DGIdb - RESVERATROL Drug Record

RESVERATROL chembl:CHEMBL165 Antineoplastic

Alternate Names:

BIA 6-512
(E)-RESVERATROL
NSC-327430
RESVERATROL
BIA-6-512
3,5,4'-TRIHYDROXY-TRANS-STILBENE

Drug Info:

Drug Indications	antidiabetic,antineoplastic agent
FDA Approval	not approved
Drug Class	small molecule
Drug Indications	for treatment of herpes simplex virus 1
Drug Categories	vasodilator agents
Drug Categories	therapeutic uses
Drug Categories	specialty uses of chemicals
Drug Categories	sensory system agents
Drug Categories	ribonucleotide reductases, antagonists & inhibitors
Drug Categories	protective agents
Drug Categories	platelet aggregation inhibitors
Drug Categories	physiological effects of drugs
Drug Categories	phenols
Drug Categories	pharmacologic actions
Drug Categories	peripheral nervous system agents
Drug Categories	organic chemicals
Drug Categories	molecular mechanisms of pharmacological action
Drug Categories	hydrocarbons, cyclic
Drug Categories	hydrocarbons, aromatic
Drug Categories	hydrocarbons
Drug Categories	hematologic agents
Drug Categories	enzyme inhibitors
Drug Categories	cytochrome p-450 cyp3a inhibitors
Drug Categories	cytochrome p-450 cyp1a2 substrates
Drug Categories	cytochrome p-450 cyp1a2 inhibitors
Drug Categories	cytochrome p-450 cyp1a2 inducers
Drug Categories	chemical actions and uses
Drug Categories	central nervous system agents
Drug Categories	benzylidene compounds
Drug Categories	benzene derivatives
Drug Categories	antirheumatic agents
Drug Categories	antioxidants
Drug Categories	antineoplastic agents, phytogenic
Drug Categories	antineoplastic agents
Drug Categories	antimutagenic agents
Drug Categories	anticarcinogenic agents
Drug Categories	anti-inflammatory agents, non-steroidal
Drug Categories	anti-inflammatory agents
Drug Categories	angiogenesis inhibitors
Drug Categories	analgesics, non-narcotic
Drug Categories	analgesics
Drug Groups	investigational
Drug Groups	experimental
Drug Type	small molecule
Drug Categories	vasodilating agents
Drug Categories	stilbenes
Drug Categories	pyrans
Drug Categories	polyphenols
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	flavonoids
Drug Categories	flavones
Drug Categories	cytochrome p-450 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp1a2 inhibitors (strength unknown)
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	chromones
Drug Categories	benzopyrans
Drug Categories	antiplatelet agents

(2 More Sources)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Wang et al., 2004, Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography., Biochem. Biophys. Res. Commun.
Buryanovskyy et al., 2004, Crystal structure of quinone reductase 2 in complex with resveratrol., Biochemistry
Ota H et al., 2013, trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence., J Nat Prod
Milne et al., 2007, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes., Nature
Wu J et al., 2013, Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate., J Med Chem
Lakshminarasimhan M et al., 2013, Sirt1 activation by resveratrol is substrate sequence-selective., Aging (Albany NY)
Hubbard BP et al., 2013, Evidence for a common mechanism of SIRT1 regulation by allosteric activators., Science
Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem
Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.
Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.
Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis
Boissy et al., 2005, Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation., Cancer Res.
Park JB, 2001, Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells., J Nat Prod
Stewart et al., 2000, Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation., Biochem. Pharmacol.
Aziz et al., 2005, Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?, FASEB J.
Aziz et al., Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin., Photochem. Photobiol.
Baek et al., 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53., Carcinogenesis
Sbarra et al., 2005, In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim. Biophys. Acta
Mollerup et al., 2001, Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells., Int. J. Cancer
Lu C et al., 2013, Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease., J Med Chem
Ahn JS et al., 2007, Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol., Anal Biochem
Poolman et al., 2005, Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling., Free Radic. Biol. Med.
Gagliano et al., 2005, Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells., Biomed. Pharmacother.
Tseng et al., 2004, Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats., Clin. Cancer Res.
Reagan-Shaw et al., 2004, Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin., Oncogene
Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med
Hsieh TC et al., 2014, Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2., PLoS One
Lekli et al., 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am. J. Physiol. Heart Circ. Physiol.
Lappano R et al., 2009, Structure-activity relationships of resveratrol and derivatives in breast cancer cells., Mol Nutr Food Res
Bezstarosti et al., Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol., J. Cell. Mol. Med.
Wang et al., 2006, Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts., Biochem. Biophys. Res. Commun.
Sakoguchi-Okada et al., 2007, Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells., Biochem. Pharmacol.
Fulda et al., 2004, Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol., Cancer Res.
de Medina P et al., 2005, Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators., J Med Chem
Das et al., 2006, Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J. Pharmacol. Exp. Ther.
Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem
Ito Y et al., 2013, Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4'-amino-3,5-dihydroxy-trans-stilbene., J Nutr Sci Vitaminol (Tokyo)
Sajish M et al., 2015, A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol., Nature
Bollmann F et al., 2014, Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity., Nucleic Acids Res
Srivastava R et al., 2005, Resveratrol inhibits type II phosphatidylinositol 4-kinase: a key component in pathways of phosphoinositide turn over., Biochem Pharmacol
Davis PJ et al., 2013, Small molecule hormone or hormone-like ligands of integrin αVβ3: implications for cancer cell behavior., Horm Cancer
Wang Y et al., 2010, Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines., Hum Mol Genet
MacCarrone M et al., 1999, Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity., Eur J Biochem
Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact
Ferry G et al., 2010, Old and new inhibitors of quinone reductase 2., Chem Biol Interact
Salas M et al., 2013, Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation., Am J Physiol Cell Physiol

RESVERATROL PTGS2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
RESVERATROL PPARG

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

Publications:

Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med

RESVERATROL AKT1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem

Hsieh TC et al., 2014, Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2., PLoS One

RESVERATROL PTGS1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

RESVERATROL CBR1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Ito Y et al., 2013, Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4'-amino-3,5-dihydroxy-trans-stilbene., J Nutr Sci Vitaminol (Tokyo)

RESVERATROL YARS1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Sajish M et al., 2015, A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol., Nature
RESVERATROL PDE4D

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resveratrol

Novel drug target Established target

Trial Name SRT501

Publications:
RESVERATROL PDE4B

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SRT501

Novel drug target Established target

Trial Name Resveratrol

Publications:

RESVERATROL NQO2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wang et al., 2004, Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography., Biochem. Biophys. Res. Commun.

Buryanovskyy et al., 2004, Crystal structure of quinone reductase 2 in complex with resveratrol., Biochemistry

RESVERATROL SIRT1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ota H et al., 2013, trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence., J Nat Prod

Milne et al., 2007, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes., Nature

Wu J et al., 2013, Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate., J Med Chem

RESVERATROL FOXO3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem
RESVERATROL IL1B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.
RESVERATROL RIPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.

RESVERATROL HGF

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis

RESVERATROL BGLAP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Boissy et al., 2005, Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation., Cancer Res.
RESVERATROL SLC2A3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Park JB, 2001, Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells., J Nat Prod

RESVERATROL PRKD1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stewart et al., 2000, Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation., Biochem. Pharmacol.

RESVERATROL CSNK2A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

RESVERATROL DIABLO

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Aziz et al., 2005, Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?, FASEB J.

Aziz et al., Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin., Photochem. Photobiol.

RESVERATROL GDF15

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Baek et al., 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53., Carcinogenesis
RESVERATROL CEL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sbarra et al., 2005, In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim. Biophys. Acta
RESVERATROL GSTP1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Mollerup et al., 2001, Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells., Int. J. Cancer

RESVERATROL APP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lu C et al., 2013, Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease., J Med Chem

Ahn JS et al., 2007, Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol., Anal Biochem

RESVERATROL PIK3CA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Poolman et al., 2005, Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling., Free Radic. Biol. Med.

RESVERATROL MMP2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Gagliano et al., 2005, Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells., Biomed. Pharmacother.

