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THEOPHYLLINE Drug Record

  • Summary
  • Interactions
  • Claims
  • THEOPHYLLINE chembl:CHEMBL190 Approved

    Alternate Names:

    THEOCLEAR-100
    DIMETHYLXANTHINE
    AEROLATE SR
    NUELIN SA-250
    LABID
    NUELIN SA
    UNIPHYL
    T-PHYL
    SOMOPHYLLIN-CRT
    UNIPHYLLIN CONTINUS
    AEROLATE III
    ELIXOMIN
    PRO-VENT
    SLO-BID
    THEOCLEAR-80
    SUSTAIRE
    AEROLATE
    SOMOPHYLLIN-T
    THEOLAIR-SR
    THEOCLEAR L.A.-130
    THEOCLEAR-200
    THEOPHYL
    NSC-2066
    THEOPHYL-SR
    LANOPHYLLIN
    UNI-DUR
    THEOGRAD
    THEOPHYL-225
    QUIBRON-T
    BRONKODYL
    THEOPHYLLINE MONOHYDRATE
    QUIBRON
    LASMA
    THEOCLEAR L.A.-260
    ELIXOPHYLLIN
    THEOLAIR
    THEOBID JR.
    QUIBRON-T/SR
    THEOLIXIR
    SLO-PHYLLIN
    NUELIN
    THEOVENT
    THEOCHRON
    AEROLATE JR
    RESPBID
    ACCURBRON
    THEOPHYLLINE
    THEOPHYLLINE MELTING POINT STANDARD
    THEOBID
    THEO-24
    ELIXICON
    THEOCIN
    DURAPHYL
    THEO-DUR
    THEOPHYLLINE-SR
    AQUAPHYLLIN
    ELIXOPHYLLIN SR
    THEACITIN
    UNIFYL
    SYNOPHYLATE-L.A. CENULES
    SLO-BID®
    THEOCLEAR 80
    AMINOPHYLLINE
    TEFAMIN
    PSEUDOTHEOPHYLLINE
    AUSTYN
    ACET-THEOCIN
    MEDAPHYLLIN
    THEOPHYLLINE, ANHYDROUS
    TEOFYLLAMIN
    EUPHYLONG
    DIPHYLLIN
    THEOFOL
    UNIPHYLLIN
    XANTHIUM
    ELIXEX
    SOLOSIN
    SYNOPHYLATE
    TEOLAIR
    THEOCLEAR LA
    THEOSTAT 80
    MAPHYLLINE
    THEAL TABLETS
    THEOPHYLLINE ANHYDROUS
    TEOFILINA
    THEOCLAIR-SR
    1,3-DIMETHYL-7H-PURINE-2,6-DIONE
    OPTIPHYLLIN
    DORAPHYLLIN
    NUELIN®
    PARKOPHYLLIN
    ELIXOPHYLLINE
    THEOPHYLLIN
    ASBRON
    THEAL TABL.
    THEO-DUR-SPRINKLE
    BRONKODYL SR
    QUIBRON T/SR
    SOMOPHYLLIN-DF
    THEODEL
    DYSPNE-INHAL
    ASMAX
    LIQUOPHYLLINE
    THEOLIX
    ARMOPHYLLINE
    THEOLAIR®
    THEONA P
    CHOLEDYL SA
    XANTIVENT
    SPOPHYLLIN RETARD
    THEOPHYLINE
    1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
    THEOCONTIN
    EUPHYLLINE
    CONSTANT-T
    1,3-DIMETHYLXANTHINE
    chembl:CHEMBL190
    pubchem.compound:2153
    chemidplus:58-55-9
    drugbank:00277
    rxcui:91178

    Drug Info:

    Year of Approval approved before 1982
    Drug Class bronchodilator agents
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications bronchodilator
    (4 More Sources)

    Publications:

