DGIdb - RANITIDINE Drug Record

RANITIDINE chembl:CHEMBL1790041 Approved

Alternate Names:

TRITEC
ZANTAC
RANITIDINE
RAN
chemidplus:66357-35-5
drugbank:00863
pubchem.compound:5039
chembl:CHEMBL1790041
rxcui:9143

Drug Info:

Drug Categories	elements
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiulcer agent
Drug Class	gi anti-ulcer agents, antihistamines
Year of Approval	1981
Drug Groups	withdrawn
Drug Categories	acid reducers
Drug Categories	agents causing muscle toxicity
Drug Categories	cholinesterase inhibitors
Drug Categories	cytochrome p-450 cyp1a2 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (weak)
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	gastric acid lowering agents
Drug Categories	oat1/slc22a6 inhibitors
Drug Categories	oat1/slc22a6 substrates
Drug Categories	oat3/slc22a8 substrates
Drug Categories	oct1 inhibitors
Drug Categories	oct1 substrates
Drug Categories	oct2 inhibitors
Drug Categories	oct2 substrates
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates

(5 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Pattichis et al., 1995, Histamine, histamine H2-receptor antagonists, gastric acid secretion and ulcers: an overview., Drug Metabol Drug Interact
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Grant SM et al., 1989, Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases., Drugs
Ottlecz et al., 1999, Effect of ranitidine bismuth citrate on the phospholipase A2 activity of Naja naja venom and Helicobacter pylori: a biochemical analysis., Aliment. Pharmacol. Ther.
Fiore et al., 1985, Long-term effects of histamine H2-receptor antagonists on serum parathyroid hormone in chronic renal failure., Clin. Endocrinol. (Oxf)
Biagi et al., 1985, [Effects of H2 blockers on blood levels of parathormones and calcitonin in normal subjects]., Minerva Med.
Collett et al., 1999, Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2., J. Pharmacol. Exp. Ther.
Tao et al., 2001, Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats., J. Tongji Med. Univ.
Hu et al., 1990, [A new therapy of hemophilia with ranitidine]., Zhonghua Nei Ke Za Zhi
el-Omar et al., 1996, Marked rebound acid hypersecretion after treatment with ranitidine., Am. J. Gastroenterol.
Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
Aono M et al., 1986, Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase., Gastroenterol Jpn
Laine-Cessac P et al., 1993, Inhibition of cholinesterases by histamine 2 receptor antagonist drugs., Res Commun Chem Pathol Pharmacol
Petroianu GA et al., 2005, Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of ranitidine., J Appl Toxicol
Kounenis G et al., 1986, The inhibition of acetylcholinesterase by ranitidine: a study on the guinea pig ileum., J Pharmacobiodyn

RANITIDINE GRP

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8607506

Sources:
NCI
RANITIDINE F8

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2120016

Sources:
NCI
RANITIDINE HRH2

Interaction Score: 0.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ranitidine bismuth citrate,Tritec

Novel drug target Established target

Trial Name Zantac,ranitidine hydrochloride

PMIDs:
7554999 11752352 2667937

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD
RANITIDINE PTH

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3878237 2864665

Sources:
NCI
RANITIDINE CALCA

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12495560

Sources:
NCI
RANITIDINE ACHE

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
2874096 8095733 15669026 3559884

Sources:
DrugBank
RANITIDINE PLA2G1B

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10383521

Sources:
NCI
RANITIDINE HSPA4

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11523209

Sources:
NCI
RANITIDINE ABCB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9862768

Sources:
NCI PharmGKB
RANITIDINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
RANITIDINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
RANITIDINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
RANITIDINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
RANITIDINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
RANITIDINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00863

Version: 5.1.7

Alternate Names:

Sandoz Ranitidine Drug Brand

RANITIDINE DrugBank Drug Name

66357-35-5 CAS Number

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups withdrawn

Publications:

Kounenis G et al., 1986, The inhibition of acetylcholinesterase by ranitidine: a study on the guinea pig ileum., J Pharmacobiodyn

Petroianu GA et al., 2005, Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of ranitidine., J Appl Toxicol

Laine-Cessac P et al., 1993, Inhibition of cholinesterases by histamine 2 receptor antagonist drugs., Res Commun Chem Pathol Pharmacol

TEND: RANITIDINE
- Version: 01-August-2011
Alternate Names:

RANITIDINE Primary Drug Name

Drug Info:

Year of Approval 1981

Drug Class gi anti-ulcer agents, antihistamines

Publications:
TdgClinicalTrial: RANITIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiulcer agent

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: RANITIDINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1790041 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: RANITIDINE

Version: 14-September-2017

Alternate Names:

C29412 NCI drug code

Drug Info:

Publications:

Tao et al., 2001, Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats., J. Tongji Med. Univ.

Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.

el-Omar et al., 1996, Marked rebound acid hypersecretion after treatment with ranitidine., Am. J. Gastroenterol.

TTD: Ranitidine
- Version: 2020.06.01
Alternate Names:

D0B8WN TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650887
- Version: 29-September-2020
Alternate Names:

RANITIDINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1790041
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: ranitidine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	ranitidine bismuth citrate,Tritec
Novel drug target	Established target
Trial Name	Zantac,ranitidine hydrochloride

Sandoz Ranitidine	Drug Brand
RANITIDINE	DrugBank Drug Name
66357-35-5	CAS Number

Drug Type	small molecule
Drug Groups	approved
Drug Groups	withdrawn

RANITIDINE Drug Record

RANITIDINE chembl:CHEMBL1790041 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8607506

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2120016

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name ranitidine bismuth citrate,Tritec Novel drug target Established target Trial Name Zantac,ranitidine hydrochloride

PMIDs: 7554999 11752352 2667937

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3878237 2864665

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12495560

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 2874096 8095733 15669026 3559884

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10383521

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11523209

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9862768

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00863

Alternate Names: Sandoz Ranitidine Drug Brand RANITIDINE DrugBank Drug Name 66357-35-5 CAS Number

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups withdrawn

TEND: RANITIDINE

Alternate Names: RANITIDINE Primary Drug Name

Drug Info: Year of Approval 1981 Drug Class gi anti-ulcer agents, antihistamines

Publications:

TdgClinicalTrial: RANITIDINE

Alternate Names:

Drug Info: Drug Indications antiulcer agent Drug Class Small Molecule FDA Approval approved

Publications:

DTC: RANITIDINE

Alternate Names: CHEMBL1790041 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

Interaction Types & Directionality:

n/a

PMIDs:
8607506

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2120016

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ranitidine bismuth citrate,Tritec

Novel drug target Established target

Trial Name Zantac,ranitidine hydrochloride

PMIDs:
7554999 11752352 2667937

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
3878237 2864665

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12495560

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
2874096 8095733 15669026 3559884

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10383521

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11523209

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9862768

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

Sandoz Ranitidine Drug Brand

RANITIDINE DrugBank Drug Name

66357-35-5 CAS Number

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups withdrawn

Alternate Names:

RANITIDINE Primary Drug Name

Drug Info:

Year of Approval 1981

Drug Class gi anti-ulcer agents, antihistamines

Drug Info:

Drug Indications antiulcer agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1790041 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

C29412 NCI drug code

Alternate Names:

D0B8WN TTD Drug ID

Alternate Names:

RANITIDINE GuideToPharmacology Ligand Name