DGIdb - RUFINAMIDE Drug Record

RUFINAMIDE chembl:CHEMBL1201754 Approved

Alternate Names:

60231/4
E2080
RUF-331
CGP-33101
BANZEL
INOVELON
E-2080
RUFINAMIDE
BANZEL®
XILEP
INOVELON®
RUF331
pubchem.compound:129228
chembl:CHEMBL1201754
rxcui:69036
drugbank:06201
chemidplus:106308-44-5

Drug Info:

Drug Categories	cardiovascular agents
Drug Categories	central nervous system agents
Drug Categories	central nervous system depressants
Drug Categories	cytochrome p-450 cyp2e1 inhibitors (weak)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 cyp3a4 substrates (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	membrane transport modulators
Drug Categories	miscellaneous anticonvulsants
Drug Categories	sodium channel blockers
Drug Categories	voltage-gated sodium channel blockers

(1 More Sources)

Publications:

Suter et al., 2013, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state., Anesthesiology
Wier et al., 2011, Rufinamide for pediatric patients with Lennox-Gastaut syndrome: a comprehensive overview., Paediatr Drugs

RUFINAMIDE GRM5

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21351809

Sources:
DrugBank
RUFINAMIDE SCN9A

Interaction Score: 0.21

Interaction Types & Directionality:

blocker (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23221868

Sources:
DrugBank ChemblInteractions
RUFINAMIDE SCN7A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN8A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN3A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN11A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN2A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN4A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN10A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN5A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE CBX1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB06201

Version: 5.1.7

Alternate Names:

RUFINAMIDE DrugBank Drug Name

106308-44-5 CAS Number

Banzel Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories anticonvulsants

Publications:

Wier et al., 2011, Rufinamide for pediatric patients with Lennox-Gastaut syndrome: a comprehensive overview., Paediatr Drugs

Suter et al., 2013, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state., Anesthesiology

TTD: Rufinamide
- Version: 2020.06.01
Alternate Names:

D0MD2L TTD Drug ID

Drug Info:

Publications:
DTC: RUFINAMIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL1201754 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201754
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201754
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

RUFINAMIDE	DrugBank Drug Name
106308-44-5	CAS Number
Banzel	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	anticonvulsants

blocker (inhibitory)
modulator

RUFINAMIDE Drug Record

RUFINAMIDE chembl:CHEMBL1201754 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21351809

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory) modulator

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 23221868

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB06201

Alternate Names: RUFINAMIDE DrugBank Drug Name 106308-44-5 CAS Number Banzel Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories anticonvulsants

TTD: Rufinamide

Alternate Names: D0MD2L TTD Drug ID

Drug Info:

Publications:

DTC: RUFINAMIDE

Alternate Names: CHEMBL1201754 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201754

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201754

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21351809

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23221868

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

RUFINAMIDE DrugBank Drug Name

106308-44-5 CAS Number

Banzel Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories anticonvulsants

Alternate Names:

D0MD2L TTD Drug ID

Alternate Names:

CHEMBL1201754 ChEMBL Drug ID