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RASAGILINE Drug Record

  • Summary
  • Interactions
  • Claims
  • RASAGILINE chembl:CHEMBL887 Approved

    Alternate Names:

    TV-1030
    AGN-1135
    RASAGILINE
    AZILECT
    (1R)-N-PROPARGYLINDAN-1-AMINE
    (R)-INDAN-1-YL-PROP-2-YNYL-AMINE
    (R)-N-2-PROPYNYL-1-INDANAMINE
    RAS
    TVP-1012
    AZILECT®
    chembl:CHEMBL887
    chemidplus:136236-51-6
    rxcui:134748
    pubchem.compound:3052776
    drugbank:01367

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiparkinson agent
    Drug Class antiparkinson agents
    Year of Approval 2006
    Drug Categories serotonin modulators
    Drug Categories agents that produce hypertension
    Drug Categories agents that reduce seizure threshold
    Drug Categories antidepressive agents
    Drug Categories central nervous system depressants
    Drug Categories compounds used in a research, industrial, or household setting
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin agents
    (3 More Sources)

    Publications:

    Youdim et al., 2001, Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]., Cell. Mol. Neurobiol.
    Naoi et al., 2009, Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease., Expert Rev Neurother
    Uzun et al., Investigation of oral selegiline and rasagiline administration on QT interval in conscious rabbits., Eur Rev Med Pharmacol Sci
    Chau et al., 2010, Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells., Neurochem. Int.
    Chen et al., 2007, Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease., Clin Ther
    Youdim et al., Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition., J. Neurosci. Res.
    Weinreb et al., 2010, Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity., Prog. Neurobiol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Leegwater-Kim et al., 2010, The role of rasagiline in the treatment of Parkinson's disease., Clin Interv Aging
    Masellis M et al., 2016, Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study., Brain
    Youdim et al., 2003, The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline., Biochem. Pharmacol.
    Bar-Am et al., 2005, Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine., FASEB J.
    Maruyama et al., Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes., Neurotoxicol Teratol
    Akao et al., 2002, An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells., Neurosci. Lett.
  • RASAGILINE   MAOB

    Interaction Score: 3.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name rasagiline mesylate, TVP-1012,Agilect
    Novel drug target Established target
    Specific Action of the Ligand Inhibition

    PMIDs:
    12043833 19673610 19499843 20624440 18035186 15573406 20600573 11752352 20517484


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • RASAGILINE   BCL2

    Interaction Score: 2.32

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    14555244 16148027 12043833 12200198 12057839


    Sources:
    DrugBank

  • RASAGILINE   DRD2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27190009


    Sources:
    PharmGKB

  • DrugBank: DB01367

    • Version: 5.1.7

    Alternate Names:
    RASAGILINE DrugBank Drug Name
    136236-51-6 CAS Number
    Apo-rasagiline Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories agents that produce hypertension

    Publications:
    Youdim et al., 2003, The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline., Biochem. Pharmacol.
    Bar-Am et al., 2005, Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine., FASEB J.
    Youdim et al., 2001, Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]., Cell. Mol. Neurobiol.

  • TEND: RASAGILINE

    • Version: 01-August-2011

    Alternate Names:
    RASAGILINE Primary Drug Name

    Drug Info:
    Year of Approval 2006
    Drug Class antiparkinson agents

    Publications:

  • TdgClinicalTrial: RASAGILINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiparkinson agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • PharmGKB: rasagiline

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Masellis M et al., 2016, Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study., Brain

  • GuideToPharmacology: 178103254

    • Version: 29-September-2020

    Alternate Names:
    RASAGILINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: Rasagiline

    • Version: 2020.06.01

    Alternate Names:
    D06OMW TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL887

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21