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RANITIDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • RANITIDINE chembl:CHEMBL1790041 Approved

    Alternate Names:

    TRITEC
    ZANTAC
    RANITIDINE
    RAN
    chemidplus:66357-35-5
    drugbank:00863
    pubchem.compound:5039
    chembl:CHEMBL1790041
    rxcui:9143

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiulcer agent
    Drug Class gi anti-ulcer agents, antihistamines
    Year of Approval 1981
    (3 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Pattichis et al., 1995, Histamine, histamine H2-receptor antagonists, gastric acid secretion and ulcers: an overview., Drug Metabol Drug Interact
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Grant SM et al., 1989, Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases., Drugs
    Ottlecz et al., 1999, Effect of ranitidine bismuth citrate on the phospholipase A2 activity of Naja naja venom and Helicobacter pylori: a biochemical analysis., Aliment. Pharmacol. Ther.
    Fiore et al., 1985, Long-term effects of histamine H2-receptor antagonists on serum parathyroid hormone in chronic renal failure., Clin. Endocrinol. (Oxf)
    Biagi et al., 1985, [Effects of H2 blockers on blood levels of parathormones and calcitonin in normal subjects]., Minerva Med.
    Collett et al., 1999, Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2., J. Pharmacol. Exp. Ther.
    Tao et al., 2001, Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats., J. Tongji Med. Univ.
    Hu et al., 1990, [A new therapy of hemophilia with ranitidine]., Zhonghua Nei Ke Za Zhi
    el-Omar et al., 1996, Marked rebound acid hypersecretion after treatment with ranitidine., Am. J. Gastroenterol.
    Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
  • RANITIDINE   HRH2

    Interaction Score: 1.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ranitidine bismuth citrate,Tritec
    Novel drug target Established target
    Trial Name Zantac,ranitidine hydrochloride

    PMIDs:
    7554999 11752352 2667937


    Sources:
    TdgClinicalTrial TEND TTD

  • RANITIDINE   F8

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2120016


    Sources:
    NCI

  • RANITIDINE   GRP

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8607506


    Sources:
    NCI

  • RANITIDINE   PTH

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3878237 2864665


    Sources:
    NCI

  • RANITIDINE   CALCA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12495560


    Sources:
    NCI

  • RANITIDINE   PLA2G1B

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10383521


    Sources:
    NCI

  • RANITIDINE   HSPA4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11523209


    Sources:
    NCI

  • RANITIDINE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9862768


    Sources:
    NCI PharmGKB

  • RANITIDINE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • RANITIDINE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • RANITIDINE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • RANITIDINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • RANITIDINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • RANITIDINE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: RANITIDINE

    • Version: 01-August-2011

    Alternate Names:
    RANITIDINE Primary Drug Name

    Drug Info:
    Year of Approval 1981
    Drug Class gi anti-ulcer agents, antihistamines

    Publications:

  • TdgClinicalTrial: RANITIDINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiulcer agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: RANITIDINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1790041 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • NCI: RANITIDINE

    • Version: 14-September-2017

    Alternate Names:
    C29412 NCI drug code

    Drug Info:

    Publications:
    Tao et al., 2001, Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats., J. Tongji Med. Univ.
    Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
    el-Omar et al., 1996, Marked rebound acid hypersecretion after treatment with ranitidine., Am. J. Gastroenterol.

  • TTD: Ranitidine

    • Version: 2020.06.01

    Alternate Names:
    D0B8WN TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1790041

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: ranitidine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21