RESVERATROL PECAM1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Tseng et al., 2004, Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats., Clin. Cancer Res.
RESVERATROL CDK2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Reagan-Shaw et al., 2004, Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin., Oncogene

RESVERATROL SLC2A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lekli et al., 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am. J. Physiol. Heart Circ. Physiol.

RESVERATROL ESR1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lappano R et al., 2009, Structure-activity relationships of resveratrol and derivatives in breast cancer cells., Mol Nutr Food Res

RESVERATROL HSPB2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bezstarosti et al., Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol., J. Cell. Mol. Med.

Wang et al., 2006, Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts., Biochem. Biophys. Res. Commun.

RESVERATROL BIRC5

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sakoguchi-Okada et al., 2007, Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells., Biochem. Pharmacol.

Aziz et al., 2005, Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?, FASEB J.

Fulda et al., 2004, Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol., Cancer Res.

RESVERATROL AHR

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

de Medina P et al., 2005, Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators., J Med Chem

RESVERATROL MAPK14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Das et al., 2006, Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J. Pharmacol. Exp. Ther.

RESVERATROL PRKCA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem
RESVERATROL SNCA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ahn JS et al., 2007, Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol., Anal Biochem
RESVERATROL KHSRP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bollmann F et al., 2014, Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity., Nucleic Acids Res
RESVERATROL PI4K2B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Srivastava R et al., 2005, Resveratrol inhibits type II phosphatidylinositol 4-kinase: a key component in pathways of phosphoinositide turn over., Biochem Pharmacol
RESVERATROL ITGB3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Davis PJ et al., 2013, Small molecule hormone or hormone-like ligands of integrin αVβ3: implications for cancer cell behavior., Horm Cancer
RESVERATROL CLEC14A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wang Y et al., 2010, Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines., Hum Mol Genet
RESVERATROL ALOX15

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

MacCarrone M et al., 1999, Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity., Eur J Biochem
RESVERATROL NR1I2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact
RESVERATROL ALOX5

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

MacCarrone M et al., 1999, Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity., Eur J Biochem
RESVERATROL PPARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med
RESVERATROL MTNR1A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ferry G et al., 2010, Old and new inhibitors of quinone reductase 2., Chem Biol Interact
RESVERATROL MTNR1B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ferry G et al., 2010, Old and new inhibitors of quinone reductase 2., Chem Biol Interact
RESVERATROL ITGA5

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Davis PJ et al., 2013, Small molecule hormone or hormone-like ligands of integrin αVβ3: implications for cancer cell behavior., Horm Cancer
RESVERATROL NR1I3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact

RESVERATROL SLC2A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Salas M et al., 2013, Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation., Am J Physiol Cell Physiol

RESVERATROL POLK

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL AR

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL HSD17B10

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL SMN2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL SMN1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL NFKB2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL NFKB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL TP53

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL GFER

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL ATAD5

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL NFE2L2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL RELA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL NPC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL EHMT2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL HTT

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL CYP3A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL BRCA1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL MAPT

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RESVERATROL HIF1A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

DrugBank: DB02709

Version: 5.1.7

Alternate Names:

RESVERATROL DrugBank Drug Name

501-36-0 CAS Number

Co-Balamin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories analgesics

Publications:

Ahn JS et al., 2007, Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol., Anal Biochem

Sajish M et al., 2015, A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol., Nature

Bollmann F et al., 2014, Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity., Nucleic Acids Res

TdgClinicalTrial: RESVERATROL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of herpes simplex virus 1

Drug Class small molecule

FDA Approval not approved

Publications:

NCI: RESVERATROL

Version: 14-September-2017

Alternate Names:

C1215 NCI drug code

Drug Info:

Publications:

Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.

Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.

Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis

DTC: RESVERATROL

Version: 02-September-2020

Alternate Names:

CHEMBL165 ChEMBL Drug ID

Drug Info:

Publications:

Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem

Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem

Wu J et al., 2013, Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate., J Med Chem

GuideToPharmacologyInteractions: 252827399
- Version: 20-July-2020
Alternate Names:

RESVERATROL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL165
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	Resveratrol
Novel drug target	Established target
Trial Name	SRT501

RESVERATROL	DrugBank Drug Name
501-36-0	CAS Number
Co-Balamin	Drug Brand

RESVERATROL Drug Record

RESVERATROL chembl:CHEMBL165 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications: Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

Publications: Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Ito Y et al., 2013, Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4'-amino-3,5-dihydroxy-trans-stilbene., J Nutr Sci Vitaminol (Tokyo)

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Sajish M et al., 2015, A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol., Nature

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Resveratrol Novel drug target Established target Trial Name SRT501

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name SRT501 Novel drug target Established target Trial Name Resveratrol

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wang et al., 2004, Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography., Biochem. Biophys. Res. Commun. Buryanovskyy et al., 2004, Crystal structure of quinone reductase 2 in complex with resveratrol., Biochemistry

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Boissy et al., 2005, Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation., Cancer Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Park JB, 2001, Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Stewart et al., 2000, Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation., Biochem. Pharmacol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Aziz et al., 2005, Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?, FASEB J. Aziz et al., Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin., Photochem. Photobiol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Baek et al., 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53., Carcinogenesis

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Sbarra et al., 2005, In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim. Biophys. Acta

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Mollerup et al., 2001, Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells., Int. J. Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Poolman et al., 2005, Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling., Free Radic. Biol. Med.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Gagliano et al., 2005, Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells., Biomed. Pharmacother.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Tseng et al., 2004, Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats., Clin. Cancer Res.

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

Publications:

Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Ito Y et al., 2013, Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4'-amino-3,5-dihydroxy-trans-stilbene., J Nutr Sci Vitaminol (Tokyo)

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Sajish M et al., 2015, A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol., Nature

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resveratrol

Novel drug target Established target

Trial Name SRT501

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SRT501

Novel drug target Established target

Trial Name Resveratrol

Interaction Types & Directionality:

n/a

Publications:

Wang et al., 2004, Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography., Biochem. Biophys. Res. Commun.

Buryanovskyy et al., 2004, Crystal structure of quinone reductase 2 in complex with resveratrol., Biochemistry

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem

Interaction Types & Directionality:

n/a

Publications:

Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.

Interaction Types & Directionality:

n/a

Publications:

Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.

Interaction Types & Directionality:

n/a

Publications:

Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis

Interaction Types & Directionality:

n/a

Publications:

Boissy et al., 2005, Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation., Cancer Res.

Interaction Types & Directionality:

n/a

Publications:

Park JB, 2001, Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Stewart et al., 2000, Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation., Biochem. Pharmacol.

Interaction Types & Directionality:

n/a

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Aziz et al., 2005, Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?, FASEB J.

Aziz et al., Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin., Photochem. Photobiol.

Interaction Types & Directionality:

n/a

Publications:

Baek et al., 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53., Carcinogenesis

Interaction Types & Directionality:

n/a

Publications:

Sbarra et al., 2005, In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim. Biophys. Acta

Interaction Types & Directionality:

n/a

Publications:

Mollerup et al., 2001, Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells., Int. J. Cancer

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Poolman et al., 2005, Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling., Free Radic. Biol. Med.

Interaction Types & Directionality:

n/a

Publications:

Gagliano et al., 2005, Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells., Biomed. Pharmacother.

Interaction Types & Directionality:

n/a

Publications:

Tseng et al., 2004, Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats., Clin. Cancer Res.

Interaction Types & Directionality:

n/a

Publications:

Reagan-Shaw et al., 2004, Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin., Oncogene

Interaction Types & Directionality:

n/a

Publications:

Lekli et al., 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am. J. Physiol. Heart Circ. Physiol.

Interaction Types & Directionality:

n/a

Publications:

Lappano R et al., 2009, Structure-activity relationships of resveratrol and derivatives in breast cancer cells., Mol Nutr Food Res

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

de Medina P et al., 2005, Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators., J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Das et al., 2006, Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J. Pharmacol. Exp. Ther.

Interaction Types & Directionality:

n/a

Publications:

Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Ahn JS et al., 2007, Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol., Anal Biochem

Interaction Types & Directionality:

n/a

Publications:

Bollmann F et al., 2014, Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity., Nucleic Acids Res