DGIdb - TETRACAINE Drug Record

TETRACAINE chembl:CHEMBL698 Approved

Alternate Names:

AMETHOCAINE
DICAINE
TETRACAINE
AMETOP
METRASPRAY
MEDIHALER-TETRACAINE
PONTOCAINE
2-(DIMETHYLAMINO)ETHYL 4-(BUTYLAMINO)BENZOATE
P-(BUTYLAMINO)BENZOIC ACID Β-(DIMETHYLAMINO)ETHYL ESTER
P-BUTYLAMINOBENZOYL-2-DIMETHYLAMINOETHANOL
TETRACAINE HCL
P-(BUTYLAMINO)BENZOIC ACID BETA-(DIMETHYLAMINO)ETHYL ESTER
TETRACAÍNA
AMETHOCAINE HCL
2-(DIMETHYLAMINO)ETHYL P-(BUTYLAMINO)BENZOATE
TET150
TÉTRACAÏNE
DIÄTHYLAMINOÄTHANOL ESTER DER P-BUTYLAMINOBENZÖSÄURE
rxcui:10391
chemidplus:94-24-6
chembl:CHEMBL698
pubchem.compound:5411
drugbank:09085

Drug Info:

Drug Categories	aminobenzoates
Drug Categories	anesthetics for topical use
Drug Categories	anesthetics, general
Drug Categories	antipruritics and local anesthetics
Drug Categories	antipruritics, incl. antihistamines, anesthetics, etc.
Drug Categories	dental agents
Drug Categories	dermatologicals
Drug Categories	ester local anesthetic
Drug Categories	esters of aminobenzoic acid
Drug Categories	local anesthesia
Drug Categories	nervous system
Drug Categories	ophthalmologicals
Drug Categories	sensory organs

(1 More Sources)

Publications:

Lanner et al., 2010, Ryanodine receptors: structure, expression, molecular details, and function in calcium release., Cold Spring Harb Perspect Biol
Laver et al., 2011, Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels., J. Mol. Cell. Cardiol.
Gammaitoni AR et al., 2013, Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain., J Pain Res
Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol

TETRACAINE RYR2

Interaction Score: 1.09

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
20961976 21624373

Sources:
DrugBank
TETRACAINE RYR1

Interaction Score: 0.77

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
20961976 21624373

Sources:
DrugBank
TETRACAINE SCN1A

Interaction Score: 0.23

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
23888118 22053156

Sources:
DrugBank ChemblInteractions
TETRACAINE SCN10A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
TTD ChemblInteractions
TETRACAINE SCN7A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE SCN8A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE SCN11A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE SCN2A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE SCN4A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE SCN9A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE G6PD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Tetracaine

Combination therapy Oxymetazoline,Tetracaine

PMIDs:
None found

Sources:
FDA
TETRACAINE SCN5A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

DrugBank: DB09085

Version: 5.1.7

Alternate Names:

TETRACAINE DrugBank Drug Name

94-24-6 CAS Number

Altacaine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Publications:

Lanner et al., 2010, Ryanodine receptors: structure, expression, molecular details, and function in calcium release., Cold Spring Harb Perspect Biol

Laver et al., 2011, Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels., J. Mol. Cell. Cardiol.

Gammaitoni AR et al., 2013, Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain., J Pain Res

TTD: Tetracaine
- Version: 2020.06.01
Alternate Names:

D08HQK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL698
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL698
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Tetracaine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Sodium channel alpha subunit blocker

Combination therapy	Lidocaine,Tetracaine
Combination therapy	Oxymetazoline,Tetracaine

TETRACAINE	DrugBank Drug Name
94-24-6	CAS Number
Altacaine	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	vet_approved

TETRACAINE Drug Record

TETRACAINE chembl:CHEMBL698 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 20961976 21624373

Sources: DrugBank

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 20961976 21624373

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 23888118 22053156

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: TTD ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Lidocaine,Tetracaine Combination therapy Oxymetazoline,Tetracaine

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

DrugBank: DB09085

Alternate Names: TETRACAINE DrugBank Drug Name 94-24-6 CAS Number Altacaine Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups vet_approved

TTD: Tetracaine

Alternate Names: D08HQK TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL698

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL698

Alternate Names:

Drug Info:

Publications:

FDA: Tetracaine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

modulator

PMIDs:
20961976 21624373

Sources:
DrugBank

Interaction Types & Directionality:

modulator

PMIDs:
20961976 21624373

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
23888118 22053156

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Tetracaine

Combination therapy Oxymetazoline,Tetracaine

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

TETRACAINE DrugBank Drug Name

94-24-6 CAS Number

Altacaine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Alternate Names:

D08HQK TTD Drug ID