DGIdb - TACRINE Drug Record

TACRINE chembl:CHEMBL95 Approved

Alternate Names:

TACRINE
THA
1,2,3,4-TETRAHYDRO-9-AMINOACRIDINE
TACRINUM
5-AMINO-6,7,8,9-TETRAHYDROACRIDINE
TACRIN
TETRAHYDROAMINACRINE
TETRAHYDROAMINOACRIDINE
COGNEX®
CI-970
1,2,3,4-TETRAHYDROACRIDIN-9-AMINE
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE
rxcui:10318
pubchem.compound:1935
chemidplus:321-64-2
drugbank:00382
chembl:CHEMBL95

Drug Info:

Year of Approval	1993
Drug Class	nootropic agents
FDA Approval	1993
Drug Class	small molecule
Drug Indications	Nootropic Agents
Drug Groups	approved
Drug Groups	investigational
Drug Categories	agents causing muscle toxicity
Drug Categories	cytochrome p-450 substrates
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	p-glycoprotein substrates

(3 More Sources)

Publications:

Du et al., 2004, Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease., Curr. Pharm. Des.
Wang et al., 1999, Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE., Neuroreport
Villarroya et al., 2004, New classes of AChE inhibitors with additional pharmacological effects of interest for the treatment of Alzheimer's disease., Curr. Pharm. Des.
Traykov et al., 1999, In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects., Eur. J. Neurol.
Ahmed et al., 2006, Inhibition of two different cholinesterases by tacrine., Chem. Biol. Interact.
Kosasa et al., 1999, Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats., Eur. J. Pharmacol.
Davis, 1999, Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington., Geriatrics
Huang L et al., 2014, Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease., Eur J Med Chem
Marco et al., 2003, Recent developments in the synthesis of acetylcholinesterase inhibitors., Mini Rev Med Chem
Wang et al., 1998, Anticholinesterase effects of huperzine A, E2020, and tacrine in rats., Zhongguo Yao Li Xue Bao
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Takatori, 2006, [Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease]., Yakugaku Zasshi
Krustev et al., 2006, Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles., Can. J. Physiol. Pharmacol.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Bencharit S et al., 2003, Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition., Chem Biol

TACRINE ACHE

Interaction Score: 2.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Inhibition

PMIDs:
15544504 10208549 15544507 10210906 16860785 10513568 10024872 25282266 12871155 10375753 11752352 16880719 17218977

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology
TACRINE BCHE

Interaction Score: 1.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16860785 12871155 10375753 17218977

Sources:
DrugBank GuideToPharmacology
TACRINE CES1

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12725862

Sources:
DrugBank
TACRINE ALOX15

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TACRINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TACRINE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TACRINE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DrugBank: DB00382

Version: 5.1.7

Alternate Names:

TACRINE DrugBank Drug Name

321-64-2 CAS Number

Cognex Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Ahmed et al., 2006, Inhibition of two different cholinesterases by tacrine., Chem. Biol. Interact.

Marco et al., 2003, Recent developments in the synthesis of acetylcholinesterase inhibitors., Mini Rev Med Chem

Wang et al., 1998, Anticholinesterase effects of huperzine A, E2020, and tacrine in rats., Zhongguo Yao Li Xue Bao

TEND: TACRINE
- Version: 01-August-2011
Alternate Names:

TACRINE Primary Drug Name

Drug Info:

Drug Class nootropic agents

Year of Approval 1993

Publications:
TdgClinicalTrial: TACRINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Nootropic Agents

Drug Class small molecule

FDA Approval 1993

Publications:

DTC: TACRINE

Version: 02-September-2020

Alternate Names:

CHEMBL95 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Huang L et al., 2014, Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease., Eur J Med Chem

GuideToPharmacology: 178103299
- Version: 29-September-2020
Alternate Names:

TACRINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Tacrine
- Version: 2020.06.01
Alternate Names:

D0E6YQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL95
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

TACRINE Drug Record

TACRINE chembl:CHEMBL95 Approved

Alternate Names:

Drug Info:

Publications:

TACRINE ACHE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Specific Action of the Ligand Inhibition

PMIDs: 15544504 10208549 15544507 10210906 16860785 10513568 10024872 25282266 12871155 10375753 11752352 16880719 17218977

Sources: TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology

TACRINE BCHE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 16860785 12871155 10375753 17218977

Sources: DrugBank GuideToPharmacology

TACRINE CES1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12725862

Sources: DrugBank

TACRINE ALOX15

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TACRINE CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TACRINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TACRINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

DrugBank: DB00382

Alternate Names: TACRINE DrugBank Drug Name 321-64-2 CAS Number Cognex Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: TACRINE

Alternate Names: TACRINE Primary Drug Name

Drug Info: Drug Class nootropic agents Year of Approval 1993

Publications:

TdgClinicalTrial: TACRINE

Alternate Names:

Drug Info: Drug Indications Nootropic Agents Drug Class small molecule FDA Approval 1993

Publications:

DTC: TACRINE

Alternate Names: CHEMBL95 ChEMBL Drug ID

Drug Info:

GuideToPharmacology: 178103299

Alternate Names: TACRINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Tacrine

Alternate Names: D0E6YQ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL95

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Inhibition

PMIDs:
15544504 10208549 15544507 10210906 16860785 10513568 10024872 25282266 12871155 10375753 11752352 16880719 17218977

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16860785 12871155 10375753 17218977

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
12725862

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

TACRINE DrugBank Drug Name

321-64-2 CAS Number

Cognex Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

TACRINE Primary Drug Name

Drug Info:

Drug Class nootropic agents

Year of Approval 1993

Drug Info:

Drug Indications Nootropic Agents

Drug Class small molecule

FDA Approval 1993

Alternate Names:

CHEMBL95 ChEMBL Drug ID

Alternate Names:

TACRINE GuideToPharmacology Ligand Name

Alternate Names:

D0E6YQ TTD Drug ID