DGIdb - RESVERATROL Drug Record

RESVERATROL chembl:CHEMBL165 Antineoplastic

Alternate Names:

BIA 6-512
(E)-RESVERATROL
NSC-327430
RESVERATROL
BIA-6-512
3,5,4'-TRIHYDROXY-TRANS-STILBENE

Drug Info:

Drug Indications	antidiabetic,antineoplastic agent
FDA Approval	not approved
Drug Class	small molecule
Drug Indications	for treatment of herpes simplex virus 1

(1 More Sources)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ota H et al., 2013, trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence., J Nat Prod
Milne et al., 2007, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes., Nature
Wu J et al., 2013, Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate., J Med Chem
Hubbard BP et al., 2013, Evidence for a common mechanism of SIRT1 regulation by allosteric activators., Science
Lakshminarasimhan M et al., 2013, Sirt1 activation by resveratrol is substrate sequence-selective., Aging (Albany NY)
Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem
Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.
Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.
Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis
Boissy et al., 2005, Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation., Cancer Res.
Park JB, 2001, Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells., J Nat Prod
Stewart et al., 2000, Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation., Biochem. Pharmacol.
Aziz et al., 2005, Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?, FASEB J.
Aziz et al., Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin., Photochem. Photobiol.
Baek et al., 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53., Carcinogenesis
Sbarra et al., 2005, In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim. Biophys. Acta
Mollerup et al., 2001, Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells., Int. J. Cancer
Lu C et al., 2013, Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease., J Med Chem
Ahn JS et al., 2007, Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol., Anal Biochem
Poolman et al., 2005, Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling., Free Radic. Biol. Med.
Gagliano et al., 2005, Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells., Biomed. Pharmacother.
Tseng et al., 2004, Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats., Clin. Cancer Res.
Reagan-Shaw et al., 2004, Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin., Oncogene
Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med
Hsieh TC et al., 2014, Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2., PLoS One
Lekli et al., 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am. J. Physiol. Heart Circ. Physiol.
Lappano R et al., 2009, Structure-activity relationships of resveratrol and derivatives in breast cancer cells., Mol Nutr Food Res
Bezstarosti et al., Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol., J. Cell. Mol. Med.
Wang et al., 2006, Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts., Biochem. Biophys. Res. Commun.
Sakoguchi-Okada et al., 2007, Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells., Biochem. Pharmacol.
Fulda et al., 2004, Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol., Cancer Res.
de Medina P et al., 2005, Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators., J Med Chem
Das et al., 2006, Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J. Pharmacol. Exp. Ther.
Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem

RESVERATROL PECAM1

Interaction Score: 2.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15041740

Sources:
NCI
RESVERATROL FOXO3

Interaction Score: 1.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17513867

Sources:
DTC
RESVERATROL DIABLO

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15837718 15469386

Sources:
NCI
RESVERATROL SLC2A3

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11277764

Sources:
DTC
RESVERATROL RIPK1

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16116226

Sources:
NCI
RESVERATROL CEL

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16099206

Sources:
NCI
RESVERATROL GDF15

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11895857

Sources:
NCI
RESVERATROL HSPB2

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17125593 16759640

Sources:
NCI
RESVERATROL SIRT1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859249 18046409 23316803 23471411 23524286

Sources:
DTC
RESVERATROL PRKD1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11008129

Sources:
NCI
RESVERATROL HGF

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15672869

Sources:
NCI
RESVERATROL BIRC5

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17270149 15837718 14729643

Sources:
NCI
RESVERATROL APP

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23799643 17597573

Sources:
DTC
RESVERATROL PRKCA

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21880495

Sources:
DTC
RESVERATROL BGLAP

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16267019

Sources:
NCI
RESVERATROL MMP2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16084059

Sources:
NCI
RESVERATROL IL1B

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16389574

Sources:
NCI
RESVERATROL SLC2A4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18065527

Sources:
NCI
RESVERATROL GSTP1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11279601

Sources:
NCI
RESVERATROL AKT1

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17513867 24968355

Sources:
DTC
RESVERATROL AHR

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15634023

Sources:
DTC
RESVERATROL PDE4D

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resveratrol

Novel drug target Established target

Trial Name SRT501

PMIDs:
None found

Sources:
TdgClinicalTrial
RESVERATROL PDE4B

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SRT501

Novel drug target Established target

Trial Name Resveratrol

PMIDs:
None found

Sources:
TdgClinicalTrial
RESVERATROL CDK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15122319

Sources:
NCI
RESVERATROL MAPK14

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16525036

Sources:
NCI
RESVERATROL NFKB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL GFER

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL PTGS2

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
11752352

Sources:
GuideToPharmacology
RESVERATROL RELA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
24454499

Sources:
GuideToPharmacology
RESVERATROL PIK3CA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15925284

Sources:
NCI
RESVERATROL NFKB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL BRCA1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL ESR1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19496085

Sources:
DTC
RESVERATROL SMN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL SMN1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL NPC1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL HIF1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL HTT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL POLK

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL ATAD5

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL TP53

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL MAPT

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: RESVERATROL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of herpes simplex virus 1

Drug Class small molecule

FDA Approval not approved

Publications:

NCI: RESVERATROL

Version: 14-September-2017

Alternate Names:

C1215 NCI drug code

Drug Info:

Publications:

Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.

Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.

Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis

DTC: RESVERATROL

Version: 02-September-2020

Alternate Names:

CHEMBL165 ChEMBL Drug ID

Drug Info:

Publications:

Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem

Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem

Wu J et al., 2013, Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate., J Med Chem

GuideToPharmacology: 252827399
- Version: 29-September-2020
Alternate Names:

RESVERATROL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL165
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	Resveratrol
Novel drug target	Established target
Trial Name	SRT501

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	False

RESVERATROL Drug Record

RESVERATROL chembl:CHEMBL165 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15041740

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17513867

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15837718 15469386

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11277764

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16116226

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16099206

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11895857

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17125593 16759640

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23859249 18046409 23316803 23471411 23524286

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11008129

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15672869

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17270149 15837718 14729643

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23799643 17597573

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21880495

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16267019

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16084059

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16389574

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18065527

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11279601

Interaction Types & Directionality:

n/a

PMIDs:
15041740

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17513867

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15837718 15469386

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11277764

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16116226

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16099206

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11895857

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17125593 16759640

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23859249 18046409 23316803 23471411 23524286

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11008129

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15672869

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17270149 15837718 14729643

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23799643 17597573

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21880495

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16267019

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16084059

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16389574

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18065527

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11279601

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17513867 24968355

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15634023

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resveratrol

Novel drug target Established target

Trial Name SRT501

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SRT501

Novel drug target Established target

Trial Name Resveratrol

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
15122319

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16525036

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC