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SIPONIMOD Drug Record

  • Summary
  • Interactions
  • Claims
  • SIPONIMOD chembl:CHEMBL2336071 ApprovedImmunotherapy

    Alternate Names:

    BAF-312
    SIPONIMOD
    NVP-BAF312-NX
    MAYZENT
    BAF312
    chembl:CHEMBL2336071
    drugbank:12371
    chemidplus:1230487-00-9
    pubchem.compound:44599207

    Drug Info:

    (1 More Sources)

    Publications:

    Gianguzza M et al., 1979, On the ultrastructure of the test cells of Ascidia malaca during oogenesis., Acta Embryol Exp (Palermo)
    Pan S et al., 2013, Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator., ACS Med Chem Lett
    Gajofatto A, 2017, Spotlight on siponimod and its potential in the treatment of secondary progressive multiple sclerosis: the evidence to date., Drug Des Devel Ther
    Glaenzel U et al., 2018, Metabolism and Disposition of Siponimod, a Novel Selective S1P<sub>1</sub>/S1P<sub>5</sub> Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism., Drug Metab Dispos
    O'Sullivan C et al., 2016, The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures., J Neuroinflammation
  • SIPONIMOD   S1PR5

    Interaction Score: 20.61

    Interaction Types & Directionality:
    agonist (activating)
    modulator

    Interaction Info:
    Mechanism of Interaction Sphingosine 1-phosphate receptor Edg-8 agonist
    Direct Interaction yes

    PMIDs:
    29735753 26856814 29138536


    Sources:
    ChemblInteractions

  • SIPONIMOD   S1PR1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Sphingosine 1-phosphate receptor Edg-1 agonist
    Direct Interaction yes

    PMIDs:
    517042 24900670 29138536


    Sources:
    ChemblInteractions TTD

  • SIPONIMOD   CYP2C9

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TTD: BAF312

    • Version: 2020.06.01

    Alternate Names:
    D07FKQ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2336071

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL2336071

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: siponimod

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Siponimod

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21