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REMIFENTANIL Drug Record

  • Summary
  • Interactions
  • Claims
  • REMIFENTANIL chembl:CHEMBL1005 Approved

    Alternate Names:

    IDS-NR-005
    GI 87084X
    ULTIVA
    REMIFENTANIL
    REMIFENTANYL
    ULTIVA®
    GI-87084B
    pubchem.compound:60815
    drugbank:00899
    chembl:CHEMBL1005
    chemidplus:132875-61-7
    rxcui:73032

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    Year of Approval 1996
    Drug Class analgesics, opioid
    (1 More Sources)

    Publications:

    Guy et al., 1997, Comparison of remifentanil and fentanyl in patients undergoing craniotomy for supratentorial space-occupying lesions., Anesthesiology
    Scott et al., 2005, Spotlight on remifentanil for general anaesthesia., CNS Drugs
    Scott et al., 2005, Remifentanil: a review of its use during the induction and maintenance of general anaesthesia., Drugs
    Patel et al., 1996, Remifentanil., Drugs
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Warner et al., 1996, Intracranial pressure and hemodynamic effects of remifentanil versus alfentanil in patients undergoing supratentorial craniotomy., Anesth. Analg.
    Hoke et al., 1997, Comparative pharmacokinetics and pharmacodynamics of remifentanil, its principle metabolite (GR90291) and alfentanil in dogs., J. Pharmacol. Exp. Ther.
    Zhang Y et al., 2017, Correlation of MDR1 gene polymorphism with propofol combined with remifentanil anesthesia in pediatric tonsillectomy., Oncotarget
    Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
    Nishizawa D et al., 2018, Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy., Pharmacogenomics
    Aubrun F et al., 2018, Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study., Eur J Anaesthesiol
    Matic M et al., 2017, Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement., Pharmacogenomics
    Hronová K et al., 2016, Sufentanil and midazolam dosing and pharmacogenetic factors in pediatric analgosedation and withdrawal syndrome., Physiol Res
    Elens L et al., 2016, Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation., Ther Drug Monit
    De Gregori M et al., 2016, Human Genetic Variability Contributes to Postoperative Morphine Consumption., J Pain
    Candiotti KA et al., 2014, Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain., Anesth Analg
    Matic M et al., 2014, Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype., Pharmacogenomics
    Cargnin S et al., 2013, An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans., J Pain
    De Gregori M et al., 2013, Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain., Eur J Clin Pharmacol
    Landau R et al., 2013, The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia., Anesth Analg
    Klepstad P et al., 2011, Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients., Pain
    Lötsch J et al., 2009, Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers., Pharmacogenet Genomics
  • REMIFENTANIL   PGAP6

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29207912


    Sources:
    PharmGKB

  • REMIFENTANIL   COMT

    Interaction Score: 5.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29474345 28745577 28006928 27027462 26902643 25185591 25155931 23773341 23686330 23302985 21398039 19514130


    Sources:
    PharmGKB

  • REMIFENTANIL   OPRM1

    Interaction Score: 1.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name remifentanil,Ultiva
    Novel drug target Established target

    PMIDs:
    9066316 16332149 16114980 8875131 11752352 8694317 9103501


    Sources:
    TdgClinicalTrial TEND

  • REMIFENTANIL   ADRB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26771271


    Sources:
    PharmGKB

  • REMIFENTANIL   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29755652


    Sources:
    PharmGKB

  • TEND: REMIFENTANIL

    • Version: 01-August-2011

    Alternate Names:
    REMIFENTANIL Primary Drug Name

    Drug Info:
    Drug Class analgesics, opioid
    Year of Approval 1996

    Publications:

  • TdgClinicalTrial: REMIFENTANIL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • PharmGKB: remifentanil

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Nishizawa D et al., 2018, Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy., Pharmacogenomics
    Zhang Y et al., 2017, Correlation of MDR1 gene polymorphism with propofol combined with remifentanil anesthesia in pediatric tonsillectomy., Oncotarget
    Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg

  • TTD: Remifentanil

    • Version: 2020.06.01

    Alternate Names:
    D0T5OX TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1005

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21