR
QUIBRON T/SR
SOMOPHYLLIN-DF
THEODEL
DYSPNE-INHAL
ASMAX
LIQUOPHYLLINE
THEOLIX
ARMOPHYLLINE
THEOLAIR®
THEONA P
CHOLEDYL SA
XANTIVENT
SPOPHYLLIN RETARD
THEOPHYLINE
1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
THEOCONTIN
EUPHYLLINE
CONSTANT-T
1,3-DIMETHYLXANTHINE
chembl:CHEMBL190
pubchem.compound:2153
chemidplus:58-55-9
drugbank:00277
rxcui:91178

Drug Info:

Year of Approval	approved before 1982
Drug Class	bronchodilator agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	bronchodilator

(4 More Sources)

Publications:

Phelps et al., 2006, Characterization of adenosine receptors in the human bladder carcinoma T24 cell line., Eur. J. Pharmacol.
Philipp et al., 2006, Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade., Cardiovasc. Res.
Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
Holgate, 2005, The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Fozard et al., 2003, Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog., Eur. J. Pharmacol.
Lipworth, Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease., Lancet
Usta et al., 2004, The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations., Prostaglandins Leukot. Essent. Fatty Acids
Haider, 2003, Cyclic AMP level and phosphodiesterase activity during 17alpha,20beta-dihydroxy-4-pregnen-3-one induction and theophylline inhibition of oocyte maturation in the catfish, Clarias batrachus., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
Wang et al., 2002, Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45., Acta Pharmacol. Sin.
Lee et al., 2004, Modulation of thyroidal radioiodine uptake by theophylline., Exp. Mol. Pathol.
Rickards et al., 2003, Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation., J. Vet. Pharmacol. Ther.
Kajikawa et al., 2006, Changes in submaxillary gland gene expression in F344 rats by multiple dosing of theophylline., Exp. Anim.
Wu et al., 2004, KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels., Br. J. Pharmacol.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Pedersen et al., 1996, Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking., Am. J. Respir. Crit. Care Med.
Nakano et al., 2000, Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK., Circ. Res.
Pechlivanova et al., 2005, Effects of single and long-term theophylline treatment on the threshold of mechanical nociception: contribution of adenosine A1 and alpha2-adrenoceptors., Methods Find Exp Clin Pharmacol
Nantwi et al., 2003, Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection., J Spinal Cord Med
Zarrindast et al., 2002, Role of nitric oxide in systemic effect of theophylline on mouse body temperature., Eur. J. Pharmacol.
Sikorska et al., 1988, The regulatory and catalytic subunits of cAMP-dependent protein kinases are associated with transcriptionally active chromatin during changes in gene expression., J. Biol. Chem.
Gunes A et al., 2008, Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms., Pharmacogenomics
Nie et al., 2002, Effects of theophylline on CD4+ T lymphocyte, interleukin-5, and interferon gamma in induced sputum of asthmatic subjects., Acta Pharmacol. Sin.
Hancock et al., 1988, Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E., J. Immunol.
Spoelstra et al., 1998, Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro., Eur. Respir. J.

THEOPHYLLINE PRKAR2B

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2893795

Sources:
NCI
THEOPHYLLINE ADORA2B

Interaction Score: 1.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
16581066 16545350 3588607 15980878 11752352 12954362

Sources:
TdgClinicalTrial ChemblInteractions TEND
THEOPHYLLINE MAPKAPK2

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10666409

Sources:
NCI
THEOPHYLLINE PDE3A

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Trial Name ADC4022, low-dose inhaled theophylline

PMIDs:
16651698 15237094 12887610

Sources:
TdgClinicalTrial ChemblInteractions TEND
THEOPHYLLINE PDE4A

Interaction Score: 0.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ADC4022, low-dose inhaled theophylline

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
15253881 12547256 12421478 15351234 12887610

Sources:
TdgClinicalTrial ChemblInteractions TEND
THEOPHYLLINE ITGAM

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9762784

Sources:
NCI
THEOPHYLLINE ADORA1

Interaction Score: 0.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
3588607 14992338

