DGIdb - TEZAMPANEL Drug Record

TEZAMPANEL chembl:CHEMBL14935

Alternate Names:

NGX-424
LY-293558
LY-293,558

Drug Info:

FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antimigraine agent,analgesic
Drug Type	small molecule
Drug Groups	investigational
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	receptors, ampa, antagonists & inhibitors

(1 More Sources)

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

TEZAMPANEL GRIK1

Interaction Score: 3.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

Trial Name tezampanel, NGX424,NGX426

PMIDs:
10592235

Sources:
TdgClinicalTrial DrugBank ChemblInteractions
TEZAMPANEL GRIK3

Interaction Score: 1.89

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name tezampanel, NGX424,NGX426

Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
TEZAMPANEL GRIK4

Interaction Score: 1.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

Direct Interaction yes

Trial Name tezampanel, NGX424,NGX426

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
TEZAMPANEL GRIK5

Interaction Score: 1.42

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
TEZAMPANEL GABBR1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
TEZAMPANEL GRIA4

Interaction Score: 0.77

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions
TEZAMPANEL GRIA3

Interaction Score: 0.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Established target

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions
TEZAMPANEL GRIA1

Interaction Score: 0.52

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions
TEZAMPANEL GRIK2

Interaction Score: 0.52

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
TEZAMPANEL GRIA2

Interaction Score: 0.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions

DrugBank: DB06354
- Version: 5.1.7
Alternate Names:

TEZAMPANEL DrugBank Drug Name

154652-83-2 CAS Number

CHEMBL14935 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories heterocyclic compounds, fused-ring

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
TdgClinicalTrial: TEZAMPANEL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antimigraine agent,analgesic

Drug Class small molecule

FDA Approval not approved

Publications:
GuideToPharmacology: 178101062
- Version: 29-September-2020
Alternate Names:

TEZAMPANEL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblInteractions: CHEMBL14935
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL14935
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Glutamate receptor ionotropic kainate antagonist
Trial Name	tezampanel, NGX424,NGX426

Novel drug target	Novel Target
Trial Name	tezampanel, NGX424,NGX426
Mechanism of Interaction	Glutamate receptor ionotropic kainate antagonist

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Antagonist

TEZAMPANEL	DrugBank Drug Name
154652-83-2	CAS Number
CHEMBL14935	ChEMBL ID

TEZAMPANEL Drug Record

TEZAMPANEL chembl:CHEMBL14935

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist Trial Name tezampanel, NGX424,NGX426

PMIDs: 10592235

Sources: TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name tezampanel, NGX424,NGX426 Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist Direct Interaction yes Trial Name tezampanel, NGX424,NGX426

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name tezampanel, NGX424,NGX426 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tezampanel, NGX424,NGX426 Novel drug target Established target Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tezampanel, NGX424,NGX426 Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist Direct Interaction yes Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tezampanel, NGX424,NGX426 Novel drug target Established target Direct Interaction yes

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology ChemblInteractions

DrugBank: DB06354

Alternate Names: TEZAMPANEL DrugBank Drug Name 154652-83-2 CAS Number CHEMBL14935 ChEMBL ID

Drug Info: Drug Type small molecule Drug Groups investigational Drug Categories heterocyclic compounds, fused-ring

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

TdgClinicalTrial: TEZAMPANEL

Alternate Names:

Drug Info: Drug Indications antimigraine agent,analgesic Drug Class small molecule FDA Approval not approved

Publications:

GuideToPharmacology: 178101062

Alternate Names: TEZAMPANEL GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblInteractions: CHEMBL14935

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL14935

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

Trial Name tezampanel, NGX424,NGX426

PMIDs:
10592235

Sources:
TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name tezampanel, NGX424,NGX426

Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

Direct Interaction yes

Trial Name tezampanel, NGX424,NGX426

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Established target

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions

Alternate Names:

TEZAMPANEL DrugBank Drug Name

154652-83-2 CAS Number

CHEMBL14935 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories heterocyclic compounds, fused-ring

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Drug Info:

Drug Indications antimigraine agent,analgesic

Drug Class small molecule

FDA Approval not approved

Alternate Names:

TEZAMPANEL GuideToPharmacology Ligand Name