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SULFORAPHANE Drug Record

  • Summary
  • Interactions
  • Claims
  • SULFORAPHANE chembl:CHEMBL48802

    Alternate Names:

    4-(METHYLSULFINYL)BUTYL ISOTHIOCYANATE
    SULFORAPHANE

    Drug Info:

    (0 More Sources)

    Publications:

    Emmert SW et al., 2010, Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane., Bioorg Med Chem Lett
    Choi et al., 2005, Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent., Cancer Res.
    Gasper et al., 2005, Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli., Am. J. Clin. Nutr.
    Brooks et al., 2001, Potent induction of phase 2 enzymes in human prostate cells by sulforaphane., Cancer Epidemiol. Biomarkers Prev.
    Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem
    Zhang et al., 1992, A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure., Proc. Natl. Acad. Sci. U.S.A.
    Jakubíková et al., 2005, Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells., Biochem. Pharmacol.
  • SULFORAPHANE   GCLM

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11535546


    Sources:
    NCI

  • SULFORAPHANE   NQO1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20395150


    Sources:
    DTC

  • SULFORAPHANE   GSTM1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16332662


    Sources:
    NCI

  • SULFORAPHANE   GSTP1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1549603


    Sources:
    NCI

  • SULFORAPHANE   BAX

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15753404


    Sources:
    NCI

  • SULFORAPHANE   PIK3CG

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15896333


    Sources:
    NCI

  • SULFORAPHANE   NFE2L2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20304643


    Sources:
    DTC

  • NCI: SULFORAPHANE

    • Version: 14-September-2017

    Alternate Names:
    C1424 NCI drug code

    Drug Info:

    Publications:
    Gasper et al., 2005, Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli., Am. J. Clin. Nutr.
    Jakubíková et al., 2005, Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells., Biochem. Pharmacol.
    Choi et al., 2005, Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent., Cancer Res.

  • DTC: SULFORAPHANE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL48802 ChEMBL Drug ID

    Drug Info:

    Publications:
    Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem
    Emmert SW et al., 2010, Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane., Bioorg Med Chem Lett

  • ChemblDrugs: chembl:CHEMBL48802

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21