Sources:
TdgClinicalTrial ChemblInteractions TEND
THEOPHYLLINE PDE5A

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND
THEOPHYLLINE PDE3B

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE ADORA2A

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
16357952 3588607

Sources:
ChemblInteractions TEND
THEOPHYLLINE PDE4B

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ADC4022, low-dose inhaled theophylline

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
15639300

Sources:
TdgClinicalTrial ChemblInteractions TEND
THEOPHYLLINE IFNG

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11918854

Sources:
NCI
THEOPHYLLINE MPO

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8630596

Sources:
NCI
THEOPHYLLINE NOS2

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12223230

Sources:
NCI
THEOPHYLLINE PDE4C

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE IL2RA

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3129507

Sources:
NCI
THEOPHYLLINE NOS1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12223230

Sources:
NCI
THEOPHYLLINE ADORA3

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE XDH

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
THEOPHYLLINE CYP2E1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
THEOPHYLLINE PDE4D

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18466106

Sources:
PharmGKB
THEOPHYLLINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
THEOPHYLLINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: THEOPHYLLINE
- Version: 01-August-2011
Alternate Names:

THEOPHYLLINE Primary Drug Name

Drug Info:

Drug Class bronchodilator agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: THEOPHYLLINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications bronchodilator

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: THEOPHYLLINE

Version: 14-September-2017

Alternate Names:

C872 NCI drug code

Drug Info:

Publications:

Hancock et al., 1988, Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E., J. Immunol.

Spoelstra et al., 1998, Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro., Eur. Respir. J.

Nakano et al., 2000, Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK., Circ. Res.

PharmGKB: theophylline

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Gunes A et al., 2008, Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms., Pharmacogenomics

DTC: THEOPHYLLINE
- Version: 02-September-2020
Alternate Names:

CHEMBL190 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Theophylline
- Version: 2020.06.01
Alternate Names:

D0F8RA TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL190
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL190
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	ADC4022, low-dose inhaled theophylline
Novel drug target	Established target
Mechanism of Interaction	Adenosine receptor antagonist

Direct Interaction	yes
Mechanism of Interaction	Phosphodiesterase 3 inhibitor
Trial Name	ADC4022, low-dose inhaled theophylline

Mechanism of Interaction	Phosphodiesterase 4 inhibitor
Direct Interaction	yes

THEOPHYLLINE Drug Record

THEOPHYLLINE chembl:CHEMBL190 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2893795

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name ADC4022, low-dose inhaled theophylline Novel drug target Established target Mechanism of Interaction Adenosine receptor antagonist

PMIDs: 16581066 16545350 3588607 15980878 11752352 12954362

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10666409

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3 inhibitor Trial Name ADC4022, low-dose inhaled theophylline

PMIDs: 16651698 15237094 12887610

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ADC4022, low-dose inhaled theophylline Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 15253881 12547256 12421478 15351234 12887610

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9762784

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name ADC4022, low-dose inhaled theophylline Novel drug target Established target Mechanism of Interaction Adenosine receptor antagonist

PMIDs: 3588607 14992338

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ADC4022, low-dose inhaled theophylline Novel drug target Established target

PMIDs: 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: 16357952 3588607

Sources: ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ADC4022, low-dose inhaled theophylline Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 15639300

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11918854

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8630596

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12223230

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3129507

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12223230

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
2893795

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
16581066 16545350 3588607 15980878 11752352 12954362

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
10666409

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Trial Name ADC4022, low-dose inhaled theophylline

PMIDs:
16651698 15237094 12887610

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ADC4022, low-dose inhaled theophylline

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
15253881 12547256 12421478 15351234 12887610

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
9762784

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
3588607 14992338

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
16357952 3588607

Sources:
ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ADC4022, low-dose inhaled theophylline

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
15639300

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
11918854

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8630596

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12223230

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
3129507

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12223230

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18466106

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB