DGIdb - SPIRONOLACTONE Drug Record

SPIRONOLACTONE chembl:CHEMBL1393 Approved

Alternate Names:

SPIRETIC
SPIROCTAN 100
SPIROCTAN 25
SC-9420
NSC-150399
ALDACTONE
ABBOLACTONE
SPIRONOLACTONE
LARACTONE
SPIROCTAN 50
SPIROSPARE 100
DIATENSEC
GX SPIRONOL
CAROSPIR
SPIROSPARE 25
SPIRONOLATTONE
ESPIRONOLACTONA
SPIRNOLACTONE
SPIRACTIN
SPIROTONE
ALDACTONE®
SPIRONOLACTONUM
pubchem.compound:5833
chembl:CHEMBL1393
drugbank:00421
chemidplus:52-01-7
rxcui:9997

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Class	antihypertensive agents
Year of Approval	1960
Drug Class	diuretics

(4 More Sources)

Publications:

Cicoira M et al., 2004, Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure., Am J Med
Ghanem et al., 2006, Induction of rat intestinal P-glycoprotein by spironolactone and its effect on absorption of orally administered digoxin., J. Pharmacol. Exp. Ther.
Kim KM et al., 2012, Pharmacogenetics and healthcare outcomes in patients with chronic heart failure., Eur J Clin Pharmacol
Ye et al., 2009, Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis., Horm. Metab. Res.
Fujita et al., 1982, Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities., Res. Commun. Chem. Pathol. Pharmacol.
Sica, 2005, Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis., Heart Fail Rev
Rogerson et al., 2003, Determinants of spironolactone binding specificity in the mineralocorticoid receptor., J. Mol. Endocrinol.
Rogerson et al., 2004, Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor., Clin. Exp. Pharmacol. Physiol.
Gertner et al., 2004, Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor., J. Am. Soc. Nephrol.
Frishman et al., 2004, Aldosterone and aldosterone antagonism in systemic hypertension., Curr. Hypertens. Rep.
Sitruk-Ware, Progestogens in hormonal replacement therapy: new molecules, risks, and benefits., Menopause
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rossi et al., 2005, Aldosterone as a cardiovascular risk factor., Trends Endocrinol. Metab.
Kretschmer XC et al., 2005, CAR and PXR: xenosensors of endocrine disrupters?, Chem Biol Interact
Matsumoto et al., 2006, The effect of spironolactone on circulating adipocytokines in patients with type 2 diabetes mellitus complicated by diabetic nephropathy., Metab. Clin. Exp.
Cheng et al., 1976, Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria., Endocrinology
Yang YY et al., 2011, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites., Clin Sci (Lond)
Miura et al., 2006, Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells., J. Pharmacol. Sci.
Gauer et al., 2007, Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor., Nephrol. Dial. Transplant.

SPIRONOLACTONE NR3C2

Interaction Score: 2.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

Trial Name HTI-101

PMIDs:
15947888 14664717 15554912 14978157 15128471 11791081 11752352 15808807

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
SPIRONOLACTONE CYP4A11

Interaction Score: 1.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SPIRONOLACTONE ADD1

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21692745

Sources:
PharmGKB
SPIRONOLACTONE ADIPOQ

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17142138

Sources:
NCI
SPIRONOLACTONE CYP7B1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
976190

Sources:
NCI
SPIRONOLACTONE CCN2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17602195

Sources:
NCI
SPIRONOLACTONE CYP1A1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7079590

Sources:
NCI
SPIRONOLACTONE NOS3

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
SPIRONOLACTONE CYP1B1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7079590

Sources:
NCI
SPIRONOLACTONE ACE

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15121491

Sources:
PharmGKB
SPIRONOLACTONE TNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16837769

Sources:
NCI
SPIRONOLACTONE ADRB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
SPIRONOLACTONE NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16054614

Sources:
PharmGKB
SPIRONOLACTONE ADRB2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
SPIRONOLACTONE ABCB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16740618

Sources:
NCI PharmGKB
SPIRONOLACTONE THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SPIRONOLACTONE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SPIRONOLACTONE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7079590

Sources:
NCI
SPIRONOLACTONE AR

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
18819053

Sources:
DTC

TEND: SPIRONOLACTONE
- Version: 01-August-2011
Alternate Names:

SPIRONOLACTONE Primary Drug Name

Drug Info:

Drug Class diuretics

Year of Approval 1960

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: SPIRONOLACTONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: SPIRONOLACTONE

Version: 14-September-2017

Alternate Names:

C840 NCI drug code

Drug Info:

Publications:

Fujita et al., 1982, Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities., Res. Commun. Chem. Pathol. Pharmacol.

Miura et al., 2006, Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells., J. Pharmacol. Sci.

Ghanem et al., 2006, Induction of rat intestinal P-glycoprotein by spironolactone and its effect on absorption of orally administered digoxin., J. Pharmacol. Exp. Ther.

PharmGKB: spironolactone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Cicoira M et al., 2004, Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure., Am J Med

Kim KM et al., 2012, Pharmacogenetics and healthcare outcomes in patients with chronic heart failure., Eur J Clin Pharmacol

Yang YY et al., 2011, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites., Clin Sci (Lond)

DTC: SPIRONOLACTONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1393 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Spironolactone
- Version: 2020.06.01
Alternate Names:

D0EP0C TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1393
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1393
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Mineralocorticoid receptor antagonist
Direct Interaction	yes
Trial Name	HTI-101

SPIRONOLACTONE Drug Record

SPIRONOLACTONE chembl:CHEMBL1393 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes Trial Name HTI-101

PMIDs: 15947888 14664717 15554912 14978157 15128471 11791081 11752352 15808807

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21692745

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17142138

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 976190

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17602195

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7079590

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543981

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7079590

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15121491

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16837769

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543981

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16054614

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543981

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16740618

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7079590

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 18819053

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

Trial Name HTI-101

PMIDs:
15947888 14664717 15554912 14978157 15128471 11791081 11752352 15808807

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21692745

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17142138

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
976190

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17602195

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7079590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22543981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7079590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15121491

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16837769

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22543981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16054614

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22543981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16740618

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7079590

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
18819053

Sources:
DTC

Alternate Names:

SPIRONOLACTONE Primary Drug Name

Drug Info:

Drug Class diuretics

Year of Approval 1960

Drug Class antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C840 NCI drug code

Alternate Names:

CHEMBL1393 ChEMBL Drug ID

Alternate Names:

D0EP0C TTD Drug ID