    Phelps et al., 2006, Characterization of adenosine receptors in the human bladder carcinoma T24 cell line., Eur. J. Pharmacol.
    Philipp et al., 2006, Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade., Cardiovasc. Res.
    Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
    Holgate, 2005, The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Fozard et al., 2003, Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog., Eur. J. Pharmacol.
    Lipworth, Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease., Lancet
    Usta et al., 2004, The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations., Prostaglandins Leukot. Essent. Fatty Acids
    Haider, 2003, Cyclic AMP level and phosphodiesterase activity during 17alpha,20beta-dihydroxy-4-pregnen-3-one induction and theophylline inhibition of oocyte maturation in the catfish, Clarias batrachus., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
    Wang et al., 2002, Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45., Acta Pharmacol. Sin.
    Lee et al., 2004, Modulation of thyroidal radioiodine uptake by theophylline., Exp. Mol. Pathol.
    Rickards et al., 2003, Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation., J. Vet. Pharmacol. Ther.
    Kajikawa et al., 2006, Changes in submaxillary gland gene expression in F344 rats by multiple dosing of theophylline., Exp. Anim.
    Wu et al., 2004, KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels., Br. J. Pharmacol.
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Pedersen et al., 1996, Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking., Am. J. Respir. Crit. Care Med.
    Nakano et al., 2000, Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK., Circ. Res.
    Pechlivanova et al., 2005, Effects of single and long-term theophylline treatment on the threshold of mechanical nociception: contribution of adenosine A1 and alpha2-adrenoceptors., Methods Find Exp Clin Pharmacol
    Nantwi et al., 2003, Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection., J Spinal Cord Med
    Zarrindast et al., 2002, Role of nitric oxide in systemic effect of theophylline on mouse body temperature., Eur. J. Pharmacol.
    Sikorska et al., 1988, The regulatory and catalytic subunits of cAMP-dependent protein kinases are associated with transcriptionally active chromatin during changes in gene expression., J. Biol. Chem.
    Gunes A et al., 2008, Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms., Pharmacogenomics
    Nie et al., 2002, Effects of theophylline on CD4+ T lymphocyte, interleukin-5, and interferon gamma in induced sputum of asthmatic subjects., Acta Pharmacol. Sin.
    Hancock et al., 1988, Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E., J. Immunol.
    Spoelstra et al., 1998, Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro., Eur. Respir. J.
  • THEOPHYLLINE   PRKAR2B

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2893795


    Sources:
    NCI

  • THEOPHYLLINE   ADORA2B

    Interaction Score: 1.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ADC4022, low-dose inhaled theophylline
    Novel drug target Established target
    Mechanism of Interaction Adenosine receptor antagonist

    PMIDs:
    16581066 16545350 3588607 15980878 11752352 12954362


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • THEOPHYLLINE   MAPKAPK2

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10666409


    Sources:
    NCI

  • THEOPHYLLINE   PDE3A

    Interaction Score: 0.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Phosphodiesterase 3 inhibitor
    Trial Name ADC4022, low-dose inhaled theophylline

    PMIDs:
    16651698 15237094 12887610


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • THEOPHYLLINE   PDE4A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ADC4022, low-dose inhaled theophylline
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    15253881 12547256 12421478 15351234 12887610


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • THEOPHYLLINE   ITGAM

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9762784


    Sources:
    NCI

  • THEOPHYLLINE   ADORA1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ADC4022, low-dose inhaled theophylline
    Novel drug target Established target
    Mechanism of Interaction Adenosine receptor antagonist

    PMIDs:
    3588607 14992338


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • THEOPHYLLINE   PDE5A

    Interaction Score: 0.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ADC4022, low-dose inhaled theophylline
    Novel drug target Established target

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial TEND

  • THEOPHYLLINE   PDE3B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE   ADORA2A

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    16357952 3588607


    Sources:
    ChemblInteractions TEND

  • THEOPHYLLINE   PDE4B

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ADC4022, low-dose inhaled theophylline
    Mechanism of Interaction Phosphodiesterase 4 inhibitor

    PMIDs:
    15639300


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • THEOPHYLLINE   IFNG

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11918854


    Sources:
    NCI

  • THEOPHYLLINE   MPO

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8630596


    Sources:
    NCI

  • THEOPHYLLINE   NOS2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12223230


    Sources:
    NCI

  • THEOPHYLLINE   PDE4C

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE   IL2RA

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3129507


    Sources:
    NCI

  • THEOPHYLLINE   NOS1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12223230


    Sources:
    NCI

  • THEOPHYLLINE   ADORA3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE   XDH

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • THEOPHYLLINE   CYP2E1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • THEOPHYLLINE   PDE4D

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18466106


    Sources:
    PharmGKB

  • THEOPHYLLINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • THEOPHYLLINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: THEOPHYLLINE

    • Version: 01-August-2011

    Alternate Names:
    THEOPHYLLINE Primary Drug Name

    Drug Info:
    Drug Class bronchodilator agents
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: THEOPHYLLINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications bronchodilator
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: THEOPHYLLINE

    • Version: 14-September-2017

    Alternate Names:
    C872 NCI drug code

    Drug Info:

    Publications:
    Hancock et al., 1988, Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E., J. Immunol.
    Spoelstra et al., 1998, Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro., Eur. Respir. J.
    Nakano et al., 2000, Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK., Circ. Res.

  • PharmGKB: theophylline

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Gunes A et al., 2008, Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms., Pharmacogenomics

  • DTC: THEOPHYLLINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL190 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Theophylline

    • Version: 2020.06.01

    Alternate Names:
    D0F8RA TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL190

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL190

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21