DGIdb - ROCURONIUM Drug Record

ROCURONIUM chembl:CHEMBL1201244 Approved

Alternate Names:

ROCURONIUM
ZEMURON®
ESMERON®
ORG-9426
chemidplus:143558-00-3
chembl:CHEMBL1201244
pubchem.compound:441290
drugbank:00728
rxcui:68139

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	muscle relaxant
Drug Class	muscle relaxants, skeletal
Year of Approval	1994

(1 More Sources)

Publications:

Milchert et al., 2009, Skeletal muscle relaxants inhibit rat tracheal smooth muscle tone in vitro., J. Physiol. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Mei Y et al., 2015, Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients., J Clin Pharmacol
Jonsson Fagerlund et al., 2009, Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor., Anesthesiology
Liu et al., 2008, Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors., Anesth. Analg.
Jonsson et al., 2006, Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade., Anesthesiology
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Min et al., 2000, Nondepolarizing neuromuscular blockers inhibit the serotonin-type 3A receptor expressed in Xenopus oocytes., Anesth. Analg.
Costa ACC et al., 2017, The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries., Eur J Clin Pharmacol

ROCURONIUM CHRNA2

Interaction Score: 5.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax

Novel drug target Established target

PMIDs:
19417616 18633030 16931985 11752352 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
ROCURONIUM SLCO1A2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28409297

Sources:
PharmGKB
ROCURONIUM CHRM2

Interaction Score: 1.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax

Novel drug target Established target

PMIDs:
20400785 17016423 17139284

Sources:
TdgClinicalTrial TEND
ROCURONIUM HTR3A

Interaction Score: 0.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax

Novel drug target Established target

PMIDs:
10648343

Sources:
TdgClinicalTrial
ROCURONIUM SLCO1B1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25279974

Sources:
PharmGKB
ROCURONIUM ABCB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25279974

Sources:
PharmGKB

TEND: ROCURONIUM
- Version: 01-August-2011
Alternate Names:

ROCURONIUM Primary Drug Name

Drug Info:

Year of Approval 1994

Drug Class muscle relaxants, skeletal

Publications:
TdgClinicalTrial: ROCURONIUM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications muscle relaxant

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: rocuronium

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Mei Y et al., 2015, Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients., J Clin Pharmacol

Costa ACC et al., 2017, The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries., Eur J Clin Pharmacol

TTD: Rocuronium
- Version: 2020.06.01
Alternate Names:

D0L5CZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201244
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	rocuronium bromide,Esmeron, Zemuron, Eslax
Novel drug target	Established target

ROCURONIUM Drug Record

ROCURONIUM chembl:CHEMBL1201244 Approved

Alternate Names:

Drug Info:

Publications:

ROCURONIUM CHRNA2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax Novel drug target Established target

PMIDs: 19417616 18633030 16931985 11752352 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

ROCURONIUM SLCO1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28409297

Sources: PharmGKB

ROCURONIUM CHRM2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax Novel drug target Established target

PMIDs: 20400785 17016423 17139284

Sources: TdgClinicalTrial TEND

ROCURONIUM HTR3A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax Novel drug target Established target

PMIDs: 10648343

Sources: TdgClinicalTrial

ROCURONIUM SLCO1B1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25279974

Sources: PharmGKB

ROCURONIUM ABCB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25279974

Sources: PharmGKB

TEND: ROCURONIUM

Alternate Names: ROCURONIUM Primary Drug Name

Drug Info: Year of Approval 1994 Drug Class muscle relaxants, skeletal

Publications:

TdgClinicalTrial: ROCURONIUM

Alternate Names:

Drug Info: Drug Indications muscle relaxant Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: rocuronium

Alternate Names:

Drug Info:

TTD: Rocuronium

Alternate Names: D0L5CZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201244

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax

Novel drug target Established target

PMIDs:
19417616 18633030 16931985 11752352 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
28409297

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax

Novel drug target Established target

PMIDs:
20400785 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax

Novel drug target Established target

PMIDs:
10648343

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
25279974

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25279974

Sources:
PharmGKB

Alternate Names:

ROCURONIUM Primary Drug Name

Drug Info:

Year of Approval 1994

Drug Class muscle relaxants, skeletal

Drug Info:

Drug Indications muscle relaxant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0L5CZ TTD Drug ID