DGIdb - TENECTEPLASE Drug Record

TENECTEPLASE chembl:CHEMBL2108791 Approved

Alternate Names:

TNK-TPA
TENECTEPLASE
METALYSE
TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR
T-PLASMINOGEN ACTIVATOR
T- PA
TPA
chembl:CHEMBL2108791
rxcui:259280
drugbank:00031
chemidplus:191588-94-0

Drug Info:

Year of Approval	2000
Drug Class	thrombolytic agents
FDA Approval	2000
Drug Class	recombinant protein
Drug Indications	Thrombolytic Agents

(2 More Sources)

Publications:

Melandri et al., 2009, Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction., Vasc Health Risk Manag
Longstaff et al., 2008, Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy., Cardiovasc Hematol Agents Med Chem
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hilleman et al., 2007, Fibrinolytic agents for the management of ST-segment elevation myocardial infarction., Pharmacotherapy
Brügger-Andersen et al., 2007, The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction., Thromb. Res.

TENECTEPLASE PLG

Interaction Score: 8.53

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Plasminogen activator

Direct Interaction yes

Trial Name -

PMIDs:
19436656 18673235 11752352 17963464

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
TENECTEPLASE MPO

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16650886

Sources:
NCI

TEND: TENECTEPLASE
- Version: 01-August-2011
Alternate Names:

TENECTEPLASE Primary Drug Name

Drug Info:

Drug Class thrombolytic agents

Year of Approval 2000

Publications:
TdgClinicalTrial: TENECTEPLASE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Thrombolytic Agents

Drug Class recombinant protein

FDA Approval 2000

Publications:

NCI: TENECTEPLASE

Version: 14-September-2017

Alternate Names:

C29489 NCI drug code

Drug Info:

Publications:

Brügger-Andersen et al., 2007, The effect of primary percutaneous coronary intervention as compared to tenecteplase on myeloperoxidase, pregnancy-associated plasma protein A, soluble fibrin and D-dimer in acute myocardial infarction., Thromb. Res.

TTD: Tenecteplase
- Version: 2020.06.01
Alternate Names:

D0FX8A TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL2108791
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL2108791
- Version: chembl_23
Alternate Names:

Drug Info:

Publications: