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TENECTEPLASE Drug Record

  • Summary
  • Interactions
  • Claims
  • TENECTEPLASE chembl:CHEMBL2108791 Approved

    Alternate Names:

    TNK-TPA
    TENECTEPLASE
    METALYSE
    TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR
    T-PLASMINOGEN ACTIVATOR
    T- PA
    TPA
    chembl:CHEMBL2108791
    rxcui:259280
    drugbank:00031
    chemidplus:191588-94-0

    Drug Info:

    Year of Approval 2000
    Drug Class thrombolytic agents
    FDA Approval 2000
    Drug Class recombinant protein
    Drug Indications Thrombolytic Agents
    (2 More Sources)

    Publications:

    Melandri et al., 2009, Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction., Vasc Health Risk Manag
    Longstaff et al., 2008, Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy., Cardiovasc Hematol Agents Med Chem
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Hilleman et al., 2007, Fibrinolytic agents for the management of ST-segment elevation myocardial infarction., Pharmacotherapy
    Brügger-Andersen et al., 2007, The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction., Thromb. Res.
  • TENECTEPLASE   PLG

    Interaction Score: 8.53

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Plasminogen activator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    19436656 18673235 11752352 17963464


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • TENECTEPLASE   MPO

    Interaction Score: 3.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16650886


    Sources:
    NCI

  • TEND: TENECTEPLASE

    • Version: 01-August-2011

    Alternate Names:
    TENECTEPLASE Primary Drug Name

    Drug Info:
    Drug Class thrombolytic agents
    Year of Approval 2000

    Publications:

  • TdgClinicalTrial: TENECTEPLASE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Thrombolytic Agents
    Drug Class recombinant protein
    FDA Approval 2000

    Publications:

  • NCI: TENECTEPLASE

    • Version: 14-September-2017

    Alternate Names:
    C29489 NCI drug code

    Drug Info:

    Publications:
    Brügger-Andersen et al., 2007, The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction., Thromb. Res.

  • TTD: Tenecteplase

    • Version: 2020.06.01

    Alternate Names:
    D0FX8A TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2108791

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL2108791

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21