DGIdb - REMIFENTANIL Drug Record

REMIFENTANIL chembl:CHEMBL1005 Approved

Alternate Names:

IDS-NR-005
GI 87084X
ULTIVA
REMIFENTANIL
REMIFENTANYL
ULTIVA®
GI-87084B
pubchem.compound:60815
drugbank:00899
chembl:CHEMBL1005
chemidplus:132875-61-7
rxcui:73032

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic
Year of Approval	1996
Drug Class	analgesics, opioid

(1 More Sources)

Publications:

Guy et al., 1997, Comparison of remifentanil and fentanyl in patients undergoing craniotomy for supratentorial space-occupying lesions., Anesthesiology
Scott et al., 2005, Spotlight on remifentanil for general anaesthesia., CNS Drugs
Scott et al., 2005, Remifentanil: a review of its use during the induction and maintenance of general anaesthesia., Drugs
Patel et al., 1996, Remifentanil., Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Warner et al., 1996, Intracranial pressure and hemodynamic effects of remifentanil versus alfentanil in patients undergoing supratentorial craniotomy., Anesth. Analg.
Hoke et al., 1997, Comparative pharmacokinetics and pharmacodynamics of remifentanil, its principle metabolite (GR90291) and alfentanil in dogs., J. Pharmacol. Exp. Ther.
Zhang Y et al., 2017, Correlation of MDR1 gene polymorphism with propofol combined with remifentanil anesthesia in pediatric tonsillectomy., Oncotarget
Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
Nishizawa D et al., 2018, Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy., Pharmacogenomics
Aubrun F et al., 2018, Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study., Eur J Anaesthesiol
Matic M et al., 2017, Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement., Pharmacogenomics
Hronová K et al., 2016, Sufentanil and midazolam dosing and pharmacogenetic factors in pediatric analgosedation and withdrawal syndrome., Physiol Res
Elens L et al., 2016, Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation., Ther Drug Monit
De Gregori M et al., 2016, Human Genetic Variability Contributes to Postoperative Morphine Consumption., J Pain
Candiotti KA et al., 2014, Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain., Anesth Analg
Matic M et al., 2014, Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype., Pharmacogenomics
Cargnin S et al., 2013, An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans., J Pain
De Gregori M et al., 2013, Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain., Eur J Clin Pharmacol
Landau R et al., 2013, The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia., Anesth Analg
Klepstad P et al., 2011, Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients., Pain
Lötsch J et al., 2009, Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers., Pharmacogenet Genomics

REMIFENTANIL PGAP6

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29207912

Sources:
PharmGKB
REMIFENTANIL COMT

Interaction Score: 5.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29474345 28745577 28006928 27027462 26902643 25185591 25155931 23773341 23686330 23302985 21398039 19514130

Sources:
PharmGKB
REMIFENTANIL OPRM1

Interaction Score: 1.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name remifentanil,Ultiva

Novel drug target Established target

PMIDs:
9066316 16332149 16114980 8875131 11752352 8694317 9103501

Sources:
TdgClinicalTrial TEND
REMIFENTANIL ADRB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26771271

Sources:
PharmGKB
REMIFENTANIL ABCB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29755652

Sources:
PharmGKB

TEND: REMIFENTANIL
- Version: 01-August-2011
Alternate Names:

REMIFENTANIL Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval 1996

Publications:
TdgClinicalTrial: REMIFENTANIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: remifentanil

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Nishizawa D et al., 2018, Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy., Pharmacogenomics

Zhang Y et al., 2017, Correlation of MDR1 gene polymorphism with propofol combined with remifentanil anesthesia in pediatric tonsillectomy., Oncotarget

Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg

TTD: Remifentanil
- Version: 2020.06.01
Alternate Names:

D0T5OX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1005
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	remifentanil,Ultiva
Novel drug target	Established target

REMIFENTANIL Drug Record

REMIFENTANIL chembl:CHEMBL1005 Approved

Alternate Names:

Drug Info:

Publications:

REMIFENTANIL PGAP6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29207912

Sources: PharmGKB

REMIFENTANIL COMT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29474345 28745577 28006928 27027462 26902643 25185591 25155931 23773341 23686330 23302985 21398039 19514130

Sources: PharmGKB

REMIFENTANIL OPRM1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name remifentanil,Ultiva Novel drug target Established target

PMIDs: 9066316 16332149 16114980 8875131 11752352 8694317 9103501

Sources: TdgClinicalTrial TEND

REMIFENTANIL ADRB2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26771271

Sources: PharmGKB

REMIFENTANIL ABCB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29755652

Sources: PharmGKB

TEND: REMIFENTANIL

Alternate Names: REMIFENTANIL Primary Drug Name

Drug Info: Drug Class analgesics, opioid Year of Approval 1996

Publications:

TdgClinicalTrial: REMIFENTANIL

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: remifentanil

Alternate Names:

Drug Info:

TTD: Remifentanil

Alternate Names: D0T5OX TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1005

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
29207912

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29474345 28745577 28006928 27027462 26902643 25185591 25155931 23773341 23686330 23302985 21398039 19514130

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name remifentanil,Ultiva

Novel drug target Established target

PMIDs:
9066316 16332149 16114980 8875131 11752352 8694317 9103501

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
26771271

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29755652

Sources:
PharmGKB

Alternate Names:

REMIFENTANIL Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval 1996

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0T5OX TTD Drug ID