DGIdb - SULFORAPHANE Drug Record

SULFORAPHANE chembl:CHEMBL48802

Alternate Names:

4-(METHYLSULFINYL)BUTYL ISOTHIOCYANATE
SULFORAPHANE

Drug Info:

(0 More Sources)

Publications:

Emmert SW et al., 2010, Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane., Bioorg Med Chem Lett
Choi et al., 2005, Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent., Cancer Res.
Gasper et al., 2005, Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli., Am. J. Clin. Nutr.
Brooks et al., 2001, Potent induction of phase 2 enzymes in human prostate cells by sulforaphane., Cancer Epidemiol. Biomarkers Prev.
Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem
Zhang et al., 1992, A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure., Proc. Natl. Acad. Sci. U.S.A.
Jakubíková et al., 2005, Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells., Biochem. Pharmacol.

SULFORAPHANE GCLM

Interaction Score: 6.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11535546

Sources:
NCI
SULFORAPHANE NQO1

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20395150

Sources:
DTC
SULFORAPHANE GSTM1

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16332662

Sources:
NCI
SULFORAPHANE GSTP1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1549603

Sources:
NCI
SULFORAPHANE BAX

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15753404

Sources:
NCI
SULFORAPHANE PIK3CG

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15896333

Sources:
NCI
SULFORAPHANE NFE2L2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20304643

Sources:
DTC

NCI: SULFORAPHANE

Version: 14-September-2017

Alternate Names:

C1424 NCI drug code

Drug Info:

Publications:

Gasper et al., 2005, Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli., Am. J. Clin. Nutr.

Jakubíková et al., 2005, Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells., Biochem. Pharmacol.

Choi et al., 2005, Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent., Cancer Res.

DTC: SULFORAPHANE

Version: 02-September-2020

Alternate Names:

CHEMBL48802 ChEMBL Drug ID

Drug Info:

Publications:

Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem

Emmert SW et al., 2010, Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane., Bioorg Med Chem Lett

ChemblDrugs: chembl:CHEMBL48802
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

SULFORAPHANE Drug Record

SULFORAPHANE chembl:CHEMBL48802

Alternate Names:

Drug Info:

Publications:

SULFORAPHANE GCLM

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11535546

Sources: NCI

SULFORAPHANE NQO1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20395150

Sources: DTC

SULFORAPHANE GSTM1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16332662

Sources: NCI

SULFORAPHANE GSTP1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1549603

Sources: NCI

SULFORAPHANE BAX

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15753404

Sources: NCI

SULFORAPHANE PIK3CG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15896333

Sources: NCI

SULFORAPHANE NFE2L2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20304643

Sources: DTC

NCI: SULFORAPHANE

Alternate Names: C1424 NCI drug code

Drug Info:

DTC: SULFORAPHANE

Alternate Names: CHEMBL48802 ChEMBL Drug ID

Drug Info:

Publications: Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem Emmert SW et al., 2010, Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane., Bioorg Med Chem Lett

ChemblDrugs: chembl:CHEMBL48802

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
11535546

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20395150

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16332662

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1549603

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15753404

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15896333

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20304643

Sources:
DTC

Alternate Names:

C1424 NCI drug code

Alternate Names:

CHEMBL48802 ChEMBL Drug ID

Publications:

Andreani A et al., 2010, Antitumor activity and COMPARE analysis of bis-indole derivatives., Bioorg Med Chem

Emmert SW et al., 2010, Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane., Bioorg Med Chem Lett