DGIdb - SIBUTRAMINE Drug Record

SIBUTRAMINE chembl:CHEMBL1419

Alternate Names:

REDUCTIL
SIBUTRAMINE
BUTRAMIN
SIBUTRAMINUM
SIBUTRAMINE HYDROCHLORIDE
MERIDIA®
SIBUTRAMINA
chemidplus:106650-56-0
drugbank:01105
chembl:CHEMBL1419
pubchem.compound:5210
rxcui:36514

Drug Info:

Drug Class	appetite depressants
Year of Approval	1997
FDA Approval	withdrawn
Drug Class	Small Molecule
Drug Indications	appetite suppressant

(1 More Sources)

Publications:

Heusser et al., 2006, Influence of sibutramine treatment on sympathetic vasomotor tone in obese subjects., Clin. Pharmacol. Ther.
Gomis Barbará, [Pharmacological treatment of obesity]., Rev Med Univ Navarra
Birkenfeld et al., 2005, Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure., Clin. Auton. Res.
Jordan et al., 2005, Influence of Sibutramine on blood pressure: evidence from placebo-controlled trials., Int J Obes (Lond)
Birkenfeld et al., 2002, Paradoxical effect of sibutramine on autonomic cardiovascular regulation., Circulation
Krahn et al., 2001, Narcolepsy and obesity: remission of severe cataplexy with sibutramine., Sleep Med.
Vazquez Roque et al., 2007, Alteration of gastric functions and candidate genes associated with weight reduction in response to sibutramine., Clin. Gastroenterol. Hepatol.
Tziomalos et al., 2009, The use of sibutramine in the management of obesity and related disorders: an update., Vasc Health Risk Manag
Berke et al., 2000, Medical management of obesity., Am Fam Physician
Heusser et al., 2007, Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment., J. Clin. Endocrinol. Metab.
Sharma et al., 2008, Sibutramine: current status as an anti-obesity drug and its future perspectives., Expert Opin Pharmacother
Nakagawa et al., 2001, Effects of sibutramine on the central dopaminergic system in rodents., Neurotox Res
Balcioglu et al., 2000, Sibutramine, a serotonin uptake inhibitor, increases dopamine concentrations in rat striatal and hypothalamic extracellular fluid., Neuropharmacology
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Hauner H et al., 2003, Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism., Pharmacogenetics

SIBUTRAMINE SLC6A2

Interaction Score: 4.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

PMIDs:
16678551 15382615 15944869 15685250 12417543 11152984 11752352 19475780 10929704 17284621 18671470

Sources:
TdgClinicalTrial TEND
SIBUTRAMINE SLC6A4

Interaction Score: 3.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

Novel drug target Established target

PMIDs:
16678551 15382615 15944869 15685250 12417543 11152984 17544870 19475780 10929704 17284621 18671470

Sources:
TdgClinicalTrial TEND
SIBUTRAMINE GNB3

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12893983

Sources:
PharmGKB
SIBUTRAMINE SLC6A3

Interaction Score: 1.7

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

PMIDs:
15382615 15111248 11152984 10974319 19475780 10929704

Sources:
TdgClinicalTrial
SIBUTRAMINE CYP3A5

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB

TEND: SIBUTRAMINE
- Version: 01-August-2011
Alternate Names:

SIBUTRAMINE Primary Drug Name

Drug Info:

Year of Approval 1997

Drug Class appetite depressants

Publications:
TdgClinicalTrial: SIBUTRAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications appetite suppressant

Drug Class Small Molecule

FDA Approval withdrawn

Publications:

PharmGKB: sibutramine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Hauner H et al., 2003, Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism., Pharmacogenetics

TTD: Sibutramine
- Version: 2020.06.01
Alternate Names:

D08KVZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1419
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

SIBUTRAMINE Drug Record

SIBUTRAMINE chembl:CHEMBL1419

Alternate Names:

Drug Info:

Publications:

SIBUTRAMINE SLC6A2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

PMIDs: 16678551 15382615 15944869 15685250 12417543 11152984 11752352 19475780 10929704 17284621 18671470

Sources: TdgClinicalTrial TEND

SIBUTRAMINE SLC6A4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium Novel drug target Established target

PMIDs: 16678551 15382615 15944869 15685250 12417543 11152984 17544870 19475780 10929704 17284621 18671470

Sources: TdgClinicalTrial TEND

SIBUTRAMINE GNB3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12893983

Sources: PharmGKB

SIBUTRAMINE SLC6A3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

PMIDs: 15382615 15111248 11152984 10974319 19475780 10929704

Sources: TdgClinicalTrial

SIBUTRAMINE CYP3A5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

TEND: SIBUTRAMINE

Alternate Names: SIBUTRAMINE Primary Drug Name

Drug Info: Year of Approval 1997 Drug Class appetite depressants

Publications:

TdgClinicalTrial: SIBUTRAMINE

Alternate Names:

Drug Info: Drug Indications appetite suppressant Drug Class Small Molecule FDA Approval withdrawn

Publications:

PharmGKB: sibutramine

Alternate Names:

Drug Info:

TTD: Sibutramine

Alternate Names: D08KVZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1419

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

PMIDs:
16678551 15382615 15944869 15685250 12417543 11152984 11752352 19475780 10929704 17284621 18671470

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

Novel drug target Established target

PMIDs:
16678551 15382615 15944869 15685250 12417543 11152984 17544870 19475780 10929704 17284621 18671470

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
12893983

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name sibutramine HCl monohydrate,Meridia, Reductil, Reduxade, Zelium

PMIDs:
15382615 15111248 11152984 10974319 19475780 10929704

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Alternate Names:

SIBUTRAMINE Primary Drug Name

Drug Info:

Year of Approval 1997

Drug Class appetite depressants

Drug Info:

Drug Indications appetite suppressant

Drug Class Small Molecule

FDA Approval withdrawn

Alternate Names:

D08KVZ TTD Drug ID