RUCAPARIB Drug Record
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RUCAPARIB chembl:CHEMBL1173055 ApprovedAntineoplastic
Alternate Names:
AG-014699 RUCAPARIB AG-14447 AG014699 PF-01367338 AG14447 RUBRACA chemidplus:283173-50-2 pubchem.compound:9931954 drugbank:12332 chembl:CHEMBL1173055 rxcui:1862579 Drug Info:
FDA Approval Ovarian cancer (with BRCA mutation) Drug Class Small molecule inhibitor Drug Categories antineoplastic and immunomodulating agents Drug Categories bcrp/abcg2 inhibitors Drug Categories bcrp/abcg2 substrates Drug Categories cytochrome p-450 cyp1a2 inducers Drug Categories cytochrome p-450 cyp1a2 inducers (moderate) Drug Categories cytochrome p-450 cyp1a2 inhibitors Drug Categories cytochrome p-450 cyp1a2 inhibitors (weak) Drug Categories cytochrome p-450 cyp1a2 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp2c19 inhibitors Drug Categories cytochrome p-450 cyp2c19 inhibitors (weak) Drug Categories cytochrome p-450 cyp2c8 inhibitors Drug Categories cytochrome p-450 cyp2c8 inhibitors (weak) Drug Categories cytochrome p-450 cyp2c9 inhibitors Drug Categories cytochrome p-450 cyp2c9 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp2d6 inhibitors Drug Categories cytochrome p-450 cyp2d6 inhibitors (moderate) Drug Categories cytochrome p-450 cyp2d6 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp3a inhibitors Drug Categories cytochrome p-450 cyp3a substrates Drug Categories cytochrome p-450 cyp3a4 inhibitors Drug Categories cytochrome p-450 cyp3a4 inhibitors (weak) Drug Categories cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp3a5 inhibitors Drug Categories cytochrome p-450 cyp3a5 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp3a7 inhibitors Drug Categories cytochrome p-450 cyp3a7 inhibitors (strength unknown) Drug Categories cytochrome p-450 enzyme inducers Drug Categories cytochrome p-450 enzyme inhibitors Drug Categories cytochrome p-450 substrates Drug Categories heterocyclic compounds, fused-ring Drug Categories mate 1 inhibitors Drug Categories mate 2 inhibitors Drug Categories mate inhibitors Drug Categories oat1/slc22a6 inhibitors Drug Categories oat3/slc22a8 inhibitors Drug Categories oatp1b1/slco1b1 inhibitors Drug Categories oatp1b3 inhibitors Drug Categories oct1 inhibitors Drug Categories p-glycoprotein inhibitors Drug Categories p-glycoprotein substrates Drug Categories ugt1a1 inhibitors Publications:
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Interaction Types & Directionality:
antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction PARP 1, 2 and 3 inhibitor Direct Interaction yes PMIDs:
None found
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Interaction Types & Directionality:
antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction PARP 1, 2 and 3 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True PMIDs:
None found
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Interaction Types & Directionality:
n/a Interaction Info:
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Interaction Types & Directionality:
n/a Interaction Info:
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- Version: 20-Jun-2017
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RUCAPARIB Generic Name RUBRACA Trade Name Drug Info:
Drug Class Small molecule inhibitor FDA Approval Ovarian cancer (with BRCA mutation) Publications:
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RUCAPARIB DrugBank Drug Name 283173-50-2 CAS Number Rubraca Drug Brand Drug Info:
Drug Type small molecule Drug Groups approved Drug Groups investigational Publications:
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RUCAPARIB Primary Drug Name RUCAPARIB Drug Generic Name Drug Info:
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CHEMBL1173055 ChEMBL Drug ID Drug Info:
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- Version: 29-September-2020
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RUCAPARIB GuideToPharmacology Ligand Name Drug Info:
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D01SHZ TTD Drug ID Drug Info:
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- Version: ChEMBL_27
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- Version: 26-July-2013
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- Version: 15-June-2013
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- Version: chembl_23
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